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CAMK1D (human)

Overview CAMK1D a calcium/calmodulin-dependent S/T protein kinase of the CAMK group. Binding of calmodulin is thought to result in a conformational change and can lead to subsequent activation through phosphorylation by CAMKK1 and CAMKK2. Can be activated by CAMKK1 in a calcium-independent manner. Its Ca(2+)/CaM-dependent activity is enhanced 30-fold in vitro by phosphorylation at Thr180 by CaMKK1. Broadly expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. May regulate calcium-mediated granulocyte function. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta and probably CREB1. Expression increases upon treatment of EC cells with DMSO and retinoic acid. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.17; Protein kinase, CAMK; Kinase, protein; CAMK group; CAMK1 family Cellular Component: cytoplasm; calcium- and calmodulin-dependent protein kinase complex; nucleus Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; ATP binding Biological Process: regulation of apoptosis; positive regulation of phagocytosis; activation of CREB transcription factor; regulation of dendrite development; inflammatory response Reference #:  Q8IU85 (UniProtKB) Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase ID; Calcium/calmodulin-dependent protein kinase type 1D; CaM kinase I delta; CaM kinase ID; CaM-K1; CaM-KI delta; CAMK1D; CaMKI delta; CaMKI-like protein kinase; CaMKID; CKLiK; KCC1D Gene Symbols: CAMK1D Molecular weight: 42,914 Da Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Regulation of Microtubule Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CAMK1D 2JC6 - A/C=1-333 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S8-p	MARENGEsSSSWKKQ
0	4		K52-u	TGKLFAVkCIPKKAL
0	1		S122-p	FYTEKDAsTLIRQVL
0	1		K146	GIVHRDLKPENLLyy
0	1		Y152-p	LKPENLLyySQDEES
0	1		Y153-p	KPENLLyySQDEESK
0	1		K174-a	GLSKMEGkGDVMstA
0	3		S179-p	EGkGDVMstACGTPG
1	19		T180-p	GkGDVMstACGTPGY
0	1		T184	VMstACGTPGYVAPE
0	1		K196-a	APEVLAQkPYSKAVD
0	1		Y238-p	EQILKAEyEFDSPYW
0	1		K262-a	FIRNLMEkDPNKRYT
0	1		K262	FIRNLMEKDPNKRYT
0	2		S326-p	MRKLHLGssLDSSNA
0	2		S327-p	RKLHLGssLDSSNAS
0	1		S330	HLGssLDSSNASVSS
0	1		S338-p	SNASVSSsLSLASQK
0	4		-	gap

	mouse ► Hide Isoforms
S8	MARENGESSSSWKKQ
K52	TGKLFAVKCIPKKAL
S122	FYTEKDASTLIRQVL
K146-a	GIVHRDLkPENLLYY
Y152	LkPENLLYYSQDEES
Y153	kPENLLYYSQDEESK
K174	GLSKMEGKGDVMstA
S179-p	EGKGDVMstACGtPG
T180-p	GKGDVMstACGtPGY
T184-p	VMstACGtPGYVAPE
K196	APEVLAQKPYSKAVD
Y238	EQILKAEYEFDSPYW
K262	FIRNLMEKDPNKRYT
K262	FIRNLMEKDPNKRYT
S326	MRRLQLGSSLDSSNA
S327	RRLQLGSSLDSSNAS
S330	QLGSSLDSSNASVSS
N338	SNASVSSNLSLASQK
-	gap

	CAMK1D iso4
S8	MARENGESSSSWKKQ
K52	TGKLFAVKCIPKKAL
S97	FYTEKDASTLIRQVL
K121	GIVHRDLKPENLLYY
Y127	LKPENLLYYSQDEES
Y128	KPENLLYYSQDEESK
K149	GLSKMEGKGDVMSTA
S154	EGKGDVMSTACGTPG
T155	GKGDVMSTACGTPGY
T159	VMSTACGTPGYVAPE
K171	APEVLAQKPYSKAVD
Y213	EQILKAEYEFDSPYW
K237	FIRNLMEKDPNKRYT
K237	FIRNLMEKDPNKRYT
S301	MRRLQLGSSLDSSNV
S302	RRLQLGSSLDSSNVW
S305	QLGSSLDSSNVWHLP
-	gap
S324-p	SFLLRRGsQESELRG

	rat
S8	MARENGESSSSWKKQ
K52-u	TGKLFAVkCIPKKAL
S122	FYTEKDASTLIRQVL
K146	GIVHRDLKPENLLYY
Y152	LKPENLLYYSQDEES
Y153	KPENLLYYSQDEESK
K174	GLSKMEGKGDVMSTA
S179	EGKGDVMSTACGTPG
T180	GKGDVMSTACGTPGY
T184	VMSTACGTPGYVAPE
K196	APEVLAQKPYSKAVD
Y238-p	EQILKAEyEFDSPYW
K262	FIRNLMEKDPNKRYT
K262-u	FIRNLMEkDPNKRYT
S326-p	MRRLQLGssLDsSNA
S327-p	RRLQLGssLDsSNAS
S330-p	QLGssLDsSNASVSS
N338	SNASVSSNLSLASQK
-	gap

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