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HELLS (human)

Overview HELLS Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis. By concanavalin-A in peripheral blood leukocytes. Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias. Belongs to the SNF2/RAD54 helicase family. 9 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.6.1.-; Apoptosis; EC 3.6.4.-; Helicase Cellular Component: centric heterochromatin; nucleus; chromosome, pericentric region Molecular Function: DNA binding; chromatin binding; helicase activity; ATP binding Biological Process: lymphocyte proliferation; mitosis; methylation-dependent chromatin silencing; maintenance of DNA methylation; transcription, DNA-dependent; cell division; multicellular organismal development; centric heterochromatin formation; urogenital system development Reference #:  Q9NRZ9 (UniProtKB) Alt. Names/Synonyms: FLJ10339; helicase, lymphoid-specific; HELLS; LSH; Lymphoid-specific helicase; Nbla10143; PASG; Proliferation-associated SNF2-like protein; SMARCA6; SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6 Gene Symbols: HELLS Molecular weight: 97,074 Da Basal Isoelectric point: 8.07  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HELLS

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K74-u	RLQHLLEkSNIYSkF
0	1		K80-u	EkSNIYSkFLLTKME
0	4		K99-a	EEQKKKEkLERkkEs
0	4		K103-a	KKEkLERkkEsLKVK
0	4		K104-a	KEkLERkkEsLKVKK
0	3		S106-p	kLERkkEsLKVKKGK
0	1		S139	EDESYNISEVMSKEE
0	2		S188-p	SIIKDRLsEtVRQNT
0	3		T190-p	IKDRLsEtVRQNTKF
0	2		Y469	PKREVVVYAPLsKKQ
0	1		S473-p	VVVYAPLsKKQEIFY
0	1		K475	VYAPLsKKQEIFYtA
0	2		T481-p	KKQEIFYtAIVNRtI
0	1		T487-p	YtAIVNRtIANMFGS
0	2		T499-p	FGSSEKEtIELsPtG
0	2		S503-p	EKEtIELsPtGRPKR
0	2		T505-p	EtIELsPtGRPKRRT
0	11		S515-p	PKRRTRKsINYSkID
0	1		Y518	RTRKsINYSkIDDFP
0	1		K520-u	RKsINYSkIDDFPNE
0	1		K559	VESEVNLKLQNIMML
0	1		S648-p	NFSRLDGsMsysERE
0	1		S650-p	SRLDGsMsysEREKN
0	2		Y651-p	RLDGsMsysEREKNM
0	1		S652-p	LDGsMsysEREKNMH
0	1		T714-p	RCHRIGQtKPVVVYR
0	1		K763-u	QSGLNLSkNFLDPKE
0	1		K795-u	REKVISDkDLELLLD
0	1		S832-p	ILENSEDsSPECLF_

	mouse
K58	RLQHLLEKSNIYSKF
K64	EKSNIYSKFLLTKME
K83	EEQKKKEKLEKKKRs
K87	KKEKLEKKKRsLKLT
K88	KEKLEKKKRsLKLTE
S90-p	KLEKKKRsLKLTEGK
S123	EDESYNISEVMSKEE
S171-p	SMIKDRLsQTVRQNS
T173	IKDRLsQTVRQNSKF
Y452-p	PKREVVVyAPLCNkQ
C456	VVVyAPLCNkQEIFY
K458-u	VyAPLCNkQEIFYTA
T464	NkQEIFYTAIVNRTI
T470	YTAIVNRTIANMFGS
T482	FGSCEKETVELsPtG
S486-p	EKETVELsPtGRPKR
T488-p	ETVELsPtGRPKRRS
S498-p	PKRRSRKsINySELD
Y501-p	RSRKsINySELDQFP
E503	RKsINySELDQFPSE
K542-u	IESEVNLkLRNIMML
S631	IFSRLDGSMSYSERE
S633	SRLDGSMSYSEREKN
Y634	RLDGSMSYSEREKNI
S635	LDGSMSYSEREKNIY
T697	RCHRIGQTKPVVVYR
K746	QSGLSQSKNFLDAKE
E778	REKVISDEDLELLLD
S815	ILENSEDSSAECLF_

	rat
K74	RLQHLLEKSNIYSKF
K80	EKSNIYSKFLLTKME
K99	EEQKKKEKLEKKKRS
K103	KKEKLEKKKRSLKVT
K104	KEKLEKKKRSLKVTE
S106	KLEKKKRSLKVTEGK
S139-p	EDESYNIsEVMSKEE
S187	SMIKDRLSQTVRQNS
T189	IKDRLSQTVRQNSKF
Y468	PKREVVVYAPLCNKQ
C472	VVVYAPLCNKQEIFY
K474	VYAPLCNKQEIFYTA
T480	NKQEIFYTAIVNRTI
T486	YTAIVNRTIANMFGS
T498	FGSCEKETVELSPTG
S502	EKETVELSPTGRPKR
T504	ETVELSPTGRPKRRS
S514	PKRRSRKSINYSELD
Y517	RSRKSINYSELDQFP
E519	RKSINYSELDQFPSE
K558	IESEVNLKLQNIMML
S647	TFSRLDGSMSySERE
S649	SRLDGSMSySEREKN
Y650-p	RLDGSMSySEREKNI
S651	LDGSMSySEREKNIY
T713	RCHRIGQTKPVVVYR
K762	QSGLSQSKNFLDAKE
E794	REKVISDEDLELLLD
S831	ILENSEDSSAECLF_

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