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MARK2 (human)

Overview MARK2 a CAMK protein kinase of the CAMKL group. Plays a role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection. 12 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; EC 2.7.11.26; Protein kinase, CAMK; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; MARK subfamily Cellular Component: membrane; plasma membrane; basal cortex; nucleus Molecular Function: protein serine/threonine kinase activity; protein binding; tau-protein kinase activity; magnesium ion binding; lipid binding; ATP binding Biological Process: establishment and/or maintenance of epithelial cell polarity; Wnt receptor signaling pathway; establishment of cell polarity; protein amino acid autophosphorylation; protein kinase cascade; neuron migration; response to oxidative stress; regulation of axonogenesis; protein amino acid phosphorylation; regulation of cytoskeleton organization and biogenesis Reference #:  Q7KZI7 (UniProtKB) Alt. Names/Synonyms: ELKL motif kinase 1; EMK-1; EMK1; MAP/microtubule affinity-regulating kinase 2; MARK2; MGC99619; PAR-1; PAR1 homolog; Par1b; Ser/Thr protein kinase PAR-1B; serine/threonine protein kinase EMK; Serine/threonine-protein kinase MARK2 Gene Symbols: MARK2 Molecular weight: 87,911 Da Basal Isoelectric point: 9.73  Predict pI for various phosphorylation states CST Pathways:  Regulation of Microtubule Dynamics  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MARK2 3IEC - A/D/C/B=49-363 (human) 1Y8G - A/B=39-364 (rat) 1ZMU - A/B=39-364 (rat) 1ZMV - A/B=39-364 (rat) 1ZMW - A/B=39-364 (rat) 2R0I - A/B=39-364 (rat) 2WZJ - F/A/D/C/E/B=39-364 (rat) Substrate Sequence Logo

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	Sites Implicated In
cell differentiation, altered: S212‑p cytoskeletal reorganization: S212‑p enzymatic activity, inhibited: S212‑p, T596‑p intracellular localization: S400‑p, T596‑p molecular association, regulation: S400‑p, T596‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T20-p	ERDTEQPtLGHLDsK
0	1		S26-p	PtLGHLDsKPssKSN
0	1		S29-p	GHLDsKPssKSNMIR
