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Smc1 (human)

Overview Smc1 a component of the cohesin multiprotein complex that is required for sister chromatid cohesion. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Thought to be an important part of functional kinetochores. Interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. Note: This description may include information from UniProtKB. Protein type: DNA replication; RNA splicing Cellular Component: nucleoplasm; kinetochore; condensed nuclear chromosome; cohesin core heterodimer; cytoplasm; nucleolus; nucleus Molecular Function: protein binding; protein heterodimerization activity; microtubule motor activity; chromatin binding; ATP binding Biological Process: meiosis; mitotic sister chromatid segregation; RNA splicing; mitotic sister chromatid cohesion; DNA damage response, signal transduction; sister chromatid cohesion; negative regulation of DNA endoreduplication; DNA repair; DNA recombination; chromosome condensation; nuclear mRNA splicing, via spliceosome; M phase of mitotic cell cycle; response to radiation; mitotic spindle organization and biogenesis; cell division; gene expression; mitotic cell cycle; cell cycle checkpoint; mitotic prometaphase; mitotic metaphase/anaphase transition Reference #:  Q14683 (UniProtKB) Alt. Names/Synonyms: CDLS2; DKFZp686L19178; DXS423E; KIAA0178; MGC138332; SB1.8; segregation of mitotic chromosomes 1; SMC protein 1A; SMC-1-alpha; SMC-1A; SMC1; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 1; SMC1A; SMC1alpha; SMC1L1; SMCB; structural maintenance of chromosomes 1A; Structural maintenance of chromosomes protein 1A Gene Symbols: SMC1A Molecular weight: 143,233 Da Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Smc1 2WD5 - A=461-685 (mouse)

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	Sites Implicated In
cell cycle regulation: S957‑p, S966‑p cytoskeletal reorganization: S957‑p, S966‑p intracellular localization: S957‑p, S966‑p molecular association, regulation: S957‑p, S966‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K5-u	___MGFLkLIEIENF
0	1		K13-u	LIEIENFkSYkGRQI
0	1		K16-u	IENFkSYkGRQIIGP
0	1		T28-p	IGPFQRFtAIIGPNG
0	1		K52-u	ISFVLGEkTSNLRVK
0	1		K72-u	IHGAPVGkPAANRAF
0	1		R92-m1	SEEGAEDrTFARVIV
0	1		K110-u	SEYKINNkVVQLHEY
0	1		K149-m1	SIAMKNPkERTALFE
0	1		R160-m1	ALFEEISrSGELAQE
0	5		Y168-p	SGELAQEyDkRKKEM
0	1		K170-u	ELAQEyDkRKKEMVk
0	1		K177-u	kRKKEMVkAEEDTQF
0	1		S244	KLNKELASKNKEIEK
0	1		K282-a	REQQQIEkEIKEKDS
0	1		K300-u	QKRPQYIkAKENTSH
0	28		S358-p	EERMEEEsQsQGRDL
0	40		S360-p	RMEEEsQsQGRDLtL
0	2		T366-p	QsQGRDLtLEENQVK
0	1		K437-a	ENQKRIEkLEEYITT
0	1		K437	ENQKRIEKLEEYITT
0	1		K453	KQSLEEQKkLEGELT
0	1		K454-m2	QSLEEQKkLEGELTE
0	1		K508-a	AEIMESIkRLYPGSV
0	1		K508-u	AEIMESIkRLYPGSV
0	1		Y511	MESIkRLYPGSVYGR
0	1		Y516	RLYPGSVYGRLIDLC
0	1		K528-u	DLCQPTQkKyQIAVT
0	1		Y530-p	CQPTQkKyQIAVTkV
0	1		K536-a	KyQIAVTkVLGkNMD
0	1		K536-u	KyQIAVTkVLGkNMD
0	2		K540-u	AVTkVLGkNMDAIIV
0	7		K561-u	RDCIQYIkEQRGEPE
0	1		Y575-p	ETFLPLDyLEVkPTD
0	1		K579-u	PLDyLEVkPTDEKLR
0	1		Y600-p	LVIDVIRyEPPHIKK
0	10		Y611-p	HIKKALQyACGNALV
0	2		K637-u	FGGHQRHkTVALDGT
0	1		K648-a	LDGTLFQkSGVIsGG
0	8		K648-u	LDGTLFQkSGVIsGG
0	1		S653-p	FQkSGVIsGGAsDLk
0	1		S657-p	GVIsGGAsDLkAKAR
0	2		K660-u	sGGAsDLkAKARRWD
0	2		S703-p	AELRQVQsQAHGLQM
0	1		K713-a	HGLQMRLkysQSDLE
0	7		Y714-p	GLQMRLkysQSDLEQ
0	1		S715-p	LQMRLkysQSDLEQT
0	1		S735-p	ALNLQEKskLESELA
0	1		K736-u	LNLQEKskLESELAN
0	1		K805	KRQNEIAKKRLEFEN
0	1		K806	RQNEIAKKRLEFENQ
0	1		K903-a	KKLGGANkEMTHLQK
0	1		K944-u	DIKLPLSkGTMDDIs
0	9		S951-p	kGTMDDIsQEEGssQ
0	10		S956-p	DIsQEEGssQGEDsV
14	60		S957-p	IsQEEGssQGEDsVs
0	16		S962-p	GssQGEDsVsGsQRI
0	5		S964-p	sQGEDsVsGsQRIsS
18	71		S966-p	GEDsVsGsQRIsSIy
0	4		S970-p	VsGsQRIsSIyAREA
0	4		Y973-p	sQRIsSIyAREALIE
0	1		K1030-u	PNMKAMEkLEsVRDk
0	1		S1033-p	KAMEkLEsVRDkFQE
0	21		K1037-u	kLEsVRDkFQETSDE
0	1		K1133-m1	DNLSGGEkTVAALAL
0	2		T1217-p	CVISKVLtFDLtkYP
0	2		T1221-p	KVLtFDLtkYPDANP
0	21		K1222-u	VLtFDLtkYPDANPN

