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Protein Page:
AGO3 (human)

Overview
AGO3 Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Belongs to the argonaute family. Ago subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Translation initiation; Translation
Cellular Component: membrane; cytosol
Molecular Function: protein binding; miRNA binding
Biological Process: epidermal growth factor receptor signaling pathway; Notch signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; mRNA catabolic process; innate immune response; miRNA-mediated gene silencing, negative regulation of translation; gene expression
Reference #:  Q9H9G7 (UniProtKB)
Alt. Names/Synonyms: AGO3; argonaute 3; Argonaute3; eIF-2C 3; eIF2C 3; EIF2C3; Eukaryotic translation initiation factor 2C 3; eukaryotic translation initiation factor 2C, 3; FLJ12765; hAgo3; MGC86946; Protein argonaute-3
Gene Symbols: AGO3
Molecular weight: 97,360 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AGO3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5-p ___MEIGsAGPAGAQ
0 2 Y175 RHLPSMKYTPVGRSF
0 66 Y189-p FFSAPEGyDHPLGGG
0 1 Y317-p AQYFREKyTLQLKyP
0 1 Y323-p KyTLQLKyPHLPCLQ
0 3 Y339-p GQEQKHTyLPLEVCN
0 1 T445-p MRGKQFHtGVEIKMW
0 1 T527-p IVILPGKtPVYAEVK
0 2 Y682-p GQFRQVLyyELLAIR
0 6 Y683-p QFRQVLyyELLAIRE
0 1 Y705-p DYQPGITyIVVQKRH
0 3 S825-p LVDKEHDsAEGsHVs
0 2 S829-p EHDsAEGsHVsGQsN
0 2 S832-p sAEGsHVsGQsNGRD
0 1 S835-p GsHVsGQsNGRDPQA
  mouse

 
S5 ___MEIGSAGPIGAQ
Y175 RHLPSMKYTPVGRSF
Y189 FFSAPEGYDHPLGGG
Y317 AQYFREKYTLQLKYP
Y323 KYTLQLKYPHLPCLQ
Y339 GQEQKHTYLPLEVCN
T445 MRGKQFHTGVEIKMW
T527 IVILPGKTPVYAEVK
Y682 GQFRQVLYYELLAIR
Y683 QFRQVLYYELLAIRE
Y705 DYQPGITYIVVQKRH
S825 LVDKEHDSAEGSHVS
S829 EHDSAEGSHVSGQSN
S832 SAEGSHVSGQSNGRD
S835 GSHVSGQSNGRDPQA
  rat

 
S5 ___MEIGSAGPIGAQ
Y175-p RHLPSMKyTPVGRSF
Y189 FFSAPEGYDHPLGGG
Y317 AQYFREKYTLQLKYP
Y323 KYTLQLKYPHLPCLQ
Y339 GQEQKHTYLPLEVCN
T445 MRGKQFHTGVEIKMW
T527 IVILPGKTPVYAEVK
Y682 GQFRQVLYYELLAIR
Y683 QFRQVLYYELLAIRE
Y705 DYQPGITYIVVQKRH
S825 LVDKEHDSAEGSHVS
S829 EHDSAEGSHVSGQSN
S832 SAEGSHVSGQSNGRD
S835 GSHVSGQSNGRDPQA
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