a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CAMK; EC 188.8.131.52; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; CAMK2 family
Cellular Component: nucleoplasm; sarcoplasmic reticulum membrane; T-tubule; plasma membrane; neuromuscular junction; cytosol; calcium- and calmodulin-dependent protein kinase complex
Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; ATP binding
Biological Process: synaptic transmission; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; calcium ion transport; regulation of cell growth; protein amino acid phosphorylation; regulation of heart contraction; cardiac muscle contraction; G1/S transition of mitotic cell cycle
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II delta subunit; CaM kinase II subunit delta; CaM-kinase II delta chain; CaMK-II delta subunit; CaMK-II subunit delta; CAMK2D; CAMKD; CaMKII; DKFZp686G23119; DKFZp686I2288; KCC2D; MGC44911
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.