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Protein Page:
TRAIL-R3 (human)

Overview
TRAIL-R3 Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, anchored
Cellular Component: integral to plasma membrane
Molecular Function: transmembrane receptor activity; TRAIL binding
Biological Process: apoptosis; signal transduction
Reference #:  O14798 (UniProtKB)
Alt. Names/Synonyms: Antagonist decoy receptor for TRAIL/Apo-2L; CD263; DCR1; Decoy receptor 1; Decoy TRAIL receptor without death domain; decoy without an intracellular domain; LIT; Lymphocyte inhibitor of TRAIL; MGC149501; MGC149502; TNF related apoptosis-inducing ligand receptor 3; TNF related TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 3; TNFRSF10C; TR10C; TRAIL receptor 3; TRAIL receptor without an intracellular domain; TRAIL-R3; TRAILR3; TRID; Tumor necrosis factor receptor superfamily member 10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Gene Symbols: TNFRSF10C
Molecular weight: 27,407 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TRAIL-R3

Protein Structure Not Found.


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