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MARK1 (human)

Overview MARK1 a member of the CAMKL family of protein kinases. The MARK group of kinases is apparently involved in the control of cell polarity, microtubule stability and cancer. MARK1 forms a tight association with Tau in neurofibrillary tangles in Alzheimer disease tissue. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.26; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, CAMK; CAMK group; CAMKL family; MARK subfamily Cellular Component: microtubule cytoskeleton; cytoskeleton; cytoplasm; plasma membrane Molecular Function: protein serine/threonine kinase activity; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; tau-protein kinase activity; magnesium ion binding; ATP binding Biological Process: Wnt receptor signaling pathway; neuron migration; protein kinase cascade; cytoskeleton organization and biogenesis; microtubule cytoskeleton organization and biogenesis; protein amino acid phosphorylation Reference #:  Q9P0L2 (UniProtKB) Alt. Names/Synonyms: KIAA1477; MAP/microtubule affinity-regulating kinase 1; MARK; MARK1; MGC126512; MGC126513; Serine/threonine-protein kinase MARK1 Gene Symbols: MARK1 Molecular weight: 89,003 Da Basal Isoelectric point: 9.42  Predict pI for various phosphorylation states CST Pathways:  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MARK1 2HAK - A/B/C/D/E/F/G/H=45-371 (human) 3OSE - A=683-795 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T5-p	___MSARtPLPTVNE
0	2		S36-p	IQPTKSSsRQNIPRC
0	2		S46-p	NIPRCRNsITSATDE
3	46		T215-p	TVGNKLDtFCGsPPY
1	14		S219-p	KLDtFCGsPPYAAPE
0	1		K298	LLVLNPIKRGSLEQI
0	2		S382	FEGGESLSSGNLCQR
0	1		S383	EGGESLSSGNLCQRS
0	3		N385	GESLSSGNLCQRSRP
0	4		S390	SGNLCQRSRPsSDLN
0	3		S393-p	LCQRSRPsSDLNNsT
0	3		S394	CQRSRPsSDLNNsTL
0	1		S399-p	PsSDLNNsTLQsPAH
0	6		S403-p	LNNsTLQsPAHLKVQ
0	3		S423-p	NQKQRRFsDHAGPSI
0	4		S463-p	DVARKLGsTtVGsKs
0	1		T465-p	ARKLGsTtVGsKsEM
0	2		S468-p	LGsTtVGsKsEMTAs
0	1		S470-p	sTtVGsKsEMTAsPL
0	3		S475-p	sKsEMTAsPLVGPER
0	4		Y494-p	TIPSNNVySGGSMAR
0	35		T504-p	GSMARRNtyVCERTT
0	1		Y505-p	SMARRNtyVCERTTD
0	1		Y514	CERTTDRYVALQNGK
0	1		S556	PRHQKSMSTSGHPIK
0	1		S573-p	LPTIKDGsEAYRPGt
0	1		T580-p	sEAYRPGttQRVPAA
0	1		T581-p	EAYRPGttQRVPAAs
0	5		S588-p	tQRVPAAsPsAHSIs
0	2		S590-p	RVPAAsPsAHSIstA
0	1		S593	AAsPsAHSIstAtPD
0	1		S595-p	sPsAHSIstAtPDRT
0	1		T596-p	PsAHSIstAtPDRTR
0	1		T598-p	AHSIstAtPDRTRFP
0	3		S612-p	PRGSSSRstFHGEQL
0	2		T613-p	RGSSSRstFHGEQLR
0	7		S633-p	AYNGPPAsPSHETGA
0	4		S635	NGPPAsPSHETGAFA
0	2		T638	PAsPSHETGAFAHAR
0	1		T648-p	FAHARRGtsTGIISK
0	1		S649-p	AHARRGtsTGIISKI
0	2		S666	KFVRRDPSEGEASGR
0	1		S679-p	GRTDTSRsTsGEPKE
0	1		S681-p	TDTSRsTsGEPKERD
0	4		S699-p	GKDSKPRsLRFTWSM
0	5		Y732	LDANNCDYEQKERFL
0	2		K783-u	SGTSIAFkNIASKIA

