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Protein Page:
Rhodopsin (human)

Overview
Rhodopsin a G-protein coupled receptor. The light-absorbing visual pigment in Rod photoreceptor cells. Mediates vision in dim light. Consists of the apoprotein, opsin, covalently linked to cis-retinal. Defects in RHO are a cause of autosomal retinitis pigmentosa and congenital stationary night blindness. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Cellular Component: Golgi apparatus; photoreceptor outer segment; photoreceptor inner segment; integral to plasma membrane; plasma membrane; rough endoplasmic reticulum membrane
Molecular Function: G-protein coupled receptor activity; protein binding; metal ion binding; photoreceptor activity; retinal binding
Biological Process: rhodopsin mediated signaling; phototransduction, visible light; G-protein coupled receptor protein signaling pathway; red, far-red light phototransduction; regulation of rhodopsin mediated signaling; visual perception; retina development in camera-type eye; retinoid metabolic process; protein-chromophore linkage; protein amino acid phosphorylation
Reference #:  P08100 (UniProtKB)
Alt. Names/Synonyms: CSNBAD1; MGC138309; MGC138311; OPN2; OPSD; opsin 2, rod pigment; Opsin-2; retinitis pigmentosa 4, autosomal dominant; RHO; Rhodopsin; rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant); RP4
Gene Symbols: RHO
Molecular weight: 38,893 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Rhodopsin

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y136-p VVLAIERyVVVCKPM
0 2 Y301-p FAKSAAIyNPVIyIM
0 1 Y306-p AIyNPVIyIMMNKQF
7 4 S334 PLGDDEASATVSKTE
1 0 A335 LGDDEASATVSKTET
1 1 T336 GDDEASATVSKTETS
7 4 S338 DEASATVSKTETSQV
2 1 T340 ASATVSKTETSQVAP
1 2 T342 ATVSKTETSQVAPA_
4 4 S343 TVSKTETSQVAPA__
  mouse

 
Y136 VVLAIERYVVVCKPM
Y301 FAKSSSIYNPVIYIM
Y306 SIYNPVIYIMLNKQF
S334-p PLGDDDAsATAsKtE
A335 LGDDDAsATAsKtEt
T336 GDDDAsATAsKtEts
S338-p DDAsATAsKtEtsQV
T340-p AsATAsKtEtsQVAP
T342-p ATAsKtEtsQVAPA_
S343-p TAsKtEtsQVAPA__
  rat

 
Y136 VVLAIERYVVVCKPM
Y301 FAKTASIYNPIIYIM
Y306 SIYNPIIYIMMNKQF
S334-p PLGDDEAsAtAsKTE
A335 LGDDEAsAtAsKTEt
T336-p GDDEAsAtAsKTEts
S338-p DEAsAtAsKTEtsQV
T340 AsAtAsKTEtsQVAP
T342-p AtAsKTEtsQVAPA_
S343-p tAsKTEtsQVAPA__
  cow

 
Y136 VVLAIERYVVVCKPM
Y301 FAKTSAVYNPVIYIM
Y306 AVYNPVIYIMMNKQF
S334-p PLGDDEAsttVsKtE
T335-p LGDDEAsttVsKtEt
T336-p GDDEAsttVsKtEts
S338-p DEAsttVsKtEtsQV
T340-p AsttVsKtEtsQVAP
T342-p ttVsKtEtsQVAPA_
S343-p tVsKtEtsQVAPA__
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