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Protein Page:
PEX1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PEX1 Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Belongs to the AAA ATPase family. Interacts directly with PEX6. Interacts indirectly with PEX26, via its interaction with PEX6. Note: This description may include information from UniProtKB.
Protein type: Hydrolase
Cellular Component: peroxisomal membrane; intracellular membrane-bound organelle; cytoplasm; peroxisome; cytosol
Molecular Function: protein C-terminus binding; protein binding; protein complex binding; ATPase activity, coupled; ATP binding
Biological Process: ATP catabolic process; protein targeting to peroxisome; peroxisome organization and biogenesis; microtubule-based peroxisome localization; protein import into peroxisome matrix
Reference #:  O43933 (UniProtKB)
Alt. Names/Synonyms: Peroxin-1; peroxisomal biogenesis factor 1; Peroxisome biogenesis disorder protein 1; Peroxisome biogenesis factor 1; PEX1; Zellweger syndrome; ZWS; ZWS1
Gene Symbols: PEX1
Molecular weight: 142,867 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
Select Structure to View Below

PEX1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y202-p EYKKLHSyGRDQKGM
0 2 K349 KQQQSKTKQNVLsPE
0 1 S354-p KTKQNVLsPEKEKQM
0 1 K357 QNVLsPEKEKQMSEP
0 1 K411 VEVLHLGKVWIPDDL
0 1 T438-p RITPVEVtPKIPRSL
0 1 K455 QPRENLPKDISEEDI
0 1 D461 PKDISEEDIKTVFYS
0 1 T475 SWLQQSTTTMLPLVI
0 1 T476 WLQQSTTTMLPLVIS
0 1 S483 TMLPLVISEEEFIKL
0 1 K614 TLAKAICKEAFDKLD
0 1 K630 HVERVDCKALRGKRL
0 1 K806-u QSISTREkLVLTTLD
0 1 K816 LTTLDFQKALRGFLP
1 1 K833-u LRSVNLHkPRDLGWD
0 1 K841 PRDLGWDKIGGLHEV
0 8 Y880-p QRTGILLyGPPGTGK
0 1 K913 KGPELLSKYIGASEQ
0 2 S1114 SLVSLEMSEILPDES
0 2 S1121 SEILPDESKFNMYRL
0 2 Y1126 DESKFNMYRLYFGSS
0 2 T1179-p SQPPVLRtAsQEGCQ
0 9 S1181-p PPVLRtAsQEGCQEL
0 18 S1209-p IIKGRYRsQsGEDES
0 33 S1211-p KGRYRsQsGEDESMN
0 2 S1216 sQsGEDESMNQPGPI
0 1 K1224-u MNQPGPIkTRLAISQ
0 1 S1270-p PKRRKNQsGTMFRPG
  mouse

 
Y202 AHGQVHSYGREQKGL
K348-u KQQQDKSkQGVLLPD
L353 KSkQGVLLPDkEKQL
K356-u QGVLLPDkEKQLSKS
K410-u LELLHRGkVWIPDDL
T437 RITPLETTPKIPRSL
K454-u QPRENLPkDVNEEtI
T460-p PkDVNEEtIKTVFSS
T474-p SWVQQSAttMLPLVI
T475-p WVQQSAttMLPLVIs
S482-p tMLPLVIsKEERIKL
K615-u TFAKAICkEAQDTLD
K631-u RVETVDCkALRGKRL
- gap
K817-u LTTSDFQkALRGFLP
K834 LRNVNLHKPRDLGWD
K842-u PRDLGWDkIGGLHEV
Y881-p QRTGILLyGPPGTGK
K914-u KGPELLSkYIGASEQ
S1115-p SLLSLEMsEILPDEs
S1122-p sEILPDEsKFNMyRL
Y1127-p DEsKFNMyRLYFGSS
T1180-p TQHPVFRtPsQEGCQ
S1182-p HPVFRtPsQEGCQDL
S1210-p IIKGRYRsQsGEDEs
S1212-p KGRYRsQsGEDEsLN
S1217-p sQsGEDEsLNQPGPI
K1225 LNQPGPIKTTFAISQ
S1271 PKKRKNQSGTVFRTG
  rat

 
Y202 ARGQAHNYGREQKGT
K348 KQQQDKSKQGVLLPE
L353 KSKQGVLLPEKEKQL
K356 QGVLLPEKEKQLSQS
K410 LEPLHHGKVWIPADL
T437 RITPLETTPVIPRAL
R454 QPAENLPRDVSEEEV
E460 PRDVSEEEVKAVFSS
T474 SWLQESATTMFPLII
T475 WLQESATTMFPLIIS
S482 TMFPLIISKQECIKL
K614 TLAKAICKEAHDALD
K630 HVEMVDCKALRGKRL
- gap
K816 LTTADFQKALRGFLP
K833 LRNVNLHKPRDLGWD
K841 PRDLGWDKIGGLHEV
Y880 QRTGILLYGPPGTGK
K913 QGPELLSKYIGASEQ
S1114 SLVSLEMSEILPDES
S1121 SEILPDESKFNMYRL
Y1126 DESKFNMYRLYFGSS
T1179 TQHPVFRTPsQEGSQ
S1181-p HPVFRTPsQEGSQDL
S1209 IIKGRYQSQSGEDES
S1211 KGRYQSQSGEDESLN
S1216 SQSGEDESLNQPGPI
K1224 LNQPGPIKTSFAISQ
S1270 PKKRKNQSGTVFRTG
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