0	1		S30-p	HLDsKPssKSNMIRG
0	12		S40-p	NMIRGRNsAtsADEQ
0	3		T42-p	IRGRNsAtsADEQPH
0	6		S43-p	RGRNsAtsADEQPHI
0	3		Y53	EQPHIGNYRLLKtIG
0	7		T58-p	GNYRLLKtIGKGNFA
0	1		T87-p	AVKIIDKtQLNSSSL
1	0		S91	IDKtQLNSSSLQKLF
1	0		S92	DKtQLNSSSLQKLFR
0	3		S197-p	KIADFGFsNEFtFGN
0	1		T201-p	FGFsNEFtFGNKLDt
6	53		T208-p	tFGNKLDtFCGsPPY
5	14		S212-p	KLDtFCGsPPYAAPE
0	1		S290-p	KFLILNPsKRGTLEQ
1	0		T294	LNPsKRGTLEQIMKD
0	1		Y323-p	YVEPLPDyKDPRRTE
0	1		Y351-p	DSLVGQRyNEVMATy
1	0		T357	RyNEVMATyLLLGyK
0	2		Y358-p	yNEVMATyLLLGyKs
0	1		Y363-p	ATyLLLGyKsSELEG
0	2		S365-p	yLLLGyKsSELEGDT
0	1		T384	PRPSADLTNSSAPsP
0	5		S390-p	LTNSSAPsPSHKVQR
1	0		S400-p	HKVQRSVsANPKQRR
0	11		S409-p	NPKQRRFsDQAAGPA
0	1		S420	AGPAIPTSNsySKKT
0	3		S422-p	PAIPTSNsySKKTQS
0	5		Y423-p	AIPTSNsySKKTQSN
0	1		S448	RESGRKASSTAKVPA
0	1		S449	ESGRKASSTAKVPAs
0	1		T450	SGRKASSTAKVPAsP
0	40		S456-p	STAKVPAsPLPGLER
0	7		T466-p	PGLERKKttPtPstN
0	4		T467-p	GLERKKttPtPstNS
0	2		T469-p	ERKKttPtPstNSVL
0	3		S471-p	KKttPtPstNSVLsT
0	2		T472-p	KttPtPstNSVLsTs
0	1		S477-p	PstNSVLsTsTNRsR
0	1		T478	stNSVLsTsTNRsRN
0	4		S479-p	tNSVLsTsTNRsRNs
0	3		S483-p	LsTsTNRsRNsPLLE
0	26		S486-p	sTNRsRNsPLLERAs
0	3		S493-p	sPLLERAsLGQAsIQ
0	3		S498-p	RAsLGQAsIQNGKDS
0	1		S533-p	RPRQHQKsMsASVHP
0	2		S535-p	RQHQKsMsASVHPNK
0	11		S569-p	PQRVPVAsPsAHNIs
0	12		S571-p	RVPVAsPsAHNIsSs
0	1		S576-p	sPsAHNIsSsGGAPD
0	1		S578-p	sAHNIsSsGGAPDRT
0	2		S592-p	TNFPRGVssRstFHA
0	1		S593-p	NFPRGVssRstFHAG
0	5		S595-p	PRGVssRstFHAGQL
4	2		T596-p	RGVssRstFHAGQLR
0	30		Y613-p	RDQQNLPyGVtPAsP
0	1		T616-p	QNLPyGVtPAsPsGH
0	105		S619-p	PyGVtPAsPsGHsQG
0	7		S621-p	GVtPAsPsGHsQGRR
0	22		S624-p	PAsPsGHsQGRRGAs
0	9		S631-p	sQGRRGAsGSIFSkF
0	1		K637-u	AsGSIFSkFTSKFVR
0	1		T639	GSIFSkFTSKFVRRN
0	1		S640	SIFSkFTSKFVRRNL
0	3		S648-p	KFVRRNLsFRFARRN
0	4		T667-p	ESKDRVEtLRPHVVG
0	2		S675-p	LRPHVVGsGGNDKEK
0	6		S692-p	FREAKPRsLRFTWsM
0	1		T696	KPRsLRFTWsMKTTS
0	1		S698-p	RsLRFTWsMKTTSSM
0	1		K716	EMMREIRKVLDANsC
0	1		S722-p	RKVLDANsCQSELHE

	MARK2 iso3
-	gap
-	gap
-	gap
-	gap
S7	_MIRGRNSATSADEQ
T9	IRGRNSATSADEQPH
S10	RGRNSATSADEQPHI
Y20	EQPHIGNYRLLKTIG
T25	GNYRLLKTIGKGNFA
