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Protein Page:
DNMT3A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DNMT3A a DNA methyltransferase required for genome wide de novo methylation and essential for development. DNA methylation is coordinated with methylation of histones. Prefers CpG methylation to CpA, CpT, and CpC methylation. Methylates CpG sites at a rate much slower than DNMT1, but greater than DNMT3b. Methylation is coordinated with methylation of histones. Binds the ZNF238 transcriptional repressor. Interacts with SETDB1 and DNMT1. Can co-localize with heterochromatin protein (HP1 ) and methyl-CpG binding protein (MeCBP). Associates with HDAC1 through its ADD-type zinc-finger. Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.37; Methyltransferase; Methyltransferase, DNA
Cellular Component: euchromatin; nuclear matrix; cytoplasm; nucleolus; nuclear heterochromatin; nucleus; chromosome, pericentric region
Molecular Function: DNA (cytosine-5-)-methyltransferase activity; protein binding; DNA binding; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; unmethylated CpG binding; metal ion binding; chromatin binding
Biological Process: cytosine methylation within a CG sequence; genetic imprinting; methylation-dependent chromatin silencing; DNA methylation during gametogenesis; DNA methylation; S-adenosylmethioninamine metabolic process; S-adenosylhomocysteine metabolic process; spermatogenesis; negative regulation of transcription from RNA polymerase II promoter; DNA methylation during embryonic development
Reference #:  Q9Y6K1 (UniProtKB)
Alt. Names/Synonyms: DNA (cytosine-5)-methyltransferase 3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA cytosine methyltransferase 3A2; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNM3A; DNMT3A; DNMT3A2; M.HsaIIIA
Gene Symbols: DNMT3A
Molecular weight: 101,858 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DNMT3A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T65-p PPVESGDtPKDPAVI
0 31 S105-p EPQPEEGsPAGGQKG
0 2 A122 PAEGEGAAETLPEAS
0 5 T124 EGEGAAETLPEASRA
0 1 T138-p AVENGCCtPKEGRGA
0 1 T156-p AGKEQKEtNIESMKM
0 12 R171-m1 EGSRGRLrGGLGWEs
0 1 S178-p rGGLGWEssLRQRPM
0 1 S179-p GGLGWEssLRQRPMP
0 2 K200-ub GDPYYISkRKRDEWL
0 1 P233 AVEENQGPGEsQKVE
0 3 S236-p ENQGPGEsQKVEEAs
0 5 S243-p sQKVEEAsPPAVQQP
1 9 S255-p QQPTDPAsPTVATtP
0 4 T261-p AsPTVATtPEPVGsD
0 2 S267-p TtPEPVGsDAGDKNA
0 1 K367-ub NKQPMYRkAIYEVLQ
0 6 S377-p YEVLQVAsSRAGKLF
1 1 S390-p LFPVCHDsDEsDTAK
1 1 S393-p VCHDsDEsDTAKAVE
0 1 S638 RKPIRVLSLFDGIAT
0 1 T645 SLFDGIATGLLVLKD
0 1 K721-ub SIVNPARkGLYEGTG
  mouse

 
T62 PPVESSDTPKDPAVT
S102-p EPQPEEGsPAAGQKG
T118-p APAEGEGtEtPPEAS
T120-p AEGEGtEtPPEASRA
V134 AVENGCCVTKEGRGA
T152 EGKEQKQTNIESMKM
R167-m1 EGSRGRLrGGLGWES
S174 rGGLGWESSLRQRPM
S175 GGLGWESSLRQRPMP
K196-ub GDPYYISkRKRDEWL
S229 AVEENQASGESQKVE
S232 ENQASGESQKVEEAs
S239-p SQKVEEAsPPAVQQP
S251-p QQPTDPAsPTVATtP
T257-p AsPTVATtPEPVGGD
G263 TtPEPVGGDAGDKNA
K363 NKQPMYRKAIYEVLQ
S373 YEVLQVASSRAGKLF
S386-p LFPACHDsDEsDSGK
S389-p ACHDsDEsDSGKAVE
S634 RKPIRVLSLFDGIAT
T641 SLFDGIATGLLVLKD
K717 SIVNPARKGLYEGTG
  rat

 
T62 PPVESSDTPKDPAVT
S102-p EPQPEEGsPAAGQKG
T118 APAEGEGTEtPPEAS
T120-p AEGEGTEtPPEASRA
V134 AVENGCCVTKEGRGA
T152 EGKEQKQTNIESMKM
R167 EGSRGRLRGGLGWES
S174 RGGLGWESSLRQRPM
S175 GGLGWESSLRQRPMP
K196 GDPYYISKRKRDEWL
S229-p AVEESQAsGEsQKVE
S232-p ESQAsGEsQKVEEAs
S239-p sQKVEEAsPPAVQQP
S251-p QQPTDPAsPTVATtP
T257-p AsPTVATtPEPVGAD
A263 TtPEPVGADAGDKNA
K363 NKQPMYRKAIYEVLQ
S373 YEVLQVASSRAGKLF
S386 LFPACHDSDESDTGK
S389 ACHDSDESDTGKAVE
S634-p RKPIRVLsLFDGIAt
T641-p sLFDGIAtGLLVLKD
K717 SIVNPARKGLYEGTG
  chicken

 
- under review  
- gap
T62 GRPEEDETESLADGE
S64 PEEDETESLADGETG
T80 ALENGRCTPKEGLDA
N122 SKEEKEENNFDSLKM
R137 EGSRGRLRGGLGWES
S144 RGGLGWESSLRQRPM
S145 GGLGWESSLRQRPMQ
K166 GDPYYISKRKRDEWL
R198 NVVEETPRAEPQKEE
P201 EETPRAEPQKEEEAS
S208 PQKEEEASPPASQQP
S220-p QQPTDPAsPNVATTP
T226 AsPNVATTPEPVVAD
A232 TTPEPVVADAVDKNT
K332 NKQPMYRKAIYEVLQ
S342 YEVLQVASSRAGKIF
N355 IFPACPENDETDTSK
T358 ACPENDETDTSKVVE
S603 RKPIRVLSLFDGIAT
T610 SLFDGIATGLLVLKD
K686 SIVNPARKGLYEGTG
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