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Protein Page:
DNAPK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DNAPK an atypical protein kinase of the PIKK family. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. and modulation of transcription. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Defects cause severe combined immune deficiency (SCID) which is characterized by a lack of mature functional lymphocytes and a high susceptibility to lethal opportunistic infections. Required for repair of radiation-induced dsDNA breaks. Loss of function in mice or horses leads to the SCID (severe combined immune deficiency) phenotype due to failure of immunoglobulin rearrangement. Target of mutation in mismatch repair-deficient colorectal cancer. Inhibitor: KU-7059. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Protein kinase, atypical; EC 2.7.11.1; DNA repair, damage; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; PIKK family; DNAPK subfamily
Cellular Component: nucleoplasm; transcription factor complex; membrane; nucleolus; DNA-dependent protein kinase complex; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; enzyme binding; DNA binding; DNA-dependent protein kinase activity; transcription factor binding; ATP binding; protein kinase activity
Biological Process: pro-B cell differentiation; somitogenesis; protein destabilization; immunoglobulin V(D)J recombination; positive regulation of apoptosis; heart development; B cell lineage commitment; germ cell programmed cell death; rhythmic process; T cell differentiation in the thymus; protein modification process; DNA repair; regulation of circadian rhythm; double-strand break repair via nonhomologous end joining; peptidyl-serine phosphorylation; T cell lineage commitment; cellular response to insulin stimulus; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of protein amino acid phosphorylation; double-strand break repair; positive regulation of interferon type I production; T cell receptor V(D)J recombination; response to gamma radiation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; brain development; telomere maintenance
Reference #:  P78527 (UniProtKB)
Alt. Names/Synonyms: DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNAPK; DNPK1; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; p350; p460; PRKDC; protein kinase, DNA-activated, catalytic polypeptide; XRCC7
Gene Symbols: PRKDC
Molecular weight: 469,089 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DNAPK

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell growth, altered: S2056‑p, T2609‑p, S2612‑p, T2638‑p, T2647‑p
chromatin organization, altered: S2056‑p, T2609‑p, S2612‑p, T2638‑p, T2647‑p
enzymatic activity, induced: T2609‑p
enzymatic activity, inhibited: T3950‑p
intracellular localization: T2609‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K99-ub FLEKMGQkIAPYSVE
0 1 K108-ub APYSVEIkNTCTSVY
0 1 K117-ac TCTSVYTkDRAAKCK
0 14 K117-ub TCTSVYTkDRAAKCK
0 1 T137-p LLIKLLQtFRSSRLM
0 7 K148-ub SRLMDEFkIGELFSk
