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Protein Page:
Ku70 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Ku70 a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division. Note: This description may include information from UniProtKB.
Protein type: EC 4.2.99.-; EC 3.6.4.-; Helicase; DNA binding protein; DNA repair, damage
Cellular Component: nucleoplasm; transcription factor complex; nuclear telomere cap complex; membrane; nucleolus; cytosol
Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; protein binding; DNA binding; double-stranded DNA binding; damaged DNA binding; double-stranded telomeric DNA binding; 5'-deoxyribose-5-phosphate lyase activity; ATP binding
Biological Process: positive regulation of neurogenesis; V(D)J recombination; viral reproduction; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA repair; DNA duplex unwinding; double-strand break repair via nonhomologous end joining; DNA ligation; double-strand break repair; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; telomere maintenance
Reference #:  P12956 (UniProtKB)
Alt. Names/Synonyms: 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22P1; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku70; Lupus Ku autoantigen protein p70; ML8; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); Thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6; XRCC6
Gene Symbols: XRCC6
Molecular weight: 69,843 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ku70

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S155‑p
phosphorylation: S155‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2-p ______MsGWEsyyK
3 2 S6-p __MsGWEsyyKTEGD
0 2 Y7-p _MsGWEsyyKTEGDE
0 2 Y8-p MsGWEsyyKTEGDEE
0 3 S27-p QEENLEAsGDYkYSG
0 1 K31-a LEAsGDYkYSGRDSL
0 1 K31-u LEAsGDYkYSGRDSL
2 0 S51-p ASKAMFEsQSEDELT
0 1 K92-m1 VVFYGTEkDkNSVNF
0 1 K92-u VVFYGTEkDkNSVNF
0 1 K94-u FYGTEkDkNSVNFkN
0 3 K100-u DkNSVNFkNIyVLQE
0 9 Y103-p SVNFkNIyVLQELDN
0 13 K114-a ELDNPGAkRILELDQ
0 1 K114-m1 ELDNPGAkRILELDQ
0 17 K114-u ELDNPGAkRILELDQ
0 3 K123-u ILELDQFkGQQGQKR
1 0 S155-p WVCANLFsDVQFKMS
0 1 S180-p DNPHGNDsAkASRAR
0 1 K182-u PHGNDsAkASRARTK
0 1 K207-m1 LDLMHLKkPGGFDIS
0 1 S222-p LFYRDIIsIAEDEDL
0 1 S237-p RVHFEESskLEDLLR
0 4 K238-u VHFEESskLEDLLRK
1 0 K282-a NLVQKALkPPPIkLY
0 1 K282-u NLVQKALkPPPIkLY
0 2 K287-u ALkPPPIkLYREtNE
0 1 T292-p PIkLYREtNEPVkTK
0 1 K297-u REtNEPVkTKTRTFN
0 2 S306-p KTRTFNTsTGGLLLP
3 43 K317-a LLLPSDTkRSQIYGs
0 36 K317-u LLLPSDTkRSQIYGs
0 1 S324-p kRSQIYGsRQIILEk
3 1 K331-a sRQIILEkEETEELk
0 1 K331-u sRQIILEkEETEELk
