Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Belongs to the peptidase S8 family. Furin subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; Protease
Cellular Component: Golgi apparatus; extracellular space; transport vesicle; rough endoplasmic reticulum; cell soma; perinuclear region of cytoplasm; dendrite; nerve terminal; trans-Golgi network; secretory granule
Biological Process: response to nutrient levels; response to drug; response to peptide hormone stimulus; metabolic process; response to glucocorticoid stimulus; peptide hormone processing; response to morphine; response to lipopolysaccharide; proteolysis; peptide biosynthetic process; response to chlorate; protein autoprocessing; embryonic development; positive regulation of protein secretion; cell-cell signaling; neurogenesis; pituitary gland development; pancreas development; energy reserve metabolic process; response to glucose stimulus; response to axon injury; response to calcium ion; regulation of insulin secretion
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.