Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CAMK2D (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CAMK2D a protein kinase of the calcium/calmodulin-dependent protein kinase (CAMK) group that interacts with the sarcoplasmic reticulum membrane in cardiac and skeletal muscle. Regulates Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart. Calmodulin binding induces conformational changes that relieve autoinhibition, permitting autophosphorylation at T287, rendering the kinase constitutively active and independent of Ca2+-binding. Targets ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. Also targets transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca2+ release via direct phosphorylation of RYR2 Ca2+ channel on S2808. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca2+ influx to myocytes by binding and phosphorylating the L-type Ca2+ channel subunit beta-2 CACNB2. In addition to Ca2+ channels, can target and regulate the cardiac sarcolemmal Na+ channel SCN5A and the K+ channel Kv4.3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLB), an endogenous inhibitor of SERCA2A, contributing to the enhancement of SR Ca2+ uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca2+ transport through phosphorylation of PLB and TRDN, a ryanodine receptor-coupling factor. CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with RRAD and CACNB2. Ten isoforms of the human protein are produced by alternative splicing. Isoform Delta3, isoform Delta2, isoform Delta8 and isoform Delta9 are expressed in cardiac muscle. Isoform Delta11 is expressed in skeletal muscle. Activity is induced in skeletal muscle during exercise. The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CAMK; EC 2.7.11.17; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK2 family
Cellular Component: nucleoplasm; sarcoplasmic reticulum membrane; cell soma; T-tubule; cytoplasm; plasma membrane; calcium- and calmodulin-dependent protein kinase complex; cytosol; nucleus; neuromuscular junction
Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; titin binding; ATP binding
Biological Process: cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; regulation of sodium ion transport; protein amino acid phosphorylation; regulation of heart contraction; regulation of transcription from RNA polymerase II promoter; synaptic transmission; peptidyl-serine phosphorylation; calcium ion transport; regulation of cell growth; regulation of the force of heart contraction; G1/S transition of mitotic cell cycle
Reference #:  Q13557 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II delta subunit; CaM kinase II subunit delta; CaM-kinase II delta chain; CaMK-II delta subunit; CaMK-II subunit delta; CaMK2-delta; CAMK2D; CAMKD; CaMKII; KCC2D; MGC44911
Gene Symbols: CAMK2D