0 1 K155-ub kIGELFSkFYGELAL
0 2 K163-ub FYGELALkkKIPDTV
0 2 K164-ub YGELALkkKIPDTVL
0 5 K205-ub RAFLGELkTQMTsAV
0 1 S210-p ELkTQMTsAVREPKL
0 21 K225-ub PVLAGCLkGLSSLLC
0 5 K236-ub SLLCNFTkSMEEDPQ
0 1 K254-ac EIFNFVLkAIRPQID
0 13 K254-ub EIFNFVLkAIRPQID
0 3 K263-ac IRPQIDLkRYAVPSA
0 17 K263-ub IRPQIDLkRYAVPSA
0 2 K310-ub HTNVELKkAALSALE
0 1 S318-p AALSALEsFLkQVSN
0 2 K321-ub SALEsFLkQVSNMVA
0 1 K329-ub QVSNMVAkNAEMHKN
0 1 K337-ub NAEMHKNkLQYFMEQ
0 1 K357-ac RNVDSNNkELSIAIR
0 5 K357-ub RNVDSNNkELSIAIR
0 1 Y366 LSIAIRGYGLFAGPC
0 1 K374-ub GLFAGPCkVINAkDV
0 1 K379-ub PCkVINAkDVDFMYV
0 1 Y385 AkDVDFMYVELIQRC
0 1 K393-ub VELIQRCkQMFLTQT
0 4 K471-ub VFLALAAkGPVLRNC
0 1 S492-p QGLIRICskPVVLPK
0 11 K493-ub GLIRICskPVVLPKG
0 1 S503-p VLPKGPEsEsEDHRA
0 1 S505-p PKGPEsEsEDHRAsG
0 4 S511-p EsEDHRAsGEVRtGK
0 1 T516-p RAsGEVRtGKWKVPT
0 2 K525-ub KWKVPTYkDYVDLFR
0 1 S552-p LADEAFFsVNSSSES
0 1 K574-ub EFVKSVLkIVEKLDL
0 1 Y647 EFFEPWVYSFSYELI
0 1 Y667-p LPLISGFyKLLSITV
0 2 K681-ub VRNAKKIkyFEGVsP
0 14 Y682-p RNAKKIkyFEGVsPk
0 2 S687-p IkyFEGVsPkSLkHS
0 10 K689-ub yFEGVsPkSLkHSPE
0 1 K692-ub GVsPkSLkHSPEDPE
0 1 K712-ub ALFVKFGkEVAVkMK
0 1 A715 VKFGkEVAVkMKQyK
0 2 K717-ac FGkEVAVkMKQyKDE
0 1 Y721-p VAVkMKQyKDELLAS
0 2 Y779-p ALEEWSIyIDRHVMQ
0 6 K801-ub PCLDGYLkTSALSDE
0 1 K810-ac SALSDETkNNWEVSA
0 31 K810-ub SALSDETkNNWEVSA
0 1 R820-m1 WEVSALSrAAQkGFN
0 1 K824-ub ALSrAAQkGFNkVVL
0 1 K828-ac AAQkGFNkVVLkHLK
0 4 K828-ub AAQkGFNkVVLkHLK
0 1 K832-ac GFNkVVLkHLKKTkN
0 16 K838-ub LkHLKKTkNLssNEA
0 2 S841-p LKKTkNLssNEAIsL
0 2 S842-p KKTkNLssNEAIsLE
0 1 S847-p LssNEAIsLEEIRIR
0 1 S861-p RVVQMLGsLGGQINk
0 4 K868-ub sLGGQINkNLLTVTs
0 1 S875-p kNLLTVTssDEMMks
0 1 S876-p NLLTVTssDEMMksy
0 1 K881-ub TssDEMMksyVAWDR
0 1 S882-p ssDEMMksyVAWDRE
0 23 Y883-p sDEMMksyVAWDREK
0 7 S893-p WDREKRLsFAVPFRE
0 25 K902-ub AVPFREMkPVIFLDV
0 1 S922-p TELALTAsDRQTKVA
0 2 K963-ub PPMYQLYkRTFPVLL
0 1 K1038-ub RCIREFLkWSIkQIT
0 1 K1042-ub EFLkWSIkQITPQQQ
0 2 K1051-ub ITPQQQEksPVNTkS
0 1 S1052-p TPQQQEksPVNTkSL
0 3 K1057-ac EksPVNTkSLFKRLy
0 8 K1057-ub EksPVNTkSLFKRLy
0 1 S1058 ksPVNTkSLFKRLys
0 1 Y1064-p kSLFKRLysLALHPN
0 2 S1065-p SLFKRLysLALHPNA
0 2 K1074-ac ALHPNAFkRLGASLA
0 2 K1074-ub ALHPNAFkRLGASLA
0 32 Y1086-p SLAFNNIyREFREEE
0 1 K1141-ub LCRIIEKkHVSLNkA
0 1 K1147-ub KkHVSLNkAKKRRLP
0 10 K1186-ub PQTECRHksIELFYk
0 1 S1187-p QTECRHksIELFYkF
0 11 K1193-ub ksIELFYkFVPLLPG
0 1 K1209-ac RSPNLWLkDVLKEEG
0 2 K1209-ub RSPNLWLkDVLKEEG
0 1 T1275-p NTFIGERtVGALQVL
0 5 K1311-ub HDIIAAEkCFGTGAA
0 6 K1334-ub GERYNYSkCTVVVRI
0 1 K1357-ub NTSPEGWkLLKKDLC
0 1 K1407-ub VNLMKALkMSPYkDI
0 2 K1412-ub ALkMSPYkDILETHL
0 15 K1422-ub LETHLREkITAQSIE
0 39 K1456-ub AAVVSACkQLHRAGL
0 1 S1470-p LLHNILPsQSTDLHH
0 1 T1481-p DLHHSVGtELLSLVY
0 10 K1489-ub ELLSLVYkGIAPGDE
0 1 S1545-p LSTASLGssQGSVIH
0 1 S1546-p STASLGssQGSVIHF
0 2 K1612-ub FRERANQkHQGLKLA
0 1 T1620-p HQGLKLAttILQHWk
0 1 T1621-p QGLKLAttILQHWkK
0 2 K1627-ub ttILQHWkKCDSWWA
0 1 K1642-ub KDSPLETkMAVLALL
0 1 T1856-p DVLKSRFtkLNESTF
0 21 K1857-ub VLKSRFtkLNESTFD
0 33 K1869-ub TFDTQITkkMGYYkI
