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Protein Page:
SIX3 (mouse)

SIX3 May be involved in visual system development. Defects in SIX3 are the cause of holoprosencephaly type 2 (HPE2). Holoprosencephaly (HPE) is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Belongs to the SIX/Sine oculis homeobox family. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator
Cellular Component: nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity; receptor binding
Biological Process: transcription from RNA polymerase II promoter; camera-type eye development; negative regulation of Wnt receptor signaling pathway; multicellular organismal development; diencephalon development; circadian behavior; telencephalon development; eye development; regulation of transcription, DNA-dependent; protein import into nucleus; forebrain anterior/posterior pattern formation; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent
Reference #:  Q62233 (UniProtKB)
Alt. Names/Synonyms: E130112M24Rik; Homeobox protein SIX3; Sine oculis homeobox homolog 3; sine oculis-related homeobox 3 homolog (Drosophila); Six3; Six3a; Six3alpha; Six3b; Six3beta
Gene Symbols: Six3
Molecular weight: 35,593 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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