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Protein Page:
IVNS1ABP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IVNS1ABP Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines. May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 1q25.1-q31.1
Cellular Component: nucleoplasm; spliceosome; transcription factor complex; cytoskeleton; cytoplasm
Biological Process: transcription from RNA polymerase III promoter; viral reproduction; response to virus; RNA splicing
Reference #:  Q9Y6Y0 (UniProtKB)
Alt. Names/Synonyms: ARA3; aryl hydrocarbon receptor-associated 3; Aryl hydrocarbon receptor-associated protein 3; DKFZp686K06216; FLARA3; FLJ10069; FLJ10411; FLJ10962; FLJ35593; FLJ36593; HSPC068; influenza virus NS1A binding protein; Influenza virus NS1A-binding protein; IVNS1ABP; KIAA0850; KLHL39; NCX downstream gene 1; ND1; NS-1; NS1; NS1-binding protein; NS1-BP; NS1BP
Gene Symbols: IVNS1ABP
Molecular weight: 71,729 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Select Structure to View Below

IVNS1ABP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S28-p KLNALRKsGQFCDVR
0 1 S54-p RAVLACCsPYLFEIF
0 1 S63-p YLFEIFNsDSDPHGI
0 1 S71-p DSDPHGIsHVKFDDL
0 1 K103-ub KADKELVkDVYSAAK
0 1 K193 VCLPSNGKLYTKVIN
0 1 K197 SNGKLYTKVINWVQR
0 7 S246-p GQAEVFGsDDDHIQF
0 1 S268 ENGHKQISsSStGCL
0 1 S269-p NGHKQISsSStGCLs
0 1 S271 HKQISsSStGCLssP
0 1 T272-p KQISsSStGCLssPN
0 2 S276-p sSStGCLssPNATVQ
0 6 S277-p SStGCLssPNATVQs
0 2 S284-p sPNATVQsPKHEWKI
0 8 S322-p IFLHGRNsPQssPts
0 2 S325-p HGRNsPQssPtstPK
0 14 S326-p GRNsPQssPtstPKL
0 2 T328-p NsPQssPtstPKLSK
0 1 S329-p sPQssPtstPKLSKs
0 11 T330-p PQssPtstPKLSKsL
0 7 S336-p stPKLSKsLsFEMQQ
0 19 S338-p PKLSKsLsFEMQQDE
0 2 S352-p ELIEKPMsPMQyARS
0 1 Y356-p KPMsPMQyARSGLGt
0 1 T363-p yARSGLGtAEMNGKL
0 1 K369 GtAEMNGKLIAAGGY
0 27 Y474-p IVGGSDPyGQkGLKN
0 2 K477-ub GSDPyGQkGLKNCDV
  mouse

 
S28 KLNALRKSGQFCDVR
S54 RAVLACCSPYLFEIF
S63 YLFEIFNSDSDPHGV
S71 DSDPHGVSHVKLDDL
K103 KADKELVKDVYSAAK
K193-ub VCLPSNGkLYTkVIN
K197-ub SNGkLYTkVINWVQR
S246-p GQAEVFGsDDDHIQF
S268-p ENGHKQIsGSSTGCL
G269 NGHKQIsGSSTGCLs
S271 HKQIsGSSTGCLssP
T272 KQIsGSSTGCLssPN
S276-p GSSTGCLssPNASMQ
S277-p SSTGCLssPNASMQS
S284 sPNASMQSPKHEWKI
S322-p IFLHGRNsPQssPtS
S325-p HGRNsPQssPtSTPK
S326-p GRNsPQssPtSTPKL
T328-p NsPQssPtSTPKLSK
S329 sPQssPtSTPKLSKs
T330 PQssPtSTPKLSKsL
S336-p STPKLSKsLsFEMQP
S338-p PKLSKsLsFEMQPDE
S352 ELLEKPMSPMQYARS
Y356 KPMSPMQYARSGLGT
T363 YARSGLGTAEMNGkL
K369-ub GTAEMNGkLIAAGGY
Y474 IVGGSDPYGQkGLKN
K477-ub GSDPYGQkGLKNCDV
  rat

 
S28 KLNALRKSGQFCDVR
S54 RAVLACCSPYLFEIF
S63 YLFEIFNSDSDPHGV
S71 DSDPHGVSHVKLDDL
K103 KADKELVKDVYSAAK
K193 VCLPSNGKLYTKVIN
K197 SNGKLYTKVINWVQR
S246 GQAEVFGSDDDHIQF
S268 ENGHKQISGSsTGCL
G269 NGHKQISGSsTGCLS
S271-p HKQISGSsTGCLSsP
T272 KQISGSsTGCLSsPN
S276 GSsTGCLSsPNASVQ
S277-p SsTGCLSsPNASVQS
S284 sPNASVQSPKHEWKI
S322 IFLHGRNSPQSSPTS
S325 HGRNSPQSSPTSTPK
S326 GRNSPQSSPTSTPKL
T328 NSPQSSPTSTPKLSK
S329 SPQSSPTSTPKLSKs
T330 PQSSPTSTPKLSKsL
S336-p STPKLSKsLsFEMQP
S338-p PKLSKsLsFEMQPDE
S352 ELLEKPMSPMQYARS
Y356 KPMSPMQYARSGLGT
T363 YARSGLGTAEMNGKL
K369 GTAEMNGKLIAAGGY
Y474 IVGGSDPYGQKGLKN
K477 GSDPYGQKGLKNCDV
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