	mouse
K5	___MGFLKLIEIENF
K13	LIEIENFKSYKGRQI
K16	IENFKSYKGRQIIGP
T28	IGPFQRFTAIIGPNG
K52	ISFVLGEKTSNLRVK
K72	IHGAPVGKPAANRAF
R92	SEEGAEDRTFARVIV
K110	SEYKINNKVVQLHEY
K149	SIAMKNPKERTALFE
R160	ALFEEISRSGELAQE
Y168	SGELAQEYDKRKKEM
K170	ELAQEYDKRKKEMVK
K177	KRKKEMVKAEEDTQF
S244-p	KLNKELAsKNKEIEK
K282	REQQQIEKEIKEKDS
K300	QKRPQYIKAKENTSH
S358-p	EERMEEEsQSQGRDL
S360	RMEEEsQSQGRDLTL
T366	QSQGRDLTLEENQVK
K437	ENQKRIEKLEEYITT
K437	ENQKRIEKLEEYITT
K453	KQSLEEQKKLEGELT
K454	QSLEEQKKLEGELTE
K508-a	AEIMESIkRLYPGSV
K508	AEIMESIKRLYPGSV
Y511	MESIkRLYPGSVYGR
Y516	RLYPGSVYGRLIDLC
K528	DLCQPTQKKYQIAVT
Y530	CQPTQKKYQIAVTKV
K536	KYQIAVTKVLGkNMD
K536	KYQIAVTKVLGkNMD
K540-u	AVTKVLGkNMDAIIV
K561-u	RDCIQYIkEQRGEPE
Y575	ETFLPLDYLEVKPTD
K579	PLDYLEVKPTDEKLR
Y600	LVIDVIRYEPPHIKK
Y611-p	HIKKALQyACGNALV
K637-u	FGGHQRHkTVALDGT
K648	LDGTLFQKSGVISGG
K648	LDGTLFQKSGVISGG
S653	FQKSGVISGGASDLK
S657	GVISGGASDLKAKAR
K660	SGGASDLKAKARRWD
S703	AELRQVQSQAHGLQM
K713	HGLQMRLKYSQSDLE
Y714	GLQMRLKYSQSDLEQ
S715	LQMRLKYSQSDLEQT
S735	ALNLQEKSKLESELA
K736	LNLQEKSKLESELAN
K805-a	KRQNEIAkkRLEFEN
K806-a	RQNEIAkkRLEFENQ
K903	KKLGGANKEMTHLQK
K944	DIKLPLSKGTMDDIS
S951	KGTMDDISQEEGSsQ
S956	DISQEEGSsQGEESV
S957-p	ISQEEGSsQGEESVS
S962	GSsQGEESVSGsQRT
S964	sQGEESVSGsQRTsS
S966-p	GEESVSGsQRTsSIY
S970-p	VSGsQRTsSIYAREA
Y973	sQRTsSIYAREALIE
K1030	PNMKAMEKLESVRDK
S1033	KAMEKLESVRDKFQE
K1037	KLESVRDKFQETSDE
K1133	DNLSGGEKTVAALAL
T1217	CVISKVLTFDLTkYP
T1221	KVLTFDLTkYPDANP
K1222-u	VLTFDLTkYPDANPN

