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ANXA7 (human)

Overview ANXA7 Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Interacts with PDCD6. Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta. Belongs to the annexin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Calcium-binding protein; Lipid binding protein; Motility/polarity/chemotaxis Cellular Component: plasma membrane; nuclear envelope; cytosol; vesicle Molecular Function: protein binding; calcium-dependent phospholipid binding; calcium ion binding; calcium-dependent protein binding Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell proliferation; cellular water homeostasis; hemostasis; social behavior; response to salt stress Reference #:  P20073 (UniProtKB) Alt. Names/Synonyms: Annexin A7; Annexin VII; Annexin-7; ANX7; ANXA7; SNX; Synexin Gene Symbols: ANXA7 Molecular weight: 52,739 Da Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ANXA7

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K196-a	RDAEILRkAMkGFGT
0	9		K199-u	EILRkAMkGFGTDEQ
0	1		K228	QKIKAAFKTSYGkDL
0	1		K233-a	AFKTSYGkDLIkDLK
0	1		K233-u	AFKTSYGkDLIkDLK
0	3		K237-u	SYGkDLIkDLKSELS
0	1		T286-p	VLIEILCtRTNQEIR
0	1		K309	EFGRDLEKDIRSDTS
0	1		S336	GNRDENQSINHQMAQ
0	1		R377	TRSFPQLRATMEAYS
0	1		Y383	LRATMEAYSRMANRD
0	1		Y402	VSREFSGYVESGLKT
0	40		Y427-p	FFAERLYyAMkGAGT
0	4		K430-u	ERLYyAMkGAGTDDS
0	1		K455-u	EIDLVQIkQMFAQMY

	mouse
K171	RDAEILRKAMkGFGT
K174-u	EILRKAMkGFGTDEQ
K203-u	QQIKAAFkTMYGKDL
K208	AFkTMYGKDLIkDLK
K208	AFkTMYGKDLIkDLK
K212-u	MYGKDLIkDLKSELS
T261	VLIEILCTRTNQEIR
K284-u	EFGRDLEkDIRSDTS
S311-p	GNRDERQsVNHQMAQ
K352-u	TRSFPQLkATMEAYS
Y358	LkATMEAYSRMANRD
Y377	VSREFSGYVESGLKT
Y402	FFAERLYYSMkGAGT
K405-u	ERLYYSMkGAGTDDS
K430	EIDLVQIKQMFTQMY

	rat
K171	RDAEILRKAMKGFGT
K174	EILRKAMKGFGTDEQ
K203	QQIKAAFKTMYGKDL
K208	AFKTMYGKDLIKDLK
K208	AFKTMYGKDLIKDLK
K212	MYGKDLIKDLKSELS
T261	VLIEILCTRTNQEIR
R284	EFGRELERDIRSDTS
S311	GNRDESPSINHQMAQ
R352	TRSFPQLRATMEAyS
Y358-p	LRATMEAySRMANRD
Y377-p	VSREFSGyVESGLKT
Y402	FFAERLYYSMKGAGT
K405	ERLYYSMKGAGTDDS
K430	EIDLVQIKQMFTQMY

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