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Protein Page:
PSME1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSME1 Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Heterodimer of PSME1 and PSME2, which forms a hexadimeric ring. PSME1 can form homoheptamers. By IFNG/IFN-gamma. Belongs to the PA28 family. Note: This description may include information from UniProtKB.
Protein type: Proteasome complex
Cellular Component: nucleoplasm; proteasome complex; proteasome activator complex; cytoplasm; cytosol
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mRNA metabolic process; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Reference #:  Q06323 (UniProtKB)
Alt. Names/Synonyms: 11S regulator complex alpha subunit; 11S regulator complex subunit alpha; 29-kD MCP activator subunit; Activator of multicatalytic protease subunit 1; IFI5111; IGUP I-5111; Interferon gamma up-regulated I-5111 protein; interferon-gamma IEF SSP 5111; interferon-gamma-inducible protein 5111; MGC8628; PA28a; PA28alpha; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha); Proteasome activator 28 subunit alpha; Proteasome activator complex subunit 1; proteasome activator subunit-1; PSME1; REG-alpha; REGalpha
Gene Symbols: PSME1
Molecular weight: 28,723 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSME1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K13 VQPEAQAKVDVFRED
0 1 T23-p VFREDLCtktENLLG
0 2 K24-ub FREDLCtktENLLGS
0 1 T25-p REDLCtktENLLGSY
0 4 K35-ac LLGSYFPkkISELDA
0 5 K35-ub LLGSYFPkkISELDA
0 1 K35-sc LLGSYFPkkISELDA
0 2 K36-ub LGSYFPkkISELDAF
0 1 K45 SELDAFLKEPALNEA
0 1 S55-p ALNEANLsNLKAPLD
0 1 K70 IPVPDPVKEKEKEER
0 1 K90-ac KEDKDEKkKGEDEDK
0 1 K155 FGVAVQEKVFELMTS
0 1 K155-ub FGVAVQEkVFELMTS
0 2 K176-ub GFHTQISkYFSERGD
0 14 K232-ac VLYDIILkNFEKLKK
0 1 K245-ub KKPRGETkGMIy___
0 1 Y249-p GETkGMIy_______
0 1 - gap
  PSME1 iso2  
K13 VQPEAQAKVDVFRED
T23 VFREDLCTKTENLLG
K24 FREDLCTKTENLLGS
T25 REDLCTKTENLLGSY
K35 LLGSYFPKKISELDA
K35 LLGSYFPKKISELDA
K35 LLGSYFPKKISELDA
K36 LGSYFPKKISELDAF
K45 SELDAFLKEPALNEA
S55 ALNEANLSNLKAPLD
K70 IPVPDPVKEKEKEER
K90 KEDKDEKKKGEDEDK
K155 FGVAVQEKVFELMTS
K155 FGVAVQEKVFELMTS
K176 GFHTQISKYFSERGD
- gap
- gap
- gap
S238-p RGGQRQLsQATHSLT
  mouse

 
K13-ub VHPEAQAkVDVFRED
S23 VFREDLCSKTENLLG
K24 FREDLCSKTENLLGS
T25 REDLCSKTENLLGSY
K35-ac LLGSYFPkKISELDA
K35-ub LLGSYFPkKISELDA
K35-sc LLGSYFPkKISELDA
K36 LGSYFPkKISELDAF
K45-ac SELDAFLkEPALNEA
S55 ALNEANLSNLKAPLD
K70-ub IPVPDPVkEKEKEER
K90 KEEKEEKKKGDEDDK
K155-ac FGVAVQEkVFELMTN
K155 FGVAVQEKVFELMTN
K176 GFHTQISKYFSERGD
K232 VLYDIILKNFEKLKK
K245 KKPRGETKGMIY___
Y249 GETKGMIY_______
- gap
  rat

 
K13 VHPEAQAKVDVFRED
S23 VFREDLCSKTENLLG
K24 FREDLCSKTENLLGS
T25 REDLCSKTENLLGSY
K35 LLGSYFPKKISELDA
K35 LLGSYFPKKISELDA
K35 LLGSYFPKKISELDA
K36 LGSYFPKKISELDAF
K45 SELDAFLKEPALNEA
S55 ALNEANLSNLKAPLD
K70 IPVPDPVKEKEKEER
K90 KEEKDEKKKGDEDDK
K155 FGVAVQAKVFELMTS
K155 FGVAVQAKVFELMTS
K176 GFQTQISKYFSERGD
K232 VLYDIILKNFEKLKK
K245 KKPRGETKGMIY___
Y249 GETKGMIY_______
- gap
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