	rat
K5	___MGFLKLIEIENF
K13	LIEIENFKSYKGRQI
K16	IENFKSYKGRQIIGP
T28	IGPFQRFTAIIGPNG
K52	ISFVLGEKTSNLRVK
K72	IHGAPVGKPAANRAF
R92	SEEGAEDRTFARVIV
K110	SEYKINNKVVQLHEY
K149	SIAMKNPKERTALFE
R160	ALFEEISRSGELAQE
Y168	SGELAQEYDKRKKEM
K170	ELAQEYDKRKKEMVK
K177	KRKKEMVKAEEDTQF
S244	KLNKELASKNKEIEK
K282	REQQQIEKEIKEKDS
K300	QKRPQYIKAKENTSH
S358	EERMEEESQSQGRDL
S360	RMEEESQSQGRDLTL
T366	QSQGRDLTLEENQVK
K437	ENQKRIEKLEEYITT
K437-u	ENQKRIEkLEEYITT
K453-u	KQSLEEQkKLEGELT
K454	QSLEEQkKLEGELTE
K508	AEIMESIKRLyPGSV
K508	AEIMESIKRLyPGSV
Y511-p	MESIKRLyPGSVyGR
Y516-p	RLyPGSVyGRLIDLC
K528	DLCQPTQKKYQIAVT
Y530	CQPTQKKYQIAVTKV
K536	KYQIAVTKVLGKNMD
K536	KYQIAVTKVLGKNMD
K540	AVTKVLGKNMDAIIV
K561	RDCIQYIKEQRGEPE
Y575	ETFLPLDYLEVKPTD
K579	PLDYLEVKPTDEKLR
Y600	LVIDVIRYEPPHIKK
Y611	HIKKALQYACGNALV
K637	FGGHQRHKTVALDGT
K648	LDGTLFQKSGVISGG
K648	LDGTLFQKSGVISGG
S653	FQKSGVISGGASDLK
S657	GVISGGASDLKAKAR
K660	SGGASDLKAKARRWD
S703	AELRQVQSQAHGLQM
K713	HGLQMRLKYSQSDLE
Y714	GLQMRLKYSQSDLEQ
S715	LQMRLKYSQSDLEQT
S735	ALNLQEKSKLESELA
K736	LNLQEKSKLESELAN
K805	KRQNEIAKKRLEFEN
K806	RQNEIAKKRLEFENQ
K903	KKLGGANKEMTHLQK
K944	DIKLPLSKGTMDDIS
S951	KGTMDDISQEEGGSQ
G956	DISQEEGGSQGEESV
S957	ISQEEGGSQGEESVS
S962	GGSQGEESVSGSQRT
S964	SQGEESVSGSQRTSS
S966	GEESVSGSQRTSSIY
S970	VSGSQRTSSIYAREA
Y973	SQRTSSIYAREALIE
K1030	PNMKAMEKLESVRDK
S1033	KAMEKLESVRDKFQE
K1037	KLESVRDKFQETSDE
K1133	DNLSGGEKTVAALAL
T1217	CVISKVLTFDLTKYP
T1221	KVLTFDLTKYPDANP
K1222	VLTFDLTKYPDANPN

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