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Protein Page:
CAMK2G (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CAMK2G a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.17; CAMK group; CAMK2 family
Cellular Component: nucleoplasm; sarcoplasmic reticulum membrane; plasma membrane; cytosol; calcium- and calmodulin-dependent protein kinase complex
Molecular Function: calmodulin binding; calcium-dependent protein serine/threonine phosphatase activity; calmodulin-dependent protein kinase activity; ATP binding
Biological Process: nervous system development; regulation of skeletal muscle adaptation; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; regulation of calcium ion transport; protein amino acid phosphorylation; synaptic transmission; insulin secretion; calcium ion transport; response to hypoxia; response to oxidative stress; cell differentiation; G1/S transition of mitotic cell cycle
Reference #:  Q13555 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II gamma; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; CAMK; CAMK-II; CaMK-II subunit gamma; CAMK2G; CAMKG; CaMKII; FLJ16043; KCC2G; MGC26678
Gene Symbols: CAMK2G
Molecular weight: 62,609 Da
Basal Isoelectric point: 7.9  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Regulation of Microtubule Dynamics
Select Structure to View Below

CAMK2G
Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
enzymatic activity, inhibited: S26‑p
phosphorylation: S26‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 12 Y14-p CTRFTDDyQLFEELG
0 6 K22 QLFEELGKGAFsVVR
1 3 S26-p ELGKGAFsVVRRCVK
0 1 S36 RRCVKKTSTQEYAAK
0 1 T37 RCVKKTSTQEYAAKI
0 6 K43 STQEYAAKIINTKKL
0 7 K48 AAKIINTKKLSARDH
0 1 K48 AAKIINTKKLSARDH
0 7 K49 AKIINTKKLSARDHQ
0 10 K69-u ARICRLLkHPNIVRL
0 1 S114-p YYSEADAsHCIHQIL
0 8 K138 DIVHRDLKPENLLLA
0 8 K147 ENLLLASKCKGAAVK
0 6 K149 LLLASKCKGAAVKLA
0 4 K154 KCKGAAVKLADFGLA
0 1 Y223 DEDQHKLYQQIkAGA
0 2 K227-a HKLYQQIkAGAyDFP
0 18 K227-u HKLYQQIkAGAyDFP
0 28 Y231-p QQIkAGAyDFPsPEW
0 6 S235-p AGAyDFPsPEWDTVT
0 17 K246-u DTVTPEAkNLINQML
0 4 T254-p NLINQMLtINPAkRI
0 2 K259-a MLtINPAkRITADQA
0 8 K259-u MLtINPAkRITADQA
0 7 K268 ITADQALKHPWVCQR
0 4 S276-p HPWVCQRsTVAsMMH
0 1 T277 PWVCQRsTVAsMMHR
2 5 S280-p CQRsTVAsMMHRQEt
5 217 T287-p sMMHRQEtVECLRKF
0 1 K301 FNARRKLKGAILtTM
0 1 T306-p KLKGAILtTMLVsRN
0 1 T307 LKGAILtTMLVsRNF
0 8 S311-p ILtTMLVsRNFsAAK
0 7 S315-p MLVsRNFsAAKsLLN
0 1 - gap
0 2 - gap
0 4 K318 sRNFsAAKsLLNKKs
1 6 S319-p RNFsAAKsLLNKKsD
0 4 S325-p KsLLNKKsDGGVKKR
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 S349-p PQSNNKNsLVsPAQE
0 2 S352-p NNKNsLVsPAQEPAP
0 3 T369 TAMEPQTTVVHNATD
0 2 S381 ATDGIKGStEsCNTT
