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Protein Page:
VMP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
VMP1 Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Interacts with BECN1. Interacts with TJP1. Interacts with TP53INP2. Belongs to the VMP1 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Endoplasmic reticulum
Cellular Component: ER-Golgi intermediate compartment membrane; endoplasmic reticulum; integral to membrane; plasma membrane
Molecular Function: protein binding
Biological Process: cell-cell adhesion; autophagy; regulation of autophagy; embryo implantation
Reference #:  Q96GC9 (UniProtKB)
Alt. Names/Synonyms: DKFZp566I133; TDC1; TMEM49; TMM49; Transmembrane protein 49; Vacuole membrane protein 1; VMP1
Gene Symbols: VMP1
Molecular weight: 46,238 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VMP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 N23 NKEHHNGNFTDPSSV
0 2 T25 EHHNGNFTDPSSVNE
0 1 K33-u DPSSVNEkKRREREE
0 24 Y224-p AEPDDEEyQEFEEML
0 1 S401 RIQQRLNSEEKTK__
  mouse

 
S23-p SKDQHNGsLtDPSSV
T25-p DQHNGsLtDPSSVHE
K33 DPSSVHEKKRRDREE
Y224 AEPDDEEYQEFEEML
S401-p RIQQRLNsEEKTK__
  rat

 
S23 SKEQHNGSFTDPSSV
T25 EQHNGSFTDPSSVNE
K33 DPSSVNEKKRRDREE
Y224 AEPDDEEYQEFEEML
S401 RIQQRLNSEEKTK__
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