0 17 K1870-ub FDTQITkkMGYYkIL
0 2 K1875-ub TkkMGYYkILDVMYS
0 1 K1892-ub PKDDVHAkESkINQV
0 8 K1895-ub DVHAkESkINQVFHG
0 19 K1913-ub TEGNELTkTLIkLCY
0 12 K1917-ub ELTkTLIkLCYDAFT
0 2 K1970-ac QGFLFSEkPEkNLLI
0 2 K1970-ub QGFLFSEkPEkNLLI
0 1 K1973-ub LFSEkPEkNLLIFEN
0 10 K1985-ac FENLIDLkRRYNFPV
0 75 K1985-ub FENLIDLkRRYNFPV
0 8 K2003-ub VPMERKKkYIEIRKE
1 0 S2023-p NGDSDGPsYMSSLsY
1 0 S2029-p PsYMSSLsYLADsTL
0 1 S2034-p SLsYLADsTLSEEMs
1 0 S2041-p sTLSEEMsQFDFSTG
0 1 S2051-p DFSTGVQsYsYSsQD
1 2 S2053-p STGVQsYsYSsQDPR
21 3 S2056-p VQsYsYSsQDPRPAT
0 1 S2107-p LVKHMHRsLGPPQGE
0 1 S2117-p PPQGEEDsVPRDLPS
0 1 K2127-ub RDLPSWMkFLHGkLG
0 1 K2132-ub WMkFLHGkLGNPIVP
0 1 S2250-p ECWKDCLsIPYRLIF
0 1 K2259-ac PYRLIFEkFSGkDPN
0 3 K2259-ub PYRLIFEkFSGkDPN
0 1 K2263-ub IFEkFSGkDPNSKDN
0 2 Y2329-p VLGLILRyVMERkNI
0 2 K2334-ub LRyVMERkNILEESL
0 4 K2347-ub SLCELVAkQLkQHQN
0 9 K2350-ub ELVAkQLkQHQNTME
0 4 K2359-ac HQNTMEDkFIVCLNk
0 1 K2366-ub kFIVCLNkVTkSFPP
0 2 K2369-ub VCLNkVTkSFPPLAD
0 2 K2418-ub LYFQLKSkDFVQVMR
0 2 K2433-ub HRDDERQkVCLDIIy
0 3 Y2440-p kVCLDIIyKMMPkLk
0 1 K2445-ac IIyKMMPkLkPVELR
0 3 K2447-ub yKMMPkLkPVELREL
0 1 S2489 DNYRDPESETDNDSQ
0 16 K2503-ub QEIFKLAkDVLIQGL
0 1 T2535-p ETRLPSNtLDRLLAL
0 1 Y2546-p LLALNSLySPkIEVH
0 12 K2549-ub LNSLySPkIEVHFLS
0 2 S2599-p DSDWRFRstVLtPMF
0 2 T2600-p SDWRFRstVLtPMFV
0 34 T2603-p RFRstVLtPMFVEtQ
20 15 T2609-p LtPMFVEtQAsQGtL
4 56 S2612-p MFVEtQAsQGtLQtR
0 7 T2615-p EtQAsQGtLQtRtQE
0 3 T2618-p AsQGtLQtRtQEGsL
2 11 T2620-p QGtLQtRtQEGsLsA
2 2 S2624-p QtRtQEGsLsARWPV
0 1 S2626-p RtQEGsLsARWPVAG
5 17 T2638-p VAGQIRAtQQQHDFt
0 11 T2645-p tQQQHDFtLtQTADG
9 16 T2647-p QQHDFtLtQTADGRs
0 1 S2654-p tQTADGRssFDWLTG
1 2 S2655-p QTADGRssFDWLTGS
1 1 T2671-p TDPLVDHtsPssDsL
1 1 S2672-p DPLVDHtsPssDsLL
1 1 S2674-p LVDHtsPssDsLLFA
1 0 S2675-p VDHtsPssDsLLFAH
1 0 S2677-p HtsPssDsLLFAHkR
0 9 K2683-ac DsLLFAHkRSERLQR
0 3 K2683-ub DsLLFAHkRSERLQR
0 1 K2694-ac RLQRAPLkSVGPDFG
0 2 K2694-ub RLQRAPLkSVGPDFG
0 2 K2702-ac SVGPDFGkkRLGLPG
0 1 K2702-m1 SVGPDFGkkRLGLPG
0 1 K2702-ub SVGPDFGkkRLGLPG
0 1 K2703-ub VGPDFGkkRLGLPGD
0 4 K2715-ub PGDEVDNkVKGAAGR
0 1 K2738-ac RFMRDQEkLSLMyAR
0 1 K2738-ub RFMRDQEkLSLMyAR
0 1 Y2743-p QEkLSLMyARKGVAE
0 1 R2745 kLSLMyARKGVAEQk
0 1 K2752-ub RKGVAEQkREKEIkS
0 1 K2758-ub QkREKEIkSELKMkQ
0 6 K2764-ub IkSELKMkQDAQVVL
0 4 K2786-ub DLPDIQIkHSsLITP
0 1 S2789-p DIQIkHSsLITPLQA
0 8 K2806-ub QRDPIIAkQLFSSLF
0 1 S2814-p QLFSSLFsGILKEMD
0 34 K2829-ub KFKTLSEkNNITQkL
0 12 K2835-ub EkNNITQkLLQDFNR
0 20 K2908-ub LPAELPAkRVRGKAR
0 21 K2928-ub LRWVELAkLYRsIGE
0 1 S2932-p ELAkLYRsIGEyDVL
0 7 Y2936-p LYRsIGEyDVLRGIF
0 42 K2950-ub FTSEIGTkQITQsAL
0 1 S2955-p GTkQITQsALLAEAR
0 1 K2970-ub SDYSEAAkQYDEALN
0 1 K2978-ub QYDEALNkQDWVDGE
0 11 K3050-ub YMIRSKLkLLLQGEA
0 2 K3067-ub SLLTFIDkAMHGELQ
0 3 K3075-ub AMHGELQkAILELHY
0 2 K3128-ub LHQSRLTkLQSVQAL
0 1 K3147-ub EFISFISkQGNLSSQ
0 29 K3158-ub LSSQVPLkRLLNTWT
0 1 K3172-ub TNRYPDAkMDPMNIW
0 12 K3192-ub NRCFFLSkIEEkLtP
0 1 K3196-ub FLSkIEEkLtPLPED
0 1 T3198-p SkIEEkLtPLPEDNs
3 18 S3205-p tPLPEDNsMNVDQDG
0 2 S3215-p VDQDGDPsDRMEVQE
