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Protein Page:
FGB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGB Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGB are a cause of congenital afibrinogenemia (CAFBN). This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Secreted, signal peptide; Adaptor/scaffold; Secreted
Cellular Component: extracellular space; cell surface; fibrinogen complex; plasma membrane; extracellular region; cell cortex; external side of plasma membrane
Molecular Function: protein binding, bridging; protein binding; chaperone binding; cell adhesion molecule binding; structural molecule activity; receptor binding
Biological Process: protein polymerization; platelet activation; extracellular matrix organization and biogenesis; positive regulation of heterotypic cell-cell adhesion; cell-matrix adhesion; signal transduction; platelet degranulation; cellular protein complex assembly; positive regulation of protein secretion; positive regulation of vasoconstriction; response to calcium ion; blood coagulation; positive regulation of exocytosis
Reference #:  P02675 (UniProtKB)
Alt. Names/Synonyms: FGB; FIBB; Fibrinogen beta chain; fibrinogen, B beta polypeptide; fibrinogen, beta chain; Fibrinopeptide B; MGC104327; MGC120405
Gene Symbols: FGB
Molecular weight: 55,928 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Select Structure to View Below

FGB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R53 HRPLDKKREEAPsLR
0 1 S58-p KKREEAPsLRPAPPP
0 4 Y71-p PPISGGGyRARPAKA
0 1 S138-p NNNVEAVsQTSSSSF
1 1 Y182-p ELEKHQLyIDETVNS
0 1 K208-ac ILENLRSkIQKLESD
0 1 K247 ECEEIIRKGGETSEM
0 1 Y255-p GGETSEMyLIQPDss
0 1 S261-p MyLIQPDssVKPyRV
0 1 S262-p yLIQPDssVKPyRVy
0 1 K264 IQPDssVKPyRVyCD
0 5 Y266-p PDssVKPyRVyCDMN
0 1 Y269-p sVKPyRVyCDMNTEN
0 1 N273 yRVyCDMNTENGGWt
0 1 T280-p NTENGGWtVIQNRQD
0 1 Y299-p FGRKWDPykQGFGNV
0 1 K300-ac GRKWDPykQGFGNVA
0 4 K313-ac VATNTDGkNyCGLPG
0 1 K313 VATNTDGKNyCGLPG
0 1 K313 VATNTDGKNyCGLPG
0 1 Y315-p TNTDGkNyCGLPGEY
0 1 T333-p NDKISQLtRMGPtEL
0 2 T338-p QLtRMGPtELLIEME
0 2 K348-ac LIEMEDWkGDKVKAH
0 1 K353 DWkGDKVKAHyGGFT
0 2 Y356-p GDKVKAHyGGFTVQN
0 2 Y368-p VQNEANKyQISVNKY
0 1 K374 KyQISVNKYRGTAGN
0 1 T396-p QLMGENRtMTIHNGM
0 1 Y408-p NGMFFSTyDRDNDGW
0 1 K426 DPRKQCSKEDGGGWW
0 1 Y452-p RYYWGGQyTWDMAKH
0 5 K471-ac GVVWMNWkGSWySMR
0 1 Y475-p MNWkGSWySMRKMSM
  mouse

 
K43-ub HRPVDRRkEEPPSLR
S48 RRkEEPPSLRPAPPP
Y61 PPISGGGYRARPAKA
S128 NNNIQSVSDTSSVTF
Y172 ILEDQRLYIDETVND
K198 ILEDLRSKIQKLESD
K237-ub ECEEIIRkGGETSEM
Y245 GGETSEMYLIQPDTS
T251 MYLIQPDTSIkPYRV
S252 YLIQPDTSIkPYRVY
K254-ub IQPDTSIkPYRVYCD
Y256 PDTSIkPYRVYCDMk
Y259 SIkPYRVYCDMkTEN
K263-ub YRVYCDMkTENGGWT
T270 kTENGGWTVIQNRQD
Y289 FGRKWDPYKKGFGNI
K290 GRKWDPYKKGFGNIA
K303-ac IATNEDAkKYCGLPG
K303-ub IATNEDAkKYCGLPG
K303-sc IATNEDAkKYCGLPG
Y305 TNEDAkKYCGLPGEY
T323 NDKISQLTRMGPTEL
T328 QLTRMGPTELLIEME
K338 LIEMEDWKGDKVkAH
K343-ub DWKGDKVkAHYGGFT
Y346 GDKVkAHYGGFTVQN
Y358 VQNEASKYQVSVNkY
K364-ub KYQVSVNkYKGTAGN
T386 QLVGENRTMTIHNGM
Y398 NGMFFSTYDRDNDGW
K416-ub DPRKQCSkEDGGGWW
Y442 RYYWGGLYSWDMSKH
K461 GVVWMNWKGSWYSMR
Y465 MNWKGSWYSMRRMSM
  rat

 
K41 HRPVDRRKEEPPSLR
S46 RRKEEPPSLRPAPPP
Y59 PPISGGGYRARPAKV
S126 NSNINSVSETSSVTF
Y170 ILEDQKLYIDETVND
K196 ILEDLRSKIQKLESD
K235 ECEEIIRKGGETSEM
Y243 GGETSEMYLIQPDTS
T249 MYLIQPDTSSKPYRV
S250 YLIQPDTSSKPYRVY
K252 IQPDTSSKPYRVYCD
Y254 PDTSSKPYRVYCDMK
Y257 SSKPYRVYCDMKTEN
K261 YRVYCDMKTENGGWT
T268 KTENGGWTVIQNRQD
Y287 FGRKWDPYKKGFGNI
K288 GRKWDPYKKGFGNIA
K301 IATNEDTKKYCGLPG
K301 IATNEDTKKYCGLPG
K301 IATNEDTKKYCGLPG
Y303 TNEDTKKYCGLPGEY
T321 NDKISQLTRIGPTEL
T326 QLTRIGPTELLIEME
K336 LIEMEDWKGDKVKAH
K341 DWKGDKVKAHYGGFT
Y344 GDKVKAHYGGFTVQT
Y356 VQTEANKYQVSVNKY
K362 KYQVSVNKYKGTAGN
T384 QLVGENRTMTIHNGM
Y396 NGMFFSTYDRDNDGW
K414 DPRKQCSKEDGGGWW
Y440 RYYWGGLYSWDMSKH
K459 GVVWMNWKGSWYSMR
Y463 MNWKGSWYSMRRMSM
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