Home

DNA-PK (human)

Overview DNA-PK an atypical protein kinase of the PIKK family. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. and modulation of transcription. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Defects cause severe combined immune deficiency (SCID) which is characterized by a lack of mature functional lymphocytes and a high susceptibility to lethal opportunistic infections. Required for repair of radiation-induced dsDNA breaks. Loss of function in mice or horses leads to the SCID (severe combined immune deficiency) phenotype due to failure of immunoglobulin rearrangement. Target of mutation in mismatch repair-deficient colorectal cancer. Inhibitor: KU-7059. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protein kinase, ATYPICAL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; DNA repair; ATYPICAL group; PIKK family; DNAPK subfamily Cellular Component: nucleoplasm; transcription factor complex; nucleolus; DNA-dependent protein kinase complex Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; enzyme binding; DNA binding; DNA-dependent protein kinase activity; transcription factor binding; ATP binding; protein kinase activity Biological Process: pro-B cell differentiation; somitogenesis; protein destabilization; immunoglobulin V(D)J recombination; positive regulation of apoptosis; apoptosis; B cell lineage commitment; heart development; germ cell programmed cell death; T cell differentiation in the thymus; protein modification process; DNA repair; double-strand break repair via nonhomologous end joining; T cell lineage commitment; peptidyl-serine phosphorylation; cellular response to insulin stimulus; double-strand break repair; response to gamma radiation; T cell receptor V(D)J recombination; positive regulation of transcription from RNA polymerase II promoter; brain development; telomere maintenance Reference #:  P78527 (UniProtKB) Alt. Names/Synonyms: DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNAPK; DNPK1; hyper-radiosensitivity of murine scid mutation, complementing 1; HYRC; HYRC1; p350; p460; PRKDC; protein kinase, DNA-activated, catalytic polypeptide; XRCC7 Gene Symbols: PRKDC Molecular weight: 469,089 Da Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G2/M DNA Damage Checkpoint  |  ErbB/HER Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DNA-PK Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: S2056‑p, T2609‑p, S2612‑p, T2638‑p, T2647‑p chromatin organization, altered: S2056‑p, T2609‑p, S2612‑p, T2638‑p, T2647‑p enzymatic activity, induced: T2609‑p enzymatic activity, inhibited: T3950‑p intracellular localization: T2609‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K99-u	FLEKMGQkIAPYSVE
