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Protein Page:
EphA2 (rat)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EphA2 a receptor tyrosine kinase. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 AND -A5. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Overexpressed in many cancers including aggressive ovarian, cervical and breast carcinomas, and lung cancer. Expression correlates with degree of angiogenesis, metastasis and xenograft tumor growth. Soluble receptor inhibits tumor growth and angiogenesis in mice. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; TK group; Eph family
Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane
Molecular Function: ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: neural tube development; axial mesoderm formation; blood vessel development; cell migration; negative regulation of protein kinase B signaling cascade; peptidyl-tyrosine phosphorylation; activation of Rac GTPase; notochord formation; mammary gland epithelial cell proliferation; osteoclast differentiation; bone remodeling; regulation of blood vessel endothelial cell migration; regulation of angiogenesis; keratinocyte differentiation; neuron differentiation; osteoblast differentiation; notochord morphogenesis; regulation of cell adhesion mediated by integrin; DNA damage response, signal transduction resulting in induction of apoptosis; notochord cell development; ephrin receptor signaling pathway; protein kinase B signaling cascade; vasculogenesis; skeletal development
Reference #:  NP_001102447 (RefSeq)
Alt. Names/Synonyms: Eph receptor A2; Epha2; ephrin type-A receptor 2
Gene Symbols: Epha2
Molecular weight: 108,741 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EphA2

Protein Structure Not Found.


BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
0 1 Y66 NDMPIYMYSVCNVVS
0 1 S112 NSFPGGASSCKETFN
0 1 S113 SFPGGASSCKETFNL
0 1 K135 DYGTNFQKRQFTKID
0 1 K140 FQKRQFTKIDTIAPD
0 1 S152 APDEITVSSDFEARN
0 1 K161 DFEARNVKLNVEERM
0 1 S374 CEQCWPESGECGSCE
0 1 S427 SDLVNSRSFRTASVS
0 1 S434 SFRTASVSINQTEPP
0 1 T438 ASVSINQTEPPKVRL
0 9 S571-p RNLRARQsSEDVYFS
0 329 Y576 RQsSEDVYFSKSEQL
0 2 S578 sSEDVYFSKSEQLKP
0 4 K579 SEDVYFSKSEQLKPL
0 5 S580 EDVYFSKSEQLKPLK
0 6 K584 FSKSEQLKPLKTYVD
0 1 K587 SEQLKPLKTYVDPHT
0 78 T588 EQLKPLKTYVDPHTY
