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SNAP-25
a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Part of the SNARE core complex containing SNAP25, VAMP2 and syntaxin 1A. Associates with proteins involved in vesicle docking and membrane fusion. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Vesicle protein |
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Cellular Component: voltage-gated potassium channel complex; neuron projection; trans-Golgi network; actin cytoskeleton; lipid raft; SNARE complex; growth cone; cell soma; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; plasma membrane; synapse; cell junction; endosome; filopodium
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Molecular Function: protein domain specific binding; protein binding; voltage-gated potassium channel activity; myosin binding; syntaxin-1 binding; protein N-terminus binding
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Biological Process: neurotransmitter secretion; calcium ion-dependent exocytosis of neurotransmitter; positive regulation of insulin secretion; endosome transport; sleep; synaptic transmission; growth hormone secretion; long-term memory; glutamate secretion; regulation of synaptogenesis; axonogenesis; energy reserve metabolic process; neurotransmitter uptake; regulation of insulin secretion; synaptic vesicle docking during exocytosis
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Reference #:
P60880 (UniProtKB)
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| Alt. Names/Synonyms: bA416N4.2; dJ1068F16.2; FLJ23079; resistance to inhibitors of cholinesterase 4 homolog; RIC-4; RIC4; SEC9; SNAP; SNAP-25; SNAP25; SNP25; SUP; Super protein; Synaptosomal-associated 25 kDa protein; Synaptosomal-associated protein 25; synaptosomal-associated protein, 25kDa |
| Gene Symbols: SNAP25 |
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Molecular weight: 23,315 Da
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Basal Isoelectric point: 4.66
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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