0	1		K108-u	APYSVEIkNTCTSVY
0	1		K117-a	TCTSVYTkDRAAKCK
0	14		K117-u	TCTSVYTkDRAAKCK
0	1		T137-p	LLIKLLQtFRSSRLM
0	7		K148-u	SRLMDEFkIGELFSk
0	1		K155-u	kIGELFSkFYGELAL
0	2		K163-u	FYGELALkkKIPDTV
0	2		K164-u	YGELALkkKIPDTVL
0	5		K205-u	RAFLGELkTQMTSAV
0	21		K225-u	PVLAGCLkGLSSLLC
0	5		K236-u	SLLCNFTkSMEEDPQ
0	1		K254-a	EIFNFVLkAIRPQID
0	13		K254-u	EIFNFVLkAIRPQID
0	3		K263-a	IRPQIDLkRYAVPSA
0	17		K263-u	IRPQIDLkRYAVPSA
0	2		K310-u	HTNVELKkAALSALE
0	2		K321-u	SALESFLkQVSNMVA
0	1		K329-u	QVSNMVAkNAEMHKN
0	1		K337-u	NAEMHKNkLQYFMEQ
0	5		K357-u	RNVDSNNkELSIAIR
0	1		Y366	LSIAIRGYGLFAGPC
0	1		K374-u	GLFAGPCkVINAkDV
0	1		K379-u	PCkVINAkDVDFMYV
0	1		Y385	AkDVDFMYVELIQRC
0	1		K393-u	VELIQRCkQMFLTQT
0	4		K471-u	VFLALAAkGPVLRNC
0	1		S492-p	QGLIRICskPVVLPK
0	11		K493-u	GLIRICskPVVLPKG
0	1		S503-p	VLPKGPEsEsEDHRA
0	1		S505-p	PKGPEsEsEDHRAsG
0	2		S511-p	EsEDHRAsGEVRtGK
0	1		T516-p	RAsGEVRtGKWKVPT
0	2		K525-u	KWKVPTYkDYVDLFR
0	1		S552-p	LADEAFFsVNSSSES
0	1		K574-u	EFVKSVLkIVEKLDL
0	1		Y647	EFFEPWVYSFSYELI
0	1		Y667-p	LPLISGFyKLLSITV
0	2		K681-u	VRNAKKIkyFEGVsP
0	15		Y682-p	RNAKKIkyFEGVsPk
0	1		S687-p	IkyFEGVsPkSLkHS
0	10		K689-u	yFEGVsPkSLkHSPE
0	1		K692-u	GVsPkSLkHSPEDPE
0	1		K712-u	ALFVKFGkEVAVkMK
0	1		A715	VKFGkEVAVkMKQyK
0	2		K717-a	FGkEVAVkMKQyKDE
0	1		Y721-p	VAVkMKQyKDELLAS
0	2		Y779-p	ALEEWSIyIDRHVMQ
0	6		K801-u	PCLDGYLkTSALSDE
0	31		K810-u	SALSDETkNNWEVSA
0	1		R820-m1	WEVSALSrAAQkGFN
0	1		K824-u	ALSrAAQkGFNkVVL
0	1		K828-a	AAQkGFNkVVLkHLK
0	4		K828-u	AAQkGFNkVVLkHLK
0	1		K832-a	GFNkVVLkHLKKTkN
0	16		K838-u	LkHLKKTkNLssNEA
0	1		S841-p	LKKTkNLssNEAIsL
0	1		S842-p	KKTkNLssNEAIsLE
0	1		S847-p	LssNEAIsLEEIRIR
0	4		K868-u	SLGGQINkNLLTVTS
0	1		K881-u	TSSDEMMksyVAWDR
0	1		S882-p	SSDEMMksyVAWDRE
0	22		Y883-p	SDEMMksyVAWDREK
0	4		S893-p	WDREKRLsFAVPFRE
0	25		K902-u	AVPFREMkPVIFLDV
0	2		K963-u	PPMYQLYkRTFPVLL
0	1		K1038-u	RCIREFLkWSIkQIT
0	1		K1042-u	EFLkWSIkQITPQQQ
0	2		K1051-u	ITPQQQEksPVNTkS
0	1		S1052-p	TPQQQEksPVNTkSL
0	2		K1057-a	EksPVNTkSLFKRLy
0	8		K1057-u	EksPVNTkSLFKRLy
0	1		S1058	ksPVNTkSLFKRLys
0	1		Y1064-p	kSLFKRLysLALHPN
0	1		S1065-p	SLFKRLysLALHPNA
0	2		K1074-a	ALHPNAFkRLGASLA
0	2		K1074-u	ALHPNAFkRLGASLA
0	32		Y1086-p	SLAFNNIyREFREEE
0	1		K1141-u	LCRIIEKkHVSLNkA
0	1		K1147-u	KkHVSLNkAKKRRLP
0	10		K1186-u	PQTECRHkSIELFYk
0	11		K1193-u	kSIELFYkFVPLLPG
0	1		K1209-a	RSPNLWLkDVLKEEG
0	2		K1209-u	RSPNLWLkDVLKEEG
0	5		K1311-u	HDIIAAEkCFGTGAA
0	6		K1334-u	GERYNYSkCTVVVRI
0	1		K1357-u	NTSPEGWkLLKKDLC
0	1		K1407-u	VNLMKALkMSPYkDI
0	2		K1412-u	ALkMSPYkDILETHL
0	15		K1422-u	LETHLREkITAQSIE
0	39		K1456-u	AAVVSACkQLHRAGL
0	1		S1470-p	LLHNILPsQSTDLHH
0	1		T1481-p	DLHHSVGtELLSLVY
0	10		K1489-u	ELLSLVYkGIAPGDE