0 1 S3233-p DISSLIRsCkFSMkM
0 1 K3235-ub SSLIRsCkFSMkMkM
0 2 K3239-ac RsCkFSMkMkMIDSA
0 1 K3241-ac CkFSMkMkMIDSARk
0 1 K3241-ub CkFSMkMkMIDSARk
0 15 K3248-ub kMIDSARkQNNFsLA
0 1 S3253-p ARkQNNFsLAMkLLk
0 1 K3257-ub NNFsLAMkLLkELHk
0 1 K3260-ac sLAMkLLkELHkESk
0 11 K3260-ub sLAMkLLkELHkESk
0 1 K3264-ub kLLkELHkESkTRDD
0 1 K3267-ac kELHkESkTRDDWLV
0 8 S3290-p LSHCRSRsQGCsEQV
0 2 S3294-p RSRsQGCsEQVLTVL
0 4 K3302-ub EQVLTVLkTVSLLDE
0 1 N3310 TVSLLDENNVSSYLS
0 1 S3313 LLDENNVSSYLSkNI
0 40 K3318-ub NVSSYLSkNILAFRD
0 18 K3355-ub LAEIEEDkARRILEL
0 1 S3366-p ILELSGSsSEDSEkV
0 1 K3372-m1 SsSEDSEkVIAGLyQ
0 32 K3372-ub SsSEDSEkVIAGLyQ
0 2 Y3378-p EkVIAGLyQRAFQHL
0 1 K3426-ub FCDQQLRkEEENASV
0 3 K3449-ub YPALVVEkMLkALkL
0 1 K3452-ub LVVEkMLkALkLNSN
0 8 K3455-ub EkMLkALkLNSNEAR
0 1 S3489-p LMTKEISsVPCWQFI
0 1 S3497-p VPCWQFIsWIsHMVA
0 1 S3500-p WQFIsWIsHMVALLD
0 1 T3545 ESYSFKDTSTGHKNk
0 1 S3546 SYSFKDTSTGHKNkE
0 12 K3552-ub TSTGHKNkEFVARIK
0 1 R3593 KDWSNDVRAELAkTP
0 13 K3598-ub DVRAELAkTPVNKKN
0 1 K3608-ac VNKKNIEkMYERMYA
0 2 K3621-ac YAALGDPkAPGLGAF
0 12 K3621-ub YAALGDPkAPGLGAF
0 3 K3631-ub GLGAFRRkFIQTFGk
0 1 K3638-ac kFIQTFGkEFDkHFG
0 1 K3638-ub kFIQTFGkEFDkHFG
0 1 K3638-sc kFIQTFGkEFDkHFG
0 1 K3642-ac TFGkEFDkHFGKGGS
0 1 S3657-p KLLRMKLsDFNDItN
0 1 T3663-p LsDFNDItNMLLLkM
0 10 K3669-ub ItNMLLLkMNKDSKP
0 8 K3691-ac SPWMSDFkVEFLRNE
0 6 K3691-ub SPWMSDFkVEFLRNE
0 15 K3710-ub GQYDGRGkPLPEYHV
0 1 S3731-p ERVTVMAsLRRPKRI
0 1 H3748 RGHDEREHPFLVkGG
0 3 K3753-ub REHPFLVkGGEDLRQ
0 1 Y3791-p RALQLRTySVVPMTS
0 1 T3811-p EWLENTVtLKDLLLN
0 2 S3821-p DLLLNTMsQEEkAAy
0 10 K3825-ub NTMsQEEkAAyLSDP
0 1 Y3828-p sQEEkAAyLSDPRAP
0 1 K3840-ub RAPPCEYkDWLTkMS
0 2 K3845-ub EYkDWLTkMSGKHDV
0 1 H3850 LTkMSGKHDVGAyML
0 1 Y3855-p GKHDVGAyMLMykGA
0 1 Y3859-p VGAyMLMykGANRTE
0 5 K3860-ub GAyMLMykGANRTET
0 1 S3870-p NRTETVTsFRKRESK
0 5 K3884-ub KVPADLLkRAFVRMS
2 1 T3950-p GHAFGSAtQFLPVPE
0 1 S3993-p HALRAFRsDPGLLTN
0 12 K4007-ub NTMDVFVkEPSFDWK
0 4 K4019-ub DWKNFEQkMLKkGGs
0 4 K4023-ub FEQkMLKkGGsWIQE
0 13 S4026-p kMLKkGGsWIQEINV
0 2 K4036-ub QEINVAEkNWYPRQK
0 4 K4048-ac RQKICYAkRkLAGAN
0 2 K4050-ub KICYAkRkLAGANPA
0 6 K4070-ub ELLLGHEkAPAFRDY
0 1 S4096-p IRAQEPEsGLSEETQ
4215 : Phospho-DNA-PK (Ser2056) Antibody
  mouse

 
K99 FLEKIDQKVMHYSLD
K108 MHYSLDIKNTCTSVY
K117 TCTSVYTKDRTAKCK
K117 TCTSVYTKDRTAKCK
I137 LLIKLLQILRSTRLM
K148 TRLMDEFKIGELFNK
K155 KIGELFNKFYGELAS
K163 FYGELASKSKLPDTV
S164 YGELASKSKLPDTVL
K205 RAFLGELKTQMTSTV
S210 ELKTQMTSTVREPKF
K225 PVLAGCLKGLSSLLC
K236 SLLCNFTKSMEEDPQ
K254 EIFGFTFKAIRPQIE
K254 EIFGFTFKAIRPQIE
K263 IRPQIEMKRYAVPLA
K263 IRPQIEMKRYAVPLA
K310 HTNVELKKAAHSALE
S318 AAHSALESFLRQISF
R321 SALESFLRQISFTVA
E329 QISFTVAEDAELHKS
R337 DAELHKSRLKYFMEQ
K357 RNTDSNNKELAIAIR
K357 RNTDSNNKELAIAIR
Y366-p LAIAIRGyGLFAGPC
K374 GLFAGPCKVINAKDV
K379 PCKVINAKDVDFMyV
Y385-p AKDVDFMyVELIQRC
K393 VELIQRCKQMFLTHA
K471 LFLALSEKGPVHWNC
S492 QGLIRICSKPVVLQK
K493 GLIRICSKPVVLQKD
S503 VLQKDVESRSDNRSA
S505 QKDVESRSDNRSASE
S511 RSDNRSASEEVRTGR
T516 SASEEVRTGRWKVPT
K525 RWKVPTYKDYVDLFQ
F552 LGDETFLFVNSSLKS
