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Protein Page:
JIP3 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
JIP3 a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies in the mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: Golgi membrane; Golgi apparatus; neuron projection; cell projection; smooth endoplasmic reticulum; cytoplasm; dendrite; plasma membrane; cytoplasmic vesicle; axolemma
Molecular Function: JUN kinase binding; MAP-kinase scaffold activity; protein binding; kinesin binding; mitogen-activated protein kinase kinase binding; kinase activity; mitogen-activated protein kinase kinase kinase binding; protein kinase binding
Biological Process: axon guidance; positive regulation of JNK activity; in utero embryonic development; respiratory gaseous exchange; regulation of JNK cascade; activation of JNK activity; post-embryonic development; vesicle-mediated transport; protein localization; regulation of gene expression; forebrain development; JNK cascade; positive regulation of neuron differentiation; phosphorylation; alveolus development
Reference #:  Q9ESN9 (UniProtKB)
Alt. Names/Synonyms: BB120594; c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1; C-Jun-amino-terminal kinase-interacting protein 3; D17Wsu15e; JIP-3; Jip3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1; JNK/SAPK-associated protein 1c; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; JUN/SAPK-associated protein 1; Mapk8ip3; mitogen activated protein kinase 8 interacting protein 3; mitogen-activated protein kinase 8 interacting protein 3; Mitogen-activated protein kinase 8-interacting protein 3; mKIAA1066; Sunday driver 2; Syd2
Gene Symbols: Mapk8ip3
Molecular weight: 147,561 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
Select Structure to View Below

JIP3
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        mouse

► Hide Isoforms 		 
0 1 R84 EVELELLREDNEQLL
0 1 R101 YEREKALRKQAEEKF
0 1 K102 EREKALRKQAEEKFI
0 1 S148-p KNYADQIsRLEEREs
0 1 S155-p sRLEEREsEMKKEYN
0 2 K183-u VEHIERSkMQQVGGS
0 4 S201 ESSLPGRSRKERPTS
0 1 T207 RSRKERPTSLNVFPL
2 0 T266-p GQSSAAAtPSTTGTK
2 0 T276-p TTGTKSNtPtSSVPS
0 1 T278-p GTKSNtPtSSVPSAA
2 1 T287-p SVPSAAVtPLNESLQ
1 0 S315 QAREKRNSRNMEVQV
0 1 T363-p PETRLERtGssPtQG