0	1		S1545-p	LSTASLGssQGSVIH
0	1		S1546-p	STASLGssQGSVIHF
0	2		K1612-u	FRERANQkHQGLKLA
0	1		T1620-p	HQGLKLAttILQHWk
0	1		T1621-p	QGLKLAttILQHWkK
0	2		K1627-u	ttILQHWkKCDSWWA
0	1		K1642-u	KDSPLETkMAVLALL
0	1		T1856-p	DVLKSRFtkLNESTF
0	21		K1857-u	VLKSRFtkLNESTFD
0	33		K1869-u	TFDTQITkkMGYYkI
0	17		K1870-u	FDTQITkkMGYYkIL
0	2		K1875-u	TkkMGYYkILDVMYS
0	1		K1892-u	PKDDVHAkESkINQV
0	8		K1895-u	DVHAkESkINQVFHG
0	19		K1913-u	TEGNELTkTLIkLCY
0	12		K1917-u	ELTkTLIkLCYDAFT
0	1		K1970-a	QGFLFSEkPEkNLLI
0	2		K1970-u	QGFLFSEkPEkNLLI
0	1		K1973-u	LFSEkPEkNLLIFEN
0	10		K1985-a	FENLIDLkRRYNFPV
0	75		K1985-u	FENLIDLkRRYNFPV
0	8		K2003-u	VPMERKKkYIEIRKE
0	1		S2034-p	SLSYLADsTLSEEMS
0	1		S2051-p	DFSTGVQsYsYSsQD
0	2		S2053-p	STGVQsYsYSsQDPR
16	3		S2056-p	VQsYsYSsQDPRPAT
0	1		S2117-p	PPQGEEDsVPRDLPS
0	1		K2127-u	RDLPSWMkFLHGkLG
0	1		K2132-u	WMkFLHGkLGNPIVP
0	1		K2259-a	PYRLIFEkFSGkDPN
0	3		K2259-u	PYRLIFEkFSGkDPN
0	1		K2263-u	IFEkFSGkDPNSKDN
0	2		Y2329-p	VLGLILRyVMERkNI
0	2		K2334-u	LRyVMERkNILEESL
0	4		K2347-u	SLCELVAkQLkQHQN
0	9		K2350-u	ELVAkQLkQHQNTME
0	3		K2359-a	HQNTMEDkFIVCLNk
0	1		K2366-u	kFIVCLNkVTkSFPP
0	2		K2369-u	VCLNkVTkSFPPLAD
0	2		K2418-u	LYFQLKSkDFVQVMR
0	2		K2433-u	HRDDERQkVCLDIIy
0	3		Y2440-p	kVCLDIIyKMMPkLk
0	1		K2445-a	IIyKMMPkLkPVELR
0	3		K2447-u	yKMMPkLkPVELREL
0	1		S2489	DNYRDPESETDNDSQ
0	16		K2503-u	QEIFKLAkDVLIQGL
0	12		K2549-u	LNSLYSPkIEVHFLS
0	2		S2599-p	DSDWRFRstVLtPMF
0	2		T2600-p	SDWRFRstVLtPMFV
0	33		T2603-p	RFRstVLtPMFVEtQ
16	11		T2609-p	LtPMFVEtQAsQGtL
3	42		S2612-p	MFVEtQAsQGtLQtR
0	5		T2615-p	EtQAsQGtLQtRtQE
0	3		T2618-p	AsQGtLQtRtQEGsL
1	10		T2620-p	QGtLQtRtQEGsLSA
1	1		S2624-p	QtRtQEGsLSARWPV
4	14		T2638-p	VAGQIRAtQQQHDFt
0	10		T2645-p	tQQQHDFtLtQTADG
8	14		T2647-p	QQHDFtLtQTADGRS
0	1		S2655-p	QTADGRSsFDWLTGS
0	1		S2672-p	DPLVDHTsPsSDSLL
0	1		S2674-p	LVDHTsPsSDSLLFA
0	9		K2683-a	DSLLFAHkRSERLQR
0	3		K2683-u	DSLLFAHkRSERLQR
0	2		K2694-u	RLQRAPLkSVGPDFG
0	2		K2702-a	SVGPDFGkkRLGLPG
0	1		K2702-m1	SVGPDFGkkRLGLPG
0	1		K2702-u	SVGPDFGkkRLGLPG
0	1		K2703-u	VGPDFGkkRLGLPGD
0	4		K2715-u	PGDEVDNkVKGAAGR
0	1		K2738-u	RFMRDQEkLSLMyAR
0	1		Y2743-p	QEkLSLMyARKGVAE
0	1		R2745	kLSLMyARKGVAEQk
0	1		K2752-u	RKGVAEQkREKEIkS
0	1		K2758-u	QkREKEIkSELKMkQ
0	6		K2764-u	IkSELKMkQDAQVVL
0	4		K2786-u	DLPDIQIkHSSLITP
0	8		K2806-u	QRDPIIAkQLFSSLF
0	1		S2814-p	QLFSSLFsGILKEMD
0	34		K2829-u	KFKTLSEkNNITQkL
0	12		K2835-u	EkNNITQkLLQDFNR
0	20		K2908-u	LPAELPAkRVRGKAR
0	21		K2928-u	LRWVELAkLYRSIGE
0	7		Y2936-p	LYRSIGEyDVLRGIF
0	42		K2950-u	FTSEIGTkQITQSAL
0	1		K2970-u	SDYSEAAkQYDEALN
0	1		K2978-u	QYDEALNkQDWVDGE
0	11		K3050-u	YMIRSKLkLLLQGEA
0	2		K3067-u	SLLTFIDkAMHGELQ
0	3		K3075-u	AMHGELQkAILELHY
0	2		K3128-u	LHQSRLTkLQSVQAL
0	1		K3147-u	EFISFISkQGNLSSQ