T54	AVKIIDKTQLNSSSL
S58	IDKTQLNSSSLQKLF
S59	DKTQLNSSSLQKLFR
S164	KIADFGFSNEFTFGN
T168	FGFSNEFTFGNKLDt
T175-p	TFGNKLDtFCGSPPY
S179	KLDtFCGSPPYAAPE
S257	KFLILNPSKRGTLEQ
T261	LNPSKRGTLEQIMKD
Y290	YVEPLPDYKDPRRTE
Y318	DSLVGQRYNEVMATY
T324	RYNEVMATYLLLGYK
Y325	YNEVMATYLLLGYKS
Y330	ATYLLLGYKSSELEG
S332	YLLLGYKSSELEGDT
T351	PRPSADLTNSSAPSP
S357	LTNSSAPSPSHKVQR
S367	HKVQRSVSANPKQRR
S376-p	NPKQRRFsDQAGPAI
S386	AGPAIPTSNsySKKT
S388-p	PAIPTSNsySKKTQS
Y389-p	AIPTSNsySKKTQSN
S414	RESGRKASSTAKVPA
S415	ESGRKASSTAKVPAS
T416	SGRKASSTAKVPASP
S422	STAKVPASPLPGLER
T432	PGLERKKTTPTPSTN
T433	GLERKKTTPTPSTNS
T435	ERKKTTPTPSTNSVL
S437	KKTTPTPSTNSVLST
T438	KTTPTPSTNSVLSTS
S443	PSTNSVLSTSTNRSR
T444	STNSVLSTSTNRSRN
S445	TNSVLSTSTNRSRNS
S449	LSTSTNRSRNSPLLE
S452	STNRSRNSPLLERAS
S459	SPLLERASLGQASIQ
S464	RASLGQASIQNGKDS
S499	RPRQHQKSMSASVHP
S501	RQHQKSMSASVHPNK
S535	PQRVPVASPSAHNIS
S537	RVPVASPSAHNISSS
S542	SPSAHNISSSGGAPD
S544	SAHNISSSGGAPDRT
S558	TNFPRGVSSRSTFHA
S559	NFPRGVSSRSTFHAG
S561	PRGVSSRSTFHAGQL
T562	RGVSSRSTFHAGQLR
Y579	RDQQNLPYGVTPAsP
T582	QNLPYGVTPAsPSGH
S585-p	PYGVTPAsPSGHsQG
S587	GVTPAsPSGHsQGRR
S590-p	PAsPSGHsQGRRGAS
S597	sQGRRGASGSIFSKF
K603	ASGSIFSKFTSKFVR
T605	GSIFSKFTSKFVRRN
S606	SIFSKFTSKFVRRNL
-	gap
T624	ESKDRVETLRPHVVG
S632	LRPHVVGSGGNDKEK
S649	FREAKPRSLRFTWSM
T653	KPRSLRFTWSMKTTS
S655	RSLRFTWSMKTTSSM
K673	EMMREIRKVLDANSC
S679	RKVLDANSCQSELHE

	MARK2 iso4
T20	ERDTEQPTLGHLDSK
S26	PTLGHLDSKPSSKSN
S29	GHLDSKPSSKSNMIR
S30	HLDSKPSSKSNMIRG
S40	NMIRGRNSATSADEQ
T42	IRGRNSATSADEQPH
S43	RGRNSATSADEQPHI
Y53	EQPHIGNYRLLKTIG
T58	GNYRLLKTIGKGNFA
T87	AVKIIDKTQLNSSSL
S91	IDKTQLNSSSLQKLF
S92	DKTQLNSSSLQKLFR
S197	KIADFGFSNEFTFGN
T201	FGFSNEFTFGNKLDt
T208-p	TFGNKLDtFCGSPPY
S212	KLDtFCGSPPYAAPE
S290	KFLILNPSKRGTLEQ
T294	LNPSKRGTLEQIMKD
Y323	YVEPLPDYKDPRRTE
Y351	DSLVGQRYNEVMATY
T357	RYNEVMATYLLLGYK
Y358	YNEVMATYLLLGYKS
Y363	ATYLLLGYKSSELEG
S365	YLLLGYKSSELEGDT
T384	PRPSADLTNSSAPSP
S390	LTNSSAPSPSHKVQR
S400	HKVQRSVSANPKQRR
S409	NPKQRRFSDQAAGPA
S420	AGPAIPTSNSYSKKT
S422	PAIPTSNSYSKKTQS
Y423	AIPTSNSYSKKTQSN
S448	RESGRKASSTAKVPA
S449	ESGRKASSTAKVPAS
T450	SGRKASSTAKVPASP
S456	STAKVPASPLPGLER