	mouse
T5	___MSARTPLPTVNE
S36	IPPAKSSSRQNLPRC
S46	NLPRCRNSITSATDE
T215-p	TVGNKLDtFCGsPPY
S219-p	KLDtFCGsPPYAAPE
K298-u	LLVLNPIkRGSLEQI
S382-p	FEGGESLssGsLCQR
S383-p	EGGESLssGsLCQRs
S385-p	GESLssGsLCQRsRP
S390-p	sGsLCQRsRPssDLN
S393-p	LCQRsRPssDLNNST
S394-p	CQRsRPssDLNNSTL
S399	PssDLNNSTLQsPAH
S403-p	LNNSTLQsPAHLKVQ
S423-p	NQKQRRFsDHAGPSI
S463-p	DTARRLGsTtVGsKS
T465-p	ARRLGsTtVGsKSEV
S468-p	LGsTtVGsKSEVTAs
S470	sTtVGsKSEVTAsPL
S475-p	sKSEVTAsPLVGPDR
Y494	ASPSNNVYSGGSMAR
T504-p	GSMARRNtYVCERST
Y505	SMARRNtYVCERSTD
Y514	CERSTDRYAALQNGR
S556-p	PRHQKSMsTSGHPIK
S573	LPTIKDGSEAYRPGA
A580	SEAYRPGAAQRVPAA
A581	EAYRPGAAQRVPAAS
S588	AQRVPAASPsAHsIS
S590-p	RVPAASPsAHsISAS
S593-p	AASPsAHsISASTPD
S595	SPsAHsISASTPDRT
A596	PsAHsISASTPDRTR
T598	AHsISASTPDRTRFP
S612-p	PRGSSSRstFHGEQL
T613-p	RGSSSRstFHGEQLR
S633-p	AYNGPPAsPsHEtGA
S635-p	NGPPAsPsHEtGAFA
T638-p	PAsPsHEtGAFAHAR
T648-p	FAHARRGtSTGIISK
S649	AHARRGtSTGIISKI
S666-p	KFVRRDPsEGEASGR
G679	GRADTARGSSGDPKE
S681	ADTARGSSGDPKERD
S699	GKEAKPRSLRFTWSM
Y732	LDANTCDYEQKERFL
K783-u	SGTSIAFkNIASKIA

	rat
T5	___MSARTPLPTVNE
S36	IPPTKSSSRQNIPRC
S46	NIPRCRNSITSATDE
T215-p	TVGNKLDtFCGsPPY
S219-p	KLDtFCGsPPYAAPE
K298	LLVLNPIKRGSLEQI
S382	FEGGESLSSGNLCQR
S383	EGGESLSSGNLCQRS
N385	GESLSSGNLCQRSRP
S390	SGNLCQRSRPSSDLN
S393	LCQRSRPSSDLNNST
S394	CQRSRPSSDLNNSTL
S399	PSSDLNNSTLQSPAH
S403	LNNSTLQSPAHLKVQ
S423	NQKQRRFSDHAGPSI
S463	DTARRLGSTTVGSKS
T465	ARRLGSTTVGSKSEV
S468	LGSTTVGSKSEVTAS
S470	STTVGSKSEVTASPL
S475	SKSEVTASPLVGPDR
Y494-p	AGPSNNVySGGSMTR
T504	GSMTRRNTYVCERST
Y505	SMTRRNTYVCERSTD
Y514-p	CERSTDRyAALQNGR
S556	PRHQKSMSTSGHPIK
S573	LPTIKDGSEAYRPGT
T580	SEAYRPGTAQRVPAA
A581	EAYRPGTAQRVPAAS
S588	AQRVPAASPSAHSIS
S590	RVPAASPSAHSISAS
S593	AASPSAHSISASTPD
S595	SPSAHSISASTPDRT
A596	PSAHSISASTPDRTR
T598	AHSISASTPDRTRFP
S612	PRGSSSRSTFHGEQL
T613	RGSSSRSTFHGEQLR
S633	AYSGPPASPSHDTAA
S635	SGPPASPSHDTAALA
T638	PASPSHDTAALAHAR
T648	LAHARRGTSTGIISK
S649	AHARRGTSTGIISKI
S666	KFVRRDPSEGEASGR
G679	GRTDTARGSSGEPKD
S681	TDTARGSSGEPKDKE
S697	GKEAKPRSLRFTWSM
Y730-p	LDANTCDyEQRERFL
K781	SGTSIAFKNIASKIA

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