0	29		K3158-u	LSSQVPLkRLLNTWT
0	1		K3172-u	TNRYPDAkMDPMNIW
0	12		K3192-u	NRCFFLSkIEEkLTP
0	1		K3196-u	FLSkIEEkLTPLPED
1	13		S3205-p	TPLPEDNsMNVDQDG
0	1		S3215-p	VDQDGDPsDRMEVQE
0	1		S3233-p	DISSLIRsCkFSMkM
0	1		K3235-u	SSLIRsCkFSMkMkM
0	2		K3239-a	RsCkFSMkMkMIDSA
0	1		K3241-a	CkFSMkMkMIDSARk
0	1		K3241-u	CkFSMkMkMIDSARk
0	15		K3248-u	kMIDSARkQNNFSLA
0	1		K3257-u	NNFSLAMkLLkELHk
0	1		K3260-a	SLAMkLLkELHkESk
0	11		K3260-u	SLAMkLLkELHkESk
0	1		K3264-u	kLLkELHkESkTRDD
0	1		K3267-a	kELHkESkTRDDWLV
0	3		S3290-p	LSHCRSRsQGCSEQV
0	4		K3302-u	EQVLTVLkTVSLLDE
0	1		N3310	TVSLLDENNVSSYLS
0	1		S3313	LLDENNVSSYLSkNI
0	40		K3318-u	NVSSYLSkNILAFRD
0	18		K3355-u	LAEIEEDkARRILEL
0	1		K3372-m1	SSSEDSEkVIAGLyQ
0	32		K3372-u	SSSEDSEkVIAGLyQ
0	2		Y3378-p	EkVIAGLyQRAFQHL
0	1		K3426-u	FCDQQLRkEEENASV
0	3		K3449-u	YPALVVEkMLkALkL
0	1		K3452-u	LVVEkMLkALkLNSN
0	8		K3455-u	EkMLkALkLNSNEAR
0	1		S3489-p	LMTKEISsVPCWQFI
0	1		S3497-p	VPCWQFIsWIsHMVA
0	1		S3500-p	WQFIsWIsHMVALLD
0	1		T3545	ESYSFKDTSTGHKNk
0	1		S3546	SYSFKDTSTGHKNkE
0	12		K3552-u	TSTGHKNkEFVARIK
0	13		K3598-u	DVRAELAkTPVNKKN
0	1		K3608-a	VNKKNIEkMYERMYA
0	1		K3621-a	YAALGDPkAPGLGAF
0	12		K3621-u	YAALGDPkAPGLGAF
0	3		K3631-u	GLGAFRRkFIQTFGk
0	1		K3638-a	kFIQTFGkEFDkHFG
0	1		K3638-u	kFIQTFGkEFDkHFG
0	1		K3642-a	TFGkEFDkHFGKGGS
0	1		S3657-p	KLLRMKLsDFNDItN
0	1		T3663-p	LsDFNDItNMLLLkM
0	10		K3669-u	ItNMLLLkMNKDSKP
0	7		K3691-a	SPWMSDFkVEFLRNE
0	6		K3691-u	SPWMSDFkVEFLRNE
0	15		K3710-u	GQYDGRGkPLPEYHV
0	1		H3748	RGHDEREHPFLVkGG
0	3		K3753-u	REHPFLVkGGEDLRQ
0	1		Y3791-p	RALQLRTySVVPMTS
0	1		T3811-p	EWLENTVtLKDLLLN
0	10		K3825-u	NTMSQEEkAAyLSDP
0	1		Y3828-p	SQEEkAAyLSDPRAP
0	1		K3840-u	RAPPCEYkDWLTkMS
0	2		K3845-u	EYkDWLTkMSGKHDV
0	1		H3850	LTkMSGKHDVGAyML
0	1		Y3855-p	GKHDVGAyMLMykGA
0	1		Y3859-p	VGAyMLMykGANRTE
0	5		K3860-u	GAyMLMykGANRTET
0	5		K3884-u	KVPADLLkRAFVRMS
1	1		T3950-p	GHAFGSAtQFLPVPE
0	12		K4007-u	NTMDVFVkEPSFDWK
0	4		K4019-u	DWKNFEQkMLKkGGs
0	4		K4023-u	FEQkMLKkGGsWIQE
0	8		S4026-p	kMLKkGGsWIQEINV
0	2		K4036-u	QEINVAEkNWYPRQK
0	4		K4048-a	RQKICYAkRkLAGAN
0	2		K4050-u	KICYAkRkLAGANPA
0	6		K4070-u	ELLLGHEkAPAFRDY

	mouse
K99	FLEKIDQKVMHYSLD
K108	MHYSLDIKNTCTSVY
K117	TCTSVYTKDRTAKCK
K117	TCTSVYTKDRTAKCK
I137	LLIKLLQILRSTRLM
K148	TRLMDEFKIGELFNK
K155	KIGELFNKFYGELAS
K163	FYGELASKSKLPDTV
S164	YGELASKSKLPDTVL
K205	RAFLGELKTQMTSTV
K225	PVLAGCLKGLSSLLC
K236	SLLCNFTKSMEEDPQ
K254	EIFGFTFKAIRPQIE
K254	EIFGFTFKAIRPQIE
K263	IRPQIEMKRYAVPLA
K263	IRPQIEMKRYAVPLA
K310	HTNVELKKAAHSALE
R321	SALESFLRQISFTVA
E329	QISFTVAEDAELHKS
R337	DAELHKSRLKYFMEQ
K357	RNTDSNNKELAIAIR
Y366-p	LAIAIRGyGLFAGPC
K374	GLFAGPCKVINAKDV
K379	PCKVINAKDVDFMyV
Y385-p	AKDVDFMyVELIQRC
K393	VELIQRCKQMFLTHA
K471	LFLALSEKGPVHWNC
S492	QGLIRICSKPVVLQK
