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PLXNA3 (human)

Overview PLXNA3 Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with CBFA2T3/MTG16. Belongs to the plexin family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: membrane; integral to membrane; plasma membrane; intracellular Molecular Function: transmembrane receptor activity; semaphorin receptor activity Biological Process: axon guidance; multicellular organismal development; hippocampus development; negative chemotaxis; positive regulation of cytoskeleton organization and biogenesis; pyramidal neuron development; negative regulation of axon extension involved in axon guidance Reference #:  P51805 (UniProtKB) Alt. Names/Synonyms: 6.3; HSSEXGENE; plexin 4; plexin A3; Plexin-4; Plexin-A3; PLXA3; PLXN3; PLXN4; PLXNA3; Semaphorin receptor SEX; SEX; Sex chromosome X transmembrane protein of HGF receptor family 3; XAP-6 Gene Symbols: PLXNA3 Molecular weight: 207,703 Da Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PLXNA3

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S283-p	VEFPIGCsWRGVEyR
0	1		Y289-p	CsWRGVEyRLVQSAH
0	1		T606-p	LQELRALtRGHGATR
0	1		T614-p	RGHGATRtVRLQLLS
0	1		S948	SPSRGPASGGTRLTI
0	1		T951	RGPASGGTRLTISGs
0	2		S958-p	TRLTISGsSLDAGsR
0	1		S964-p	GsSLDAGsRVTVTVR
0	1		Y1122-p	NRSSFTYyPDPSFEP
0	2		T1236-p	GLLLLAItAVLVAYK
0	1		T1380	QSRLDYATGLLKQLL
0	1		Y1461-p	AITGEARySLSEDKL
0	1		Y1475-p	LIRQQIDyKTLTLHC
0	1		S1581-p	ALVPKQVsAyNMANS
0	2		Y1583-p	VPKQVsAyNMANSFT
0	1		S1822-p	RLHASDFsVLsALNE
0	1		S1825-p	ASDFsVLsALNELYF

	mouse
S284	VEFPIGCSWRGVEYR
Y290	CSWRGVEYRLVQSAH
T607	LQELQTLTRGHGATH
T615	RGHGATHTVRLQLLS
S949-p	SPSRGPAsGGtRLTI
T952-p	RGPAsGGtRLTISGI
I959	tRLTISGISLDAGSR
S965	GISLDAGSRVTVIIR
Y1123	NRSSFTYYPDPSFEP
T1237-p	GLLLLAItVVLVAYK
T1381	QSRLDYATGLLKQLL
Y1462	AITGEARYSLSEDKL
Y1476	LIRQQIDYKTLTLHC
S1582	ALVPKQVSAYNMANS
Y1584	VPKQVSAYNMANSFT
N1823	RLHANDFNVLSALSE
S1826	ANDFNVLSALSELYF

	rat
S284	VEFPIGCSWRGVEYR
Y290	CSWRGVEYRLVQSAH
T607	LQELQTLTRGHGATH
T615	RGHGATHTVRLQLLS
S949	SPTRGPASGGTRLTI
T952	RGPASGGTRLTISGT
T959	TRLTISGTSLDAGSR
S965	GTSLDAGSRVTVIIR
Y1123	NRSSFTYYPDPSFEP
T1237	GLLLLAITVVLVAYK
T1381-p	QSRLDYAtGLLKQLL
Y1462	AITGEARYSLSEDKL
Y1476	LIRQQIDYKTLTLHC
S1582	ALVPKQVSAYNMANS
Y1584	VPKQVSAYNMANSFT
N1823	RLHANDFNVLSALSE
S1826	ANDFNVLSALSELYF

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