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Casp7 (human)

Overview Casp7 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.4.22.60; Protease; Mitochondrial; Endoplasmic reticulum; EC 3.4.22.-; Apoptosis Cellular Component: nucleoplasm; endoplasmic reticulum membrane; mitochondrial membrane; cytoplasm; cytosol; nucleus Molecular Function: protein binding; cysteine-type endopeptidase activity; aspartic-type endopeptidase activity; cysteine-type peptidase activity Biological Process: release of cytochrome c from mitochondria; apoptosis; heart development; positive regulation of neuron apoptosis; induction of apoptosis; protein processing; caspase activation via cytochrome c; proteolysis; response to UV; aging; cell structure disassembly during apoptosis Reference #:  P55210 (UniProtKB) Alt. Names/Synonyms: Apoptotic protease Mch-3; CASP-7; CASP7; caspase 7 isoform delta; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; Caspase-7; Caspase-7 subunit p11; Caspase-7 subunit p20; CMH-1; ICE-LAP3; ICE-like apoptotic protease 3; Lice2 alpha/beta/gamma; MCH3 Gene Symbols: CASP7 Molecular weight: 34,277 Da Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Casp7 1F1J - A/B=2-303 (human) 1GQF - A/B=47-303 (human) 1I4O - A/B=24-303 (human) 1I51 - A/C=51-198, B/D=199-303 (human) 1K86 - A/B=51-303 (human) 1K88 - A/B=51-303 (human) 1KMC - A/B=1-303 (human) 1MIA - A=57-193, B=211-303 (human) 1SHJ - A/B=50-303 (human) 1SHL - A/B=57-303 (human) 2QL5 - A/C=24-196, B/D=207-303 (human) 2QL7 - A/C=24-196, B/D=207-303 (human) 2QL9 - A/C=24-196, B/D=207-303 (human) 2QLB - A/C=24-196, B/D=207-303 (human) 2QLF - A/C=24-196, B/D=207-303 (human) 2QLJ - A/C=24-196, B/D=207-303 (human) 3EDR - A/C=24-196 D/B=207-303 (human) 3H1P - A/B=50-303 (human) 3IBC - A/C=24-196 D/B=207-303 (human) 3IBF - A/C=24-196 D/B=207-303 (human) 3R5K - A/B=1-303 (human) 4FDL - A/B=2-303 (human) 4FEA - A/B=57-303 (human) 3SIP - A/C=78-230 D/B=231-339 (fruit fly) 3SIR - A/D/C/B=78-332 (fruit fly)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA  |  ENZYME  |  Phospho3D  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S16	EEQGVEDSANEDSVD
0	1		A17	EQGVEDSANEDSVDA
0	2		N18	QGVEDSANEDSVDAK
0	1		S29-p	VDAKPDRssFVPSLF
1	1		S30-p	DAKPDRssFVPSLFs
0	2		S37-p	sFVPSLFsKKKKNVt
0	5		T44-p	sKKKKNVtMRsIKTT
0	6		S47-p	KKNVtMRsIKTTRDR
0	1		K80	INNKNFDKVTGMGVR
1	0		T173-p	FRGDRCKtLLEKPKL
1	0		S239-p	WRSPGRGsWFVQALC

	mouse
S16-p	AELEKVDsssEDGVD
S17-p	ELEKVDsssEDGVDA
S18-p	LEKVDsssEDGVDAK
S29	VDAKPDRSSIISSIL
S30	DAKPDRSSIISSILL
L37	SIISSILLKKKRNAS
S44	LKKKRNASAGPVRTG
P47	KRNASAGPVRTGRDR
K80-u	INNKNFDkATGMDVR
T173	FRGDRCKTLLEKPKL
S239	WRNPGKGSWFVQALC

	rat
S16	AELEMADSSTEDGVD
S17	ELEMADSSTEDGVDA
T18	LEMADSSTEDGVDAK
S29	VDAKPDRSTIISSLL
T30	DAKPDRSTIISSLLW
W37	TIISSLLWKKKKNAS
S44	WKKKKNASMCPVSTT
-	gap
K80	INNKNFDKATGMDVR
T173	FRGDRCKTLLEKPKL
S239	WRNPGKGSWFVQALC

	fruit fly ► Hide Isoforms
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
V106	FNHEHFEVPTLKSRA
S198	FTANHCPSLAGKPKL
S265	WRNTTRGSWFMQSLC

	Casp7 iso2
-	gap
-	gap
S25	NGSENRGSFIMADNT
-	gap
-	gap
-	gap
-	gap
-	gap
-	under review
S183	FTATFCPSLAGKPKL
S250	WRNINNGSWYMQSLI

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