K493	GLIRICSKPVVLQKD
S503	VLQKDVESRSDNRSA
S505	QKDVESRSDNRSASE
S511	RSDNRSASEEVRTGR
T516	SASEEVRTGRWKVPT
K525	RWKVPTYKDYVDLFQ
F552	LGDETFLFVNSSLKS
K574	EFIRSVLKIVEKLDL
Y646-p	GFFEPWVySFAYELI
Y666	LPLISGFYKLLSIAV
K680	VKNARKIKYFEGISP
Y681	KNARKIKYFEGISPK
S686	IKYFEGISPKSLKHS
K688	YFEGISPKSLKHSPE
K691	GISPKSLKHSPEDTE
K711	ALFAKFGKEVsVKMK
S714-p	AKFGKEVsVKMKQYK
K716	FGKEVsVKMKQYKDE
Y720	VsVKMKQYKDELLAS
H778	ALKEWSVHIDKSILQ
N800	PCLDGYLNTSTLSDE
K809	STLSDETKSHWGLSA
R819	WGLSALSRAAQKGFN
K823	ALSRAAQKGFNRHVV
R827	AAQKGFNRHVVKHLK
R827	AAQKGFNRHVVKHLK
K831	GFNRHVVKHLKRTRN
R837	VKHLKRTRNSSPDEA
S840	LKRTRNSSPDEALSL
P841	KRTRNSSPDEALSLE
S846	SSPDEALSLEEIRIK
K867	SLGGQINKSLVTATS
K879	ATSGERMKKyVAWDA
K880	TSGERMKKyVAWDAE
Y881-p	SGERMKKyVAWDAER
S891-p	WDAERRLsFAVPFRE
K900	AVPFREMKPVIYLDV
K960	PPMYQLYKHTFPVLL
K1035	RCVQEFLKWSIKQTT
K1039	EFLKWSIKQTTPQQQ
K1048	TTPQQQEKSPVNSKs
S1049	TPQQQEKSPVNSKsL
K1054	EKSPVNSKsLFKRLY
K1054	EKSPVNSKsLFKRLY
S1055-p	KSPVNSKsLFKRLYS
Y1061	KsLFKRLYSLALHPN
S1062	sLFKRLYSLALHPNA
K1071	ALHPNAFKRLGAALA
K1071	ALHPNAFKRLGAALA
Y1083	ALAFNHIYKEFREEG
K1138	LRRIIEKKHVSLNKA
K1144	KKHVSLNKAKKRRLP
K1183	PQTECRHKSMELFYK
K1190	KSMELFYKFVPLLPG
K1206	KSPSLWLKDLIKKKG
K1206	KSPSLWLKDLIKKKG
Q1310	HSARAVEQRFGSGAP
K1332	EEKYNYSKCTVLVRI
K1355	IASPEDCKLLEKDLC
R1405	VNLLKALRKSPYRDM
R1410	ALRKSPYRDMLETHL
K1420	LETHLKEKVTVQSVE
K1454	LSILSACKQLHKAGF
S1468	FSHVISPSQSTALNH
M1479	ALNHSVGMRLLSLVY
K1487	RLLSLVYKGIVPAEE
S1543	LSTQYLGSSQRNISF
S1544	STQYLGSSQRNISFS
K1609	FRDRAVQKHQGLKLA
T1617	HQGLKLATAILQNWR
A1618	QGLKLATAILQNWRK
R1624	TAILQNWRKCDSWWA
K1639	PDSAPESKTTVLSLL
T1853	DVLKSRFTKLNEFTF
K1854	VLKSRFTKLNEFTFD
K1866	TFDTQITKKMCYYKM
K1867	FDTQITKKMCYYKML
K1872	TKKMCYYKMLAVMYS
K1889	LKDDVHSKEAKINQA
K1892	DVHSKEAKINQAFHG
K1910	AEGNELTKTLLKLCH
K1914	ELTKTLLKLCHDAFT
K1967	QGFLFNEKPEKNLFI
K1967	QGFLFNEKPEKNLFI
K1970	LFNEKPEKNLFIFEN
K1982	FENLIDLKRCYTFPI
K1982	FENLIDLKRCYTFPI
K2000	VPMERKKKYIEIRKE
S2031	SLSYLTDSSLSEEMS
S2048	DFSTGVQSYSYSSQD
S2050	STGVQSYSYSSQDRK
S2053	VQSYSYSSQDRKPTT
S2114	APKGEEGSIPKDLPP
K2124	KDLPPWMKFLHDKLG
K2129	WMKFLHDKLGNASVS
K2255	PYRLIFEKFSHKDPN
K2255	PYRLIFEKFSHKDPN
K2259	IFEKFSHKDPNSKDN
Y2325	VLGLILQYITERKHV
K2330	LQYITERKHVIAELV
K2343	LVCELVIKQLKQHQN
K2346	ELVIKQLKQHQNTME
K2355	HQNTMEDKFIVCLNK
K2362	KFIVCLNKIAKGFPP
K2365	VCLNKIAKGFPPLAD
K2414	LYLQLKSKDFLQVMR
K2429	HRDDERQKVCLDIVY
Y2436	KVCLDIVYKMVAKLK
K2441	IVYKMVAKLKPIELR
K2443	YKMVAKLKPIELREL
S2485-p	DNYRDQEsQNDEDSQ
K2499	QEIFKLAKDVLIQGL
K2545-u	LNSLYSPkIEVHFLS
S2595	DPDWRFRSTVLTPMF
T2596	PDWRFRSTVLTPMFI
T2599	RFRSTVLTPMFIETQ
T2605	LTPMFIETQASPSIL
S2608	MFIETQASPSILHTQ
I2611	ETQASPSILHTQTQE
T2614	ASPSILHTQTQEGPL
T2616	PSILHTQTQEGPLSD
P2620	HTQTQEGPLSDQRQK
T2634	KPGQVRATQQQYDFT