3 1 K338-a kEETEELkRFDDPGL
0 17 K338-u kEETEELkRFDDPGL
0 11 K351-u GLMLMGFkPLVLLkk
0 6 K357-u FkPLVLLkkHHYLRP
0 22 K358-u kPLVLLkkHHYLRPS
0 2 K392-a LLIKCLEkEVAALCR
0 4 K443-u FLPFADDkRkMPFTE
0 1 K445-u PFADDkRkMPFTEkI
0 6 K451-u RkMPFTEkIMAtPEQ
1 28 T455-p FTEkIMAtPEQVGkM
0 6 K461-a AtPEQVGkMKAIVEk
0 10 K461-u AtPEQVGkMKAIVEk
0 2 K468-a kMKAIVEkLRFTYRS
0 2 K468-u kMKAIVEkLRFTYRS
1 5 S477-p RFTYRSDsFENPVLQ
0 3 K516-u PKVEAMNkRLGsLVD
0 13 S520-p AMNkRLGsLVDEFkE
0 2 K526-u GsLVDEFkELVYPPD
3 0 K539-a PDYNPEGkVtkRkHD
0 1 K539-u PDYNPEGkVtkRkHD
0 3 T541-p YNPEGkVtkRkHDNE
2 0 K542-a NPEGkVtkRkHDNEG
1 0 K544-a EGkVtkRkHDNEGsG
0 1 S550-p RkHDNEGsGSkRPkV
1 0 K553-a DNEGsGSkRPkVEYs
0 1 K553-u DNEGsGSkRPkVEYs
1 0 K556-a GsGSkRPkVEYsEEE
0 1 K556-u GsGSkRPkVEYsEEE
0 1 S560-p kRPkVEYsEEELkTH
0 2 K565-u EYsEEELkTHISKGT
0 2 K575-u ISKGTLGkFtVPMLK
0 1 T577-p KGTLGkFtVPMLKEA
0 11 K591-u ACRAYGLksGLKkQE
0 2 S592-p CRAYGLksGLKkQEL
0 1 K596-u GLksGLKkQELLEAL
0 1 T604-p QELLEALtkHFQD__
0 5 K605-u ELLEALtkHFQD___
  mouse

 
S2 ______MSEWEsYYK
S6-p __MSEWEsYYKTEGE
Y7 _MSEWEsYYKTEGEE
Y8 MSEWEsYYKTEGEEE
G25 EEESPDTGGEYKYSG
K29 PDTGGEYKYSGRDSL
K29 PDTGGEYKYSGRDSL
S49-p ASRAMFEsQGEDELT
K90 VVFYGTEKDKNSVNF
K90 VVFYGTEKDKNSVNF
K92 FYGTEKDKNSVNFKN
K98 DKNSVNFKNIYVLQD
Y101 SVNFKNIYVLQDLDN
K112 DLDNPGAKRVLELDQ
K112 DLDNPGAKRVLELDQ
K112 DLDNPGAKRVLELDQ
K121 VLELDQFKGQQGKKH
S153 WVCANLFSDVQLKMS
S178 DDPHGRDSAKASRAR
K180 PHGRDSAKASRARTK
K205 LDLMHLKKPGGFDVS
T220 VFYRDIITTAEDEDL
S235 GVHFEESSKLEDLLR
K236 VHFEESSKLEDLLRK
K280 NLVQKANKPFPVRLY
K280 NLVQKANKPFPVRLY
R285 ANKPFPVRLYRETNE
T290 PVRLYRETNEPVKTK
K295 RETNEPVKTKTRTFN
N304 KTRTFNVNTGSLLLP
K315 LLLPSDTKRSLTYGT
K315 LLLPSDTKRSLTYGT
T322 KRSLTYGTRQIVLEK
K329 TRQIVLEKEETEELK
K329 TRQIVLEKEETEELK
K336 KEETEELKRFDEPGL
K336 KEETEELKRFDEPGL
K349 GLILMGFKPTVMLKK
K355 FKPTVMLKKQHYLRP
K356 KPTVMLKKQHYLRPS
K390 LLTKCVEKKVIAVCR
K441 FLPYADDKRKVPFTE
K443 PYADDKRKVPFTEKV
K449 RKVPFTEKVTANQEQ
N453 FTEKVTANQEQIDKM
K459 ANQEQIDKMKAIVQK
K459 ANQEQIDKMKAIVQK
K466 KMKAIVQKLRFTYRS
K466 KMKAIVQKLRFTYRS
S475-p RFTYRSDsFENPVLQ
K514 PKVEAIKKRLGsLAD
S518-p AIKKRLGsLADEFKE
K524 GsLADEFKELVYPPG
K537 PGYNPEGKVAKRKQD
K537 PGYNPEGKVAKRKQD
A539 YNPEGKVAKRKQDDE
K540 NPEGKVAKRKQDDEG
K542 EGKVAKRKQDDEGST
S548 RKQDDEGSTSKKPKV
K551 DDEGSTSKKPKVELS
K551 DDEGSTSKKPKVELS
K554 GSTSKKPKVELSEEE
K554 GSTSKKPKVELSEEE
S558 KKPKVELSEEELKAH
K563 ELSEEELKAHFRKGT
K573 FRKGTLGKLTVPTLK
T575 KGTLGKLTVPTLKDI
K589 ICKAHGLKSGPKKQE
S590 CKAHGLKSGPKKQEL
K594 GLKSGPKKQELLDAL
I602 QELLDALIRHLEKN_
R603 ELLDALIRHLEKN__
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