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Protein Page:
FRA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FRA1 an oncogenic transcription factor of the bZIP family, Fos subfamily. The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins (c-Jun, JunB, and JunD) to form Activator Protein-1 (AP-1), a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-zipper motif that mediates dimerization and an adjacent basic domain that binds to DNA. The various Fos/Jun heterodimers differ in their ability to transactivate AP-1 dependent genes. In addition to increased expression, phosphorylation of Fos proteins by Erk kinases in response to extracellular stimuli may further increase transcriptional activity. Following growth factor stimulation, expression of FosB and c-Fos in quiescent fibroblasts is immediate but short-lived, while FRA1 and FRA2 expression persists longer. FRA1 is involved in cell motility, invasiveness, and inhibits apoptosis. Elevated in many cancers and associated with tumorigenesis and cancer progression. Involved in Erk2-mediated Epithelial-to-Mesenchymal Transition (EMT) pathway. ERK2/FRA2 regulate ZEB1/2 expression, known to be associated with the EMT. Smad2/3-Fra1 complexes may reflect activation of the Smad/AP-1-dependent TGF¿-induced breast cancer invasion program. Activation of FRA1/C-JUN by ERK/AKT pathways can induce EZH2 overexpression, silencing integrin alpha-2 expression, and increasing the metastatic potential of colorectal cancer. Belongs to the bZIP family. Fos subfamily. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: presynaptic membrane; neuron projection; cytosol; nucleus
Molecular Function: protein binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; response to drug; response to gravity; response to cAMP; positive regulation of apoptosis; in utero embryonic development; response to virus; vitellogenesis; positive regulation of cell cycle; learning; female pregnancy; chemotaxis; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; positive regulation of cell proliferation; cellular response to extracellular stimulus; cellular defense response; positive regulation of transcription factor activity; response to progesterone stimulus; response to corticosterone stimulus
Reference #:  P15407 (UniProtKB)
Alt. Names/Synonyms: FOS-like antigen 1; FOS-like antigen-1; Fos-related antigen 1; FOSL1; FRA; FRA-1; FRA1
Gene Symbols: FOSL1
Molecular weight: 29,413 Da
Basal Isoelectric point: 8.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FRA1

Protein Structure Not Found.


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Sites Implicated In
protein stabilization: T217‑p, T223‑p, S252‑p, S265‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 G16 GPSSGNGGGYGGPAQ
0 1 Y18 SSGNGGGYGGPAQPP
0 1 R66-m2 LGPSSYPrPLtYPQY
0 1 R66-m1 LGPSSYPrPLtYPQY
0 1 T69-p SSYPrPLtYPQYsPP
0 2 S74-p PLtYPQYsPPQPrPG
0 1 R79-m2 QYsPPQPrPGVIrAL
0 2 R84-m2 QPrPGVIrALGPPPG
0 4 S101-p RRPCEQIsPEEEERR
0 1 T183-p EGAKEGDtGSTSGTS
0 1 S191-p GSTSGTSsPPAPCRP
1 0 T217-p LEPEALHtPTLMTtP
2 0 T223-p HtPTLMTtPSLTPFt
1 0 T230-p tPSLTPFtPSLVFTY
1 0 T240-p LVFTYPStPEPCAsA
0 1 S246-p StPEPCAsAHRKsss
0 1 S251-p CAsAHRKsssSSGDP
3 3 S252-p AsAHRKsssSSGDPS
0 2 S253-p sAHRKsssSSGDPSS
3 10 S265-p PSSDPLGsPTLLAL_
3880 : Phospho-FRA1 (Ser265) Antibody
5841 : Phospho-FRA1 (Ser265) (D22B1) Rabbit mAb
  mouse

 
S16-p GPSSGAGsPyGRPAQ
Y18-p SSGAGsPyGRPAQPP
R66 LGPTGYPRPLAYPQY
R66 LGPTGYPRPLAYPQY
A69 TGYPRPLAYPQYSPP
S74 PLAYPQYSPPQPRPG
R79 QYSPPQPRPGVIRAL
R84 QPRPGVIRALGPPPG
S101 RRPCEQISPEEEERR
S185 DKKDPGGSGSTSGAS
S193 GSTSGASSPPAPGRP
T219 LEPEALHTPTLMTTP
T225 HTPTLMTTPSLTPFT
T232 TPSLTPFTPSLVFTY
T242 LVFTYPSTPEPCSSA
S248 STPEPCSSAHRKSSS
S253 CSSAHRKSSSSSGDP
S254 SSAHRKSSSSSGDPS
S255 SAHRKSSSSSGDPSS
S267-p PSSDPLGsPTLLAL_
3880 : Phospho-FRA1 (Ser265) Antibody
5841 : Phospho-FRA1 (Ser265) (D22B1) Rabbit mAb
  rat

 
S16 GPSSGAGSAYGRPAQ
Y18 SSGAGSAYGRPAQPQ
R68 LGPSGYPRPLTYPQY
R68 LGPSGYPRPLTYPQY
T71 SGYPRPLTYPQYSPP
S76 PLTYPQYSPPQPRPG
R81 QYSPPQPRPGVIRAL
R86 QPRPGVIRALGPPPG
S103 RRPCEQISPEEEERR
T187 DKKDTGGTSSTSGAG
S195 SSTSGAGSPPGPCRP
T221 LEPEALHTPTLMTTP
T227 HTPTLMTTPSLTPFT
T234 TPSLTPFTPSLVFTY
T244 LVFTYPSTPEPCSSA
S250 STPEPCSSAHRKSSS
S255 CSSAHRKSSSSSGDP
S256 SSAHRKSSSSSGDPS
S257 SAHRKSSSSSGDPSS
S269 PSSDPLGSPTLLAL_
3880 : Phospho-FRA1 (Ser265) Antibody
5841 : Phospho-FRA1 (Ser265) (D22B1) Rabbit mAb
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