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Protein Page:
DUSP3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DUSP3 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP3 inactivates the mitogen-activated kinases Erk2 and Jnk and is phosphorylated by ZAP-70. Phosphorylation by ZAP-70 is required for DUSP3 to inhibit the Erk2-Elk-1 pathway. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, dual-specificity; EC 3.1.3.48
Cellular Component: nucleoplasm; immunological synapse; nucleus; cytosol
Molecular Function: MAP kinase phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: negative regulation of JNK cascade; nerve growth factor receptor signaling pathway; negative regulation of MAPKKK cascade; in utero embryonic development; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; negative regulation of T cell receptor signaling pathway; toll-like receptor 3 signaling pathway; positive regulation of mitotic cell cycle; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; negative regulation of T cell activation; toll-like receptor 4 signaling pathway; inactivation of MAPK activity
Reference #:  P51452 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 3; Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; DUS3; DUSP3; serine/threonine specific protein phosphatase; vaccinia virus phosphatase VH1-related; VHR
Gene Symbols: DUSP3
Molecular weight: 20,478 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DUSP3

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: Y138‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 - gap
0 1 - gap
0 1 S8-p MSGSFELsVQDLNDL
0 2 Y38-p NEVTPRIyVGNASVA
0 1 K50-ac SVAQDIPkLQkLGIT
0 2 K53-ub QDIPkLQkLGITHVL
0 1 S81-p NANFYKDsGITYLGI
0 9 Y101-p QEFNLSAyFERAADF
0 2 K116-ub IDQALAQkNGRVLVH
0 1 T133 EGYSRSPTLVIAyLM
0 1 Y138-p SPTLVIAyLMMRQKM
0 1 S149-p RQKMDVKsALSIVRQ
  mouse

 
- gap
- gap
S8 MSSSFELSVQDLNDL
Y38 NEVVPRVYVGNASVA
Q50 SVAQDITQLQkLGIT
K53-ub QDITQLQkLGITHVL
S81 SASFYEDSGITYLGI
Y101 QEFNLSAYFERATDF
K116 IDQALAHKNGRVLVH
T133-p EGYSRSPtLVIAYLM
Y138 SPtLVIAYLMMRQKM
S149 RQKMDVKSALSTVRQ
  rat

 
S48-p RRQLPSPsGPAsGAG
S52-p PSPsGPAsGAGRGGS
S94 MSGSFELSVQDLNDL
Y124 NEVIPRVYVGNASVA
Q136 SVAQDITQLQKLGIT
K139 QDITQLQKLGITHVL
T167 SASFYKDTGITYMGI
Y187-p QEFNLSAyFERAADF
K202 IDQALAHKNGRVLVH
T219 EGYSRSPTLVIAYLM
Y224 SPTLVIAYLMLRQKM
S235 RQKMDVRSALSTVRQ
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