Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Calmodulin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Calmodulin a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding protein
Reference #:  P62158 (UniProtKB)
Alt. Names/Synonyms: CALM; CALM1; CALM2; CALM3; CALML2; Calmodulin; calmodulin 1 (phosphorylase kinase, delta); calmodulin 2 (phosphorylase kinase, delta); calmodulin 3 (phosphorylase kinase, delta); CAM; CAM1; CAM2; CAM3; CAMB; CAMC; CAMI; CAMIII; DD132; PHKD; phosphorylase kinase, delta subunit
Gene Symbols: CALM1, CALM2, CALM3
Molecular weight: 16,838 Da
Basal Isoelectric point: 4.09  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  T Cell Receptor Signaling
Select Structure to View Below

Calmodulin

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein


Sites Implicated In
protein conformation: S82‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 18 K14-ac EEQIAEFkEAFsLFD
0 1 K14-ub EEQIAEFkEAFsLFD
0 3 S18-p AEFkEAFsLFDkDGD
0 4 K22-ac EAFsLFDkDGDGTIt
0 18 K22-ub EAFsLFDkDGDGTIt
0 1 K22-sc EAFsLFDkDGDGTIt
0 1 T29-p kDGDGTIttkELGTV
0 1 T30-p DGDGTIttkELGTVM
0 78 K31-ub GDGTIttkELGTVMR
1 0 T45 RSLGQNPTEAELQDM
1 0 K76-ac FLTMMARkMkDtDsE
0 4 K76-ub FLTMMARkMkDtDsE
0 2 K78-ac TMMARkMkDtDsEEE
0 8 K78-ub TMMARkMkDtDsEEE
0 1 K78-sc TMMARkMkDtDsEEE
7 2 T80-p MARkMkDtDsEEEIR
6 5 S82-p RkMkDtDsEEEIREA
0 6 K95-ac EAFRVFDkDGNGyIs
0 36 K95-ub EAFRVFDkDGNGyIs
0 1 K95-sc EAFRVFDkDGNGyIs
3 2073 Y100-p FDkDGNGyIsAAELR
5 49 S102-p kDGNGyIsAAELRHV
0 5 K116-ac VMTNLGEkLtDEEVD
0 1 K116-m1 VMTNLGEkLtDEEVD
0 1 K116-m2 VMTNLGEkLtDEEVD
9 8 K116-m3 VMTNLGEkLtDEEVD
3 0 T118-p TNLGEkLtDEEVDEM
3 20 Y139-p DGDGQVNyEEFVQMM
1 0 K149-ac FVQMMTAk_______
0 6 K149-ub FVQMMTAk_______
  mouse

 
K14-ac EEQIAEFkEAFsLFD
K14 EEQIAEFKEAFsLFD
S18-p AEFkEAFsLFDkDGD
K22-ac EAFsLFDkDGDGTIT
K22-ub EAFsLFDkDGDGTIT
K22-sc EAFsLFDkDGDGTIT
T29 kDGDGTITTkELGTV
T30 DGDGTITTkELGTVM
K31-ub GDGTITTkELGTVMR
T45 RSLGQNPTEAELQDM
K76 FLTMMARKMkDtDsE
K76-ub FLTMMARkMkDtDsE
K78-ac TMMARkMkDtDsEEE
K78-ub TMMARkMkDtDsEEE
K78 TMMARkMKDtDsEEE
T80-p MARkMkDtDsEEEIR
S82-p RkMkDtDsEEEIREA
K95-ac EAFRVFDkDGNGyIs
K95-ub EAFRVFDkDGNGyIs
K95 EAFRVFDKDGNGyIs
Y100-p FDkDGNGyIsAAELR
S102-p kDGNGyIsAAELRHV
K116-ac VMTNLGEkLTDEEVD
K116 VMTNLGEKLTDEEVD
K116 VMTNLGEKLTDEEVD
K116 VMTNLGEKLTDEEVD
T118 TNLGEkLTDEEVDEM
Y139 DGDGQVNYEEFVQMM
K149 FVQMMTAK_______
K149 FVQMMTAK_______
  rat

 
K14 EEQIAEFKEAFSLFD
K14 EEQIAEFKEAFSLFD
S18 AEFKEAFSLFDKDGD
K22 EAFSLFDKDGDGTIT
K22 EAFSLFDKDGDGTIT
K22 EAFSLFDKDGDGTIT
T29 KDGDGTITTKELGTV
T30 DGDGTITTKELGTVM
K31 GDGTITTKELGTVMR
T45-p RSLGQNPtEAELQDM
K76 FLTMMARKMKDtDsE
K76 FLTMMARKMKDtDsE
K78 TMMARKMKDtDsEEE
K78 TMMARKMKDtDsEEE
K78 TMMARKMKDtDsEEE
T80-p MARKMKDtDsEEEIR
S82-p RKMKDtDsEEEIREA
K95-ac EAFRVFDkDGNGyIs
K95-ub EAFRVFDkDGNGyIs
K95 EAFRVFDKDGNGyIs
Y100-p FDkDGNGyIsAAELR
S102-p kDGNGyIsAAELRHV
K116 VMTNLGEKLtDEEVD
K116 VMTNLGEKLtDEEVD
K116 VMTNLGEKLtDEEVD
K116-m3 VMTNLGEkLtDEEVD
T118-p TNLGEkLtDEEVDEM
Y139-p DGDGQVNyEEFVQMM
K149 FVQMMTAK_______
K149 FVQMMTAK_______
  chicken

