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Protein Page:
CaMK2-delta (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CaMK2-delta a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CAMK; EC 2.7.11.17; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; CAMK2 family
Cellular Component: nucleoplasm; sarcoplasmic reticulum membrane; T-tubule; plasma membrane; neuromuscular junction; cytosol; calcium- and calmodulin-dependent protein kinase complex
Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; ATP binding
Biological Process: synaptic transmission; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; calcium ion transport; regulation of cell growth; protein amino acid phosphorylation; regulation of heart contraction; cardiac muscle contraction; G1/S transition of mitotic cell cycle
Reference #:  Q13557 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II delta subunit; CaM kinase II subunit delta; CaM-kinase II delta chain; CaMK-II delta subunit; CaMK-II subunit delta; CAMK2D; CAMKD; CaMKII; DKFZp686G23119; DKFZp686I2288; KCC2D; MGC44911
Gene Symbols: CAMK2D
Molecular weight: 56,369 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Regulation of Microtubule Dynamics
Select Structure to View Below

CaMK2-delta
Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 2 S3-p _____MAsTTTCTRF
0 3 Y14-p CTRFTDEyQLFEELG
0 3 S26 ELGKGAFSVVRRCMK
0 4 K33 SVVRRCMKIPTGQEY
0 3 Y40 KIPTGQEYAAkIINT
0 10 K43-u TGQEYAAkIINTKKL
0 7 K48 AAkIINTKKLSARDH
0 1 K48 AAkIINTKKLSARDH
0 7 K49 AkIINTKKLSARDHQ
0 10 K69-u ARICRLLkHPNIVRL
0 8 K138 GIVHRDLKPENLLLA
0 2 K147 ENLLLASKSKGAAVK
0 2 K154 KSKGAAVKLADFGLA
0 1 Y223 DEDQHRLYQQIkAGA
0 2 K227-a HRLYQQIkAGAyDFP
0 18 K227-u HRLYQQIkAGAyDFP
0 28 Y231-p QQIkAGAyDFPsPEW
0 6 S235-p AGAyDFPsPEWDTVT
0 17 K246-u DTVTPEAkDLINkML
0 9 K251-u EAkDLINkMLtINPA
0 2 T254-p DLINkMLtINPAKRI
0 10 K259 MLtINPAKRITASEA
0 7 K268 ITASEALKHPWICQR
0 4 S276-p HPWICQRsTVAsMMH
0 19 S280-p CQRsTVAsMMHRQEt
7 144 T287-p sMMHRQEtVDCLKKF
0 7 K292 QEtVDCLKKFNARRK
0 7 K293 EtVDCLKKFNARRKL
0 5 K299 KKFNARRKLkGAILt
0 1 K299 KKFNARRKLkGAILt
0 7 K301 FNARRKLKGAILttM
0 3 K301-m1 FNARRKLkGAILttM
0 2 T306-p KLkGAILttMLAtRN
0 5 T307-p LkGAILttMLAtRNF
0 4 T311-p ILttMLAtRNFsAAK
0 13 S315-p MLAtRNFsAAKsLLK
0 10 S319-p RNFsAAKsLLKKPDG
0 4 K322 sAAKsLLKKPDGVKE
0 1 K328 LKKPDGVKEstEssN
0 4 - gap
0 3 - gap
0 8 S330-p KPDGVKEstEssNtt
0 8 T331-p PDGVKEstEssNttI
0 12 S333-p GVKEstEssNttIED
