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Protein Page:
LAMB3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LAMB3 Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMB3 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB); also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Defects in LAMB3 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. Note: This description may include information from UniProtKB.
Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide
Cellular Component: laminin-5 complex; extracellular region
Molecular Function: protein binding; protein complex binding; structural molecule activity
Biological Process: extracellular matrix disassembly; hemidesmosome assembly; epidermis development; extracellular matrix organization and biogenesis; brown fat cell differentiation; cell adhesion
Reference #:  Q13751 (UniProtKB)
Alt. Names/Synonyms: BM600-125KDA; Epiligrin subunit bata; FLJ99565; Kalinin B1 chain; Kalinin subunit beta; kalinin-140kDa; LAM5; LAMB3; Laminin B1k chain; laminin S B3 chain; Laminin subunit beta-3; laminin, beta 3; laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD)); Laminin-5 subunit beta; LAMNB1; Nicein subunit beta; nicein-125kDa
Gene Symbols: LAMB3
Molecular weight: 129,572 Da
Basal Isoelectric point: 7.14  Predict pI for various phosphorylation states
Select Structure to View Below

LAMB3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S136-p AGMLIERsSDFGkTW
0 1 K141-ub ERsSDFGkTWRVYQY
0 1 K188-ub NARLNGGkVQLNLMD
0 1 K705-ub RKREQFEkISSADPs
0 1 S712-ga kISSADPsGAFRMLS
0 1 K766-ub GGGTGSPkLVALRLE
0 1 S791-p FNKLCGNsRQMACTP
0 2 T812-p LCPQDNGtACGsRCR
0 2 S816-p DNGtACGsRCRGVLP
0 1 K953-ub DLVLSQTkQDIARAR
0 1 S971-p AEAEEARsRAHAVEG
0 1 E1079 LSAQEGFERIKQKYA
0 1 K1127-m3 MEMMDRMkDMELELL
0 1 K1152-ub ADLTGLEkRVEQIRD
  mouse

 
S136 AGMLIERSSDFGKTW
K141 ERSSDFGKTWRVYQY
K188 NGHLTGGKVQLNLMD
K702 SKKEQFEKLSSEDPS
S709 KLSSEDPSGAFRMLT
Q762 GGGTGGAQLMALRLE
S787 INKLCGRSRQTACTP
T808 LCPQDNGTACGSHCR
S812 DNGTACGSHCRGALP
K949 DSVLSQTKQDIARAR
S967 AEAEQARSRAHAVEG
K1075-ac MNAQEGFkRLKQKYT
K1123 MEMMDKMKDMESELL
K1148 ADLSGLEKRVEQIRS
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