1 2 S365-p TRLERtGssPtQGIV
1 8 S366-p RLERtGssPtQGIVN
0 1 T368-p ERtGssPtQGIVNKA
0 1 K435-u NSQLLETkNALNVVK
0 2 S582-p QFFSRLFsssSsPPP
0 1 S583-p FFSRLFsssSsPPPA
0 1 S584-p FSRLFsssSsPPPAK
0 5 S586-p RLFsssSsPPPAKRS
0 1 S596-p PAKRSYPsVNIHYKs
1 0 Y601 YPsVNIHYKsPTAAG
0 15 S603-p sVNIHYKsPTAAGFs
0 2 A606 IHYKsPTAAGFsQRR
0 1 S610-p sPTAAGFsQRRSHAL
1 0 Y648 REQKREQYRQVREHV
0 5 S677-p PAKYKQLsPNGGQED
0 1 T685 PNGGQEDTRMKNVPV
1 0 Y695 KNVPVPVYCRPLVEK
0 1 S717 CAAGVNLSGWKPHEE
0 1 S751-p EGEGEPKsTHPsPEK
0 2 S755-p EPKsTHPsPEKKKAK
0 1 T764-p EKKKAKEtPEADATS
0 1 T780 RVWILTSTLTTSKVV
0 1 S864-p NVPRSNCssRGDtPV
0 1 S865-p VPRSNCssRGDtPVL
0 1 T869-p NCssRGDtPVLDKGQ
0 1 T914 PSESEATTVRPGPLT
0 14 S1144 GTGKLGFSFVRITAL
0 1 S1192-p GLRANKTsPTSGEGT
0 1 S1287 LKNALVLSGGEGYID
  JIP3 iso2  
R84 EVELELLREDNEQLL
R101 YEREKALRKQAEEKF
K102 EREKALRKQAEEKFI
S148 KNYADQISRLEERES
S155 SRLEERESEMKKEYN
K183 VEHIERSKMQQVGGS
- gap
T206 GRRKERPTSLNVFPL
T234-p GQSSAAAtPSTTGTK
T244-p TTGTKSNtPtSSVPS
T246-p GTKSNtPtSSVPSAA
T255-p SVPSAAVtPLNESLQ
S283 QAREKRNSRNMEVQV
T331-p PETRLERtGssPTQG
S333-p TRLERtGssPTQGIV
S334-p RLERtGssPTQGIVN
T336 ERtGssPTQGIVNKA
K403 NSQLLETKNALNVVK
S550-p QFFSRLFsSSSsPPP
S551 FFSRLFsSSSsPPPA
S552 FSRLFsSSSsPPPAK
S554-p RLFsSSSsPPPAKRS
S564 PAKRSYPSVNIHyKs
Y569-p YPSVNIHyKsPTAAG
S571-p SVNIHyKsPTAAGFS
A574 IHyKsPTAAGFSQRR
S578 sPTAAGFSQRRSHAL
Y616-p REQKREQyRQVREHV
S645-p PAKYKQLsPNGGQED
T653 PNGGQEDTRMKNVPV
Y663-p KNVPVPVyCRPLVEK
S685 CAAGVNLSGWKPHEE
S719-p EGEGEPKsTHPsPEK
S723-p EPKsTHPsPEKKKAK
T732 EKKKAKETPEADATS
T748 RVWILTSTLTTSKVV
S832-p NVPRSNCssRGDtPV
S833-p VPRSNCssRGDtPVL
T837-p NCssRGDtPVLDKGQ
T882 PSESEATTVRPGPLT
S1112 GTGKLGFSFVRITAL
S1160 GLRANKTSPTSGEGT
S1255 LKNALVLSGGEGYID
  JIP3 iso3  
R84 EVELELLREDNEQLL
R101 YEREKALRKQAEEKF
K102 EREKALRKQAEEKFI
S148 KNYADQISRLEERES
S155 SRLEERESEMKKEYN
K183 VEHIERSKMQQVGGS
S201-p ESSLPGRsPRQSWRK
T215 KSRKERPTSLNVFPL
T243 GQSSAAATPSTTGTK
T253 TTGTKSNTPTSSVPS
T255 GTKSNTPTSSVPSAA
T264 SVPSAAVTPLNESLQ
S292 QAREKRNSRNMEVQV
T340 PETRLERTGSSPTQG
S342 TRLERTGSSPTQGIV
S343 RLERTGSSPTQGIVN
T345 ERTGSSPTQGIVNKA
K412 NSQLLETKNALNVVK
S559 QFFSRLFSSSSSPPP
S560 FFSRLFSSSSSPPPA
S561 FSRLFSSSSSPPPAK
S563 RLFSSSSSPPPAKRS
S573 PAKRSYPSVNIHYKS
Y578 YPSVNIHYKSPTAAG
S580 SVNIHYKSPTAAGFS
A583 IHYKSPTAAGFSQRR
