Home

VMP1 (human)

Overview VMP1 Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Interacts with BECN1. Interacts with TJP1. Interacts with TP53INP2. Belongs to the VMP1 family. Note: This description may include information from UniProtKB. Protein type: Endoplasmic reticulum; Membrane protein, integral Cellular Component: ER-Golgi intermediate compartment membrane; endoplasmic reticulum; plasma membrane; integral to membrane Molecular Function: protein binding Biological Process: cell-cell adhesion; autophagy; regulation of autophagy; embryo implantation Reference #:  Q96GC9 (UniProtKB) Alt. Names/Synonyms: DKFZp566I133; TDC1; TMEM49; TMM49; Transmembrane protein 49; Vacuole membrane protein 1; VMP1 Gene Symbols: VMP1 Molecular weight: 46,238 Da Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below VMP1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		T25	EHHNGNFTDPSSVNE
0	5		N23	NKEHHNGNFTDPSSV
0	1		K33-u	DPSSVNEkKRREREE
0	24		Y224-p	AEPDDEEyQEFEEML
0	1		Y378	LVVVMVCYFILSIIN
0	1		S401	RIQQRLNSEEkTK__
0	1		K404-u	QRLNSEEkTK_____

	mouse
T25-p	DQHNGsLtDPSSVHE
S23-p	SKDQHNGsLtDPSSV
K33	DPSSVHEKKRRDREE
Y224	AEPDDEEYQEFEEML
Y378-p	LVVAMVCyFVLSIIN
S401-p	RIQQRLNsEEKTK__
K404	QRLNsEEKTK_____

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.