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PCSK1
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Belongs to the peptidase S8 family. Furin subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.21.93; Protease |
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Cellular Component: Golgi apparatus; extracellular space; transport vesicle; rough endoplasmic reticulum; cell soma; perinuclear region of cytoplasm; dendrite; nerve terminal; trans-Golgi network; secretory granule
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Molecular Function: insulin binding; serine-type endopeptidase activity; chaperone binding; endopeptidase activity
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Biological Process: response to nutrient levels; response to drug; response to peptide hormone stimulus; metabolic process; response to glucocorticoid stimulus; peptide hormone processing; response to morphine; response to lipopolysaccharide; proteolysis; peptide biosynthetic process; response to chlorate; protein autoprocessing; embryonic development; positive regulation of protein secretion; cell-cell signaling; neurogenesis; pituitary gland development; pancreas development; energy reserve metabolic process; response to glucose stimulus; response to axon injury; response to calcium ion; regulation of insulin secretion
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Reference #:
P29120 (UniProtKB)
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| Alt. Names/Synonyms: BMIQ12; NEC 1; NEC1; Neuroendocrine convertase 1; PC1; PC3; PCSK1; Prohormone convertase 1; prohormone convertase 3; Proprotein convertase 1; proprotein convertase subtilisin/kexin type 1; SPC3 |
| Gene Symbols: PCSK1 |
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Molecular weight: 84,152 Da
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Basal Isoelectric point: 5.66
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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