T2641	TQQQYDFTPTQASVE
T2643	QQYDFTPTQASVERS
S2651	QASVERSSFDWLTGS
V2668	DLLADHTVFSSETLS
S2670	LADHTVFSSETLSSS
K2683-a	SSLLFSHkRTEKSQR
K2683	SSLLFSHKRTEKSQR
K2694	KSQRMSCKSVGPDFG
T2702	SVGPDFGTKKLGLPD
T2702	SVGPDFGTKKLGLPD
T2702	SVGPDFGTKKLGLPD
K2703	VGPDFGTKKLGLPDD
Q2715	PDDEVDNQVKSGTPS
K2739	RFLKDREKLSLLYAk
Y2744	REKLSLLYAkRGLME
K2746-u	KLSLLYAkRGLMEQK
K2753	kRGLMEQKLEKDIKS
K2759	QKLEKDIKSEFKMKQ
K2765	IKSEFKMKQDAQVVL
Q2787	DLPDIQIQHSGLITP
K2807	QKDPIIAKQLFSSLF
S2815	QLFSSLFSGILKEMN
K2830	KFKTTSEKNIITQNL
N2836	EKNIITQNLLQDFNR
K2909	MPKEPPTKRVRGKTC
K2929	LRWMELAKLYRSIGE
Y2937	LYRSIGEYDVLRGIF
T2951	FSSELGTTQDTQNAL
K2971	SDYCQAAKLYDEALN
K2979	LYDEALNKLEWVDGE
K3051	YVIRSKLKLLLQGEG
E3068	SLLTFVDEAMNKELQ
K3076	AMNKELQKTVLELQY
K3129	LYRSRLAKLQSVQTL
K3148	EFLSFICKHGDLSSL
R3159	LSSLGPLRRLLKTWT
V3173	TSRYPDVVTDPMHIW
K3193	NRCFFLSKIEERLTA
R3197	FLSKIEERLTAPSGD
S3206	TAPSGDHSMSVDEDE
S3215	SVDEDEESIDREVYE
S3233	DVRCMLQSCRFTMKM
R3235	RCMLQSCRFTMKMKM
K3239	QSCRFTMKMKMIESA
K3241	CRFTMKMKMIESAWK
K3241	CRFTMKMKMIESAWK
K3248	KMIESAWKQSNFSLS
K3257	SNFSLSMKLLKEMHK
K3260	SLSMKLLKEMHKESK
K3260	SLSMKLLKEMHKESK
K3264	KLLKEMHKESKTREI
K3267	KEMHKESKTREIWRV
T3290	LNHCRSHTQSPREQV
K3302	EQVLNMLKTITLLDE
S3310-p	TITLLDEsDIsNYLN
S3313-p	LLDEsDIsNYLNKNI
K3318	DIsNYLNKNIQASCD
K3355	LSDLEENKVNSILTL
T3372	SNAENTETVITGLYQ
T3372	SNAENTETVITGLYQ
Y3378	ETVITGLYQRAFHHL
K3426	FCDQQLRKVEESASQ
K3449	YPALVVEKMLRALKL
R3452	LVVEKMLRALKLNSS
K3455	EKMLRALKLNSSEAR
S3489	IMTKEISSIPCWQFI
G3497	IPCWQFIGWISHMMA
S3500	WQFIGWISHMMALLD
T3545-p	ESYSFKNtsSGHNNK
S3546-p	SYSFKNtsSGHNNKA
K3552	tsSGHNNKAFVERIK
K3598	DTKDELGKNPVNKKN
K3608	VNKKNIEKLYERMYA
R3621	YAALGDLRAPGLGPF
R3621	YAALGDLRAPGLGPF
R3631	GLGPFRRRFIQAFGK
K3638	RFIQAFGKEFVKSFG
K3638	RFIQAFGKEFVKSFG
K3642	AFGKEFVKSFGNGGS
D3657	KLLTMKVDDFCKITG
T3663	VDDFCKITGSLLVRM
R3669	ITGSLLVRMKKDSKL
K3691	SPWMSEFKAQFLKNE
K3691	SPWMSEFKAQFLKNE
K3710	GQYDGKSKPLPEYHV
Y3748	RGHDEKEYPFLVKGG
K3753	KEYPFLVKGGEDLRQ
Y3791	RNMQLRTYRVVPMTS
T3811	EWIENTMTLKDLLLS
K3825	SNMSQEEKVANNSDP
N3828	SQEEKVANNSDPKAP
K3840	KAPIRDYKDWLMKVS
K3845	DYKDWLMKVSGKsDA
S3850-p	LMKVSGKsDAGAYVL
Y3855	GKsDAGAYVLMYSRA
Y3859	AGAYVLMYSRANRTE
S3860	GAYVLMYSRANRTET
K3884	QVPPDLLKRAFVKMS
T3950	GHAFGSATQFLPVPE
K4007	DTMEIFVKEPSFDWK
T4019	DWKSFEQTMLRKGGS
K4023	FEQTMLRKGGSWIQE
S4026	TMLRKGGSWIQEINV
K4036	QEINVTEKNWYPQHK
K4048	QHKIRYAKRKLAGAN
K4050	KIRYAKRKLAGANPA
A4070	ELYLGHEASSAFRSY

	rat
K99	FLEKIDQKVLHYSFD
K108	LHYSFDIKNTCISVY
K117	TCISVYTKDRTAKCK
K117	TCISVYTKDRTAKCK
I137	LLIKLLKILRSSRVM
K148	SRVMDEFKIGELFNK
K155	KIGELFNKFYGELVS
K163	FYGELVSKSKLPDTV
S164	YGELVSKSKLPDTVL
K205	RAFLGELKTQMTSTV
K225	PVLAGCLKGLSSLLC
K236	SLLCNFTKSMEEDPQ
K254	EIFGFTLKAIRPQIE
K254	EIFGFTLKAIRPQIE
