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Protein Page:
DGCR8 (human)

Overview
DGCR8 a double strand RNA binding protein (dsRBP) which is essential for the first processing step of primary miRNAs (pri-miRNAs). Apparently binds and is activated by heme. A nuclear complex of Drosha with DGCR8 cleaves pri-miRNA substrates into 60-70 nucleotide intermediates (pre-miRNA), thus initiating the microRNA maturation process. Drosha provides the catalytic site for this cleavage, whereas DGCR8 (Pasha) anchors substrate pri-miRNAs. Pre-miRNAs are then processed by the cytoplasmic Dicer-TRBP complex to approximately 20-22 nt mature miRNAs. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA binding protein
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; metal ion binding; double-stranded RNA binding
Biological Process: gene expression; primary microRNA processing
Reference #:  Q8WYQ5 (UniProtKB)
Alt. Names/Synonyms: C22orf12; DGCR8; DGCRK6; DiGeorge syndrome critical region 8; DiGeorge syndrome critical region gene 8; Gy1; Microprocessor complex subunit DGCR8
Gene Symbols: DGCR8
Molecular weight: 86,045 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DGCR8

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S8-p METDESPsPLPCGPA
0 5 S92-p LLIDPNCsGHsPRTA
0 11 S95-p DPNCsGHsPRTARHA
0 6 S109-p APAVRKFsPDLKLLK
0 9 Y267-p KRRTEEKyGGDsDHP
0 13 S271-p EEKyGGDsDHPsDGE
0 15 S275-p GGDsDHPsDGEtSVQ
0 2 T279-p DHPsDGEtSVQPMMT
0 1 S339-p PYFLGTGsIRKHDPP
0 1 S367-p DNEEREQssDLtPsG
0 1 S368-p NEEREQssDLtPsGD
0 5 T371-p REQssDLtPsGDVsP
0 6 S373-p QssDLtPsGDVsPVK
0 18 S377-p LtPsGDVsPVKPLSR
  mouse

 
S8 METYESPSPLPREPA
S92-p LLIDPNCsGHsPRTA
S95-p DPNCsGHsPRTARHA
S109-p APAVRKFsPDLKLLK
Y267-p KRRMEEKyGGDsDHP
S271-p EEKyGGDsDHPsDGE
S275-p GGDsDHPsDGEtSVQ
T279-p DHPsDGEtSVQPMMT
S339 PYFLGTGSIRKHDPP
N367 DNEEREQNCDLAPsG
C368 NEEREQNCDLAPsGE
A371 REQNCDLAPsGEVsP
S373-p QNCDLAPsGEVsPVK
S377-p LAPsGEVsPVKPLGR
  rat

 
S8 METYESPSPLPHEPT
S92 LLIDPNCSGHSPRTA
S95 DPNCSGHSPRTARHA
S109 APAVRKFSPDLKLLK
Y267-p KRRMEEKyGGDSDHP
S271 EEKyGGDSDHPSDGE
S275 GGDSDHPSDGETSVQ
T279 DHPSDGETSVQPMMT
S339 PYFLGTGSIRKHDPP
S367 DNEEREQSCDLAPSG
C368 NEEREQSCDLAPSGE
A371 REQSCDLAPSGEVsP
S373 QSCDLAPSGEVsPVK
S377-p LAPSGEVsPVKPLGR
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