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calmodulin (human)

Overview calmodulin a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity. Note: This description may include information from UniProtKB. Protein type: Calcium-binding protein Reference #:  P62158 (UniProtKB) Alt. Names/Synonyms: CALM; CALM1; CALM2; CALM3; CALML2; Calmodulin; calmodulin 1 (phosphorylase kinase, delta); CAM; CAM1; CAM2; CAM3; CAMB; CAMC; CAMI; CAMIII; DD132; PHKD; phosphorylase kinase, delta subunit Gene Symbols: CALM1 Molecular weight: 16,838 Da Basal Isoelectric point: 4.09  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Regulation of Actin Dynamics  |  T Cell Receptor Signaling

Select Structure to View Below calmodulin 1AJI - A=5-148 (human) 1CDL - A/B/C/D=1-148 (human) 1CLL - A=1-149 (human) 1CTR - A=1-149 (human) 1IWQ - A=1-149 (human) 1J7O - A=1-77 (human) 1J7P - A=83-149 (human) 1K90 - D/E/F=2-149 (human) 1K93 - D/E/F=6-149 (human) 1L7Z - A=1-149 (human) 1LVC - D/E/F=1-149 (human) 1NKF - A=94-105 (human) 1PK0 - D/E/F=1-148 (human) 1S26 - D/E/F=1-149 (human) 1SK6 - D/E/F=2-149 (human) 1SW8 - A=1-80 (human) 1UP5 - A/B=1-148 (human) 1WRZ - A=1-149 (human) 1XFU - O/P/Q/R/S/T=1-149 (human) 1XFV - O/P/Q/R/S/T=1-149 (human) 1XFW - O/P/Q/R/S/T=1-149 (human) 1XFX - O/P/Q/R/S/T=1-149 (human) 1XFY - O/P/Q/R/S/T=1-149 (human) 1XFZ - O/P/Q/R/S/T=1-149 (human) 1Y6W - A=1-149 (human) 1YR5 - A=2-149 (human) 1YRT - B=76-149 (human) 1YRU - B=76-149 (human) 1ZOT - B=71-93 (human) 1ZUZ - A=1-149 (human) 2BE6 - A/B/C=1-149 (human) 2F3Y - A=1-149 (human) 2F3Z - A=1-149 (human) 2HF5 - A=47-114 (human) 2I08 - A=3-78 (human) 2JZI - A=2-149 (human) 2K0E - A=2-149 (human) 2K0F - A=6-153 (human) 2K0J - A=3-149 (human) 2K61 - A=2-149 (human) 2KNE - A=2-149 (human) 2KUG - A=2-77 (human) 2KUH - A=83-149 (human) 2L53 - A=2-149 (human) 2LGF - A=4-149 (human) 2LL6 - A=2-149 (human) 2LL7 - A=2-149 (human) 2LQC - A=2-78 (human) 2LQP - A=79-149 (human) 2LV6 - B=566-591 (human) 2M55 - B=1-19 (human) 2R28 - A/B=1-149 (human) 2V01 - A=1-149 (human) 2V02 - A=1-149 (human) 2VAY - A=3-148 (human) 2W73 - F/A/E/B=0-148 (human) 2WEL - D=1-149 (human) 2X0G - B=2-149 (human) 2Y4V - A=1-149 (human) 3BYA - A=2-149 (human) 3DVE - A=2-149 (human) 3DVJ - A=2-149 (human) 3DVK - A=2-149 (human) 3DVM - A=2-149 (human) 3EWT - A=2-149 (human) 3EWV - A=2-149 (human) 3G43 - A/D/C/B=2-149 (human) 3HR4 - H/F/D/B=1-149 (human) 3O77 - A=3-149 (human) 3O78 - A/B=3-149 (human) 3OXQ - A/D/C/B=1-149 (human) 3SUI - B=767-801 (human) 3UCT - A/B=2-80 (human) 3UCW - A/D/C/B=2-80 (human) 3UCY - A=2-80 (human) 4DCK - B=1-149 (human) 4DJC - A=1-149 (human) 4GOW - A=522-593 (human) 2DFS - B/C/D/E/F/G/N/O/P/Q/R/S=1-149 (mouse) 2IX7 - A/B=3-147 (mouse) 4E50 - A=1-149 (mouse) 4E53 - A/B=34-57 (mouse) 4HEX - A/B=1-149 (mouse) 1G4Y - R=1-149 (rat) 1NIW - A/C/E/G=1-149 (rat) 1QX5 - B/D/I/J/K/R/T/Y=1-149 (rat) 1QX7 - A/B/I/M/R=1-149 (rat) 2HQW - A=2-149 (rat) 2PQ3 - A=2-77 (rat) 2YGG - B=1-149 (rat) 3B32 - A=2-76 (rat) 3BXK - A/C=2-149 (rat) 3BXL - A=2-149 (rat) 3CLN - A=2-149 (rat) 3EK4 - A=3-149 (rat) 3EK7 - A=3-149 (rat) 3EK8 - A=3-149 (rat) 3EKH - A=3-149 (rat) 3EKJ - A=3-149 (rat) 3EVR - A=3-148 (rat) 3EVU - A=3-148 (rat) 3EVV - A=3-148 (rat) 3IFK - A/B=2-91 (rat) 3SG2 - A=3-149 (rat) 3SG3 - A=3-149 (rat) 3SG4 - A=3-149 (rat) 3SG5 - A=3-149 (rat) 3SG6 - A=3-149 (rat) 3SG7 - A=3-149 (rat) 3SJQ - A/B=1-149 (rat) 4EHQ - G=69-88 (rat) 4G27 - R=1-149 (rat) 4G28 - R=1-149 (rat) 4J9Y - R=1-149 (rat) 4J9Z - R=1-149 (rat) 1AHR - A=1-148 (chicken) 2KZ2 - A=77-149 (chicken) 1A29 - A=1-149 (cow) 1AK8 - A=1-76 (cow) 1CDM - A=5-148 (cow) 1CM1 - A=2-149 (cow) 1CM4 - A/C/E/G=2-149 (cow) 1CMF - A=77-149 (cow) 1CMG - A=77-149 (cow) 1DEG - A=6-148 (cow) 1FW4 - A=79-149 (cow) 1LIN - A=1-149 (cow) 1PRW - A=1-149 (cow) 1QIV - A=1-149 (cow) 1QIW - A/B=1-149 (cow) 1XA5 - A=1-149 (cow) 2CLN - A=1-149 (cow) 2F2O - A/B=0-148 (cow) 2F2P - A/B=0-148 (cow) 2FOT - A=2-149 (cow) 3IF7 - A=2-149 (cow)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1UP5 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M55 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4DCK 4DJC 4GOW  |  Phospho3D  |  DISEASE 114180 114182 114183  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Sites Implicated In
protein conformation: S82‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	18		K14-a	EEQIAEFkEAFsLFD
0	1		S18-p	AEFkEAFsLFDkDGD
0	3		K22-a	EAFsLFDkDGDGTIT
0	18		K22-u	EAFsLFDkDGDGTIT
0	78		K31-u	GDGTITTkELGTVMR
1	0		T45	RSLGQNPTEAELQDM
1	0		K76-a	FLTMMARkMkDtDsE
0	4		K76-u	FLTMMARkMkDtDsE
0	8		K78-u	TMMARkMkDtDsEEE
5	2		T80-p	MARkMkDtDsEEEIR
4	4		S82-p	RkMkDtDsEEEIREA
0	5		K95-a	EAFRVFDkDGNGyIs
0	36		K95-u	EAFRVFDkDGNGyIs
3	2135		Y100-p	FDkDGNGyIsAAELR
3	48		S102-p	kDGNGyIsAAELRHV
1	5		K116-a	VMTNLGEkLtDEEVD
9	7		K116-m3	VMTNLGEkLtDEEVD
2	0		T118-p	TNLGEkLtDEEVDEM
3	24		Y139-p	DGDGQVNyEEFVQMM
1	0		K149-a	FVQMMTAk_______
0	6		K149-u	FVQMMTAk_______

	mouse
K14-a	EEQIAEFkEAFsLFD
S18-p	AEFkEAFsLFDkDGD
K22-a	EAFsLFDkDGDGTIT
K22-u	EAFsLFDkDGDGTIT
K31-u	GDGTITTkELGTVMR
T45	RSLGQNPTEAELQDM
K76	FLTMMARKMkDtDsE
K76-u	FLTMMARkMkDtDsE
K78-u	TMMARkMkDtDsEEE
T80-p	MARkMkDtDsEEEIR
S82-p	RkMkDtDsEEEIREA
K95-a	EAFRVFDkDGNGyIs
K95-u	EAFRVFDkDGNGyIs
Y100-p	FDkDGNGyIsAAELR
S102-p	kDGNGyIsAAELRHV
K116-a	VMTNLGEkLTDEEVD
K116	VMTNLGEKLTDEEVD
T118	TNLGEkLTDEEVDEM
Y139	DGDGQVNYEEFVQMM
K149	FVQMMTAK_______
K149	FVQMMTAK_______