K263	IRPQIEMKRYAVPLA
K263	IRPQIEMKRYAVPLA
K310	HTNVELKKAAHSALE
K321	SALESFLKQISFTVA
E329	QISFTVAEDAELHKS
K337	DAELHKSKLKYFMEQ
K357	RNADSNNKDLAIAIR
Y366	LAIAIRGYGLFAGPC
K374	GLFAGPCKVINAKDV
K379	PCKVINAKDVDFMYV
Y385	AKDVDFMYVELIQRC
K393	VELIQRCKQMFLTQT
K471	VFLSLTEKGPVHWNC
S492	QGLIRICSKPVVLQK
K493	GLIRICSKPVVLQKD
S503	VLQKDVESRSENRWA
S505	QKDVESRSENRWASE
S511	RSENRWASEEVRMGR
M516	WASEEVRMGRWKVPT
K525	RWKVPTYKDYVDLFQ
F552	LGDETFLFVNSSLKS
K574	EFIRSVLKIVEKLDL
Y646	SFFEPWVYSFAYELI
Y666	LPLISGFYKLLSIAV
K680	VKNARKIKYFEGVSP
Y681	KNARKIKYFEGVSPK
S686	IKYFEGVSPKCLKHS
K688	YFEGVSPKCLKHSPE
K691	GVSPKCLKHSPENTE
K711	ALFAKFGKEVSVKMK
S714	AKFGKEVSVKMKQYK
K716	FGKEVSVKMKQYKDE
Y720	VSVKMKQYKDELLAS
H778	ALKEWSVHIDKSIMQ
N800	PCLDGYLNTSTLSDE
K809	STLSDETKSHWEVSA
R819	WEVSALSRAARKGFN
K823	ALSRAARKGFNRDVV
R827	AARKGFNRDVVKLLK
R827	AARKGFNRDVVKLLK
K831	GFNRDVVKLLKRTRN
R837	VKLLKRTRNVTSDEA
T840	LKRTRNVTSDEALSL
S841	KRTRNVTSDEALSLE
S846	VTSDEALSLEEIRIR
K867	SLGGQINKNLITATS
K879	ATSGERMKKYVAWDR
K880	TSGERMKKYVAWDRE
Y881	SGERMKKYVAWDREK
S891	WDREKRLSFAVPFRE
K900	AVPFREMKPVIYLDV
K960	PPMYQLYKHMFPVLL
K1035	QCVQEFLKWSIKQTT
K1039	EFLKWSIKQTTPQQQ
K1048	TTPQQQEKSPVNSKS
S1049	TPQQQEKSPVNSKSL
K1054	EKSPVNSKSLFKRLY
K1054	EKSPVNSKSLFKRLY
S1055	KSPVNSKSLFKRLYS
Y1061	KSLFKRLYSLALHPN
S1062	SLFKRLYSLALHPNA
K1071	ALHPNAFKRLGAALA
K1071	ALHPNAFKRLGAALA
Y1083	ALAFNHIYKEFREEG
K1138	LRRIIEKKYISLNKA
K1144	KKYISLNKAKKRRLP
K1183	PQTECRHKSIELFYK
K1190	KSIELFYKFVPLLPG
R1206	KSPSLWLRDLIKAEG
R1206	KSPSLWLRDLIKAEG
Q1310	CDARTVEQRFGTGLT
K1332	EEKYNYSKCTVLVRI
K1355	VTFPEDCKLLEKDLC
R1405	VNLLKALRKSPYRDK
R1410	ALRKSPYRDKLETHL
K1420	LETHLKEKVTAQSVE
K1454	LSLLSACKQLHKAGF
S1468	FSHIISASQSTALNH
M1479	ALNHSIGMRLLSLVY
N1487	RLLSLVYNGIAPAQE
S1543	LSTQYLGSSQRNISF
S1544	STQYLGSSQRNISFS
K1609	FRDRAVQKHQGLKLA
T1617	HQGLKLATAILQNWR
A1618	QGLKLATAILQNWRK
R1624	TAILQNWRKCDSWWA
K1639	PDSAPESKTTVLSLL
T1852	DVLKSRFTKLNDTFD
K1853	VLKSRFTKLNDTFDT
K1864	TFDTQITKKMCYYKM
K1865	FDTQITKKMCYYKML
K1870	TKKMCYYKMLAVMYS
K1887	LKDDVHSKESKINQA
K1890	DVHSKESKINQAFQG
K1908	AEGNELTKTLLKLCH
K1912	ELTKTLLKLCHDAFT
K1965	QGFLFSEKPEKNLFI
K1965	QGFLFSEKPEKNLFI
K1968	LFSEKPEKNLFIFEN
K1980	FENLIDLKRCYTFPI
K1980	FENLIDLKRCYTFPI
K1998	VPMERKKKYVEIRKE
S2030	LSYLTESSLSEEMSQ
S2046	DFSTGVQSYSYSSQD
S2048	STGVQSYSYSSQDRK
S2051	VQSYSYSSQDRKPTT
S2112	APKGQEGSISKDLPP
K2122	KDLPPWMKFLHDKLE
K2127	WMKFLHDKLENASVS
K2253	PYRLIFEKFSNKDPN
K2253	PYRLIFEKFSNKDPN
K2257	IFEKFSNKDPNSKDN
H2323	VLGLILQHVTERKHV
K2328	LQHVTERKHVIAESV
K2341	SVYELVVKQLKQHQN
K2344	ELVVKQLKQHQNTME
K2353	HQNTMEDKFIVCLNK
K2360	KFIVCLNKIVKGFPP
K2363	VCLNKIVKGFPPLAD
K2412	LYLQLKSKDFLQVMR
K2427	HRDDERQKVCLDIIY
Y2434	KVCLDIIYKMVAKLK
K2439	IIYKMVAKLKPTELR
K2441	YKMVAKLKPTELREL
S2483	DNYRDPESQMDEDSQ