0 3 T382-p TDGIKGStEsCNTTT
0 5 S384-p GIKGStEsCNTTTED
0 1 T388 StEsCNTTTEDEDLK
0 2 - gap
0 1 - gap
0 2 S419-p AGMQPQPsLCSSAMR
0 2 S484 FYFENLLSKNSKPIH
0 4 K488 NLLSKNSKPIHTTIL
0 13 Y517 AYIRLTQYIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
  CAMK2G iso2  
Y14 CTRFTDDYQLFEELG
K22 QLFEELGKGAFSVVR
S26 ELGKGAFSVVRRCVK
S36 RRCVKKTSTQEYAAK
T37 RCVKKTSTQEYAAKI
K43 STQEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHPNIVRL
S114 YYSEADASHCIHQIL
K138 DIVHRDLKPENLLLA
K147 ENLLLASKCKGAAVK
K149 LLLASKCKGAAVKLA
K154 KCKGAAVKLADFGLA
Y223 DEDQHKLYQQIKAGA
K227 HKLYQQIKAGAYDFP
K227 HKLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKNLINQML
T254 NLINQMLTINPAKRI
K259 MLTINPAKRITADQA
K259 MLTINPAKRITADQA
K268 ITADQALKHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQEt
T287-p SMMHRQEtVECLRKF
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLVSRN
T307 LKGAILTTMLVSRNF
S311 ILTTMLVSRNFSAAK
S315 MLVSRNFSAAKSLLN
- gap
- gap
K318 SRNFSAAKSLLNKKs
S319 RNFSAAKSLLNKKsD
S325-p KSLLNKKsDGGVKPQ
- gap
- gap
- gap
- gap
S338 PQSNNKNSLVSPAQE
S341 NNKNSLVSPAQEPAP
T358 TAMEPQTTVVHNATD
S370 ATDGIKGSTESCNTT
T371 TDGIKGSTESCNTTT
S373 GIKGSTESCNTTTED
T377 STESCNTTTEDEDLK
- gap
- gap
S408 AGMQPQPSLCSSAMR
S473 FYFENLLSKNSKPIH
K477 NLLSKNSKPIHTTIL
Y506 AYIRLTQYIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
  CAMK2G iso5  
Y14 CTRFTDDYQLFEELG
K22 QLFEELGKGAFSVVR
S26 ELGKGAFSVVRRCVK
S36 RRCVKKTSTQEYAAK
T37 RCVKKTSTQEYAAKI
K43 STQEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHPNIVRL
S114 YYSEADASHCIHQIL
K138 DIVHRDLKPENLLLA
K147 ENLLLASKCKGAAVK
K149 LLLASKCKGAAVKLA
K154 KCKGAAVKLADFGLA
Y223 DEDQHKLYQQIKAGA
K227 HKLYQQIKAGAYDFP
K227 HKLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKNLINQML
T254 NLINQMLTINPAKRI
K259 MLTINPAKRITADQA
K259 MLTINPAKRITADQA
K268 ITADQALKHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQET
T287 SMMHRQETVECLRKF
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLVSRN
T307 LKGAILTTMLVSRNF
S311 ILTTMLVSRNFsVGR
S315-p MLVSRNFsVGRQSSA
S320 NFsVGRQSSAPASPA
S325 RQSSAPASPAASAAG
K339 GLAGQAAKSLLNKKS
S340 LAGQAAKSLLNKKSD
S346 KSLLNKKSDGGVKKR
S355-p GGVKKRKssssVHLM
S356-p GVKKRKssssVHLME
S357-p VKKRKssssVHLMEP
S358-p KKRKssssVHLMEPQ
- gap
- gap
T367 HLMEPQTTVVHNATD
S379-p ATDGIKGstEsCNTt
T380-p TDGIKGstEsCNTtT
S382-p GIKGstEsCNTtTED
T386-p stEsCNTtTEDEDLK
- gap
- gap
- gap
S453 FYFENLLSKNSKPIH
K457 NLLSKNSKPIHTTIL
Y486 AYIRLTQYIDGQGRP
  CAMK2G iso7  
Y14 CTRFTDDYQLFEELG
K22 QLFEELGKGAFSVVR
S26 ELGKGAFSVVRRCVK
S36 RRCVKKTSTQEYAAK
T37 RCVKKTSTQEYAAKI
K43 STQEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHPNIVRL
S114 YYSEADASHCIHQIL
K138 DIVHRDLKPENLLLA
K147 ENLLLASKCKGAAVK
