activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, regulatory subunit
Molecular Function: protein serine/threonine kinase activator activity; protein binding; cyclin-dependent protein kinase activity; cadherin binding; cyclin-dependent protein kinase 5 activator activity; calcium ion binding; kinase activity; protein kinase binding; protein kinase activity
Biological Process: superior olivary nucleus maturation; axon guidance; acetylcholine receptor signaling, muscarinic pathway; regulation of neuron differentiation; hippocampus development; peptidyl-threonine phosphorylation; axonal fasciculation; neuron migration; neuron differentiation; cell proliferation; embryonic development; peptidyl-serine phosphorylation; ionotropic glutamate receptor signaling pathway; positive regulation of neuron apoptosis; regulation of actin cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; cerebellum development; neuron adhesion; brain development; regulation of cyclin-dependent protein kinase activity; negative regulation of transcription, DNA-dependent; layer formation in the cerebral cortex; neurite development; serine phosphorylation of STAT3 protein
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.