a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies in the mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Molecular Function: JUN kinase binding; MAP-kinase scaffold activity; protein binding; receptor signaling complex scaffold activity; kinesin binding; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding
Biological Process: vesicle-mediated transport; positive regulation of JNK activity; axon guidance; protein localization; positive regulation of signal transduction; in utero embryonic development; regulation of gene expression; forebrain development; JNK cascade; respiratory gaseous exchange; positive regulation of neuron differentiation; alveolus development; regulation of JNK cascade; activation of JNK activity; post-embryonic development
Alt. Names/Synonyms: BB120594; c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1; C-Jun-amino-terminal kinase-interacting protein 3; D17Wsu15e; JIP-3; Jip3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1; JNK/SAPK-associated protein 1c; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; JUN/SAPK-associated protein 1; Mapk8ip3; mitogen activated protein kinase 8 interacting protein 3; mitogen-activated protein kinase 8 interacting protein 3; Mitogen-activated protein kinase 8-interacting protein 3; mKIAA1066; Sunday driver 2; Syd2
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.