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CDK5R1 (human)

Overview CDK5R1 activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, regulatory subunit Cellular Component: cyclin-dependent protein kinase 5 activator complex; contractile fiber; dendrite; postsynaptic density; dendritic spine; cytosol; growth cone; membrane; cell soma; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleus; neuromuscular junction Molecular Function: protein serine/threonine kinase activator activity; protein binding; cyclin-dependent protein kinase activity; cadherin binding; cyclin-dependent protein kinase 5 activator activity; calcium ion binding; kinase activity; protein kinase binding; protein kinase activity Biological Process: superior olivary nucleus maturation; axon guidance; acetylcholine receptor signaling, muscarinic pathway; regulation of neuron differentiation; hippocampus development; peptidyl-threonine phosphorylation; axonal fasciculation; neuron migration; neuron differentiation; cell proliferation; embryonic development; peptidyl-serine phosphorylation; ionotropic glutamate receptor signaling pathway; positive regulation of neuron apoptosis; regulation of actin cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; cerebellum development; neuron adhesion; brain development; regulation of cyclin-dependent protein kinase activity; negative regulation of transcription, DNA-dependent; layer formation in the cerebral cortex; neurite development; serine phosphorylation of STAT3 protein Reference #:  Q15078 (UniProtKB) Alt. Names/Synonyms: CD5R1; CDK5 activator 1; CDK5P35; CDK5R; CDK5R1; Cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 activator 1, p25; Cyclin-dependent kinase 5 activator 1, p35; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); MGC33831; NCK5A; neuronal CDK5 activator; p23; p25; p35; p35nck5a; regulatory partner for CDK5 kinase; Tau protein kinase II 23 kDa subunit; tau protein kinase II 23kDa subunit; TPKII regulatory subunit Gene Symbols: CDK5R1 Molecular weight: 34,060 Da Basal Isoelectric point: 9.44  Predict pI for various phosphorylation states CST Pathways:  Alzheimer's Disease Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDK5R1 1H4L - D/E=147-293 (human) 1UNG - D/E=100-307 (human) 1UNH - D/E=100-307 (human) 1UNL - D/E=100-307 (human) 3O0G - D/E=145-293 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1H4L 1UNG 1UNH 1UNL 3O0G  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: T138‑p cytoskeletal reorganization: T138‑p inhibition: T138‑p intracellular localization: S8‑p protein stabilization: S8‑p, T138‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S6	__MGTVLSLsPSYRK
5	0		S8-p	MGTVLSLsPSYRKAT
1	0		S33	HYTAVQNSKNAKDKN
1	0		S91	ENLKKSLSCANLSTF
6	0		T138-p	PAVTSAGtPKRVIVQ

	mouse
S6-p	__MGTVLsLsPSYRK
S8-p	MGTVLsLsPSYRKAT
S33-p	HYTAVQNsKNAKDKN
S91-p	ENLKKSLsCANLSTF
T138-p	PAITSAGtPKRVIVQ

	rat
S6	__MGTVLSLsPSYRK
S8-p	MGTVLSLsPSYRKAT
S33	HYTAVQNSKNAKDKN
S91-p	ENLKKSLsCANLSTF
T138-p	PAITSAGtPKRVIVQ

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