K149 LLLASKCKGAAVKLA
K154 KCKGAAVKLADFGLA
Y223 DEDQHKLYQQIKAGA
K227 HKLYQQIKAGAYDFP
K227 HKLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKNLINQML
T254 NLINQMLTINPAKRI
K259 MLTINPAKRITADQA
K259 MLTINPAKRITADQA
K268 ITADQALKHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQEt
T287-p SMMHRQEtVECLRKF
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLVSRN
T307 LKGAILTTMLVSRNF
S311 ILTTMLVSRNFsVGR
S315-p MLVSRNFsVGRQsSA
S320-p NFsVGRQsSAPAsPA
S325-p RQsSAPAsPAASAAG
K339 GLAGQAAKSLLNKKs
S340 LAGQAAKSLLNKKsD
S346-p KSLLNKKsDGGVKEP
- gap
- gap
- gap
- gap
- gap
- gap
T356 GVKEPQTTVVHNATD
S368-p ATDGIKGstEsCNTt
T369-p TDGIKGstEsCNTtT
S371-p GIKGstEsCNTtTED
T375-p stEsCNTtTEDEDLK
- gap
- gap
- gap
S442 FYFENLLSKNSKPIH
K446 NLLSKNSKPIHTTIL
Y475 AYIRLTQYIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
  CAMK2G iso9  
Y14 CTRFTDDYQLFEELG
K22 QLFEELGKGAFSVVR
S26 ELGKGAFSVVRRCVK
S36 RRCVKKTSTQEYAAK
T37 RCVKKTSTQEYAAKI
K43 STQEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHPNIVRL
S114 YYSEADASHCIHQIL
K138 DIVHRDLKPENLLLA
K147 ENLLLASKCKGAAVK
K149 LLLASKCKGAAVKLA
K154 KCKGAAVKLADFGLA
Y223 DEDQHKLYQQIKAGA
K227 HKLYQQIKAGAYDFP
K227 HKLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKNLINQML
T254 NLINQMLTINPAKRI
K259 MLTINPAKRITADQA
K259 MLTINPAKRITADQA
K268 ITADQALKHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQET
T287 SMMHRQETVECLRKF
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLVSRN
T307 LKGAILTTMLVSRNF
S311 ILTTMLVSRNFSAAK
S315 MLVSRNFSAAKSLLN
- gap
- gap
K318 SRNFSAAKSLLNKKs
S319 RNFSAAKSLLNKKsD
S325-p KSLLNKKsDGGVKPQ
- gap
- gap
- gap
- gap
S338-p PQSNNKNsLEPQTtV
- gap
T344-p NsLEPQTtVVHNATD
S356-p ATDGIKGsTEsCNTT
T357 TDGIKGsTEsCNTTT
S359-p GIKGsTEsCNTTTED
T363 sTEsCNTTTEDEDLK
T376-p LKAAPLRtGNGsSVP
S380-p PLRtGNGsSVPEGRS
S403 AGMQPQPSLCSSAMR
S468 FYFENLLSKNSKPIH
K472 NLLSKNSKPIHTTIL
Y501 AYIRLTQYIDGQGRP
  mouse

► Hide Isoforms 		 
Y14 CTRFTDDYQLFEELG
K22 QLFEELGKGAFsVVR
S26-p ELGKGAFsVVRRCVK
S36-p RRCVKKTstQEYAAk
T37-p RCVKKTstQEYAAkI
K43-u stQEYAAkIINTkkL
K48-u AAkIINTkkLSARDH
K48-a AAkIINTkkLSARDH
K49-u AkIINTkkLSARDHQ
K69-u ARICRLLkHPNIVRL
S114 YYSEADASHCIHQIL
K138-u DIVHRDLkPENLLLA
K147-u ENLLLASkCKGAAVK
K149 LLLASkCKGAAVKLA
K154 kCKGAAVKLADFGLA
Y223 DEDQHKLYQQIkAGA
K227 HKLYQQIKAGAyDFP
K227-u HKLYQQIkAGAyDFP
Y231-p QQIkAGAyDFPsPEW
S235-p AGAyDFPsPEWDTVT
K246-u DTVTPEAkNLINQML
T254-p NLINQMLtINPAkRI
K259 MLtINPAKRITADQA
K259-u MLtINPAkRITADQA
K268-u ITADQALkHPWVCQR
S276-p HPWVCQRstVAsMMH
T277-p PWVCQRstVAsMMHR
S280-p CQRstVAsMMHRQEt
T287-p sMMHRQEtVECLRKF
K301-m1 FNARRKLkGAILTtM
T306 KLkGAILTtMLVsRN
T307-p LkGAILTtMLVsRNF
S311-p ILTtMLVsRNFsAAK
S315-p MLVsRNFsAAKsLLN