K574 EFIRSVLKIVEKLDL
Y646-p GFFEPWVySFAYELI
Y666 LPLISGFYKLLSIAV
K680 VKNARKIKYFEGISP
Y681 KNARKIKYFEGISPK
S686 IKYFEGISPKSLKHS
K688 YFEGISPKSLKHSPE
K691 GISPKSLKHSPEDTE
K711 ALFAKFGKEVsVKMK
S714-p AKFGKEVsVKMKQYK
K716 FGKEVsVKMKQYKDE
Y720 VsVKMKQYKDELLAS
H778 ALKEWSVHIDKSILQ
N800 PCLDGYLNTSTLSDE
K809 STLSDETKSHWGLSA
K809 STLSDETKSHWGLSA
R819 WGLSALSRAAQKGFN
K823 ALSRAAQKGFNRHVV
R827 AAQKGFNRHVVKHLK
R827 AAQKGFNRHVVKHLK
K831 GFNRHVVKHLKRTRN
R837 VKHLKRTRNSSPDEA
S840 LKRTRNSSPDEALSL
P841 KRTRNSSPDEALSLE
S846 SSPDEALSLEEIRIK
S860 KVVQILGSLGGQINK
K867 SLGGQINKSLVTATS
S874 KSLVTATSGERMKKy
G875 SLVTATSGERMKKyV
K879 ATSGERMKKyVAWDA
K880 TSGERMKKyVAWDAE
Y881-p SGERMKKyVAWDAER
S891-p WDAERRLsFAVPFRE
K900 AVPFREMKPVIYLDV
S920 TELALSASDRQTKVA
K960 PPMYQLYKHTFPVLL
K1035 RCVQEFLKWSIKQTT
K1039 EFLKWSIKQTTPQQQ
K1048 TTPQQQEKSPVNSKs
S1049 TPQQQEKSPVNSKsL
K1054 EKSPVNSKsLFKRLY
K1054 EKSPVNSKsLFKRLY
S1055-p KSPVNSKsLFKRLYS
Y1061 KsLFKRLYSLALHPN
S1062 sLFKRLYSLALHPNA
K1071 ALHPNAFKRLGAALA
K1071 ALHPNAFKRLGAALA
Y1083 ALAFNHIYKEFREEG
K1138 LRRIIEKKHVSLNKA
K1144 KKHVSLNKAKKRRLP
K1183 PQTECRHKSMELFYK
S1184 QTECRHKSMELFYKF
K1190 KSMELFYKFVPLLPG
K1206 KSPSLWLKDLIKKKG
K1206 KSPSLWLKDLIKKKG
T1274 NTFIEKETVQGQEVL
Q1310 HSARAVEQRFGSGAP
K1332 EEKYNYSKCTVLVRI
K1355 IASPEDCKLLEKDLC
R1405 VNLLKALRKSPYRDM
R1410 ALRKSPYRDMLETHL
K1420 LETHLKEKVTVQSVE
K1454 LSILSACKQLHKAGF
S1468 FSHVISPSQSTALNH
M1479 ALNHSVGMRLLSLVY
K1487 RLLSLVYKGIVPAEE
S1543 LSTQYLGSSQRNISF
S1544 STQYLGSSQRNISFS
K1609 FRDRAVQKHQGLKLA
T1617 HQGLKLATAILQNWR
A1618 QGLKLATAILQNWRK
R1624 TAILQNWRKCDSWWA
K1639 PDSAPESKTTVLSLL
T1853 DVLKSRFTKLNEFTF
K1854 VLKSRFTKLNEFTFD
K1866 TFDTQITKKMCYYKM
K1867 FDTQITKKMCYYKML
K1872 TKKMCYYKMLAVMYS
K1889 LKDDVHSKEAKINQA
K1892 DVHSKEAKINQAFHG
K1910 AEGNELTKTLLKLCH
K1914 ELTKTLLKLCHDAFT
K1967 QGFLFNEKPEKNLFI
K1967 QGFLFNEKPEKNLFI
K1970 LFNEKPEKNLFIFEN
K1982 FENLIDLKRCYTFPI
K1982 FENLIDLKRCYTFPI
K2000 VPMERKKKYIEIRKE
H2020 NGASGSPHYMSSLSY
S2026 PHYMSSLSYLTDSSL
S2031 SLSYLTDSSLSEEMS
S2038 SSLSEEMSQFDFSTG
S2048 DFSTGVQSYSYSSQD
S2050 STGVQSYSYSSQDRK
S2053 VQSYSYSSQDRKPTT
N2104 LIKHMQRNVIAPKGE
S2114 APKGEEGSIPKDLPP
K2124 KDLPPWMKFLHDKLG
K2129 WMKFLHDKLGNASVS
S2246 ECWKECLSIPYRLIF
K2255 PYRLIFEKFSHKDPN
K2255 PYRLIFEKFSHKDPN
K2259 IFEKFSHKDPNSKDN
Y2325 VLGLILQYITERKHV
K2330 LQYITERKHVIAELV
K2343 LVCELVIKQLKQHQN
K2346 ELVIKQLKQHQNTME
K2355 HQNTMEDKFIVCLNK
K2362 KFIVCLNKIAKGFPP
K2365 VCLNKIAKGFPPLAD
K2414 LYLQLKSKDFLQVMR
K2429 HRDDERQKVCLDIVY
Y2436 KVCLDIVYKMVAKLK
K2441 IVYKMVAKLKPIELR
K2443 YKMVAKLKPIELREL
S2485-p DNYRDQEsQNDEDSQ
K2499 QEIFKLAKDVLIQGL
T2531 ETRLPSNTLDRLLAL
Y2542 LLALNSLYSPkIEVH
K2545-ub LNSLYSPkIEVHFLS
S2595 DPDWRFRSTVLTPMF
T2596 PDWRFRSTVLTPMFI
T2599 RFRSTVLTPMFIETQ
T2605 LTPMFIETQASPSIL
S2608 MFIETQASPSILHTQ
I2611 ETQASPSILHTQTQE
T2614 ASPSILHTQTQEGPL
T2616 PSILHTQTQEGPLSD
P2620 HTQTQEGPLSDQRQK
S2622 QTQEGPLSDQRQKPG
T2634 KPGQVRATQQQYDFT
T2641 TQQQYDFTPTQASVE
T2643 QQYDFTPTQASVERS
S2650 TQASVERSSFDWLTG
S2651 QASVERSSFDWLTGS
T2667 IDLLADHTVFSSETL
V2668 DLLADHTVFSSETLS
S2670 LADHTVFSSETLSSS
S2671 ADHTVFSSETLSSSL