2 653 Y589 QLKPLKTYVDPHTYE
0 149 T594 KTYVDPHTYEDPNQA
2 748 Y595 TYVDPHTYEDPNQAV
0 1 K604 DPNQAVLKFTTEIHP
0 4 K618 PSCVSRQKVIGAGEF
0 48 Y629 AGEFGEVYKGTLKSS
0 1 K640 LKSSSGKKEIPVAIK
0 3 T648 EIPVAIKTLKAGYTE
0 1 K656 LKAGYTEKQRVDFLS
0 2 Y686 LEGVVSKYKPMMIIT
0 2 K687 EGVVSKYKPMMIITE
0 2 T693 YKPMMIITEYMENGA
0 18 Y695 PMMIITEYMENGALD
0 1 S713 REKDGEFSVLQLVGM
1 15 Y736 KYLANMNYVHRDLAA
0 3 S762 KVSDFGLSRVLEDDP
0 30 T772 LEDDPEATyTTSGGK
2 873 Y773-p EDDPEATyTTSGGKI
0 23 T774 DDPEATyTTSGGKIP
0 18 T775 DPEATyTTSGGKIPI
0 2 S776 PEATyTTSGGKIPIR
0 5 K779 TyTTSGGKIPIRWTA
0 1 S791 WTAPEAISYRKFTSA
0 8 Y792 TAPEAISYRKFTSAS
0 1 S870 PKFADIVSILDKLIR
0 1 K874 DIVSILDKLIRAPDS
0 1 S881 KLIRAPDSLKTLADF
0 2 K883 IRAPDSLKTLADFDP
0 57 S893 ADFDPRVSIRLPSTS
1 179 S898 RVSIRLPSTSGSEGV
0 58 T899 VSIRLPSTSGSEGVP
0 82 S900 SIRLPSTSGSEGVPF
0 107 S902 RLPSTSGSEGVPFRT
0 2 S911 GVPFRTVSEWLESIK
1 31 Y922 ESIKMQQYTEHFMVA
0 15 T923 SIKMQQYTEHFMVAG
3 16 Y931 EHFMVAGYTAIEKVV
0 3 S941 IEKVVQMSNDDIKRI
0 1 K946 QMSNDDIKRIGVRLP
1 60 Y961 GHQKRIAYSLLGLKD
0 1 S962 HQKRIAYSLLGLKDQ
7423 : Phospho-EphA2 (Tyr588) Antibody
12677 : Phospho-EphA2 (Tyr588) (D7X2L) Rabbit mAb
3970 : Phospho-EphA2 (Tyr594) Antibody
8244 : Phospho-EphA2 (Tyr772) Antibody
8862 : Phospho-EphA3 (Tyr779) (D10H1) Rabbit mAb
6347 : Phospho-EphA2 (Ser897) (D9A1) Rabbit mAb
  human

 
Y67-p NDMPIYMySVCNVMS
S113 NSFPGGASSCKETFN
S114 SFPGGASSCKETFNL
K136-ub DYGTNFQkRLFTkID
K141-ub FQkRLFTkIDTIAPD
S153-p APDEITVsSDFEARH
K162-ub DFEARHVkLNVEERS
S373-p CEQCWPEsGECGPCE
S426-p SGLVTSRsFRTASVs
S433-p sFRTASVsINQtEPP
T437-p ASVsINQtEPPKVRL
S570-p KNQRARQsPEDVyFs
Y575-p RQsPEDVyFsksEQL
S577-p sPEDVyFsksEQLkP
K578-ub PEDVyFsksEQLkPL
S579-p EDVyFsksEQLkPLk
K583-ub FsksEQLkPLktyVD
K586-ub sEQLkPLktyVDPHt
T587-p EQLkPLktyVDPHty
Y588-p QLkPLktyVDPHtyE
T593-p ktyVDPHtyEDPNQA
Y594-p tyVDPHtyEDPNQAV
K603 DPNQAVLKFTTEIHP
K617-ub PSCVTRQkVIGAGEF
Y628-p AGEFGEVyKGMLKTS
K639-ub LKTSSGKkEVPVAIK
T647-p EVPVAIKtLKAGYTE
K655-ub LKAGYTEkQRVDFLG
Y685-p LEGVISKykPMMIIt
K686-ub EGVISKykPMMIItE
T692-p ykPMMIItEyMENGA
Y694-p PMMIItEyMENGALD
S712-p REKDGEFsVLQLVGM
Y735-p KYLANMNyVHRDLAA
S761-p KVSDFGLsRVLEDDP
T771-p LEDDPEAtyttsGGk
Y772-p EDDPEAtyttsGGkI
T773-p DDPEAtyttsGGkIP
T774-p DPEAtyttsGGkIPI
S775-p PEAtyttsGGkIPIR
K778-ub tyttsGGkIPIRWTA
S790-p WTAPEAIsyRKFTSA
Y791-p TAPEAIsyRKFTSAS
