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Protein Page:
Casp7 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Casp7 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; EC 3.4.22.60; Apoptosis; Protease; Endoplasmic reticulum; EC 3.4.22.-
Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; cysteine-type endopeptidase activity; aspartic-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: release of cytochrome c from mitochondria; apoptosis; positive regulation of neuron apoptosis; heart development; caspase activation via cytochrome c; proteolysis; cell structure disassembly during apoptosis; aging; response to UV
Reference #:  P55210 (UniProtKB)
Alt. Names/Synonyms: Apoptotic protease Mch-3; CASP-7; CASP7; caspase 7 isoform delta; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; Caspase-7; Caspase-7 subunit p11; Caspase-7 subunit p20; CMH-1; ICE-LAP3; ICE-like apoptotic protease 3; Lice2 alpha/beta/gamma; MCH3
Gene Symbols: CASP7
Molecular weight: 34,277 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Casp7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S16 EEQGVEDSANEDSVD
0 1 A17 EQGVEDSANEDSVDA
0 2 N18 QGVEDSANEDSVDAK
1 1 S30-p DAKPDRSsFVPSLFs
0 3 S37-p sFVPSLFskKKKNVt
1 0 K38-u FVPSLFskKKKNVtM
0 5 T44-p skKKKNVtMRsIKTT
0 6 S47-p KKNVtMRsIKTTRDR
1 1 K80-u INNKNFDkVTGMGVR
1 0 T173-p FRGDRCKtLLEKPKL
1 0 S239-p WRSPGRGsWFVQALC
  mouse

 
S16-p AELEKVDsssEDGVD
S17-p ELEKVDsssEDGVDA
S18-p LEKVDsssEDGVDAK
S30 DAKPDRSSIISSILL
- gap
K38 IISSILLKKKRNASA
S44 LKKKRNASAGPVRTG
- gap
K80-u INNKNFDkATGMDVR
T173 FRGDRCKTLLEKPKL
S239 WRNPGKGSWFVQALC
  rat

 
S16 AELEMADSSTEDGVD
S17 ELEMADSSTEDGVDA
T18 LEMADSSTEDGVDAK
T30 DAKPDRSTIISSLLW
- gap
K38 IISSLLWKKKKNASM
S44 WKKKKNASMCPVSTT
- gap
K80 INNKNFDKATGMDVR
T173 FRGDRCKTLLEKPKL
S239 WRNPGKGSWFVQALC
  fruit fly

► Hide Isoforms
 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S198 FTANHCPSLAGKPKL
S265 WRNTTRGSWFMQSLC
  Casp7 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S183 FTATFCPSLAGKPKL
S250 WRNINNGSWYMQSLI
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