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Protein Page:
BCHE (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BCHE Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.1.8; Nuclear envelope; Secreted; Secreted, signal peptide; Hydrolase
Cellular Component: extracellular space; membrane; nuclear envelope lumen; endoplasmic reticulum lumen; extracellular region
Molecular Function: identical protein binding; choline binding; enzyme binding; cholinesterase activity; beta-amyloid binding; acetylcholinesterase activity; catalytic activity
Biological Process: response to drug; response to alkaloid; negative regulation of cell proliferation; choline metabolic process; cellular protein metabolic process; cocaine metabolic process; response to folic acid; response to glucocorticoid stimulus; neuroblast differentiation; learning; negative regulation of synaptic transmission; synaptic transmission, cholinergic
Reference #:  P06276 (UniProtKB)
Alt. Names/Synonyms: Acylcholine acylhydrolase; BCHE; Butyrylcholine esterase; butyrylcholinesterase; CHE1; CHLE; Choline esterase II; Cholinesterase; cholinesterase 1; E1; Pseudocholinesterase
Gene Symbols: BCHE
Molecular weight: 68,418 Da
Basal Isoelectric point: 7.12  Predict pI for various phosphorylation states
Select Structure to View Below

BCHE

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K88-ac SDIWNATkYANSCCQ
0 2 Y174-p VIVVSMNyRVGALGF
0 1 T221-p GGNPKSVtLFGEsAG
1 0 S226-p SVtLFGEsAGAASVS
0 1 K436-m1 PALEFTKkFSEWGNN
0 1 K455-m1 YFEHRSSkLPWPEWM
0 1 Y505-p RWANFAKyGNPNETQ
  mouse

 
Q89 PDIHNATQYANSCYQ
Y175 VIVVSMNYRVGALGF
T222 GGNPKSITIFGESAG
S227 SITIFGESAGAASVS
K437 PALEFTKKFAELENN
K456 FFEHRSSKLPWPEWM
Y506 TWANFAKYGHPNGTQ
  rat

 
K83 PDVYNATKYANSCYQ
Y169-p VIVVSMNyRVGALGF
T216 GGNPKSVTLFGESAG
S221 SVTLFGESAGAASVS
K431 PALEFTKKFAELEIN
K450 YFEHRSSKLPWPEWM
Y500 TWANFAKYGHPNGTQ
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