K2497	QEIFKLAKDVLIQGL
K2543	LNSLYSPKIEVHFLS
S2593	DPDWRFRSTVLTPMF
T2594	PDWRFRSTVLTPMFI
T2597	RFRSTVLTPMFIETQ
T2603	LTPMFIETQAFPSTL
F2606	MFIETQAFPSTLNTQ
T2609	ETQAFPSTLNTQTQE
T2612	AFPSTLNTQTQEGSP
T2614	PSTLNTQTQEGSPSD
S2618	NTQTQEGSPSDRRQK
T2632	KPGQVRATQQQYDFT
T2639	TQQQYDFTPTQTSVE
T2641	QQYDFTPTQTSVERS
S2649	QTSVERSSFDWLTGS
V2666	DLMADHTVFSSESLS
S2668	MADHTVFSSESLSSS
K2681	SSLLFSHKKSEKSQR
K2681	SSLLFSHKKSEKSQR
K2692	KSQRVSWKSVGPDFG
T2700	SVGPDFGTKKLGLPG
T2700	SVGPDFGTKKLGLPG
T2700	SVGPDFGTKKLGLPG
K2701	VGPDFGTKKLGLPGD
Q2713	PGDEVDNQVKSGTHS
K2737	RFLKDQEKLSLLYAK
Y2742	QEKLSLLYAKRGLME
K2744	KLSLLYAKRGLMEQK
K2751	KRGLMEQKLEKDIKS
K2757	QKLEKDIKSELKMKQ
K2763	IKSELKMKQDAQVVL
Q2785	DLPDIQIQHSSLITP
K2805	QKDPIIAKQLFSSLF
S2813	QLFSSLFSGILKEMH
K2828	KFRTTSEKNIIIQNL
N2834	EKNIIIQNLLQDFNR
K2907	LPKEPPTKRIRGKTC
K2927	LRWMELAKLYRSIGE
Y2935	LYRSIGEYDVLHGIF
K2949	FSSELGTKQDTQNAL
N2969	SDYFQAANLYKEALN
K2977	LYKEALNKLEWLDGE
K3049	YVIRSKLKLLLQGED
E3066	SLLTFVDEAMHKELQ
Q3074	AMHKELQQMVLELQY
K3127	LYRSRLAKLQSVQTL
K3146	EFLNFIRKHGDLSSL
R3157	LSSLGPLRRLLKTWT
V3171	TSRYPDTVTDPMHIW
K3191	NRCFFLSKIEERLTV
R3195	FLSKIEERLTVSPGD
S3204	TVSPGDHSMSVDEDE
S3213	SVDEDEDSFAREGSE
S3231	DAHHILQSCRFTMKM
R3233	HHILQSCRFTMKMKM
K3237	QSCRFTMKMKMIESS
K3239	CRFTMKMKMIESSWK
K3239	CRFTMKMKMIESSWK
K3246	KMIESSWKQNNFSLS
K3255	NNFSLSMKLLKEMHK
K3258	SLSMKLLKEMHKESK
K3258	SLSMKLLKEMHKESK
K3262	KLLKEMHKESKIRES
K3265	KEMHKESKIRESWRM
T3288	LNHCRSHTQSPQEQV
K3300	EQVLTMLKTITLLDE
S3308	TITLLDESDISNYLN
S3311	LLDESDISNYLNKNI
K3316	DISNYLNKNIQAFCD
K3353	LSGLEKSKTESIFAL
R3370	SNTENTERVISGLYQ
R3370	SNTENTERVISGLYQ
Y3376	ERVISGLYQRAFHHL
K3424	FCDQQLRKVEESASS
K3447	YPALVVEKMLRALKL
R3450	LVVEKMLRALKLNSS
K3453	EKMLRALKLNSSEAR
S3487	IIIKEISSIPCWQFI
G3495	IPCWQFIGWIGHMVA
G3498	WQFIGWIGHMVALLD
T3543	ESYSFQNTSSGHNNK
S3544	SYSFQNTSSGHNNKA
K3550	TSSGHNNKAFVERIK
K3596	DTKDELGKNPVNKKN
K3606	VNKKNIEKLYERMYA
R3619	YAALGDFRAPGLGPF
R3619	YAALGDFRAPGLGPF
K3629	GLGPFRRKFIQTFGK
K3636	KFIQTFGKEFVKSFG
K3636	KFIQTFGKEFVKSFG
K3640	TFGKEFVKSFGNGGS
D3655	KLLTMKLDEFRNITD
T3661	LDEFRNITDSLFVRM
R3667	ITDSLFVRMRKDSKL
T3689	SPWMSEFTVKSELEI
T3689	SPWMSEFTVKSELEI
K3705	GQYDGKSKPLPEYHV
Y3743-p	RGHDEKEyPFLVKGG
K3748	KEyPFLVKGGEDLRQ
Y3785	RNMQLRTYRVVPMTS
T3805	EWIENTMTLKDLLLS
K3819	SNMSQEEKVAYDSDS
Y3822	SQEEKVAYDSDSKAP
R3834	KAPIYDYRDWLIKVS
K3839	DYRDWLIKVSGRSDV
S3844	LIKVSGRSDVKGYTL
Y3849	GRSDVKGYTLMYSRA
Y3853	VKGYTLMYSRANRTE
S3854	KGYTLMYSRANRTET
K3878	KVPADLLKRAFVKMS
T3944	GHAFGSATQFLPIPE
K4001	DTMEVFVKEPSFDWK
T4013	DWKGFEQTMLRKGGS
K4017	FEQTMLRKGGSWIQE
S4020	TMLRKGGSWIQEINV
K4030	QEINVTEKNWYPQHK
K4042	QHKIRYAKRKLAGAN
K4044	KIRYAKRKLAGANPA
A4064	ELRLGHEASPAFRSY

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.