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Ago3 (human)

Overview Ago3 Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Belongs to the argonaute family. Ago subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Translation initiation; Translation Cellular Component: cytosol Molecular Function: protein binding; RNA binding Biological Process: Notch signaling pathway; mRNA catabolic process; miRNA-mediated gene silencing, negative regulation of translation; gene expression Reference #:  Q9H9G7 (UniProtKB) Alt. Names/Synonyms: AGO3; argonaute 3; Argonaute3; eIF-2C 3; eIF2C 3; EIF2C3; Eukaryotic translation initiation factor 2C 3; eukaryotic translation initiation factor 2C, 3; FLJ12765; hAgo3; MGC86946; Protein argonaute-3 Gene Symbols: EIF2C3 Molecular weight: 97,360 Da Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Ago3

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y175	RHLPSMKYTPVGRSF
0	63		Y189-p	FFSAPEGyDHPLGGG
0	1		Y317-p	AQYFREKyTLQLKyP
0	1		Y323-p	KyTLQLKyPHLPCLQ
0	3		Y339-p	GQEQKHTyLPLEVCN
0	1		T445-p	MRGKQFHtGVEIKMW
0	1		T527-p	IVILPGKtPVYAEVK
0	2		Y682-p	GQFRQVLyyELLAIR
0	6		Y683-p	QFRQVLyyELLAIRE
0	1		Y705-p	DYQPGITyIVVQKRH
0	1		S825-p	LVDKEHDsAEGsHVs
0	1		S829-p	EHDsAEGsHVsGQsN
0	1		S832-p	sAEGsHVsGQsNGRD
0	1		S835-p	GsHVsGQsNGRDPQA

	mouse
Y175	RHLPSMKYTPVGRSF
Y189	FFSAPEGYDHPLGGG
Y317	AQYFREKYTLQLKYP
Y323	KYTLQLKYPHLPCLQ
Y339	GQEQKHTYLPLEVCN
T445	MRGKQFHTGVEIKMW
T527	IVILPGKTPVYAEVK
Y682	GQFRQVLYYELLAIR
Y683	QFRQVLYYELLAIRE
Y705	DYQPGITYIVVQKRH
S825	LVDKEHDSAEGSHVS
S829	EHDSAEGSHVSGQSN
S832	SAEGSHVSGQSNGRD
S835	GSHVSGQSNGRDPQA

	rat
Y175-p	RHLPSMKyTPVGRSF
Y189	FFSAPEGYDHPLGGG
Y317	AQYFREKYTLQLKYP
Y323	KYTLQLKYPHLPCLQ
Y339	GQEQKHTYLPLEVCN
T445	MRGKQFHTGVEIKMW
T527	IVILPGKTPVYAEVK
Y682	GQFRQVLYYELLAIR
Y683	QFRQVLYYELLAIRE
Y705	DYQPGITYIVVQKRH
S825	LVDKEHDSAEGSHVS
S829	EHDSAEGSHVSGQSN
S832	SAEGSHVSGQSNGRD
S835	GSHVSGQSNGRDPQA

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