S2677 SSETLSSSLLFSHkR
K2683-ac SSLLFSHkRTEKSQR
K2683 SSLLFSHKRTEKSQR
K2694 KSQRMSCKSVGPDFG
K2694 KSQRMSCKSVGPDFG
T2702 SVGPDFGTKKLGLPD
T2702 SVGPDFGTKKLGLPD
T2702 SVGPDFGTKKLGLPD
K2703 VGPDFGTKKLGLPDD
Q2715 PDDEVDNQVKSGTPS
K2739 RFLKDREKLSLLYAk
K2739 RFLKDREKLSLLYAk
Y2744 REKLSLLYAkRGLME
K2746-ub KLSLLYAkRGLMEQK
K2753 kRGLMEQKLEKDIKS
K2759 QKLEKDIKSEFKMKQ
K2765 IKSEFKMKQDAQVVL
Q2787 DLPDIQIQHSGLITP
G2790 DIQIQHSGLITPLQA
K2807 QKDPIIAKQLFSSLF
S2815 QLFSSLFSGILKEMN
K2830 KFKTTSEKNIITQNL
N2836 EKNIITQNLLQDFNR
K2909 MPKEPPTKRVRGKTC
K2929 LRWMELAKLYRSIGE
S2933 ELAKLYRSIGEYDVL
Y2937 LYRSIGEYDVLRGIF
T2951 FSSELGTTQDTQNAL
N2956 GTTQDTQNALLAEAR
K2971 SDYCQAAKLYDEALN
K2979 LYDEALNKLEWVDGE
K3051 YVIRSKLKLLLQGEG
E3068 SLLTFVDEAMNKELQ
K3076 AMNKELQKTVLELQY
K3129 LYRSRLAKLQSVQTL
K3148 EFLSFICKHGDLSSL
R3159 LSSLGPLRRLLKTWT
V3173 TSRYPDVVTDPMHIW
K3193 NRCFFLSKIEERLTA
R3197 FLSKIEERLTAPSGD
T3199 SKIEERLTAPSGDHS
S3206 TAPSGDHSMSVDEDE
S3215 SVDEDEESIDREVYE
S3233 DVRCMLQSCRFTMKM
R3235 RCMLQSCRFTMKMKM
K3239 QSCRFTMKMKMIESA
K3241 CRFTMKMKMIESAWK
K3241 CRFTMKMKMIESAWK
K3248 KMIESAWKQSNFSLS
S3253 AWKQSNFSLSMKLLK
K3257 SNFSLSMKLLKEMHK
K3260 SLSMKLLKEMHKESK
K3260 SLSMKLLKEMHKESK
K3264 KLLKEMHKESKTREI
K3267 KEMHKESKTREIWRV
T3290 LNHCRSHTQSPREQV
R3294 RSHTQSPREQVLNML
K3302 EQVLNMLKTITLLDE
S3310-p TITLLDEsDIsNYLN
S3313-p LLDEsDIsNYLNKNI
K3318 DIsNYLNKNIQASCD
K3355 LSDLEENKVNSILTL
N3366 ILTLSGSNAENTETV
T3372 SNAENTETVITGLYQ
T3372 SNAENTETVITGLYQ
Y3378 ETVITGLYQRAFHHL
K3426 FCDQQLRKVEESASQ
K3449 YPALVVEKMLRALKL
R3452 LVVEKMLRALKLNSS
K3455 EKMLRALKLNSSEAR
S3489 IMTKEISSIPCWQFI
G3497 IPCWQFIGWISHMMA
S3500 WQFIGWISHMMALLD
T3545-p ESYSFKNtsSGHNNK
S3546-p SYSFKNtsSGHNNKA
K3552 tsSGHNNKAFVERIK
K3593-ac KDWVSDTkDELGKNP
K3598 DTkDELGKNPVNKKN
K3608 VNKKNIEKLYERMYA
R3621 YAALGDLRAPGLGPF
R3621 YAALGDLRAPGLGPF
R3631 GLGPFRRRFIQAFGK
K3638 RFIQAFGKEFVKSFG
K3638 RFIQAFGKEFVKSFG
K3638 RFIQAFGKEFVKSFG
K3642 AFGKEFVKSFGNGGS
D3657 KLLTMKVDDFCKITG
T3663 VDDFCKITGSLLVRM
R3669 ITGSLLVRMKKDSKL
K3691 SPWMSEFKAQFLKNE
K3691 SPWMSEFKAQFLKNE
K3710 GQYDGKSKPLPEYHV
S3731 ERVKVMLSLRKPKRI
Y3748 RGHDEKEYPFLVKGG
K3753 KEYPFLVKGGEDLRQ
Y3791 RNMQLRTYRVVPMTS
T3811 EWIENTMTLKDLLLS
S3821 DLLLSNMSQEEKVAN
K3825 SNMSQEEKVANNSDP
N3828 SQEEKVANNSDPKAP
K3840 KAPIRDYKDWLMKVS
K3845 DYKDWLMKVSGKsDA
S3850-p LMKVSGKsDAGAYVL
Y3855 GKsDAGAYVLMYSRA
Y3859 AGAYVLMYSRANRTE
S3860 GAYVLMYSRANRTET
A3870 NRTETVVAFRRRESQ
K3884 QVPPDLLKRAFVKMS
T3950 GHAFGSATQFLPVPE
S3993 HALRAFRSCAGLLTD
K4007 DTMEIFVKEPSFDWK
T4019 DWKSFEQTMLRKGGS
K4023 FEQTMLRKGGSWIQE
S4026 TMLRKGGSWIQEINV
K4036 QEINVTEKNWYPQHK
K4048 QHKIRYAKRKLAGAN
K4050 KIRYAKRKLAGANPA
A4070 ELYLGHEASSAFRSY
S4096 IRAQEPESGLSEETQ
  rat

 
K99 FLEKIDQKVLHYSFD
K108 LHYSFDIKNTCISVY
K117 TCISVYTKDRTAKCK
K117 TCISVYTKDRTAKCK
I137 LLIKLLKILRSSRVM
K148 SRVMDEFKIGELFNK
K155 KIGELFNKFYGELVS
K163 FYGELVSKSKLPDTV
S164 YGELVSKSKLPDTVL
K205 RAFLGELKTQMTSTV
S210 ELKTQMTSTVREPKF
K225 PVLAGCLKGLSSLLC
K236 SLLCNFTKSMEEDPQ
K254 EIFGFTLKAIRPQIE
K254 EIFGFTLKAIRPQIE
K263 IRPQIEMKRYAVPLA
K263 IRPQIEMKRYAVPLA
K310 HTNVELKKAAHSALE
