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Protein Page:
PCSK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PCSK1 Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Belongs to the peptidase S8 family. Furin subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.21.93; Protease
Cellular Component: Golgi apparatus; extracellular space; transport vesicle
Molecular Function: serine-type endopeptidase activity
Biological Process: cellular protein metabolic process; cell-cell signaling; metabolic process; peptide hormone processing; proteolysis; regulation of insulin secretion; peptide biosynthetic process
Reference #:  P29120 (UniProtKB)
Alt. Names/Synonyms: BMIQ12; NEC 1; NEC1; Neuroendocrine convertase 1; PC1; PC3; PCSK1; Prohormone convertase 1; prohormone convertase 3; Proprotein convertase 1; proprotein convertase subtilisin/kexin type 1; SPC3
Gene Symbols: PCSK1
Molecular weight: 84,152 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PCSK1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 T87-p RRSAFHItKRLSDDD
0 1 K622 NDRRGVEKMVDPGEE
0 1 T632-ga DPGEEQPtQENPKEN
0 1 T640-ga QENPKENtLVsKSPS
0 1 S643-ga PKENtLVsKSPSSSS
  mouse

 
T87 RRSALHITKRLSDDD
K622-ub NDRRGVEkMVNVVEK
T632 NVVEKRPTQKSLNGN
- gap
- gap
  rat

 
T87 RRSALHITKRLSDDD
K622 NDRRGVEKMVNVVEE
T632 NVVEEKPTQNSLNGN
- gap
- gap
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