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rhodopsin (human)

Overview rhodopsin a G-protein coupled receptor. The light-absorbing visual pigment in Rod photoreceptor cells. Mediates vision in dim light. Consists of the apoprotein, opsin, covalently linked to cis-retinal. Defects in RHO are a cause of autosomal retinitis pigmentosa and congenital stationary night blindness. Note: This description may include information from UniProtKB. Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral Cellular Component: Golgi apparatus; photoreceptor outer segment; photoreceptor inner segment; integral to plasma membrane; plasma membrane Molecular Function: G-protein coupled receptor activity; protein binding; metal ion binding; photoreceptor activity Biological Process: rhodopsin mediated signaling; G-protein coupled receptor protein signaling pathway; phototransduction, visible light; visual perception; retina development in camera-type eye; protein-chromophore linkage; protein amino acid phosphorylation Reference #:  P08100 (UniProtKB) Alt. Names/Synonyms: CSNBAD1; MGC138309; MGC138311; OPN2; OPSD; opsin 2, rod pigment; Opsin-2; retinitis pigmentosa 4, autosomal dominant; RHO; Rhodopsin; rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant); RP4 Gene Symbols: RHO Molecular weight: 38,893 Da Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below rhodopsin 1BOJ - A=1-348 (cow) 1BOK - A=1-348 (cow) 1EDS - A=93-123 (cow) 1EDV - A=172-205 (cow) 1EDW - A=268-293 (cow) 1EDX - A=1-40 (cow) 1F88 - A/B=1-348 (cow) 1FDF - A=291-315 (cow) 1GZM - A/B=1-348 (cow) 1HZX - A/B=1-348 (cow) 1JFP - A=1-348 (cow) 1L9H - A/B=1-348 (cow) 1LN6 - A=1-348 (cow) 1N3M - A/B/C/D/E/F=1-348 (cow) 1NZS - A=330-348 (cow) 1OV0 - A=1-348 (cow) 1OV1 - A=1-348 (cow) 1U19 - A/B=1-348 (cow) 1VQX - A=330-348 (cow) 2G87 - A/B=1-348 (cow) 2HPY - A/B=1-348 (cow) 2I35 - A=1-348 (cow) 2I36 - A/B/C=1-348 (cow) 2I37 - A/B/C=1-348 (cow) 2IQK - A=1-348 (cow) 2J4Y - A/B=1-348 (cow) 2PED - A/B=1-348 (cow) 2X72 - A=1-348 (cow) 3C9L - A=1-348 (cow) 3C9M - A=1-348 (cow) 3CAP - A/B=1-348 (cow) 3DQB - A=1-348 (cow) 3OAX - A/B=1-348 (cow) 3PQR - A=1-348 (cow) 3PXO - A=1-348 (cow) 4A4M - A=1-348 (cow) 4BEY - A=1-348 (cow) 4BEZ - A=1-348 (cow)

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y136-p	VVLAIERyVVVCKPM
0	2		Y301-p	FAKSAAIyNPVIyIM
0	1		Y306-p	AIyNPVIyIMMNKQF
7	4		S334	PLGDDEASATVSKTE
1	0		A335	LGDDEASATVSKTET
1	1		T336	GDDEASATVSKTETS
7	4		S338	DEASATVSKTETSQV
2	1		T340	ASATVSKTETSQVAP
1	2		T342	ATVSKTETSQVAPA_
4	4		S343	TVSKTETSQVAPA__

	mouse
Y136	VVLAIERYVVVCKPM
Y301	FAKSSSIYNPVIYIM
Y306	SIYNPVIYIMLNKQF
S334-p	PLGDDDAsATAsKtE
A335	LGDDDAsATAsKtEt
T336	GDDDAsATAsKtEts
S338-p	DDAsATAsKtEtsQV
T340-p	AsATAsKtEtsQVAP
T342-p	ATAsKtEtsQVAPA_
S343-p	TAsKtEtsQVAPA__

	rat
Y136	VVLAIERYVVVCKPM
Y301	FAKTASIYNPIIYIM
Y306	SIYNPIIYIMMNKQF
S334-p	PLGDDEAsAtAsKTE
A335	LGDDEAsAtAsKTEt
T336-p	GDDEAsAtAsKTEts
S338-p	DEAsAtAsKTEtsQV
T340	AsAtAsKTEtsQVAP
T342-p	AtAsKTEtsQVAPA_
S343-p	tAsKTEtsQVAPA__

	cow
Y136	VVLAIERYVVVCKPM
Y301	FAKTSAVYNPVIYIM
Y306	AVYNPVIYIMMNKQF
S334-p	PLGDDEAsttVsKtE
T335-p	LGDDEAsttVsKtEt
T336-p	GDDEAsttVsKtEts
S338-p	DEAsttVsKtEtsQV
T340-p	AsttVsKtEtsQVAP
T342-p	ttVsKtEtsQVAPA_
S343-p	tVsKtEtsQVAPA__

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