|
IkB-beta
a protein of the NF-kappa-B inhibitor family. Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA- dependent inactivation. Association with inhibitor kappa B- interacting Ras-like proteins 1 and 2 may also explain the slower degradation. Interacts with ligand-binding domain of thyroid hormone receptor-beta, inhibitor kappa B-interacting Ras-like protein 1, inhibitor kappa B-interacting protein Ras2, p65 (RELA) and c-Rel. Expressed in all tissues examined. Note: This description may include information from UniProtKB.
|
| Protein type: Inhibitor protein |
|
Cellular Component: cytoplasm; nucleus; cytosol
|
|
Molecular Function: NF-kappaB binding
|
|
Biological Process: cytoplasmic sequestering of NF-kappaB; signal transduction
|
|
Reference #:
Q9JIA3 (UniProtKB)
|
| Alt. Names/Synonyms: I-kappa-B-beta; IkappaBbeta; IkB-B; IkB-beta; Ikbb; MGC93398; NF-kappa-B inhibitor beta; NF-kappa-BIB; Nfkbib; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
| Gene Symbols: Nfkbib |
|
Molecular weight: 38,081 Da
|
|
Basal Isoelectric point: 4.67
Predict pI for various phosphorylation states
|
|
CST Pathways:
B Cell Receptor Signaling
|
Death Receptor Signaling
|
Inhibition of Apoptosis
|
NF-kB Signaling
|
T Cell Receptor Signaling
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
