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Protein Page:
CAMK1D (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CAMK1D a calcium/calmodulin-dependent S/T protein kinase of the CAMK group. Binding of calmodulin is thought to result in a conformational change and can lead to subsequent activation through phosphorylation by CAMKK1 and CAMKK2. Can be activated by CAMKK1 in a calcium-independent manner. Its Ca(2+)/CaM-dependent activity is enhanced 30-fold in vitro by phosphorylation at Thr180 by CaMKK1. Broadly expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. May regulate calcium-mediated granulocyte function. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta and probably CREB1. Expression increases upon treatment of EC cells with DMSO and retinoic acid. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CAMK; EC 2.7.11.17; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK1 family
Cellular Component: cytoplasm; nucleus; calcium- and calmodulin-dependent protein kinase complex
Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; ATP binding
Biological Process: positive regulation of apoptosis; positive regulation of phagocytosis; activation of CREB transcription factor; regulation of dendrite development; inflammatory response; negative regulation of apoptosis
Reference #:  Q8IU85 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase ID; Calcium/calmodulin-dependent protein kinase type 1D; CaM kinase I delta; CaM kinase ID; CaM-K1; CaM-KI delta; CAMK1D; CaMKI delta; CaMKI-like protein kinase; CaMKID; CKLiK; KCC1D
Gene Symbols: CAMK1D
Molecular weight: 42,914 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CAMK1D

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 4 K52-u TGKLFAVkCIPKKAL
0 1 S122-p FYTEKDAsTLIRQVL
0 3 S179-p EGKGDVMstACGTPG
1 19 T180-p GKGDVMstACGTPGY
0 1 T184 VMstACGTPGYVAPE
0 2 S326-p MRKLHLGssLDSSNA
0 2 S327-p RKLHLGssLDSSNAS
0 1 S330 HLGssLDSSNASVSS
0 5 - gap
  CAMK1D iso2  
K52 TGKLFAVKCIPKKAL
S122 FYTEKDASTLIRQVL
S179 EGKGDVMSTACGTPG
T180 GKGDVMSTACGTPGY
T184 VMSTACGTPGYVAPE
S326 MRKLHLGSSLDSSNA
S327 RKLHLGSSLDSSNAS
S330 HLGSSLDSSNASVSS
- gap
  mouse

► Hide Isoforms
 
K52 TGKLFAVKCIPKKAL
S122 FYTEKDASTLIRQVL
S179-p EGKGDVMstACGtPG
T180-p GKGDVMstACGtPGY
T184-p VMstACGtPGYVAPE
S326 MRRLQLGSSLDSSNA
S327 RRLQLGSSLDSSNAS
S330 QLGSSLDSSNASVSS
- gap
  CAMK1D iso4  
K52 TGKLFAVKCIPKKAL
S97 FYTEKDASTLIRQVL
S154 EGKGDVMSTACGTPG
T155 GKGDVMSTACGTPGY
T159 VMSTACGTPGYVAPE
S301 MRRLQLGSSLDSSNV
S302 RRLQLGSSLDSSNVW
S305 QLGSSLDSSNVWHLP
S324-p SFLLRRGsQESELRG
  rat

 
K52-u TGKLFAVkCIPKKAL
S122 FYTEKDASTLIRQVL
S179 EGKGDVMSTACGTPG
T180 GKGDVMSTACGTPGY
T184 VMSTACGTPGYVAPE
S326-p MRRLQLGssLDsSNA
S327-p RRLQLGssLDsSNAS
S330-p QLGssLDsSNASVSS
- gap
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