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Protein Page:
TRAF1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRAF1 Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Homotrimer. Heterotrimer with TRAF2. Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2. Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2. Interacts with NFATC2IP, TRAFD1 and with HIVEP3. Interacts with MAP3K14. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis
Cellular Component: cytoplasm
Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; thioesterase binding; tumor necrosis factor receptor binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; protein complex assembly; signal transduction; activation of NF-kappaB transcription factor
Reference #:  Q13077 (UniProtKB)
Alt. Names/Synonyms: EBI6; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6; MGC:10353; TNF receptor-associated factor 1; TRAF1
Gene Symbols: TRAF1
Molecular weight: 46,164 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TRAF1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S66-p GEDLQSIsPGSRLRT
0 5 S69 LQSIsPGSRLRTQEK
0 1 T73 sPGSRLRTQEKAHPE
1 0 K124-ub NLLLGFMkQWKARLG
2 0 S146 MALEQNLSDLQLQAA
0 1 S172 YRAPCSESQEELALQ
1 1 K185-ub LQHFMKEkLLAELEG
1 1 K193-ub LLAELEGkLRVFENI
0 1 Y310-p YKLCLRLyLNGDGtG
0 1 T316-p LyLNGDGtGKRTHLS
  mouse

 
S60-p ADNLHPVsPGsPLtQ
S63-p LHPVsPGsPLtQEKV
T66-p VsPGsPLtQEKVHSD
K117 YLLLAVLKEWKSSPG
S139-p MALERNLsELQLQAA
S165-p YRAPCCEsQEELALQ
K178 LQHLVKEKLLAQLEE
K186 LLAQLEEKLRVFANI
Y303 YKLCLRLYLNGDGSG
S309 LYLNGDGSGKKTHLS
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