 
K14 EEQIAEFKEAFSLFD
K14 EEQIAEFKEAFSLFD
S18 AEFKEAFSLFDKDGD
K22 EAFSLFDKDGDGTIT
K22 EAFSLFDKDGDGTIT
K22 EAFSLFDKDGDGTIT
T29 KDGDGTITTKELGTV
T30 DGDGTITTKELGTVM
K31 GDGTITTKELGTVMR
T45 RSLGQNPTEAELQDM
K76 FLTMMARKMKDTDSE
K76 FLTMMARKMKDTDSE
K78 TMMARKMKDTDSEEE
K78 TMMARKMKDTDSEEE
K78 TMMARKMKDTDSEEE
T80 MARKMKDTDSEEEIR
S82 RKMKDTDSEEEIREA
K95 EAFRVFDKDGNGyIS
K95 EAFRVFDKDGNGyIS
K95 EAFRVFDKDGNGyIS
Y100-p FDKDGNGyISAAELR
S102 KDGNGyISAAELRHV
K116 VMTNLGEKLTDEEVD
K116 VMTNLGEKLTDEEVD
K116 VMTNLGEKLTDEEVD
K116-m3 VMTNLGEkLTDEEVD
T118 TNLGEkLTDEEVDEM
Y139-p DGDGQVNyEEFVQMM
K149 FVQMMTAK_______
K149 FVQMMTAK_______
  sheep

 
K14 EEQIAEFKEAFSLFD
K14 EEQIAEFKEAFSLFD
S18 AEFKEAFSLFDKDGD
K22 EAFSLFDKDGDGTIT
K22 EAFSLFDKDGDGTIT
K22 EAFSLFDKDGDGTIT
T29 KDGDGTITTKELGTV
T30 DGDGTITTKELGTVM
K31 GDGTITTKELGTVMR
T45 RSLGQNPTEAELQDM
K76 FLTMMARKMKDTDSE
K76 FLTMMARKMKDTDSE
K78 TMMARKMKDTDSEEE
K78 TMMARKMKDTDSEEE
K78 TMMARKMKDTDSEEE
T80 MARKMKDTDSEEEIR
S82 RKMKDTDSEEEIREA
K95 EAFRVFDKDGNGYIS
K95 EAFRVFDKDGNGYIS
K95 EAFRVFDKDGNGYIS
Y100 FDKDGNGYISAAELR
S102 KDGNGYISAAELRHV
K116 VMTNLGEKLTDEEVD
K116 VMTNLGEKLTDEEVD
K116 VMTNLGEKLTDEEVD
K116-m3 VMTNLGEkLTDEEVD
T118 TNLGEkLTDEEVDEM
Y139 DGDGQVNYEEFVQMM
K149 FVQMMTAK_______
K149 FVQMMTAK_______
  cow

 
K14 EEQIAEFKEAFSLFD
K14 EEQIAEFKEAFSLFD
S18 AEFKEAFSLFDKDGD
K22 EAFSLFDKDGDGTIT
K22 EAFSLFDKDGDGTIT
K22 EAFSLFDKDGDGTIT
T29 KDGDGTITTKELGTV
T30 DGDGTITTKELGTVM
K31 GDGTITTKELGTVMR
T45 RSLGQNPTEAELQDM
K76 FLTMMARKMKDTDSE
K76 FLTMMARKMKDTDSE
K78 TMMARKMKDTDSEEE
K78 TMMARKMKDTDSEEE
K78 TMMARKMKDTDSEEE
T80 MARKMKDTDSEEEIR
S82 RKMKDTDSEEEIREA
K95 EAFRVFDKDGNGYIS
K95 EAFRVFDKDGNGYIS
K95 EAFRVFDKDGNGYIS
Y100 FDKDGNGYISAAELR
S102 KDGNGYISAAELRHV
K116 VMTNLGEKLTDEEVD
K116 VMTNLGEKLTDEEVD
K116 VMTNLGEKLTDEEVD
K116-m3 VMTNLGEkLTDEEVD
T118 TNLGEkLTDEEVDEM
Y139 DGDGQVNYEEFVQMM
K149 FVQMMTAK_______
K149 FVQMMTAK_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.