S587 SPTAAGFSQRRSHAL
Y625 REQKREQYRQVREHV
S654 PAKYKQLSPNGGQED
T662 PNGGQEDTRMKNVPV
Y672 KNVPVPVYCRPLVEK
S694 CAAGVNLSGWKPHEE
S728 EGEGEPKSTHPSPEK
S732 EPKSTHPSPEKKKAK
T741 EKKKAKETPEADATS
T757 RVWILTSTLTTSKVV
S841 NVPRSNCSSRGDTPV
S842 VPRSNCSSRGDTPVL
T846 NCSSRGDTPVLDKGQ
T891 PSESEATTVRPGPLT
S1121 GTGKLGFSFVRITAL
S1169 GLRANKTSPTSGEGT
S1264 LKNALVLSGGEGYID
  human

 
R84-m1 EVELELLrEDNEQLL
R101-m1 YEREKALrrQAEEKF
R102-m1 EREKALrrQAEEKFI
S148 KNYADQISRLEERES
S155 SRLEERESEMKKEYN
K183-u VEHIERSkMQQVGGN
- gap
T206-p GRRKERPtSLNVFPL
T265 GQSSAAATPSTTGTK
T275 TTGTKSNTPTSSVPS
T277 GTKSNTPTSSVPSAA
T286 SVPSAAVTPLNESLQ
S314-p RAREKRDsRNMEVQV
T362 PETRLDRTGssPTQG
S364-p TRLDRTGssPTQGIV
S365-p RLDRTGssPTQGIVN
T367 DRTGssPTQGIVNKA
K434 NSQLLETKNALNVVK
S581 QFFSRLFSSSSsPPP
S582 FFSRLFSSSSsPPPA
S583 FSRLFSSSSsPPPAK
S585-p RLFSSSSsPPPAKRP
S595 PAKRPYPSVNIHYKs
Y600 YPSVNIHYKsPTtAG
S602-p SVNIHYKsPTtAGFs
T605-p IHYKsPTtAGFsQRR
S609-p sPTtAGFsQRRNHAM
Y647 REQKREQYRQVREHV
S676-p PAKYKQLsPNGGQED
T684-p PNGGQEDtRMKNVPV
Y694 KNVPVPVYCRPLVEK
S716-p CAAGVNLsGWRPNED
S750 EGDGEPKSAHTSPEK
S754 EPKSAHTSPEKKKAK
L763 EKKKAKELPEMDATS
T779-p RVWILTStLTTSKVV
S863 NVPRSNCSSRGDTPV
S864 VPRSNCSSRGDTPVL
T868 NCSSRGDTPVLDKGQ
T913-p PSEPETAtLRPGPLT
S1143-p GTGKLGFsFVRITAL
S1191 GLRANKTSPTSGEGA
S1286-p LRNVLVLsGGEGYID
  rat

 
R84 EVELELLREDNEQLL
R101 YEREKALRKQAEEKF
K102 EREKALRKQAEEKFI
S148 KNYADQISRLEERES
S155 SRLEERESEMKKEYN
K183 VEHIERSKMQQVGGG
S201 ESSLPGRSRKERPTS
T207 RSRKERPTSLNVFPL
T266 GQSSAAATPSTTGTK
T276 TTGTKSNTPTSSVPS
T278 GTKSNTPTSSVPSAA
T287 SVPSAAVTPLNESLQ
S315 RAREKRNSRNMEVQV
T363 PETRLDRTGSSPTQG
S365 TRLDRTGSSPTQGIV
S366 RLDRTGSSPTQGIVN
T368 DRTGSSPTQGIVNKA
K429 NSQLLETKNALNVVK
S567 QFFSRLFSSSSsPPP
S568 FFSRLFSSSSsPPPA
S569 FSRLFSSSSsPPPAK
S571-p RLFSSSSsPPPAKRS
S581 PAKRSYPSVNIHYKS
Y586 YPSVNIHYKSPTTAG
S588 SVNIHYKSPTTAGFS
T591 IHYKSPTTAGFSQRR
S595 SPTTAGFSQRRNHAL
Y633 REQKREQYRQVREHV
S662 PAKYKQLSPNGGQED
T670 PNGGQEDTRMKNVPV
Y680 KNVPVPVYCRPLVEK
S702 CAAGVNLSGWKPNEE
S736 EGEGEPKSTHPSPEK
S740 EPKSTHPSPEKKKAK
V749 EKKKAKEVPEADATS
T765 RVWILTSTLTTSKVV
S849 NVPRSNCSSRGDTPV
S850 VPRSNCSSRGDTPVL
T854 NCSSRGDTPVLDKGQ
T899 PSESEATTVRPGPLT
S1129 GTGKLGFSFVRITAL
S1177 GLRANKTSPTSGEGT
S1272 LKNALVLSGGEGYID
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