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Protein Page:
CDK5R1 (human)

Overview
CDK5R1 activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: contractile fiber; cyclin-dependent protein kinase 5 activator complex; postsynaptic density; dendrite; dendritic spine; cytosol; growth cone; cell soma; membrane; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; neuromuscular junction; nucleus
Molecular Function: protein serine/threonine kinase activator activity; protein binding; ephrin receptor binding; cadherin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase 5 activator activity; kinase activity; calcium ion binding; protein kinase binding; protein kinase activity
Biological Process: axon guidance; superior olivary nucleus maturation; regulation of neuron differentiation; rhythmic process; neuron migration; negative regulation of axon extension; neuron differentiation; positive regulation of neuron apoptosis; ephrin receptor signaling pathway; cerebellum development; neuron adhesion; neurite development; layer formation in the cerebral cortex; serine phosphorylation of STAT3 protein; acetylcholine receptor signaling, muscarinic pathway; hippocampus development; axonal fasciculation; peptidyl-threonine phosphorylation; cell proliferation; peptidyl-serine phosphorylation; embryonic development; ionotropic glutamate receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; brain development; regulation of cyclin-dependent protein kinase activity; negative regulation of transcription, DNA-dependent
Reference #:  Q15078 (UniProtKB)
Alt. Names/Synonyms: CD5R1; CDK5 activator 1; CDK5P35; CDK5R; CDK5R1; Cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 activator 1, p25; Cyclin-dependent kinase 5 activator 1, p35; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); MGC33831; NCK5A; neuronal CDK5 activator; p23; p25; p35; p35nck5a; regulatory partner for CDK5 kinase; Tau protein kinase II 23 kDa subunit; tau protein kinase II 23kDa subunit; TPKII regulatory subunit
Gene Symbols: CDK5R1
Molecular weight: 34,060 Da
Basal Isoelectric point: 9.44  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDK5R1

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: T138‑p
cytoskeletal reorganization: T138‑p
activity, inhibited: T138‑p
intracellular localization: S8‑p
molecular association, regulation: S91‑p
protein degradation: S91‑p
protein stabilization: S8‑p, T138‑p
ubiquitination: S91‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S6 __MGTVLSLsPSYRK
5 1 S8-p MGTVLSLsPSYRKAT
1 0 S33 HYTAVQNSKNAKDKN
2 0 S91-p ENLKKSLsCANLSTF
6 0 T138-p PAVTSAGtPKRVIVQ
  mouse

 
S6-p __MGTVLsLsPSYRK
S8-p MGTVLsLsPSYRKAT
S33-p HYTAVQNsKNAKDKN
S91-p ENLKKSLsCANLSTF
T138-p PAITSAGtPKRVIVQ
  rat

 
S6 __MGTVLSLsPSYRK
S8-p MGTVLSLsPSYRKAT
S33 HYTAVQNSKNAKDKN
S91-p ENLKKSLsCANLSTF
T138-p PAITSAGtPKRVIVQ
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