0 6 S334-p VKEstEssNttIEDE
0 10 T336-p EstEssNttIEDEDV
0 17 T337-p stEssNttIEDEDVK
0 1 S404-p FYFENALsKSNKPIH
0 2 S441-p LTQYMDGsGMPKTMQ
0 2 S472-p VHFHRSGsPTVPIKP
0 1 S490-p PNGKENFsGGTSLWQ
0 2 S494 ENFsGGTSLWQNI__
3356 : Phospho-CaMKII (Tyr231) Antibody
  CaMK2-delta iso8  
S3 _____MASTTTCTRF
Y14 CTRFTDEYQLFEELG
S26 ELGKGAFSVVRRCMK
K33 SVVRRCMKIPTGQEY
Y40 KIPTGQEYAAKIINT
K43 TGQEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHPNIVRL
K138 GIVHRDLKPENLLLA
K147 ENLLLASKSKGAAVK
K154 KSKGAAVKLADFGLA
Y223 DEDQHRLYQQIKAGA
K227 HRLYQQIKAGAYDFP
K227 HRLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKDLINKML
K251 EAKDLINKMLTINPA
T254 DLINKMLTINPAKRI
K259 MLTINPAKRITASEA
K268 ITASEALKHPWICQR
S276 HPWICQRSTVASMMH
S280 CQRSTVASMMHRQEt
T287-p SMMHRQEtVDCLKKF
K292 QEtVDCLKKFNARRK
K293 EtVDCLKKFNARRKL
K299 KKFNARRKLKGAILT
K299 KKFNARRKLKGAILT
K301 FNARRKLKGAILTTM
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLATRN
T307 LKGAILTTMLATRNF
T311 ILTTMLATRNFSAAK
S315 MLATRNFSAAKSLLK
S319 RNFSAAKSLLKKPDG
K322 SAAKSLLKKPDGVKE
K328 LKKPDGVKESTESSN
- gap
- gap
S330 KPDGVKESTESSNTT
T331 PDGVKESTESSNTTI
S333 GVKESTESSNTTIED
S334 VKESTESSNTTIEDE
T336 ESTESSNTTIEDEDV
T337 STESSNTTIEDEDVK
S404 FYFENALSKSNKPIH
S441 LTQYMDGSGMPKTMQ
S472 VHFHRSGSPTVPIK_
- gap
- gap
3356 : Phospho-CaMKII (Tyr231) Antibody
  mouse

► Hide Isoforms 		 
S3 _____MASTTTCTRF
Y14 CTRFTDEYQLFEELG
S26-p ELGKGAFsVVRRCMK
K33 sVVRRCMKIPTGQEY
Y40 KIPTGQEYAAkIINT
K43-u TGQEYAAkIINTkkL
K48-u AAkIINTkkLSARDH
K48-a AAkIINTkkLSARDH
K49-u AkIINTkkLSARDHQ
K69-u ARICRLLkHPNIVRL
K138-u GIVHRDLkPENLLLA
K147 ENLLLASKSKGAAVK
K154 KSKGAAVKLADFGLA
Y223 DEDQHRLYQQIkAGA
K227 HRLYQQIKAGAyDFP
K227-u HRLYQQIkAGAyDFP
Y231-p QQIkAGAyDFPsPEW
S235-p AGAyDFPsPEWDTVT
K246-u DTVTPEAkDLINkML
K251-u EAkDLINkMLtINPA
T254-p DLINkMLtINPAkRI
K259-u MLtINPAkRITASEA
K268-u ITASEALkHPWICQR
S276-p HPWICQRsTVAsMMH
S280-p CQRsTVAsMMHRQEt
T287-p sMMHRQEtVDCLkkF
K292-u QEtVDCLkkFNARRk
K293-u EtVDCLkkFNARRkL
K299 kkFNARRKLkGAILt
K299-m1 kkFNARRkLkGAILt
K301-u FNARRkLkGAILttM
K301-m1 FNARRkLkGAILttM
T306-p kLkGAILttMLAtRN
T307-p LkGAILttMLAtRNF
T311-p ILttMLAtRNFsAAK
S315-p MLAtRNFsAAKsLLK
S319-p RNFsAAKsLLKKPDG
K322 sAAKsLLKKPDGVKE
K328 LKKPDGVKEstEssN
- gap
- gap
S330-p KPDGVKEstEssNtt
T331-p PDGVKEstEssNttI
S333-p GVKEstEssNttIED
S334-p VKEstEssNttIEDE
T336-p EstEssNttIEDEDV
T337-p stEssNttIEDEDVK
S404 FYFENALSKSNKPIH
S441-p LTQYMDGsGMPKTMQ
S472 VHFHRSGSPTVPIKP
