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Protein Page:
PLXNA3 (human)

Overview
PLXNA3 Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with CBFA2T3/MTG16. Belongs to the plexin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: membrane; plasma membrane; integral to membrane; intracellular
Molecular Function: protein binding; transmembrane receptor activity; semaphorin receptor activity
Biological Process: axon guidance; multicellular organismal development; hippocampus development; negative chemotaxis; positive regulation of cytoskeleton organization and biogenesis; pyramidal neuron development; negative regulation of axon extension involved in axon guidance
Reference #:  P51805 (UniProtKB)
Alt. Names/Synonyms: 6.3; HSSEXGENE; plexin 4; plexin A3; Plexin-4; Plexin-A3; PLXA3; PLXN3; PLXN4; PLXNA3; Semaphorin receptor SEX; SEX; Sex chromosome X transmembrane protein of HGF receptor family 3; XAP-6
Gene Symbols: PLXNA3
Molecular weight: 207,703 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLXNA3

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S283-p VEFPIGCsWRGVEyR
0 1 Y289-p CsWRGVEyRLVQSAH
0 1 T606-p LQELRALtRGHGATR
0 1 T614-p RGHGATRtVRLQLLS
0 1 S948 SPSRGPASGGTRLTI
0 1 T951 RGPASGGTRLTISGs
0 2 S958-p TRLTISGsSLDAGsR
0 1 S964-p GsSLDAGsRVTVTVR
0 1 Y1122-p NRSSFTYyPDPSFEP
0 2 T1236-p GLLLLAItAVLVAYK
0 1 T1322-p PVLKELDtPPNVEKA
0 1 T1380 QSRLDYATGLLKQLL
0 1 Y1461-p AITGEARySLSEDKL
0 1 Y1475-p LIRQQIDyKTLTLHC
0 1 T1513-p AKDKLLDtVyKGIPY
0 1 Y1515-p DKLLDtVyKGIPYSQ
0 1 T1568-p SLAHYQVtDGsLVAL
0 1 S1571-p HYQVtDGsLVALVPK
0 1 S1581-p ALVPKQVsAyNMANS
0 2 Y1583-p VPKQVsAyNMANSFT
0 2 S1596-p FTFTRSLsRYESLLR
0 6 S1610-p RTASSPDsLRSRAPM
0 1 S1822-p RLHASDFsVLsALNE
0 1 S1825-p ASDFsVLsALNELyF
0 1 Y1831-p LsALNELyFYVTKYR
  mouse

 
S284 VEFPIGCSWRGVEYR
Y290 CSWRGVEYRLVQSAH
T607 LQELQTLTRGHGATH
T615 RGHGATHTVRLQLLS
S949-p SPSRGPAsGGtRLTI
T952-p RGPAsGGtRLTISGI
I959 tRLTISGISLDAGSR
S965 GISLDAGSRVTVIIR
Y1123 NRSSFTYYPDPSFEP
T1237-p GLLLLAItVVLVAYK
T1323 PVLKELDTPPNVEKA
T1381 QSRLDYATGLLKQLL
Y1462 AITGEARYSLSEDKL
Y1476 LIRQQIDYKTLTLHC
T1514 AKDKLLDTVYKGIPY
Y1516 DKLLDTVYKGIPYSQ
T1569 SLAHYQVTDGSLVAL
S1572 HYQVTDGSLVALVPK
S1582 ALVPKQVSAYNMANS
Y1584 VPKQVSAYNMANSFT
S1597 FTFTRSLSRYESLLR
S1611 RAASSPDSLRSRAPM
N1823 RLHANDFNVLSALSE
S1826 ANDFNVLSALSELYF
Y1832 LSALSELYFYVTKYR
  rat

 
S284 VEFPIGCSWRGVEYR
Y290 CSWRGVEYRLVQSAH
T607 LQELQTLTRGHGATH
T615 RGHGATHTVRLQLLS
S949 SPTRGPASGGTRLTI
T952 RGPASGGTRLTISGT
T959 TRLTISGTSLDAGSR
S965 GTSLDAGSRVTVIIR
Y1123 NRSSFTYYPDPSFEP
T1237 GLLLLAITVVLVAYK
T1323 PVLKELDTPPNVEKA
T1381-p QSRLDYAtGLLKQLL
Y1462 AITGEARYSLSEDKL
Y1476 LIRQQIDYKTLTLHC
T1514 AKDKLLDTVYKGIPY
Y1516 DKLLDTVYKGIPYSQ
T1569 SLAHYQVTDGSLVAL
S1572 HYQVTDGSLVALVPK
S1582 ALVPKQVSAYNMANS
Y1584 VPKQVSAYNMANSFT
S1597 FTFTRSLSRYESLLR
S1611 RAASSPDSLRSRAPM
N1823 RLHANDFNVLSALSE
S1826 ANDFNVLSALSELYF
Y1832 LSALSELYFYVTKYR
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