S869-p PKFADIVsILDKLIR
K873 DIVsILDKLIRAPDs
S880-p KLIRAPDsLkTLADF
K882-ub IRAPDsLkTLADFDP
S892-p ADFDPRVsIRLPsts
S897-p RVsIRLPstsGsEGV
T898-p VsIRLPstsGsEGVP
S899-p sIRLPstsGsEGVPF
S901-p RLPstsGsEGVPFRT
S910-p GVPFRTVsEWLESIK
Y921-p ESIKMQQytEHFMAA
T922-p SIKMQQytEHFMAAG
Y930-p EHFMAAGyTAIEKVV
T940-p IEKVVQMtNDDIkRI
K945-ub QMtNDDIkRIGVRLP
Y960-p GHQKRIAysLLGLKD
S961-p HQKRIAysLLGLKDQ
7423 : Phospho-EphA2 (Tyr588) Antibody
12677 : Phospho-EphA2 (Tyr588) (D7X2L) Rabbit mAb
3970 : Phospho-EphA2 (Tyr594) Antibody
8244 : Phospho-EphA2 (Tyr772) Antibody
8862 : Phospho-EphA3 (Tyr779) (D10H1) Rabbit mAb
6347 : Phospho-EphA2 (Ser897) (D9A1) Rabbit mAb
  mouse

 
Y66 DDMPIYMYSVCNVVS
S112-p NSFPGGAssCKETFN
S113-p SFPGGAssCKETFNL
K135 DYGTNFQKRQFTKID
K140 FQKRQFTKIDTIAPD
S152 APDEITVSSDFEARN
K161 DFEARNVKLNVEERM
S374 CEQCWPESGECGPCE
S427 SGLVTSRSFRTASVS
S434 SFRTASVSINQTEPP
T438 ASVSINQTEPPKVRL
S571-p RNLRARQsSEDVRFS
R576 RQsSEDVRFSksEQL
S578 sSEDVRFSksEQLkP
K579-ub SEDVRFSksEQLkPL
S580-p EDVRFSksEQLkPLK
K584-ub FSksEQLkPLKtyVD
K587 sEQLkPLKtyVDPHt
T588-p EQLkPLKtyVDPHty
Y589-p QLkPLKtyVDPHtyE
T594-p KtyVDPHtyEDPNQA
Y595-p tyVDPHtyEDPNQAV
K604-ub DPNQAVLkFTTEIHP
K618-ub PSCVARQkVIGAGEF
Y629-p AGEFGEVyKGTLKAS
K640 LKASSGKKEIPVAIK
T648 EIPVAIKTLKAGYTE
K656 LKAGYTEKQRVDFLS
Y686 LEGVVSKYKPMMIIT
K687 EGVVSKYKPMMIITE
T693 YKPMMIITEYMENGA
Y695 PMMIITEYMENGALD
S713 REKDGEFSVLQLVGM
Y736-p KYLANMNyVHRDLAA
S762-p KVSDFGLsRVLEDDP
T772-p LEDDPEAtyTtsGGK
Y773-p EDDPEAtyTtsGGKI
T774 DDPEAtyTtsGGKIP
T775-p DPEAtyTtsGGKIPI
S776-p PEAtyTtsGGKIPIR
K779 tyTtsGGKIPIRWTA
S791 WTAPEAISYRKFTSA
Y792 TAPEAISYRKFTSAS
S870 PKFADIVSILDkLIR
K874-ub DIVSILDkLIRAPDS
S881 kLIRAPDSLkTLADF
K883-ub IRAPDSLkTLADFDP
S893-p ADFDPRVsIRLPsts
S898-p RVsIRLPstsGsEGV
T899-p VsIRLPstsGsEGVP
S900-p sIRLPstsGsEGVPF
S902-p RLPstsGsEGVPFRT
S911 GVPFRTVSEWLESIK
Y922-p ESIKMQQyTEHFMVA
T923 SIKMQQyTEHFMVAG
Y931 EHFMVAGYTAIEKVV
S941 IEKVVQMSNEDIKRI
K946 QMSNEDIKRIGVRLP
Y961-p GHQKRIAySLLGLKD
S962 HQKRIAySLLGLKDQ
7423 : Phospho-EphA2 (Tyr588) Antibody
12677 : Phospho-EphA2 (Tyr588) (D7X2L) Rabbit mAb
3970 : Phospho-EphA2 (Tyr594) Antibody
8244 : Phospho-EphA2 (Tyr772) Antibody
8862 : Phospho-EphA3 (Tyr779) (D10H1) Rabbit mAb
6347 : Phospho-EphA2 (Ser897) (D9A1) Rabbit mAb
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