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IVNS1ABP (human)

Overview IVNS1ABP Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines. May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. Note: This description may include information from UniProtKB. Cellular Component: spliceosome; transcription factor complex; cytoskeleton; cytoplasm Biological Process: transcription from RNA polymerase III promoter; RNA splicing; response to virus; virus-host interaction Reference #:  Q9Y6Y0 (UniProtKB) Alt. Names/Synonyms: ARA3; aryl hydrocarbon receptor-associated 3; Aryl hydrocarbon receptor-associated protein 3; DKFZp686K06216; FLARA3; FLJ10069; FLJ10411; FLJ10962; FLJ35593; FLJ36593; HSPC068; influenza virus NS1A binding protein; Influenza virus NS1A-binding protein; IVNS1ABP; KIAA0850; KLHL39; NCX downstream gene 1; ND1; NS-1; NS1; NS1-binding protein; NS1-BP; NS1BP Gene Symbols: IVNS1ABP Molecular weight: 71,729 Da Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states

Select Structure to View Below IVNS1ABP

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K103-u	KADKELVkDVYSAAK
0	1		S54-p	RAVLACCsPYLFEIF
0	1		S63-p	YLFEIFNsDSDPHGI
0	1		S71-p	DSDPHGIsHVKFDDL
0	1		K193	VCLPSNGKLYTKVIN
0	1		K197	SNGKLYTKVINWVQR
0	4		S246-p	GQAEVFGsDDDHIQF
0	1		S271	HKQISSSSTGCLSsP
0	2		S277-p	SSTGCLSsPNATVQS
0	5		S322-p	IFLHGRNsPQSsPts
0	12		S326-p	GRNsPQSsPtstPKL
0	1		T328-p	NsPQSsPtstPKLSK
0	1		S329-p	sPQSsPtstPKLSKs
0	11		T330-p	PQSsPtstPKLSKsL
0	4		S336-p	stPKLSKsLsFEMQQ
0	11		S338-p	PKLSKsLsFEMQQDE
0	1		T363-p	YARSGLGtAEMNGKL
0	1		K369	GtAEMNGKLIAAGGY
0	24		Y474-p	IVGGSDPyGQkGLKN
0	2		K477-u	GSDPyGQkGLKNCDV

	mouse
K103	KADKELVKDVYSAAK
S54	RAVLACCSPYLFEIF
S63	YLFEIFNSDSDPHGV
S71	DSDPHGVSHVKLDDL
K193-u	VCLPSNGkLYTkVIN
K197-u	SNGkLYTkVINWVQR
S246-p	GQAEVFGsDDDHIQF
S271	HKQISGSSTGCLSSP
S277	SSTGCLSSPNASMQS
S322-p	IFLHGRNsPQSsPTS
S326-p	GRNsPQSsPTSTPKL
T328	NsPQSsPTSTPKLSK
S329	sPQSsPTSTPKLSKs
T330	PQSsPTSTPKLSKsL
S336-p	STPKLSKsLsFEMQP
S338-p	PKLSKsLsFEMQPDE
T363	YARSGLGTAEMNGkL
K369-u	GTAEMNGkLIAAGGY
Y474	IVGGSDPYGQkGLKN
K477-u	GSDPYGQkGLKNCDV

	rat
K103	KADKELVKDVYSAAK
S54	RAVLACCSPYLFEIF
S63	YLFEIFNSDSDPHGV
S71	DSDPHGVSHVKLDDL
K193	VCLPSNGKLYTKVIN
K197	SNGKLYTKVINWVQR
S246	GQAEVFGSDDDHIQF
S271-p	HKQISGSsTGCLSsP
S277-p	SsTGCLSsPNASVQS
S322	IFLHGRNSPQSSPTS
S326	GRNSPQSSPTSTPKL
T328	NSPQSSPTSTPKLSK
S329	SPQSSPTSTPKLSKS
T330	PQSSPTSTPKLSKSL
S336	STPKLSKSLsFEMQP
S338-p	PKLSKSLsFEMQPDE
T363	YARSGLGTAEMNGKL
K369	GTAEMNGKLIAAGGY
Y474	IVGGSDPYGQKGLKN
K477	GSDPYGQKGLKNCDV

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