Home

S6 (rat)

Overview S6 May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Belongs to the ribosomal protein S6e family. Note: This description may include information from UniProtKB. Protein type: Translation Cellular Component: small ribosomal subunit; cytoplasm; nucleolus; ribosome; ribonucleoprotein complex; nucleus Molecular Function: structural constituent of ribosome; protein kinase binding Biological Process: ribosomal small subunit biogenesis and assembly; TOR signaling pathway; translation; positive regulation of apoptosis; ribosomal small subunit assembly and maintenance; glucose homeostasis; rRNA processing Reference #:  P62755 (UniProtKB) Alt. Names/Synonyms: 40S ribosomal protein S6; ribosomal protein S6; Rps6; RS6 Gene Symbols: Rps6 Molecular weight: 28,681 Da Basal Isoelectric point: 10.85  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below S6 3J3A - I=1-208 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			rat
0	3		S6	__MKLNISFPATGCQ
0	5		K14	FPATGCQKLIEVDDE
0	1		Y28	ERKLRTFYEKRMATE
0	1		K30	KLRTFYEKRMATEVA
0	1		K58	RISGGNDKQGFPMKQ
0	6		K58	RISGGNDKQGFPMKQ
0	1		K64	DKQGFPMKQGVLTHG
0	2		S78	GRVRLLLSKGHSCYR
0	2		K116	LNLVIVKKGEKDIPG
0	1		K119	VIVKKGEKDIPGLTD
0	3		K143	KRASRIRKLFNLSKE
0	3		S148	IRKLFNLSKEDDVRQ
0	6		K149	RKLFNLSKEDDVRQY
0	2		T181	PKIQRLVTPRVLQHK
0	2		K203	KQRTKKNKEEAAEYA
0	4		K203	KQRTKKNKEEAAEYA
0	15		Y209	NKEEAAEYAKLLAKR
0	2		K211	EEAAEYAKLLAKRMK
0	6		K211	EEAAEYAKLLAKRMK
0	1		K218	KLLAKRMKEAKEKRQ
119	964		S235-p	IAKRRRLssLRAsts
113	1119		S236-p	AKRRRLssLRAstsK
48	859		S240-p	RLssLRAstsKsESs
0	274		T241-p	LssLRAstsKsESsQ
0	273		S242-p	ssLRAstsKsESsQK
47	569		S244-p	LRAstsKsESsQK__
0	125		S246	AstsKsESsQK____
3	305		S247-p	stsKsESsQK_____

	human
S6-p	__MKLNIsFPATGCQ
K14-u	FPATGCQkLIEVDDE
Y28-p	ERKLRTFyEkRMATE
K30-a	KLRTFyEkRMATEVA
K58	RISGGNDKQGFPMkQ
K58-u	RISGGNDkQGFPMkQ
K64-u	DkQGFPMkQGVLTHG
S78-p	GRVRLLLsKGHSCYR
K116-u	LNLVIVKkGEKDIPG
K119	VIVKkGEKDIPGLTD
K143-u	KRASRIRkLFNLskE
S148-p	IRkLFNLskEDDVRQ
K149-u	RkLFNLskEDDVRQY
T181-p	PKIQRLVtPRVLQHK
K203	KQRTKKNKEEAAEyA
K203-u	KQRTKKNkEEAAEyA
Y209-p	NkEEAAEyAkLLAKR
K211-a	EEAAEyAkLLAKRMk
K211-u	EEAAEyAkLLAKRMk
K218-a	kLLAKRMkEAKEKRQ
S235-p	IAKRRRLssLRAsts
S236-p	AKRRRLssLRAstsK
S240-p	RLssLRAstsKsEss
T241-p	LssLRAstsKsEssQ
S242-p	ssLRAstsKsEssQK
S244-p	LRAstsKsEssQK__
S246-p	AstsKsEssQK____
S247-p	stsKsEssQK_____

	mouse
S6	__MKLNISFPATGCQ
K14-u	FPATGCQkLIEVDDE
Y28	ERKLRTFYEKRMATE
K30	KLRTFYEKRMATEVA
K58-a	RISGGNDkQGFPMKQ
K58-u	RISGGNDkQGFPMKQ
K64	DkQGFPMKQGVLTHG
S78	GRVRLLLSKGHSCYR
K116-u	LNLVIVKkGEkDIPG
K119-u	VIVKkGEkDIPGLTD
K143-u	KRASRIRkLFNLskE
S148-p	IRkLFNLskEDDVRQ
K149-u	RkLFNLskEDDVRQY
T181	PKIQRLVTPRVLQHK
K203-a	KQRTKKNkEEAAEYA
K203-u	KQRTKKNkEEAAEYA
Y209	NkEEAAEYAkLLAKR
K211-a	EEAAEYAkLLAKRMK
K211-u	EEAAEYAkLLAKRMK
K218	kLLAKRMKEAKEKRQ
S235-p	IAKRRRLssLRAsts
S236-p	AKRRRLssLRAstsK
S240-p	RLssLRAstsKsEss
T241-p	LssLRAstsKsEssQ
S242-p	ssLRAstsKsEssQK
S244-p	LRAstsKsEssQK__
S246-p	AstsKsEssQK____
S247-p	stsKsEssQK_____

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.