the 80-kilodalton subunit of the Ku complex, also known as ATP-dependant DNA helicase II. A single stranded DNA-dependent ATP-dependent helicase. It functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; DNA binding protein; Nuclear receptor co-regulator; Helicase; EC 3.6.4.-
Cellular Component: nucleoplasm; nuclear telomere cap complex; nuclear chromosome, telomeric region; cytoplasm; nucleolus; DNA-dependent protein kinase complex; nucleus
Molecular Function: protein C-terminus binding; ATP-dependent DNA helicase activity; identical protein binding; protein binding; DNA binding; ubiquitin protein ligase binding; double-stranded DNA binding; telomeric DNA binding; double-stranded telomeric DNA binding; 5'-deoxyribose-5-phosphate lyase activity; ATP binding
Biological Process: cell proliferation; positive regulation of neurogenesis; transcription, DNA-dependent; viral reproduction; double-strand break repair; negative regulation of transcription, DNA-dependent; DNA repair; telomere maintenance; double-strand break repair via nonhomologous end joining; negative regulation of apoptosis; DNA recombination
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.