T466	PGLERKKTTPTPSTN
T467	GLERKKTTPTPSTNS
T469	ERKKTTPTPSTNSVL
S471	KKTTPTPSTNSVLST
T472	KTTPTPSTNSVLSTS
S477	PSTNSVLSTSTNRSR
T478	STNSVLSTSTNRSRN
S479	TNSVLSTSTNRSRNS
S483	LSTSTNRSRNSPLLE
S486	STNRSRNSPLLERAS
S493	SPLLERASLGQASIQ
S498	RASLGQASIQNGKDS
-	gap
-	gap
S515-p	PQRVPVAsPsAHNIS
S517-p	RVPVAsPsAHNISSS
S522	sPsAHNISSSGGAPD
S524	sAHNISSSGGAPDRT
S538	TNFPRGVSSRSTFHA
S539	NFPRGVSSRSTFHAG
S541	PRGVSSRSTFHAGQL
T542	RGVSSRSTFHAGQLR
Y559	RDQQNLPYGVTPAsP
T562	QNLPYGVTPAsPSGH
S565-p	PYGVTPAsPSGHsQG
S567	GVTPAsPSGHsQGRR
S570-p	PAsPSGHsQGRRGAS
S577	sQGRRGASGSIFSKF
K583	ASGSIFSKFTSKFVR
T585	GSIFSKFTSKFVRRN
S586	SIFSKFTSKFVRRNL
-	gap
T604	ESKDRVETLRPHVVG
S612	LRPHVVGSGGNDKEK
S629	FREAKPRSLRFTWSM
T633	KPRSLRFTWSMKTTS
S635	RSLRFTWSMKTTSSM
K653	EMMREIRKVLDANSC
S659	RKVLDANSCQSELHE

	MARK2 iso10
-	gap
-	gap
-	gap
-	gap
S7	_MIRGRNSATSADEQ
T9	IRGRNSATSADEQPH
S10	RGRNSATSADEQPHI
Y20	EQPHIGNYRLLKTIG
T25	GNYRLLKTIGKGNFA
T54	AVKIIDKTQLNSSSL
S58	IDKTQLNSSSLQKLF
S59	DKTQLNSSSLQKLFR
S164	KIADFGFSNEFTFGN
T168	FGFSNEFTFGNKLDT
T175	TFGNKLDTFCGSPPY
S179	KLDTFCGSPPYAAPE
S257	KFLILNPSKRGTLEQ
T261	LNPSKRGTLEQIMKD
Y290	YVEPLPDYKDPRRTE
Y318	DSLVGQRYNEVMATY
T324	RYNEVMATYLLLGYK
Y325	YNEVMATYLLLGYKS
Y330	ATYLLLGYKSSELEG
S332	YLLLGYKSSELEGDT
T351	PRPSADLTNSSAPSP
S357	LTNSSAPSPSHKVQR
S367	HKVQRSVSANPKQRR
S376	NPKQRRFSDQAAGPA
S387	AGPAIPTSNSYSKKT
S389	PAIPTSNSYSKKTQS
Y390	AIPTSNSYSKKTQSN
S415	RESGRKASSTAKVPA
S416	ESGRKASSTAKVPAS
T417	SGRKASSTAKVPASP
S423	STAKVPASPLPGLER
T433	PGLERKKTTPTPSTN
T434	GLERKKTTPTPSTNS
T436	ERKKTTPTPSTNSVL
S438	KKTTPTPSTNSVLST
T439	KTTPTPSTNSVLSTS
S444	PSTNSVLSTSTNRSR
T445	STNSVLSTSTNRSRN
S446	TNSVLSTSTNRSRNS
S450	LSTSTNRSRNSPLLE
S453	STNRSRNSPLLERAS
S460	SPLLERASLGQASIQ
S465	RASLGQASIQNGKDS
-	gap
-	gap
S482	PQRVPVASPSAHNIS
S484	RVPVASPSAHNISSS
S489	SPSAHNISSSGGAPD
S491	SAHNISSSGGAPDRT
S505	TNFPRGVSSRSTFHA
S506	NFPRGVSSRSTFHAG
S508	PRGVSSRSTFHAGQL
T509	RGVSSRSTFHAGQLR
Y526	RDQQNLPYGVTPASP
T529	QNLPYGVTPASPSGH
S532	PYGVTPASPSGHSQG
S534	GVTPASPSGHSQGRR
S537	PASPSGHSQGRRGAS
S544	SQGRRGASGSIFSKF
K550	ASGSIFSKFTSKFVR
T552	GSIFSKFTSKFVRRN
S553	SIFSKFTSKFVRRNL
S561	KFVRRNLSFRFARRP
-	gap