S318 AAHSALESFLKQISF
K321 SALESFLKQISFTVA
E329 QISFTVAEDAELHKS
K337 DAELHKSKLKYFMEQ
K357 RNADSNNKDLAIAIR
K357 RNADSNNKDLAIAIR
Y366 LAIAIRGYGLFAGPC
K374 GLFAGPCKVINAKDV
K379 PCKVINAKDVDFMYV
Y385 AKDVDFMYVELIQRC
K393 VELIQRCKQMFLTQT
K471 VFLSLTEKGPVHWNC
S492 QGLIRICSKPVVLQK
K493 GLIRICSKPVVLQKD
S503 VLQKDVESRSENRWA
S505 QKDVESRSENRWASE
S511 RSENRWASEEVRMGR
M516 WASEEVRMGRWKVPT
K525 RWKVPTYKDYVDLFQ
F552 LGDETFLFVNSSLKS
K574 EFIRSVLKIVEKLDL
Y646 SFFEPWVYSFAYELI
Y666 LPLISGFYKLLSIAV
K680 VKNARKIKYFEGVSP
Y681 KNARKIKYFEGVSPK
S686 IKYFEGVSPKCLKHS
K688 YFEGVSPKCLKHSPE
K691 GVSPKCLKHSPENTE
K711 ALFAKFGKEVSVKMK
S714 AKFGKEVSVKMKQYK
K716 FGKEVSVKMKQYKDE
Y720 VSVKMKQYKDELLAS
H778 ALKEWSVHIDKSIMQ
N800 PCLDGYLNTSTLSDE
K809 STLSDETKSHWEVSA
K809 STLSDETKSHWEVSA
R819 WEVSALSRAARKGFN
K823 ALSRAARKGFNRDVV
R827 AARKGFNRDVVKLLK
R827 AARKGFNRDVVKLLK
K831 GFNRDVVKLLKRTRN
R837 VKLLKRTRNVTSDEA
T840 LKRTRNVTSDEALSL
S841 KRTRNVTSDEALSLE
S846 VTSDEALSLEEIRIR
S860 RVVQILGSLGGQINK
K867 SLGGQINKNLITATS
S874 KNLITATSGERMKKY
G875 NLITATSGERMKKYV
K879 ATSGERMKKYVAWDR
K880 TSGERMKKYVAWDRE
Y881 SGERMKKYVAWDREK
S891 WDREKRLSFAVPFRE
K900 AVPFREMKPVIYLDV
S920 TELALSASDRQTKVA
K960 PPMYQLYKHMFPVLL
K1035 QCVQEFLKWSIKQTT
K1039 EFLKWSIKQTTPQQQ
K1048 TTPQQQEKSPVNSKS
S1049 TPQQQEKSPVNSKSL
K1054 EKSPVNSKSLFKRLY
K1054 EKSPVNSKSLFKRLY
S1055 KSPVNSKSLFKRLYS
Y1061 KSLFKRLYSLALHPN
S1062 SLFKRLYSLALHPNA
K1071 ALHPNAFKRLGAALA
K1071 ALHPNAFKRLGAALA
Y1083 ALAFNHIYKEFREEG
K1138 LRRIIEKKYISLNKA
K1144 KKYISLNKAKKRRLP
K1183 PQTECRHKSIELFYK
S1184 QTECRHKSIELFYKF
K1190 KSIELFYKFVPLLPG
R1206 KSPSLWLRDLIKAEG
R1206 KSPSLWLRDLIKAEG
T1274 NTFIEEKTVQVQEVL
Q1310 CDARTVEQRFGTGLT
K1332 EEKYNYSKCTVLVRI
K1355 VTFPEDCKLLEKDLC
R1405 VNLLKALRKSPYRDK
R1410 ALRKSPYRDKLETHL
K1420 LETHLKEKVTAQSVE
K1454 LSLLSACKQLHKAGF
S1468 FSHIISASQSTALNH
M1479 ALNHSIGMRLLSLVY
N1487 RLLSLVYNGIAPAQE
S1543 LSTQYLGSSQRNISF
S1544 STQYLGSSQRNISFS
K1609 FRDRAVQKHQGLKLA
T1617 HQGLKLATAILQNWR
A1618 QGLKLATAILQNWRK
R1624 TAILQNWRKCDSWWA
K1639 PDSAPESKTTVLSLL
T1852 DVLKSRFTKLNDTFD
K1853 VLKSRFTKLNDTFDT
K1864 TFDTQITKKMCYYKM
K1865 FDTQITKKMCYYKML
K1870 TKKMCYYKMLAVMYS
K1887 LKDDVHSKESKINQA
K1890 DVHSKESKINQAFQG
K1908 AEGNELTKTLLKLCH
K1912 ELTKTLLKLCHDAFT
K1965 QGFLFSEKPEKNLFI
K1965 QGFLFSEKPEKNLFI
K1968 LFSEKPEKNLFIFEN
K1980 FENLIDLKRCYTFPI
K1980 FENLIDLKRCYTFPI
K1998 VPMERKKKYVEIRKE
R2018 NGASGNPRYMSSLSY
S2024 PRYMSSLSYLTESSL
S2030 LSYLTESSLSEEMSQ
S2036 SSLSEEMSQFDFSTG
S2046 DFSTGVQSYSYSSQD
S2048 STGVQSYSYSSQDRK
S2051 VQSYSYSSQDRKPTT
N2102 LIKHMQRNVIAPKGQ
S2112 APKGQEGSISKDLPP
K2122 KDLPPWMKFLHDKLE
K2127 WMKFLHDKLENASVS
S2244 ECWKECLSIPYRLIF
K2253 PYRLIFEKFSNKDPN
K2253 PYRLIFEKFSNKDPN
K2257 IFEKFSNKDPNSKDN
H2323 VLGLILQHVTERKHV
K2328 LQHVTERKHVIAESV
K2341 SVYELVVKQLKQHQN
K2344 ELVVKQLKQHQNTME
K2353 HQNTMEDKFIVCLNK
K2360 KFIVCLNKIVKGFPP
K2363 VCLNKIVKGFPPLAD
K2412 LYLQLKSKDFLQVMR
K2427 HRDDERQKVCLDIIY
Y2434 KVCLDIIYKMVAKLK
K2439 IIYKMVAKLKPTELR
K2441 YKMVAKLKPTELREL
S2483 DNYRDPESQMDEDSQ
K2497 QEIFKLAKDVLIQGL
T2529 ETRLPSNTLDRLLAL
Y2540 LLALNSLYSPKIEVH
K2543 LNSLYSPKIEVHFLS
S2593 DPDWRFRSTVLTPMF
