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Ku80
the 80-kilodalton subunit of the Ku complex, also known as ATP-dependant DNA helicase II. A single stranded DNA-dependent ATP-dependent helicase. It functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.1.-; DNA binding protein; Nuclear receptor co-regulator; Helicase; EC 3.6.4.- |
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Cellular Component: nucleoplasm; nuclear telomere cap complex; nuclear chromosome, telomeric region; cytoplasm; nucleolus; DNA-dependent protein kinase complex; nucleus
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Molecular Function: protein C-terminus binding; ATP-dependent DNA helicase activity; identical protein binding; protein binding; DNA binding; ubiquitin protein ligase binding; double-stranded DNA binding; telomeric DNA binding; double-stranded telomeric DNA binding; 5'-deoxyribose-5-phosphate lyase activity; ATP binding
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Biological Process: cell proliferation; positive regulation of neurogenesis; transcription, DNA-dependent; viral reproduction; double-strand break repair; negative regulation of transcription, DNA-dependent; DNA repair; telomere maintenance; double-strand break repair via nonhomologous end joining; negative regulation of apoptosis; DNA recombination
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Reference #:
P13010 (UniProtKB)
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| Alt. Names/Synonyms: 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; FLJ39089; G22P2; KARP-1; KARP1; Ku autoantigen, 80kD); Ku autoantigen, 80kDa; Ku80; Ku86; Ku86 autoantigen related protein 1; KUB2; Lupus Ku autoantigen protein p86; NFIV; Nuclear factor IV; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair cross-complementing protein 5; X-ray repair, complementing defective, repair in Chinese hamster; XRCC5 |
| Gene Symbols: XRCC5 |
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Molecular weight: 82,705 Da
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Basal Isoelectric point: 5.55
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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