S573	RRPHVVGSGGNDKEK
S590	FREAKPRSLRFTWSM
T594	KPRSLRFTWSMKTTS
S596	RSLRFTWSMKTTSSM
K614	EMMREIRKVLDANSC
S620	RKVLDANSCQSELHE

	MARK2 iso13
-	gap
-	gap
-	gap
-	gap
S7	_MIRGRNSATSADEQ
T9	IRGRNSATSADEQPH
S10	RGRNSATSADEQPHI
Y20	EQPHIGNYRLLKTIG
T25	GNYRLLKTIGKGNFA
T54	AVKIIDKTQLNSSSL
S58	IDKTQLNSSSLQKLF
S59	DKTQLNSSSLQKLFR
S164	KIADFGFSNEFTFGN
T168	FGFSNEFTFGNKLDt
T175-p	TFGNKLDtFCGSPPY
S179	KLDtFCGSPPYAAPE
S257	KFLILNPSKRGTLEQ
T261	LNPSKRGTLEQIMKD
Y290	YVEPLPDYKDPRRTE
Y318	DSLVGQRYNEVMAtY
T324-p	RYNEVMAtYLLLGYK
Y325	YNEVMAtYLLLGYKS
Y330	AtYLLLGYKSSELEG
S332	YLLLGYKSSELEGDT
T351	PRPSADLTNSSAPSP
S357	LTNSSAPSPSHKVQR
S367	HKVQRSVSANPKQRR
S376-p	NPKQRRFsDQAGPAI
S386	AGPAIPTSNsySKKT
S388-p	PAIPTSNsySKKTQS
Y389-p	AIPTSNsySKKTQSN
S414	RESGRKASSTAKVPA
S415	ESGRKASSTAKVPAS
T416	SGRKASSTAKVPASP
S422	STAKVPASPLPGLER
T432	PGLERKKTTPTPSTN
T433	GLERKKTTPTPSTNS
T435	ERKKTTPTPSTNSVL
S437	KKTTPTPSTNSVLST
T438	KTTPTPSTNSVLSTS
S443	PSTNSVLSTSTNRSR
T444	STNSVLSTSTNRSRN
S445	TNSVLSTSTNRSRNS
S449	LSTSTNRSRNSPLLE
S452	STNRSRNSPLLERAS
S459	SPLLERASLGQASGL
S464	RASLGQASGLPPTEG
-	gap
-	gap
S489	PQRVPVASPSAHNIS
S491	RVPVASPSAHNISSS
S496	SPSAHNISSSGGAPD
S498	SAHNISSSGGAPDRT
S512	TNFPRGVSSRSTFHA
S513	NFPRGVSSRSTFHAG
S515	PRGVSSRSTFHAGQL
T516	RGVSSRSTFHAGQLR
Y533	RDQQNLPYGVTPAsP
T536	QNLPYGVTPAsPSGH
S539-p	PYGVTPAsPSGHsQG
S541	GVTPAsPSGHsQGRR
S544-p	PAsPSGHsQGRRGAS
S551	sQGRRGASGSIFSKF
K557	ASGSIFSKFTSKFVR
T559	GSIFSKFTSKFVRRN
S560	SIFSKFTSKFVRRNL
-	gap
T578	ESKDRVETLRPHVVG
S586	LRPHVVGSGGNDKEK
S603	FREAKPRSLRFTWSM
T607	KPRSLRFTWSMKTTS
S609	RSLRFTWSMKTTSSM
K627	EMMREIRKVLDANSC
S633	RKVLDANSCQSELHE

	mouse ► Hide Isoforms
T20	ERDTEQPTLGHLDSK
S26	PTLGHLDSKPSSKSN
S29	GHLDSKPSSKSNMLR
S30	HLDSKPSSKSNMLRG
S40-p	NMLRGRNsATsADEQ
T42	LRGRNsATsADEQPH
S43-p	RGRNsATsADEQPHI
Y53	EQPHIGNYRLLKtIG
T58-p	GNYRLLKtIGKGNFA
T87	AVKIIDKTQLNSSSL
S91	IDKTQLNSSSLQKLF
S92	DKTQLNSSSLQKLFR
S197	KIADFGFSNEFTFGN
T201	FGFSNEFTFGNKLDt
T208-p	TFGNKLDtFCGsPPY
S212-p	KLDtFCGsPPYAAPE
S290	KFLILNPSKRGTLEQ
T294	LNPSKRGTLEQIMKD
Y323	YVEPLPDYKDPRRTE
Y351	DSLVGQRYNEVMATY
T357	RYNEVMATYLLLGYK
Y358	YNEVMATYLLLGYKs
Y363	ATYLLLGYKsSELEG
