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Protein Page:
PEX1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PEX1 Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Belongs to the AAA ATPase family. Interacts directly with PEX6. Interacts indirectly with PEX26, via its interaction with PEX6. Note: This description may include information from UniProtKB.
Protein type: Hydrolase
Chromosomal Location of Human Ortholog: 7q21.2
Cellular Component: peroxisomal membrane; intracellular membrane-bound organelle; cytoplasm; peroxisome; cytosol
Molecular Function: protein C-terminus binding; protein binding; protein complex binding; ATPase activity, coupled; ATP binding
Biological Process: ATP catabolic process; peroxisome organization and biogenesis; protein targeting to peroxisome; microtubule-based peroxisome localization; protein import into peroxisome matrix
Reference #:  O43933 (UniProtKB)
Alt. Names/Synonyms: Peroxin-1; peroxisomal biogenesis factor 1; Peroxisome biogenesis disorder protein 1; Peroxisome biogenesis factor 1; PEX1; Zellweger syndrome; ZWS; ZWS1
Gene Symbols: PEX1
Molecular weight: 142,867 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
Select Structure to View Below

PEX1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S201 AEYKKLHSyGRDQKG
0 2 Y202-p EYKKLHSyGRDQKGM
0 1 S264-p SEKKQETsWGLTEIN
0 1 S278-p NAFKNMQsKVVPLDN
0 2 K349 KQQQSKTKQNVLsPE
0 2 S354-p KTKQNVLsPEKEKQM
0 1 K357 QNVLsPEKEKQMSEP
0 1 S362 PEKEKQMSEPLDQKK
0 1 P364 KEKQMSEPLDQKKIR
0 1 K411 VEVLHLGKVWIPDDL
0 1 T438-p RITPVEVtPKIPRSL
0 1 K455 QPRENLPKDISEEDI
0 1 D461 PKDISEEDIKTVFYS
0 1 T475 SWLQQSTTTMLPLVI
0 1 T476 WLQQSTTTMLPLVIS
0 1 S483 TMLPLVISEEEFIKL
0 1 S585-p PLSRQLMsLVAGLRN
0 1 K614 TLAKAICKEAFDKLD
0 1 K630 HVERVDCKALRGKRL
0 1 K806-ub QSISTREkLVLttLD
0 1 T810-p TREkLVLttLDFQKA
0 1 T811-p REkLVLttLDFQKAL
0 1 K816 LttLDFQKALRGFLP
1 1 K833-ub LRSVNLHkPRDLGWD
0 1 K841 PRDLGWDKIGGLHEV
0 8 Y880-p QRTGILLyGPPGtGK
0 2 T885-p LLyGPPGtGKTLLAG
0 1 K913 KGPELLSKYIGASEQ
0 2 S1114 SLVSLEMSEILPDES
0 2 S1121 SEILPDESKFNMYRL
0 2 Y1126 DESKFNMYRLYFGSS
0 1 S1172-p PGKDQLFsQPPVLRt
0 4 T1179-p sQPPVLRtAsQEGCQ
0 16 S1181-p PPVLRtAsQEGCQEL
0 1 S1201-p DQLRADIsIIKGRyR
0 1 Y1207-p IsIIKGRyRsQsGED
0 20 S1209-p IIKGRyRsQsGEDEs
0 38 S1211-p KGRyRsQsGEDEsMN
0 5 S1216-p sQsGEDEsMNQPGPI
0 1 K1224-ub MNQPGPIkTRLAISQ
0 2 S1270-p PKRRKNQsGTMFRPG
  mouse

 
S201-p DAHGQVHsYGREQKG
Y202 AHGQVHsYGREQKGL
A263 PDSKQESAWGSLELG
S277 GAFKNMQSQAAPLEG
K348-ub KQQQDKSkQGVLLPD
L353 KSkQGVLLPDkEKQL
K356-ub QGVLLPDkEKQLsKs
S361-p PDkEKQLsKsPDHKQ
S363-p kEKQLsKsPDHKQIS
K410-ub LELLHRGkVWIPDDL
T437 RITPLETTPKIPRSL
K454-ub QPRENLPkDVNEEtI
T460-p PkDVNEEtIKTVFSS
T474-p SWVQQSAttMLPLVI
T475-p WVQQSAttMLPLVIs
S482-p tMLPLVIsKEERIKL
A586 PLSRQLMALVAGLRN
K615-ub TFAKAICkEAQDTLD
K631-ub RVETVDCkALRGKRL
- gap
T811 SREDLTLTTSDFQkA
T812 REDLTLTTSDFQkAL
K817-ub LTTSDFQkALRGFLP
K834 LRNVNLHKPRDLGWD
K842-ub PRDLGWDkIGGLHEV
Y881-p QRTGILLyGPPGTGK
T886 LLyGPPGTGKTLLAG
K914-ub KGPELLSkYIGASEQ
S1115-p SLLSLEMsEILPDEs
S1122-p sEILPDEsKFNMyRL
Y1127-p DEsKFNMyRLYFGSS
T1173 PGKDPLFTQHPVFRt
T1180-p TQHPVFRtPsQEGCQ
S1182-p HPVFRtPsQEGCQDL
S1202 DQLRAEISIIKGRYR
Y1208 ISIIKGRYRsQsGED
S1210-p IIKGRYRsQsGEDEs
S1212-p KGRYRsQsGEDEsLN
S1217-p sQsGEDEsLNQPGPI
K1225 LNQPGPIKTTFAISQ
S1271 PKKRKNQSGTVFRTG
  rat

 
N201 DARGQAHNYGREQKG
Y202 ARGQAHNYGREQKGT
A263 PDNKQESAWGSLELG
S277 GAFKNMQSQTVPLDS
K348 KQQQDKSKQGVLLPE
L353 KSKQGVLLPEKEKQL
K356 QGVLLPEKEKQLSQS
S361 PEKEKQLSQSPGHKR
S363 KEKQLSQSPGHKRIG
K410 LEPLHHGKVWIPADL
T437 RITPLETTPVIPRAL
R454 QPAENLPRDVSEEEV
E460 PRDVSEEEVKAVFSS
T474 SWLQESATTMFPLII
T475 WLQESATTMFPLIIS
S482 TMFPLIISKQECIKL
A585 PLSRQLMALVAGLRN
K614 TLAKAICKEAHDALD
K630 HVEMVDCKALRGKRL
- gap
T810 TREGLTLTTADFQKA
T811 REGLTLTTADFQKAL
K816 LTTADFQKALRGFLP
K833 LRNVNLHKPRDLGWD
K841 PRDLGWDKIGGLHEV
Y880 QRTGILLYGPPGTGK
T885 LLYGPPGTGKTLLAG
K913 QGPELLSKYIGASEQ
S1114 SLVSLEMSEILPDES
S1121 SEILPDESKFNMYRL
Y1126 DESKFNMYRLYFGSS
T1172 PGKDPLFTQHPVFRT
T1179 TQHPVFRTPsQEGSQ
S1181-p HPVFRTPsQEGSQDL
S1201 DQLRADISIIKGRYQ
Y1207 ISIIKGRYQsQSGED
S1209-p IIKGRYQsQSGEDES
S1211 KGRYQsQSGEDESLN
S1216 sQSGEDESLNQPGPI
K1224 LNQPGPIKTSFAISQ
S1270 PKKRKNQSGTVFRTG
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