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Protein Page:
CAMK1D (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CAMK1D a calcium/calmodulin-dependent S/T protein kinase of the CAMK group. Binding of calmodulin is thought to result in a conformational change and can lead to subsequent activation through phosphorylation by CAMKK1 and CAMKK2. Can be activated by CAMKK1 in a calcium-independent manner. Its Ca(2+)/CaM-dependent activity is enhanced 30-fold in vitro by phosphorylation at Thr180 by CaMKK1. Broadly expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. May regulate calcium-mediated granulocyte function. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta and probably CREB1. Expression increases upon treatment of EC cells with DMSO and retinoic acid. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 2.7.11.17; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMK1 family
Cellular Component: cytoplasm; nucleus; calcium- and calmodulin-dependent protein kinase complex
Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; ATP binding
Biological Process: positive regulation of apoptosis; positive regulation of phagocytosis; activation of CREB transcription factor; regulation of dendrite development; inflammatory response; protein amino acid phosphorylation; negative regulation of apoptosis
Reference #:  Q8IU85 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase ID; Calcium/calmodulin-dependent protein kinase type 1D; CaM kinase I delta; CaM kinase ID; CaM-K1; CaM-KI delta; CAMK1D; CaMKI delta; CaMKI-like protein kinase; CaMKID; CKLiK; KCC1D
Gene Symbols: CAMK1D
Molecular weight: 42,914 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CAMK1D

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S8-p MARENGEsSSSWKKQ
0 4 K52-ub TGKLFAVkCIPKKAL
0 1 S122-p FYTEKDAsTLIRQVL
0 1 K146 GIVHRDLKPENLLyy
0 1 Y152-p LKPENLLyysQDEES
0 1 Y153-p KPENLLyysQDEESK
0 1 S154-p PENLLyysQDEESKI
0 1 K174-ac GLSKMEGkGDVMstA
0 5 S179-p EGkGDVMstACGTPG
1 20 T180-p GkGDVMstACGTPGY
0 1 T184 VMstACGTPGYVAPE
0 1 K196-ac APEVLAQkPYSKAVD
0 1 Y238 EQILKAEYEFDSPYW
0 1 K262-ac FIRNLMEkDPNKRYT
0 1 K262 FIRNLMEKDPNKRYT
0 2 S326-p MRKLHLGssLDSSNA
0 3 S327-p RKLHLGssLDSSNAS
0 1 S330 HLGssLDSSNASVSS
0 1 S338-p SNASVSSsLSLASQK
0 5 - gap
0 1 - gap
  CAMK1D iso2  
S8 MARENGESSSSWKKQ
K52 TGKLFAVKCIPKKAL
S122 FYTEKDASTLIRQVL
K146 GIVHRDLKPENLLYY
Y152 LKPENLLYYSQDEES
Y153 KPENLLYYSQDEESK
S154 PENLLYYSQDEESKI
K174 GLSKMEGKGDVMSTA
S179 EGKGDVMSTACGTPG
T180 GKGDVMSTACGTPGY
T184 VMSTACGTPGYVAPE
K196 APEVLAQKPYSKAVD
Y238 EQILKAEYEFDSPYW
K262 FIRNLMEKDPNKRYT
K262 FIRNLMEKDPNKRYT
S326 MRKLHLGSSLDSSNA
S327 RKLHLGSSLDSSNAS
S330 HLGSSLDSSNASVSS
S338 SNASVSSSLSLASQK
- gap
S355-p AYVAKPEsLS_____
  mouse

► Hide Isoforms
 
S8 MARENGESSSSWKKQ
K52 TGKLFAVKCIPKKAL
S122 FYTEKDASTLIRQVL
K146-ac GIVHRDLkPENLLYY
Y152 LkPENLLYYSQDEES
Y153 kPENLLYYSQDEESK
S154 PENLLYYSQDEESKI
K174 GLSKMEGKGDVMstA
S179-p EGKGDVMstACGtPG
T180-p GKGDVMstACGtPGY
T184-p VMstACGtPGYVAPE
K196 APEVLAQKPYSKAVD
Y238 EQILKAEYEFDSPYW
K262 FIRNLMEKDPNKRYT
K262 FIRNLMEKDPNKRYT
S326 MRRLQLGSSLDSSNA
S327 RRLQLGSSLDSSNAS
S330 QLGSSLDSSNASVSS
N338 SNASVSSNLSLASQK
- gap
- gap
  CAMK1D iso4  
S8 MARENGESSSSWKKQ
K52 TGKLFAVKCIPKKAL
S97 FYTEKDASTLIRQVL
K121 GIVHRDLKPENLLYY
Y127 LKPENLLYYSQDEES
Y128 KPENLLYYSQDEESK
S129 PENLLYYSQDEESKI
K149 GLSKMEGKGDVMSTA
S154 EGKGDVMSTACGTPG
T155 GKGDVMSTACGTPGY
T159 VMSTACGTPGYVAPE
K171 APEVLAQKPYSKAVD
Y213 EQILKAEYEFDSPYW
K237 FIRNLMEKDPNKRYT
K237 FIRNLMEKDPNKRYT
S301 MRRLQLGSSLDSSNV
S302 RRLQLGSSLDSSNVW
S305 QLGSSLDSSNVWHLP
- gap
S324-p SFLLRRGsQESELRG
- gap
  rat

 
S8 MARENGESSSSWKKQ
K52-ub TGKLFAVkCIPKKAL
S122 FYTEKDASTLIRQVL
K146 GIVHRDLKPENLLYY
Y152 LKPENLLYYsQDEES
Y153 KPENLLYYsQDEESK
S154-p PENLLYYsQDEESKI
K174 GLSKMEGKGDVMSTA
S179 EGKGDVMSTACGTPG
T180 GKGDVMSTACGTPGY
T184 VMSTACGTPGYVAPE
K196 APEVLAQKPYSKAVD
Y238-p EQILKAEyEFDSPYW
K262 FIRNLMEKDPNKRYT
K262-ub FIRNLMEkDPNKRYT
S326-p MRRLQLGssLDsSNA
S327-p RRLQLGssLDsSNAS
S330-p QLGssLDsSNASVSS
N338 SNASVSSNLSLASQK
- gap
- gap
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