S365-p	YLLLGYKsSELEGDT
T384-p	PRPSADLtNSSAPsP
S390-p	LtNSSAPsPSHKVQR
S400	HKVQRSVSANPKQRR
S409-p	NPKQRRSsDQAVPAI
S419-p	AVPAIPTsNsySKKT
S421-p	PAIPTsNsySKKTQS
Y422-p	AIPTsNsySKKTQSN
S445-p	EETGRKAsstAKVPA
S446-p	ETGRKAsstAKVPAs
T447-p	TGRKAsstAKVPAsP
S453-p	stAKVPAsPLPGLDR
T463-p	PGLDRKKttPAPsTN
T464-p	GLDRKKttPAPsTNS
A466	DRKKttPAPsTNSVL
S468-p	KKttPAPsTNSVLSt
T469	KttPAPsTNSVLSts
S474	PsTNSVLStsTNRsR
T475-p	sTNSVLStsTNRsRN
S476-p	TNSVLStsTNRsRNs
S480-p	LStsTNRsRNsPLLD
S483-p	sTNRsRNsPLLDRAs
S490-p	sPLLDRAsLGQASIQ
S495	RAsLGQASIQNGKDS
S530	RPRQHQKSMsASVHP
S532-p	RQHQKSMsASVHPNK
S566-p	PQRVPVAsPsAHNIS
S568-p	RVPVAsPsAHNISSS
S573	sPsAHNISSSSGAPD
S575	sAHNISSSSGAPDRT
S589	TNFPRGVSSRstFHA
S590	NFPRGVSSRstFHAG
S592-p	PRGVSSRstFHAGQL
T593-p	RGVSSRstFHAGQLR
Y610	RDQQNLPYGVTPAsP
T613	QNLPYGVTPAsPSGH
S616-p	PYGVTPAsPSGHSQG
S618	GVTPAsPSGHSQGRR
S621	PAsPSGHSQGRRGAs
S628-p	SQGRRGAsGSIFSKF
K634	AsGSIFSKFtsKFVR
T636-p	GSIFSKFtsKFVRRN
S637-p	SIFSKFtsKFVRRNL
-	gap
T655-p	ESKDRVEtLRPHVVG
S663-p	LRPHVVGsGGTDKDK
S680-p	FREAKPRsLRFtWSM
T684-g	KPRsLRFtWSMKTTS
S686	RsLRFtWSMKTTSSM
K704-u	EMMREIRkVLDANSC
S710	RkVLDANSCQSELHE

	MARK2 iso3
T20	ERDTEQPTLGHLDSK
S26	PTLGHLDSKPSSKSN
S29	GHLDSKPSSKSNMLR
S30	HLDSKPSSKSNMLRG
S40	NMLRGRNSATSADEQ
T42	LRGRNSATSADEQPH
S43	RGRNSATSADEQPHI
Y53	EQPHIGNYRLLKTIG
T58	GNYRLLKTIGKGNFA
T87	AVKIIDKTQLNSSSL
S91	IDKTQLNSSSLQKLF
S92	DKTQLNSSSLQKLFR
S197	KIADFGFSNEFTFGN
T201	FGFSNEFTFGNKLDT
T208	TFGNKLDTFCGSPPY
S212	KLDTFCGSPPYAAPE
S290	KFLILNPSKRGTLEQ
T294	LNPSKRGTLEQIMKD
Y323	YVEPLPDYKDPRRTE
Y351	DSLVGQRYNEVMATY
T357	RYNEVMATYLLLGYK
Y358	YNEVMATYLLLGYKS
Y363	ATYLLLGYKSSELEG
S365	YLLLGYKSSELEGDT
T384	PRPSADLTNSSAPSP
S390	LTNSSAPSPSHKVQR
S400	HKVQRSVSANPKQRR
S409	NPKQRRSSDQAVPAI
S419	AVPAIPTSNSYSKKT
S421	PAIPTSNSYSKKTQS
Y422	AIPTSNSYSKKTQSN
S445	EETGRKASSTAKVPA
S446	ETGRKASSTAKVPAS
T447	TGRKASSTAKVPASP
S453	STAKVPASPLPGLDR
T463	PGLDRKKTTPAPSTN
T464	GLDRKKTTPAPSTNS
A466	DRKKTTPAPSTNSVL
S468	KKTTPAPSTNSVLST
T469	KTTPAPSTNSVLSTS
S474	PSTNSVLSTSTNRSR
T475	STNSVLSTSTNRSRN
S476	TNSVLSTSTNRSRNS
S480	LSTSTNRSRNSPLLD
S483	STNRSRNSPLLDRAS
S490	SPLLDRASLGQASIQ
S495	RASLGQASIQNGKDS