Molecular weight: 56,369 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CAMK2D

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S3-p _____MAsTTTCTRF
0 3 Y14 CTRFTDEYQLFEELG
0 3 S26 ELGKGAFSVVRRCMK
0 4 K33 SVVRRCMKIPTGQEY
0 3 Y40 KIPTGQEYAAkIINT
0 10 K43-u TGQEYAAkIINTKKL
0 7 K48 AAkIINTKKLSARDH
0 7 K49 AkIINTKKLSARDHQ
0 10 K69 ARICRLLKHPNIVRL
0 8 K138 GIVHRDLKPENLLLA
0 2 K147 ENLLLASKSKGAAVK
0 2 K154 KSKGAAVKLADFGLA
0 2 K227 HRLYQQIKAGAyDFP
0 18 K227-u HRLYQQIkAGAyDFP
0 28 Y231-p QQIkAGAyDFPsPEW
0 6 S235-p AGAyDFPsPEWDTVT
0 17 K246 DTVTPEAKDLINkML
0 9 K251-u EAKDLINkMLtINPA
0 3 T254-p DLINkMLtINPAKRI
0 10 K259 MLtINPAKRITASEA
0 7 K268 ITASEALKHPWICQR
0 5 S276-p HPWICQRsTVAsMMH
0 19 S280-p CQRsTVAsMMHRQEt
9 145 T287-p sMMHRQEtVDCLKKF
0 7 K292 QEtVDCLKKFNARRK
0 7 K293 EtVDCLKKFNARRKL
0 5 K299 KKFNARRKLkGAILt
0 7 K301 FNARRKLKGAILttM
0 3 K301-m1 FNARRKLkGAILttM
0 2 T306-p KLkGAILttMLAtRN
0 5 T307-p LkGAILttMLAtRNF
0 4 T311-p ILttMLAtRNFsAAK
0 15 S315-p MLAtRNFsAAKsLLK
0 12 S319-p RNFsAAKsLLKKPDG
0 4 K322 sAAKsLLKKPDGVKE
0 4 - gap
0 3 - gap
0 9 S330-p KPDGVKEstEssNtt
0 9 T331-p PDGVKEstEssNttI
0 13 S333-p GVKEstEssNttIED
0 7 S334-p VKEstEssNttIEDE
0 11 T336-p EstEssNttIEDEDV
0 19 T337-p stEssNttIEDEDVK
0 1 S404-p FYFENALsKSNKPIH
0 2 S441-p LTQYMDGsGMPKTMQ
0 3 S472-p VHFHRSGsPTVPIKP
0 1 S490-p PNGKENFsGGTSLWQ
0 2 S494 ENFsGGTSLWQNI__
3356 : Phospho-CaMKII (Tyr231) Antibody
  CAMK2D iso8  
S3 _____MASTTTCTRF
Y14 CTRFTDEYQLFEELG
S26 ELGKGAFSVVRRCMK
K33 SVVRRCMKIPTGQEY
Y40 KIPTGQEYAAKIINT
K43 TGQEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHPNIVRL
K138 GIVHRDLKPENLLLA
K147 ENLLLASKSKGAAVK
K154 KSKGAAVKLADFGLA
K227 HRLYQQIKAGAYDFP
K227 HRLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKDLINKML
K251 EAKDLINKMLTINPA
T254 DLINKMLTINPAKRI
K259 MLTINPAKRITASEA
K268 ITASEALKHPWICQR
S276 HPWICQRSTVASMMH
S280 CQRSTVASMMHRQEt
T287-p SMMHRQEtVDCLKKF
K292 QEtVDCLKKFNARRK
K293 EtVDCLKKFNARRKL
K299 KKFNARRKLKGAILT
K301 FNARRKLKGAILTTM
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLATRN
T307 LKGAILTTMLATRNF
T311 ILTTMLATRNFSAAK
S315 MLATRNFSAAKSLLK
S319 RNFSAAKSLLKKPDG
K322 SAAKSLLKKPDGVKE
- gap
- gap
S330 KPDGVKESTESSNTT
T331 PDGVKESTESSNTTI
S333 GVKESTESSNTTIED
S334 VKESTESSNTTIEDE
T336 ESTESSNTTIEDEDV
T337 STESSNTTIEDEDVK
S404 FYFENALSKSNKPIH
S441 LTQYMDGSGMPKTMQ
S472 VHFHRSGSPTVPIK_
- gap
- gap
3356 : Phospho-CaMKII (Tyr231) Antibody
  mouse

► Hide Isoforms
 
S3 _____MASTTTCTRF
Y14 CTRFTDEYQLFEELG
S26-p ELGKGAFsVVRRCMK
K33 sVVRRCMKIPTGQEY
Y40 KIPTGQEYAAkIINT
K43-u TGQEYAAkIINTkkL
K48-u AAkIINTkkLSARDH
K49-u AkIINTkkLSARDHQ
K69-u ARICRLLkHPNIVRL
K138-u GIVHRDLkPENLLLA
K147 ENLLLASKSKGAAVK
K154 KSKGAAVKLADFGLA
K227 HRLYQQIKAGAyDFP
K227-u HRLYQQIkAGAyDFP
Y231-p QQIkAGAyDFPsPEW
S235-p AGAyDFPsPEWDTVT
K246-u DTVTPEAkDLINkML
K251-u EAkDLINkMLtINPA
T254-p DLINkMLtINPAkRI
K259-u MLtINPAkRITASEA