	rat
K14	EEQIAEFKEAFSLFD
S18	AEFKEAFSLFDKDGD
K22	EAFSLFDKDGDGTIT
K22	EAFSLFDKDGDGTIT
K31	GDGTITTKELGTVMR
T45-p	RSLGQNPtEAELQDM
K76	FLTMMARKMKDtDsE
K76	FLTMMARKMKDtDsE
K78	TMMARKMKDtDsEEE
T80-p	MARKMKDtDsEEEIR
S82-p	RKMKDtDsEEEIREA
K95-a	EAFRVFDkDGNGyIs
K95-u	EAFRVFDkDGNGyIs
Y100-p	FDkDGNGyIsAAELR
S102-p	kDGNGyIsAAELRHV
K116	VMTNLGEKLtDEEVD
K116-m3	VMTNLGEkLtDEEVD
T118-p	TNLGEkLtDEEVDEM
Y139-p	DGDGQVNyEEFVQMM
K149	FVQMMTAK_______
K149	FVQMMTAK_______

	chicken
K14	EEQIAEFKEAFSLFD
S18	AEFKEAFSLFDKDGD
K22	EAFSLFDKDGDGTIT
K22	EAFSLFDKDGDGTIT
K31	GDGTITTKELGTVMR
T45	RSLGQNPTEAELQDM
K76	FLTMMARKMKDTDSE
K76	FLTMMARKMKDTDSE
K78	TMMARKMKDTDSEEE
T80	MARKMKDTDSEEEIR
S82	RKMKDTDSEEEIREA
K95	EAFRVFDKDGNGyIS
K95	EAFRVFDKDGNGyIS
Y100-p	FDKDGNGyISAAELR
S102	KDGNGyISAAELRHV
K116	VMTNLGEKLTDEEVD
K116-m3	VMTNLGEkLTDEEVD
T118	TNLGEkLTDEEVDEM
Y139-p	DGDGQVNyEEFVQMM
K149	FVQMMTAK_______
K149	FVQMMTAK_______

	sheep
K14	EEQIAEFKEAFSLFD
S18	AEFKEAFSLFDKDGD
K22	EAFSLFDKDGDGTIT
K22	EAFSLFDKDGDGTIT
K31	GDGTITTKELGTVMR
T45	RSLGQNPTEAELQDM
K76	FLTMMARKMKDTDSE
K76	FLTMMARKMKDTDSE
K78	TMMARKMKDTDSEEE
T80	MARKMKDTDSEEEIR
S82	RKMKDTDSEEEIREA
K95	EAFRVFDKDGNGYIS
K95	EAFRVFDKDGNGYIS
Y100	FDKDGNGYISAAELR
S102	KDGNGYISAAELRHV
K116	VMTNLGEKLTDEEVD
K116-m3	VMTNLGEkLTDEEVD
T118	TNLGEkLTDEEVDEM
Y139	DGDGQVNYEEFVQMM
K149	FVQMMTAK_______
K149	FVQMMTAK_______

	cow
K14	EEQIAEFKEAFSLFD
S18	AEFKEAFSLFDKDGD
K22	EAFSLFDKDGDGTIT
K22	EAFSLFDKDGDGTIT
K31	GDGTITTKELGTVMR
T45	RSLGQNPTEAELQDM
K76	FLTMMARKMKDTDSE
K76	FLTMMARKMKDTDSE
K78	TMMARKMKDTDSEEE
T80	MARKMKDTDSEEEIR
S82	RKMKDTDSEEEIREA
K95	EAFRVFDKDGNGYIS
K95	EAFRVFDKDGNGYIS
Y100	FDKDGNGYISAAELR
S102	KDGNGYISAAELRHV
K116	VMTNLGEKLTDEEVD
K116-m3	VMTNLGEkLTDEEVD
T118	TNLGEkLTDEEVDEM
Y139	DGDGQVNYEEFVQMM
K149	FVQMMTAK_______
K149	FVQMMTAK_______

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