-	gap
-	gap
S512	PQRVPVASPsAHNIS
S514-p	RVPVASPsAHNISSS
S519	SPsAHNISSSSGAPD
S521	sAHNISSSSGAPDRT
S535	TNFPRGVSSRSTFHA
S536	NFPRGVSSRSTFHAG
S538	PRGVSSRSTFHAGQL
T539	RGVSSRSTFHAGQLR
Y556	RDQQNLPYGVTPASP
T559	QNLPYGVTPASPSGH
S562	PYGVTPASPSGHSQG
S564	GVTPASPSGHSQGRR
S567	PASPSGHSQGRRGAS
S574	SQGRRGASGSIFSKF
K580	ASGSIFSKFTSKFVR
T582	GSIFSKFTSKFVRRN
S583	SIFSKFTSKFVRRNL
-	gap
T601	ESKDRVETLRPHVVG
S609	LRPHVVGSGGTDKDK
S626	FREAKPRSLRFTWSM
T630	KPRSLRFTWSMKTTS
S632	RSLRFTWSMKTTSSM
K650	EMMREIRKVLDANSC
S656	RKVLDANSCQSELHE

	rat
T20	ERDTEQPTLGHLDSK
S26	PTLGHLDSKPSSKSN
S29	GHLDSKPSSKSNMLR
S30	HLDSKPSSKSNMLRG
S40	NMLRGRNSATSADEQ
T42	LRGRNSATSADEQPH
S43	RGRNSATSADEQPHI
Y53-p	EQPHIGNyRLLKTIG
T58	GNyRLLKTIGKGNFA
T87	AVKIIDKTQLNssSL
S91-p	IDKTQLNssSLQKLF
S92-p	DKTQLNssSLQKLFR
S197	KIADFGFSNEFTFGN
T201	FGFSNEFTFGNKLDt
T208-p	TFGNKLDtFCGsPPY
S212-p	KLDtFCGsPPYAAPE
S290	KFLILNPSKRGtLEQ
T294-p	LNPSKRGtLEQIMKD
Y323	YVEPLPDYKDPRRTE
Y351	DSLVGQRYNEVMATY
T357	RYNEVMATYLLLGYK
Y358	YNEVMATYLLLGYKS
Y363	ATYLLLGYKSSELEG
S365	YLLLGYKSSELEGDT
T384	PRPSADLTNSSAPSP
S390	LTNSSAPSPSHKVQR
S400	HKVQRSVSANPKQRR
S409	NPKQRRSSDQAVPAI
S419	AVPAIPTSNSYSKKT
S421	PAIPTSNSYSKKTQS
Y422	AIPTSNSYSKKTQSN
S445	EETGRKASSTAKVPA
S446	ETGRKASSTAKVPAs
T447	TGRKASSTAKVPAsP
S453-p	STAKVPAsPLPGLDR
T463	PGLDRKKTTPTPSTN
T464	GLDRKKTTPTPSTNS
T466	DRKKTTPTPSTNSVL
S468	KKTTPTPSTNSVLST
T469	KTTPTPSTNSVLSTS
S474	PSTNSVLSTSTNRSR
T475	STNSVLSTSTNRSRN
S476	TNSVLSTSTNRSRNS
S480	LSTSTNRSRNSPLLD
S483	STNRSRNSPLLDRAS
S490	SPLLDRASLGQASIQ
S495	RASLGQASIQNGKDS
-	gap
-	gap
S512	PQRVPVASPSAHNIS
S514	RVPVASPSAHNISSS
S519	SPSAHNISSSSGAPD
S521	SAHNISSSSGAPDRT
S535	TNFPRGVSSRStFHA
S536	NFPRGVSSRStFHAG
S538	PRGVSSRStFHAGQL
T539-p	RGVSSRStFHAGQLR
F556	RDQQNLPFGVTPAsP
T559	QNLPFGVTPAsPSGH
S562-p	PFGVTPAsPSGHsQG
S564	GVTPAsPSGHsQGRR
S567-p	PAsPSGHsQGRRGAS
S574	sQGRRGASGSIFSKF
K580	ASGSIFSKFTSKFVR
T582	GSIFSKFTSKFVRRN
S583	SIFSKFTSKFVRRNL
-	gap
T601	ESKDRVETLRPHVVG
G609	LRPHVVGGGGTDKEK
S626	FREAKPRSLRFTWSM
T630	KPRSLRFTWSMKTTS
S632	RSLRFTWSMKTTSSM
K650	EMMREIRKVLDANSC
S656	RKVLDANSCQSELHE

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