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Protein Page:
Telethonin (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Telethonin a muscle assembly regulating factor that interacts with the giant kinase titin. Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. Telethonin is found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Cellular Component: I band; Z disc; cytosol
Molecular Function: protein binding, bridging; protein binding; structural constituent of muscle; titin binding; FATZ binding
Biological Process: adult heart development; cardiac muscle hypertrophy; skeletal muscle contraction; somitogenesis; muscle thin filament assembly; detection of mechanical stimulus; cardiac myofibril assembly; sarcomere organization; muscle filament sliding; muscle thick filament assembly; cardiac muscle fiber development; sarcomerogenesis; cardiac muscle morphogensis; protein complex assembly; otic vesicle formation; cardiac muscle contraction
Reference #:  O15273 (UniProtKB)
Alt. Names/Synonyms: 19 kDa sarcomeric protein; CMD1N; LGMD2G; limb girdle muscular dystrophy 2G (autosomal recessive); T-cap; TCAP; TELE; Telethonin; TELT; Titin cap protein; titin-cap (telethonin)
Gene Symbols: TCAP
Molecular weight: 19,052 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
Select Structure to View Below

Telethonin

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S39-p TRPEEGCsLHEEDTQ
0 1 K98 LPIFTPAKMGATKEE
0 3 K103 PAKMGATKEEREDTP
0 1 T109 TKEEREDTPIQLQEL
0 2 K148 PPVVPVSKPGALRRs
0 3 S155-p KPGALRRsLsRSMsQ
1 5 S157-p GALRRsLsRSMsQEA
0 2 S159 LRRsLsRSMsQEAQR
1 5 S161-p RsLsRSMsQEAQRG_
  mouse

 
S39-p TRPEEGCsLHEEDTQ
K98-u LPIFTPTkVGASkEE
K103-u PTkVGASkEEREEtP
T109-p SkEEREEtPIQLREL
K148-u PPVVPVSkPGPLRRt
T155-p kPGPLRRtLsRsMsQ
S157-p GPLRRtLsRsMsQEA
S159-p LRRtLsRsMsQEAQR
S161-p RtLsRsMsQEAQRG_
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