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BCHE
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.1.8; Hydrolase; Nuclear envelope; Secreted; Secreted, signal peptide |
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Cellular Component: extracellular space; membrane; nuclear envelope lumen; endoplasmic reticulum lumen; extracellular region
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Molecular Function: choline binding; enzyme binding; cholinesterase activity; beta-amyloid binding; acetylcholinesterase activity; carboxylesterase activity; catalytic activity
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Biological Process: response to drug; response to alkaloid; cocaine metabolic process; choline metabolic process; response to folic acid; response to glucocorticoid stimulus; learning; negative regulation of synaptic transmission; synaptic transmission, cholinergic
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Reference #:
P06276 (UniProtKB)
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| Alt. Names/Synonyms: Acylcholine acylhydrolase; BCHE; Butyrylcholine esterase; butyrylcholinesterase; CHE1; CHLE; Choline esterase II; Cholinesterase; cholinesterase 1; E1; Pseudocholinesterase |
| Gene Symbols: BCHE |
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Molecular weight: 68,418 Da
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Basal Isoelectric point: 7.12
Predict pI for various phosphorylation states
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