K268-u ITASEALkHPWICQR
S276-p HPWICQRsTVAsMMH
S280-p CQRsTVAsMMHRQEt
T287-p sMMHRQEtVDCLkkF
K292-u QEtVDCLkkFNARRK
K293-u EtVDCLkkFNARRKL
K299 kkFNARRKLkGAILt
K301-u FNARRKLkGAILttM
K301-m1 FNARRKLkGAILttM
T306-p KLkGAILttMLAtRN
T307-p LkGAILttMLAtRNF
T311-p ILttMLAtRNFsAAK
S315-p MLAtRNFsAAKsLLK
S319-p RNFsAAKsLLKKPDG
K322 sAAKsLLKKPDGVKE
- gap
- gap
S330-p KPDGVKEstEssNtt
T331-p PDGVKEstEssNttI
S333-p GVKEstEssNttIED
S334-p VKEstEssNttIEDE
T336-p EstEssNttIEDEDV
T337-p stEssNttIEDEDVK
S404 FYFENALSKSNKPIH
S441-p LTQYMDGsGMPKTMQ
S472 VHFHRSGSPTVPIKP
S490 PNGKENFSGGTsLWQ
S494-p ENFSGGTsLWQNI__
3356 : Phospho-CaMKII (Tyr231) Antibody
  CAMK2D iso5  
S3 _____MASTTTCTRF
Y14 CTRFTDEYQLFEELG
S26 ELGKGAFSVVRRCMK
K33 SVVRRCMKIPTGQEY
Y40 KIPTGQEYAAKIINT
K43 TGQEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHPNIVRL
K138 GIVHRDLKPENLLLA
K147 ENLLLASKSKGAAVK
K154 KSKGAAVKLADFGLA
K227 HRLYQQIKAGAYDFP
K227 HRLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKDLINKML
K251 EAKDLINKMLTINPA
T254 DLINKMLTINPAKRI
K259 MLTINPAKRITASEA
K268 ITASEALKHPWICQR
S276 HPWICQRSTVASMMH
S280 CQRSTVASMMHRQET
T287 SMMHRQETVDCLKKF
K292 QETVDCLKKFNARRK
K293 ETVDCLKKFNARRKL
K299 KKFNARRKLKGAILT
K301 FNARRKLKGAILTTM
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLATRN
T307 LKGAILTTMLATRNF
T311 ILTTMLATRNFSAAK
S315 MLATRNFSAAKSLLK
S319 RNFSAAKSLLKKPDG
K322 SAAKSLLKKPDGVKI
K332 DGVKINNKANVVTsP
S338-p NKANVVTsPKENIPT
S364-p NPDGNKEstEssNtt
T365-p PDGNKEstEssNttI
S367-p GNKEstEssNttIED
S368-p NKEstEssNttIEDE
T370-p EstEssNttIEDEDV
T371-p stEssNttIEDEDVK
S438 FYFENALSKSNKPIH
S475 LTQYMDGSGMPKTMQ
S506 VHFHRSGSPTVPIN_
- gap
- gap
3356 : Phospho-CaMKII (Tyr231) Antibody
  rat

 
S3 _____MASTTTCTRF
Y14-p CTRFTDEyQLFEELG
S26 ELGKGAFSVVRRCMk
K33-u SVVRRCMkIPTGQEy
Y40-p kIPTGQEyAAkIINT
K43-u TGQEyAAkIINTkkL
K48-u AAkIINTkkLSARDH
K49-u AkIINTkkLSARDHQ
K69-u ARICRLLkHPNIVRL
K138-u GIVHRDLkPENLLLA
K147-u ENLLLASkSKGAAVk
K154-u kSKGAAVkLADFGLA
K227-a HRLYQQIkAGAyDFP
K227-u HRLYQQIkAGAyDFP
Y231-p QQIkAGAyDFPSPEW
S235 AGAyDFPSPEWDTVT
K246-u DTVTPEAkDLINkML
K251-u EAkDLINkMLTINPA
T254 DLINkMLTINPAkRI
K259-u MLTINPAkRITASEA
K268-u ITASEALkHPWICQR
S276 HPWICQRSTVASMMH
S280 CQRSTVASMMHRQEt
T287-p SMMHRQEtVDCLkkF
K292-u QEtVDCLkkFNARRk
K293-u EtVDCLkkFNARRkL
K299-u kkFNARRkLkGAILT
K301-u FNARRkLkGAILTTM
K301 FNARRkLKGAILTTM
T306 kLkGAILTTMLATRN
T307 LkGAILTTMLATRNF
T311 ILTTMLATRNFSAAK
S315 MLATRNFSAAKSLLk
S319 RNFSAAKSLLkKPDG
K322-u SAAKSLLkKPDGVKI
K332-u DGVKINNkANVVTSP
S338 NkANVVTSPKENIPT
S364 NPDGNKESTESSNTt
T365 PDGNKESTESSNTtI
S367 GNKESTESSNTtIED
S368 NKESTESSNTtIEDE
T370 ESTESSNTtIEDEDV
T371-p STESSNTtIEDEDVK
P438 FYFENALPKINKPIH
N475 LTQYMDGNGMPKTMQ
S506 IHFHRSGSPTVPIKP
S524 PNGKENFSGGTSLWQ
S528 ENFSGGTSLWQNI__
3356 : Phospho-CaMKII (Tyr231) Antibody
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.