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CCNA2 (human)

Overview CCNA2 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. Note: This description may include information from UniProtKB. Protein type: Nuclear receptor co-regulator Cellular Component: nucleoplasm; male pronucleus; cytoplasm; female pronucleus; nucleus Molecular Function: protein binding; protein kinase binding Biological Process: mitosis; cell division; mitotic cell cycle G2/M transition DNA damage checkpoint; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle Reference #:  P20248 (UniProtKB) Alt. Names/Synonyms: CCN1; CCNA; CCNA2; cyclin A2; Cyclin-A; Cyclin-A2 Gene Symbols: CCNA2 Molecular weight: 48,551 Da Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CCNA2 1E9H - B/D=175-432 (human) 1FIN - B/D=173-432 (human) 1FVV - B/D=173-432 (human) 1GY3 - B/D=175-432 (human) 1H1P - B/D=175-432 (human) 1H1Q - B/D=175-432 (human) 1H1R - B/D=175-432 (human) 1H1S - B/D=175-432 (human) 1H24 - B/D=174-432 (human) 1H25 - B/D=174-432 (human) 1H26 - B/D=174-432 (human) 1H27 - B/D=174-432 (human) 1H28 - B/D=174-432 (human) 1JST - B/D=175-432 (human) 1JSU - B=173-432 (human) 1OGU - B/D=174-432 (human) 1OI9 - B/D=174-432 (human) 1OIU - B/D=174-432 (human) 1OIY - B/D=174-432 (human) 1OKV - B/D=173-432 (human) 1OKW - B/D=173-432 (human) 1OL1 - B/D=173-432 (human) 1OL2 - B/D=173-432 (human) 1P5E - B/D=175-432 (human) 1PKD - B/D=175-432 (human) 1QMZ - B/D=174-432 (human) 1URC - B/D=173-432 (human) 1VYW - B/D=173-432 (human) 2BKZ - B/D=173-432 (human) 2BPM - B/D=173-432 (human) 2C4G - B/D=173-432 (human) 2C5N - B/D=174-432 (human) 2C5O - B/D=173-432 (human) 2C5P - B/D=173-432 (human) 2C5V - B/D=174-432 (human) 2C5X - B/D=174-432 (human) 2C6T - B/D=175-432 (human) 2CCH - B/D=173-432 (human) 2CCI - B/D=175-432 (human) 2CJM - B/D=175-432 (human) 2I40 - B/D=173-432 (human) 2IW6 - B/D=174-432 (human) 2IW8 - B/D=174-432 (human) 2IW9 - B/D=174-432 (human) 2UUE - B/D=174-432 (human) 2UZB - B/D=175-432 (human) 2UZD - B/D=175-432 (human) 2UZE - B/D=175-432 (human) 2UZL - B/D=175-432 (human) 2V22 - D/B=174-432 (human) 2WEV - D/B=173-432 (human) 2WFY - D/B=173-432 (human) 2WHB - D/B=173-432 (human) 2WIH - D/B=173-432 (human) 2WIP - D/B=173-432 (human) 2WMA - D/B=174-432 (human) 2WMB - D/B=174-432 (human) 2WPA - D/B=173-432 (human) 2WXV - D/B=173-432 (human) 2X1N - D/B=172-432 (human) 3EID - D/B=173-432 (human) 3EJ1 - D/B=173-432 (human) 3EOC - D/B=173-432 (human) 3F5X - D/B=177-432 (human) 4BCK - D/B=171-432 (human) 4BCM - D/B=171-432 (human) 4BCN - B=171-432 D=171-431 (human) 4BCP - D/B=171-432 (human) 4EOI - D/B=175-432 (human) 4EOJ - D/B=175-432 (human) 4EOK - D/B=175-432 (human) 4EOL - D/B=175-432 (human) 4EOM - D/B=175-432 (human) 4EON - D/B=175-432 (human) 4EOO - D/B=175-432 (human) 4EOP - D/B=175-432 (human) 4EOQ - D/B=175-432 (human) 4EOR - D/B=175-432 (human) 4EOS - D/B=175-432 (human) 4FX3 - D/B=175-432 (human) 3QHR - D/B=163-422 (mouse) 3QHW - D/B=163-422 (mouse) 4I3Z - A/C=1-296 (mouse) 4II5 - A/C=1-298 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5P 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3  |  Phospho3D  |  DISEASE  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S5-p	___MLGNsAPGPATR
0	1		S16	PATREAGSALLALQQ
0	1		K37-u	QENINPEkAAPVQQP
2	0		K54-a	RAALAVLksGNPRGL
0	4		K54-u	RAALAVLksGNPRGL
0	1		S55-p	AALAVLksGNPRGLA
2	0		K68-a	LAQQQRPkTRRVAPL
2	0		K95-a	PPWKANSkQPAFTIH
2	0		K112-a	EAEKEAQkKPAESQK
1	0		S154-p	PMDGSFEsPHTMDMS
0	1		S209-p	KQPDITNsMRAILVD
0	1		S244-p	NYIDRFLsSMSVLRG
0	1		N431	LNPPETLNL______

	mouse
S5	___MPGTSRHSGRDA
S14-p	HSGRDAGsALLSLHQ
K31	QENVNPEKLAPAQQP
K45	PRAQAVLKAGNVRGP
K45-u	PRAQAVLkAGNVRGP
A46	RAQAVLkAGNVRGPA
K59	PAPQQKLKTRRVAPL
K87	PSWKAVSKQPAFTIH
K103	DEAEETQKRPAELKE
S145	PMDGSFESPHAMDMS
S199	RQPDITNSMRAILVD
S234	NYIDRFLSSMSVLRG
S421-p	LNPPETLsV______

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