T2594 PDWRFRSTVLTPMFI
T2597 RFRSTVLTPMFIETQ
T2603 LTPMFIETQAFPSTL
F2606 MFIETQAFPSTLNTQ
T2609 ETQAFPSTLNTQTQE
T2612 AFPSTLNTQTQEGSP
T2614 PSTLNTQTQEGSPSD
S2618 NTQTQEGSPSDRRQK
S2620 QTQEGSPSDRRQKPG
T2632 KPGQVRATQQQYDFT
T2639 TQQQYDFTPTQTSVE
T2641 QQYDFTPTQTSVERS
S2648 TQTSVERSSFDWLTG
S2649 QTSVERSSFDWLTGS
T2665 IDLMADHTVFSSESL
V2666 DLMADHTVFSSESLS
S2668 MADHTVFSSESLSSS
S2669 ADHTVFSSESLSSSL
S2675 SSESLSSSLLFSHKK
K2681 SSLLFSHKKSEKSQR
K2681 SSLLFSHKKSEKSQR
K2692 KSQRVSWKSVGPDFG
K2692 KSQRVSWKSVGPDFG
T2700 SVGPDFGTKKLGLPG
T2700 SVGPDFGTKKLGLPG
T2700 SVGPDFGTKKLGLPG
K2701 VGPDFGTKKLGLPGD
Q2713 PGDEVDNQVKSGTHS
K2737 RFLKDQEKLSLLYAK
K2737 RFLKDQEKLSLLYAK
Y2742 QEKLSLLYAKRGLME
K2744 KLSLLYAKRGLMEQK
K2751 KRGLMEQKLEKDIKS
K2757 QKLEKDIKSELKMKQ
K2763 IKSELKMKQDAQVVL
Q2785 DLPDIQIQHSSLITP
S2788 DIQIQHSSLITPLQA
K2805 QKDPIIAKQLFSSLF
S2813 QLFSSLFSGILKEMH
K2828 KFRTTSEKNIIIQNL
N2834 EKNIIIQNLLQDFNR
K2907 LPKEPPTKRIRGKTC
K2927 LRWMELAKLYRSIGE
S2931 ELAKLYRSIGEYDVL
Y2935 LYRSIGEYDVLHGIF
K2949 FSSELGTKQDTQNAL
N2954 GTKQDTQNALLAEAR
N2969 SDYFQAANLYKEALN
K2977 LYKEALNKLEWLDGE
K3049 YVIRSKLKLLLQGED
E3066 SLLTFVDEAMHKELQ
Q3074 AMHKELQQMVLELQY
K3127 LYRSRLAKLQSVQTL
K3146 EFLNFIRKHGDLSSL
R3157 LSSLGPLRRLLKTWT
V3171 TSRYPDTVTDPMHIW
K3191 NRCFFLSKIEERLTV
R3195 FLSKIEERLTVSPGD
T3197 SKIEERLTVSPGDHS
S3204 TVSPGDHSMSVDEDE
S3213 SVDEDEDSFAREGSE
S3231 DAHHILQSCRFTMKM
R3233 HHILQSCRFTMKMKM
K3237 QSCRFTMKMKMIESS
K3239 CRFTMKMKMIESSWK
K3239 CRFTMKMKMIESSWK
K3246 KMIESSWKQNNFSLS
S3251 SWKQNNFSLSMKLLK
K3255 NNFSLSMKLLKEMHK
K3258 SLSMKLLKEMHKESK
K3258 SLSMKLLKEMHKESK
K3262 KLLKEMHKESKIRES
K3265 KEMHKESKIRESWRM
T3288 LNHCRSHTQSPQEQV
- under review  
K3300 EQVLTMLKTITLLDE
S3308 TITLLDESDISNYLN
S3311 LLDESDISNYLNKNI
K3316 DISNYLNKNIQAFCD
K3353 LSGLEKSKTESIFAL
- under review  
R3370 SNTENTERVISGLYQ
R3370 SNTENTERVISGLYQ
Y3376 ERVISGLYQRAFHHL
K3424 FCDQQLRKVEESASS
K3447 YPALVVEKMLRALKL
R3450 LVVEKMLRALKLNSS
K3453 EKMLRALKLNSSEAR
S3487 IIIKEISSIPCWQFI
G3495 IPCWQFIGWIGHMVA
G3498 WQFIGWIGHMVALLD
T3543 ESYSFQNTSSGHNNK
S3544 SYSFQNTSSGHNNKA
K3550 TSSGHNNKAFVERIK
- under review  
K3596 DTKDELGKNPVNKKN
K3606 VNKKNIEKLYERMYA
R3619 YAALGDFRAPGLGPF
R3619 YAALGDFRAPGLGPF
K3629 GLGPFRRKFIQTFGK
K3636 KFIQTFGKEFVKSFG
K3636 KFIQTFGKEFVKSFG
- under review  
K3640 TFGKEFVKSFGNGGS
D3655 KLLTMKLDEFRNITD
T3661 LDEFRNITDSLFVRM
R3667 ITDSLFVRMRKDSKL
T3689 SPWMSEFTVKSELEI
T3689 SPWMSEFTVKSELEI
K3705 GQYDGKSKPLPEYHV
- under review  
Y3743-p RGHDEKEyPFLVKGG
K3748 KEyPFLVKGGEDLRQ
Y3785 RNMQLRTYRVVPMTS
T3805 EWIENTMTLKDLLLS
- under review  
K3819 SNMSQEEKVAYDSDS
Y3822 SQEEKVAYDSDSKAP
R3834 KAPIYDYRDWLIKVS
K3839 DYRDWLIKVSGRSDV
S3844 LIKVSGRSDVKGYTL
Y3849 GRSDVKGYTLMYSRA
Y3853 VKGYTLMYSRANRTE
S3854 KGYTLMYSRANRTET
- under review  
K3878 KVPADLLKRAFVKMS
T3944 GHAFGSATQFLPIPE
- under review  
K4001 DTMEVFVKEPSFDWK
T4013 DWKGFEQTMLRKGGS
K4017 FEQTMLRKGGSWIQE
S4020 TMLRKGGSWIQEINV
K4030 QEINVTEKNWYPQHK
K4042 QHKIRYAKRKLAGAN
K4044 KIRYAKRKLAGANPA
A4064 ELRLGHEASPAFRSY
- under review  
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