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Protein Page:
CCNA2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CCNA2 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator
Cellular Component: nucleoplasm; male pronucleus; cytoplasm; female pronucleus; nucleus
Molecular Function: protein binding; protein kinase binding
Biological Process: mitosis; positive regulation of fibroblast proliferation; organ regeneration; response to glucagon stimulus; mitotic cell cycle G2/M transition DNA damage checkpoint; positive regulation of transcription, DNA-dependent; regulation of G2/M transition of mitotic cell cycle; Ras protein signal transduction; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle; response to estradiol stimulus
Reference #:  P20248 (UniProtKB)
Alt. Names/Synonyms: CCN1; CCNA; CCNA2; cyclin A2; Cyclin-A; Cyclin-A2
Gene Symbols: CCNA2
Molecular weight: 48,551 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCNA2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S5-p ___MLGNsAPGPATR
0 1 S16 PATREAGSALLALQQ
0 1 K37-ub QENINPEkAAPVQQP
2 0 K54-ac RAALAVLksGNPRGL
0 4 K54-ub RAALAVLksGNPRGL
0 1 S55-p AALAVLksGNPRGLA
2 0 K68-ac LAQQQRPkTRRVAPL
0 1 K76-ac TRRVAPLkDLPVNDE
2 0 K95-ac PPWKANSkQPAFTIH
2 0 K112-ac EAEKEAQkKPAESQK
1 0 S154-p PMDGSFEsPHTMDMS
0 1 S209-p KQPDITNsMRAILVD
0 1 S244-p NYIDRFLsSMSVLRG
0 1 N431 LNPPETLNL______
  mouse

 
S5 ___MPGTSRHSGRDA
S14-p HSGRDAGsALLSLHQ
K31 QENVNPEKLAPAQQP
K45 PRAQAVLKAGNVRGP
K45-ub PRAQAVLkAGNVRGP
A46 RAQAVLkAGNVRGPA
K59 PAPQQKLKTRRVAPL
K67 TRRVAPLKDLPINDE
K87 PSWKAVSKQPAFTIH
K103 DEAEETQKRPAELKE
S145 PMDGSFESPHAMDMS
S199 RQPDITNSMRAILVD
S234 NYIDRFLSSMSVLRG
S421-p LNPPETLsV______
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