- gap
- gap
K318 sRNFsAAKsLLNKKS
S319-p RNFsAAKsLLNKKSD
S325 KsLLNKKSDGGVKKR
- gap
- gap
- gap
- gap
S349 PQSNNKNSLVSPAQE
S352 NNKNSLVSPAQEPAP
T369-p TAMEPQTtVVHNATD
S381-p ATDGIKGstEsCNTt
T382-p TDGIKGstEsCNTtT
S384-p GIKGstEsCNTtTED
T388-p stEsCNTtTEDEDLK
- gap
- gap
- gap
S455-p FYFENLLsKNSKPIH
K459 NLLsKNSKPIHTTIL
Y488 AYIRLTQYIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
  CAMK2G iso3  
Y14 CTRFTDDYQLFEELG
K22 QLFEELGKGAFSVVR
S26 ELGKGAFSVVRRCVK
S36 RRCVKKTSTQEYAAK
T37 RCVKKTSTQEYAAKI
K43 STQEYAAKIINTKKL
K48 AAKIINTKKLSARDH
K48 AAKIINTKKLSARDH
K49 AKIINTKKLSARDHQ
K69 ARICRLLKHPNIVRL
S114 YYSEADASHCIHQIL
K138 DIVHRDLKPENLLLA
K147 ENLLLASKCKGAAVK
K149 LLLASKCKGAAVKLA
K154 KCKGAAVKLADFGLA
Y223 DEDQHKLYQQIKAGA
K227 HKLYQQIKAGAYDFP
K227 HKLYQQIKAGAYDFP
Y231 QQIKAGAYDFPSPEW
S235 AGAYDFPSPEWDTVT
K246 DTVTPEAKNLINQML
T254 NLINQMLTINPAKRI
K259 MLTINPAKRITADQA
K259 MLTINPAKRITADQA
K268 ITADQALKHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQET
T287 SMMHRQETVECLRKF
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLVSRN
T307 LKGAILTTMLVSRNF
S311 ILTTMLVSRNFSAAK
S315 MLVSRNFSAAKSLLN
- gap
- gap
K318 SRNFSAAKSLLNKKS
S319 RNFSAAKSLLNKKSD
S325 KSLLNKKSDGGVKEP
- gap
- gap
- gap
- gap
- gap
- gap
T335 GVKEPQTTVVHNATD
S347 ATDGIKGSTESCNTT
T348 TDGIKGSTESCNTTT
S350 GIKGSTESCNTTTED
T354 STESCNTTTEDEDLK
- gap
- gap
- gap
S421 FYFENLLSKNSKPIH
K425 NLLSKNSKPIHTTIL
Y454 AYIRLTQYIDGQGRP
  rat

 
Y14-p CTRFTDDyQLFEELG
K22-u QLFEELGkGAFSVVR
S26 ELGkGAFSVVRRCVK
S36 RRCVKKTSTQEYAAk
T37 RCVKKTSTQEYAAkI
K43-u STQEYAAkIINTkkL
K48-u AAkIINTkkLSARDH
K48 AAkIINTKkLSARDH
K49-u AkIINTkkLSARDHQ
K69-u ARICRLLkHPNIVRL
S114 YYSEADASHCIHQIL
K138-u DIVHRDLkPENLLLA
K147-u ENLLLASkCkGAAVk
K149-u LLLASkCkGAAVkLA
K154-u kCkGAAVkLADFGLA
Y223-p DEDQHKLyQQIkAGA
K227-a HKLyQQIkAGAyDFP
K227-u HKLyQQIkAGAyDFP
Y231-p QQIkAGAyDFPSPEW
S235 AGAyDFPSPEWDTVT
K246-u DTVTPEAkNLINQML
T254 NLINQMLTINPAkRI
K259-a MLTINPAkRITADQA
K259-u MLTINPAkRITADQA
K268-u ITADQALkHPWVCQR
S276 HPWVCQRSTVASMMH
T277 PWVCQRSTVASMMHR
S280 CQRSTVASMMHRQET
T287 SMMHRQETVECLRKF
K301 FNARRKLKGAILTTM
T306 KLKGAILTTMLVSRN
T307 LKGAILTTMLVSRNF
S311 ILTTMLVSRNFSVGR
S315 MLVSRNFSVGRQSSA
S320 NFSVGRQSSAPAsPA
S325-p RQSSAPAsPAASAAG
K339-u GLAGQAAkSLLNKKS
S340 LAGQAAkSLLNKKSD
S346 kSLLNKKSDGGVKKR
S355 GGVKKRKSSSSVHLM
S356 GVKKRKSSSSVHLME
S357 VKKRKSSSSVHLMEP
S358 KKRKSSSSVHLMEPQ
- gap
- gap
T367 HLMEPQTTVVHNATD
S379 ATDGIKGSTESCNTT
T380 TDGIKGSTESCNTTT
S382 GIKGSTESCNTTTED
T386 STESCNTTTEDEDLK
- gap
- gap
- gap
S453 FYFENLLSKNSkPIH
K457-u NLLSKNSkPIHTTIL
Y486-p AYIRLTQyIDGQGRP
3356 : Phospho-CaMKII (Tyr231) Antibody
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