S490 PNGKENFSGGTsLWQ
S494-p ENFSGGTsLWQNI__
3356 : Phospho-CaMKII (Tyr231) Antibody
  CaMK2-delta iso5  
S3 _____MASTTTCTRF
Y14 CTRFTDEYQLFEELG
S26 ELGKGAFSVVRRCMK
K33 SVVRRCMKIPTGQEY
Y40 KIPTGQEYAAKIINT
K43 TGQEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHPNIVRL
K138 GIVHRDLKPENLLLA
K147 ENLLLASKSKGAAVK
K154 KSKGAAVKLADFGLA
Y223 DEDQHRLYQQIKAGA
K227 HRLYQQIKAGAYDFP
K227 HRLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKDLINKML
K251 EAKDLINKMLTINPA
T254 DLINKMLTINPAKRI
K259 MLTINPAKRITASEA
K268 ITASEALKHPWICQR
S276 HPWICQRSTVASMMH
S280 CQRSTVASMMHRQET
T287 SMMHRQETVDCLKKF
K292 QETVDCLKKFNARRK
K293 ETVDCLKKFNARRKL
K299 KKFNARRKLKGAILT
K299 KKFNARRKLKGAILT
K301 FNARRKLKGAILTTM
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLATRN
T307 LKGAILTTMLATRNF
T311 ILTTMLATRNFSAAK
S315 MLATRNFSAAKSLLK
S319 RNFSAAKSLLKKPDG
K322 SAAKSLLKKPDGVKI
K328 LKKPDGVKINNKANV
K332 DGVKINNKANVVTsP
S338-p NKANVVTsPKENIPT
S364-p NPDGNKEstEssNtt
T365-p PDGNKEstEssNttI
S367-p GNKEstEssNttIED
S368-p NKEstEssNttIEDE
T370-p EstEssNttIEDEDV
T371-p stEssNttIEDEDVK
S438 FYFENALSKSNKPIH
S475 LTQYMDGSGMPKTMQ
S506 VHFHRSGSPTVPIN_
- gap
- gap
3356 : Phospho-CaMKII (Tyr231) Antibody
  rat

 
S3 _____MASTTTCTRF
Y14-p CTRFTDEyQLFEELG
S26 ELGKGAFSVVRRCMk
K33-u SVVRRCMkIPTGQEy
Y40-p kIPTGQEyAAkIINT
K43-u TGQEyAAkIINTkkL
K48-u AAkIINTkkLSARDH
K48 AAkIINTKkLSARDH
K49-u AkIINTkkLSARDHQ
K69-u ARICRLLkHPNIVRL
K138-u GIVHRDLkPENLLLA
K147-u ENLLLASkSKGAAVk
K154-u kSKGAAVkLADFGLA
Y223-p DEDQHRLyQQIkAGA
K227-a HRLyQQIkAGAyDFP
K227-u HRLyQQIkAGAyDFP
Y231-p QQIkAGAyDFPSPEW
S235 AGAyDFPSPEWDTVT
K246-u DTVTPEAkDLINkML
K251-u EAkDLINkMLTINPA
T254 DLINkMLTINPAkRI
K259-u MLTINPAkRITASEA
K268-u ITASEALkHPWICQR
S276 HPWICQRSTVASMMH
S280 CQRSTVASMMHRQEt
T287-p SMMHRQEtVDCLkkF
K292-u QEtVDCLkkFNARRk
K293-u EtVDCLkkFNARRkL
K299-u kkFNARRkLkGAILT
K299 kkFNARRKLkGAILT
K301-u FNARRkLkGAILTTM
K301 FNARRkLKGAILTTM
T306 kLkGAILTTMLATRN
T307 LkGAILTTMLATRNF
T311 ILTTMLATRNFSAAK
S315 MLATRNFSAAKSLLk
S319 RNFSAAKSLLkKPDG
K322-u SAAKSLLkKPDGVkI
K328-u LkKPDGVkINNkANV
K332-u DGVkINNkANVVTSP
S338 NkANVVTSPKENIPT
S364 NPDGNKESTESSNTT
T365 PDGNKESTESSNTTI
S367 GNKESTESSNTTIED
S368 NKESTESSNTTIEDE
T370 ESTESSNTTIEDEDV
T371 STESSNTTIEDEDVK
P438 FYFENALPKINKPIH
N475 LTQYMDGNGMPKTMQ
S506 IHFHRSGSPTVPIKP
S524 PNGKENFSGGTSLWQ
S528 ENFSGGTSLWQNI__
3356 : Phospho-CaMKII (Tyr231) Antibody
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