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DUSP3 (human)

Overview DUSP3 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP3 inactivates the mitogen-activated kinases Erk2 and Jnk and is phosphorylated by ZAP-70. Phosphorylation by ZAP-70 is required for DUSP3 to inhibit the Erk2-Elk-1 pathway. Note: This description may include information from UniProtKB. Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, dual-specificity Cellular Component: nucleoplasm; immunological synapse; nucleus; cytosol Molecular Function: MAP kinase phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity Biological Process: negative regulation of JNK cascade; nerve growth factor receptor signaling pathway; negative regulation of MAPKKK cascade; in utero embryonic development; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; negative regulation of T cell receptor signaling pathway; toll-like receptor 3 signaling pathway; positive regulation of mitotic cell cycle; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; negative regulation of T cell activation; toll-like receptor 4 signaling pathway; inactivation of MAPK activity Reference #:  P51452 (UniProtKB) Alt. Names/Synonyms: dual specificity phosphatase 3; Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; DUS3; DUSP3; serine/threonine specific protein phosphatase; vaccinia virus phosphatase VH1-related; VHR Gene Symbols: DUSP3 Molecular weight: 20,478 Da Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DUSP3 1J4X - A=2-185 (human) 1VHR - A/B=2-185 (human) 2F4D - A=2-185 (human) 3F81 - A/B=3-185 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1J4X 1VHR 2F4D 3F81  |  ENZYME 3.1.3.16 3.1.3.48  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: Y138‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		-	gap
0	1		-	gap
0	1		S8-p	MSGSFELsVQDLNDL
0	1		Y23-p	LSDGSGCySLPSQPC
0	2		Y38-p	NEVTPRIyVGNASVA
0	2		K53-u	QDIPKLQkLGITHVL
0	9		Y101-p	QEFNLSAyFERAADF
0	2		K116-u	IDQALAQkNGRVLVH
0	1		T133	EGYSRSPTLVIAyLM
0	1		Y138-p	SPTLVIAyLMMRQKM
0	1		S149-p	RQKMDVKsALSIVRQ

	mouse
-	gap
-	gap
S8	MSSSFELSVQDLNDL
Y23	LSDGSGCYSLPSQPC
Y38	NEVVPRVYVGNASVA
K53-u	QDITQLQkLGITHVL
Y101	QEFNLSAYFERATDF
K116	IDQALAHKNGRVLVH
T133-p	EGYSRSPtLVIAYLM
Y138	SPtLVIAYLMMRQKM
S149	RQKMDVKSALSTVRQ

	rat
S48-p	RRQLPSPsGPAsGAG
S52-p	PSPsGPAsGAGRGGS
S94	MSGSFELSVQDLNDL
Y109	LSDGSGCYSLPSQPC
Y124	NEVIPRVYVGNASVA
K139	QDITQLQKLGITHVL
Y187-p	QEFNLSAyFERAADF
K202	IDQALAHKNGRVLVH
T219	EGYSRSPTLVIAYLM
Y224	SPTLVIAYLMLRQKM
S235	RQKMDVRSALSTVRQ

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