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Protein Page:
SALL4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SALL4 a transcription factor and oncofetal protein expressed embryonically and in the testis. Plays a key role in maintenance and self-renewal of embryonic stem cells. Interacts with NANOG and OCT4. Ectopically expressed in acute B-cell lymphoblastic leukemia (B-ALL) and myeloid leukemia (AML), playing a role in the survival of B-ALL cells and in myeloid leukemogenesis. Aberrantly expressed in multiple carcinomas including human gastric carcinoma and hepatocellular carcinoma. Maintains the stem cell qualities of EpCAM-positive hepatocellular carcinoma cells. Expressed in primary human endometrial cancer samples but not normal or hyperplastic endometrial cells. Its expression in carcinomas positively correlates with metastatic potential and poor patient survival. Specifically binds the c-Myc promoter region in endometrial cancer cells, apparently increasing c-Myc expression. Belongs to the sal C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Cancer Testis Antigen (CTA); C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: heterochromatin; protein complex; cytoplasm; nucleus
Molecular Function: DNA binding; metal ion binding
Biological Process: transcription, DNA-dependent; neural tube closure; stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; inner cell mass cell proliferation; embryonic limb morphogenesis
Reference #:  Q9UJQ4 (UniProtKB)
Alt. Names/Synonyms: dJ1112F19.1; DRRS; HSAL4; MGC133050; sal-like 4 (Drosophila); Sal-like protein 4; SALL4; Zinc finger protein SALL4; ZNF797
Gene Symbols: SALL4
Molecular weight: 112,231 Da
Basal Isoelectric point: 7.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SALL4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 H49 ELGAPVNHPGNDEVA
1 0 K156 AESVVYLKTETALPP
0 1 K173-ac QDISYLAkGKVANTN
0 2 K278 AVALLSQKAGSQGLS
0 1 S307-p PSATSSLsPGLAPFT
1 0 K316 GLAPFTLKPDGTRVL
0 1 K357 TVALDTSKKGKGKPP
1 0 K374 SAVDVKPKDEAALYK
0 1 T393-p YCSKVFGtDsSLQIH
0 1 S395-p SKVFGtDsSLQIHLR
0 1 S530-p GVGPNYNsPRAGGFQ
0 3 T541-p GGFQGSGtPEPGSET
0 1 S576-p LICHRVLsCQSSLKM
0 1 S748-p FNLQRQGsRENGsVE
0 1 S753-p QGsRENGsVESDGLT
0 1 S764 DGLTNDSSsLMGDQE
0 2 S765-p GLTNDSSsLMGDQEY
0 6 S776-p DQEYQSRsPDILETT
0 1 L780 QSRsPDILETTSFQA
0 10 S789-p TTSFQALsPANsQAE
0 6 S793-p QALsPANsQAESIKS
0 1 S824-p TEMEGRSsLPSTFIR
1 0 K838 RAPPTYVKVEVPGTF
0 2 S852-p FVGPSTLsPGMTPLL
0 1 T873-p QAKQHGCtRCGKNFs
0 1 S880-p tRCGKNFssAsALQI
0 1 S881-p RCGKNFssAsALQIH
0 1 S883-p GKNFssAsALQIHER
0 1 S1019-p TVSKMDGsQSGISAD
  SALL4 iso3  
H49 ELGAPVNHPGNDEVA
K156-sm AESVVYLkTETALPP
K173 QDISYLAKGKVANTN
K278 AVALLSQKAGSQGLS
S307 PSATSSLSPGLAPFT
K316-sm GLAPFTLkPDGTRVL
K357 TVALDTSKKGKGKPP
K374-sm SAVDVKPkDEAALYK
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S387 YKHKCRSSLPSTFIR
K401-sm RAPPTYVkVEVPGTF
S415 FVGPSTLSPGMTPLL
T436 QAKQHGCTRCGKNFS
S443 TRCGKNFSSASALQI
S444 RCGKNFSSASALQIH
S446 GKNFSSASALQIHER
S582 TVSKMDGSQSGISAD
  mouse

► Hide Isoforms
 
S45 EPGAPVNSPGNCDEA
K151 TDSILYLKTEATQPS
K168 QDISYLPKGKVANTN
K279-ub AVALLSQkASNPALS
S308 PSAASPLSSGLTSFT
K317 GLTSFTLKPDGTRVL
K358-ac AVTLDQSkKGKGKPQ
K379 SVLDVKAKDEVVLGK
T398 YCPKVFGTDSSLQIH
S400 PKVFGTDSSLQIHLR
P537 GVGMIHNPPKAGGFQ
A548 GGFQGTGAPESGSET
S583 LICHRVLSCQSSLKM
S755 LALQRQSSRENSSLE
S760 QSSRENSSLEGGDTG
S773-p TGPANDSsLLVGDQE
L774 GPANDSsLLVGDQEC
S785-p DQECQSRsPDAtETM
T789-p QSRsPDAtETMCYQA
S798-p TMCYQAVsPANsQAG
S802-p QAVsPANsQAGSVKS
S832 VDTEGRTSLPPTFIR
K846 RAQPTFVKVEVPGTF
P860 FVGPPSMPSGMPPLL
T883 QAKQHCCTRCGKNFS
S890 TRCGKNFSSASALQI
S891 RCGKNFSSASALQIH
S893 GKNFSSASALQIHER
S1029 TISKLDGSQTGVSMP
  SALL4 iso2  
S45 EPGAPVNSPGNCDEA
K151 TDSILYLKTEATQPS
K168 QDISYLPKGKVANTN
K279 AVALLSQKASNPALS
S308 PSAASPLSSGLTSFT
K317 GLTSFTLKPDGTRVL
K358 AVTLDQSKKGKGKPQ
K379 SVLDVKAKDEVVLGR
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S388 EVVLGRTSLPPTFIR
K402 RAQPTFVKVEVPGTF
P416 FVGPPSMPSGMPPLL
T439 QAKQHCCTRCGKNFS
S446 TRCGKNFSSASALQI
S447 RCGKNFSSASALQIH
S449 GKNFSSASALQIHER
S585 TISKLDGSQTGVSMP
  SALL4 iso4  
S14-p TPGAPVNsPGNCDEA
K120 TDSILYLKTEATQPS
K137 QDISYLPKGKVANTN
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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