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Protein Page:
TRIO (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TRIO Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Guanine nucleotide exchange factor, misc.; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Apoptosis; EC 2.7.11.1; CAMK group; Trio family
Cellular Component: cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; phospholipid binding; ATP binding
Biological Process: axon guidance; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; apoptosis; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; transmembrane receptor protein tyrosine phosphatase signaling pathway
Reference #:  O75962 (UniProtKB)
Alt. Names/Synonyms: ARHGEF23; FLJ42780; PTPRF-interacting protein; tgat; TRIO; triple functional domain (PTPRF interacting); Triple functional domain protein
Gene Symbols: TRIO
Molecular weight: 346,900 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Regulation of Microtubule Dynamics
Select Structure to View Below

TRIO
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 S116-p SYLACIPsEEVCKRG
0 1 K265-a EEHSQLKkKVIKAPI
0 1 K281 DLDLEGQKLLQRIQS
0 2 S297-p ESFPKKNsGsGNADL
0 2 S299-p FPKKNsGsGNADLQN
0 1 S520 QRPLTPGSSDSLTAS
0 1 T525 PGSSDSLTASANYSK
0 1 K681-a VSFHTHVkELWTWLE
0 1 T724-p QQTTLQVtVNVIKEG
0 1 K1131-u LHYWTMRkRRLDQCQ
0 1 Y1228-p VTAVDKRyRDFSLRM
0 1 S1271 IPASIPGSEVKLRDA
0 1 S1459-p DGLEVMLsVPKRAND
0 1 T1545-p FTSELGVtEHVEGDP
0 2 T1562 FALWVGRTPTSDNKI
0 1 S1627 RDGEDLDSQGDGSSQ
0 1 S1633 DSQGDGSSQPDTISI
0 1 S1724-p CIAHSRSsMEMEGIF
0 1 S1745 SVSSNDASPPASVAS
0 3 T1778-p NTLRKWLtsPVRRLs
0 8 S1779-p TLRKWLtsPVRRLss
0 56 S1785-p tsPVRRLssGKADGH
0 54 S1786-p sPVRRLssGKADGHV
0 1 K1808-a KKSREVRksADAGsQ
0 1 S1809-p KSREVRksADAGsQK
0 1 S1814-p RksADAGsQKDSDDS
0 1 S1818 DAGsQKDSDDSAAtP
0 1 S1821 sQKDSDDSAAtPQDE
0 1 T1824-p DSDDSAAtPQDETVE
0 1 S1840 RGRNEGLSSGtLSKs
0 1 T1843-p NEGLSSGtLSKsSSS
0 1 S1847-p SSGtLSKsSSSGMQs
0 1 S1854-p sSSSGMQsCGEEEGE
0 2 T1899-p SRLLVRPtssEtPSA
0 1 S1900-p RLLVRPtssEtPSAA
0 3 S1901-p LLVRPtssEtPSAAE
0 1 T1903-p VRPtssEtPSAAELV
0 1 S1911 PSAAELVSAIEELVK
0 1 S1919 AIEELVKSKMALEDR
0 1 S1945 SSPSFNPSDNSLLSS
0 1 Y2058-p HERRLHMyIAYCQNK
0 1 Y2075-p SEHIVSEyIDTFFED
0 1 K2099 QLTDLLIKPVQRIMK
0 1 S2198 FEQIVIFSEPLDKKK
0 1 S2208-p LDKKKGFsMPGFLFK
0 6 S2282-p NFLNALTsPIEyQRN
0 3 Y2286-p ALTsPIEyQRNHSGG
0 1 P2314 GSGGGGAPSGGSGHS
0 1 G2328 SGGPSSCGGAPSTSR
0 1 G2329 GGPSSCGGAPSTSRS
0 1 S2334 CGGAPSTSRSRPSRI
0 1 S2388-p AAPEAGPsAPsRRPP
0 1 S2391-p EAGPsAPsRRPPGAD
0 1 S2417-p PKMKVLEsPRKGAAN
0 1 T2443 DARASLGTLPLGKPR
0 1 P2449 GTLPLGKPRAGAAsP
0 1 P2449 GTLPLGKPRAGAAsP
0 16 S2455-p KPRAGAAsPLNsPLS
0 13 S2459-p GAAsPLNsPLSSAVP
0 2 S2462 sPLNsPLSSAVPSLG
0 1 A2464 LNsPLSSAVPSLGKE
0 3 S2467 PLSSAVPSLGKEPFP
0 1 K2481-a PPSSPLQkGGSFWSS
0 6 S2492-p FWSSIPAsPAsRPGS
0 1 S2495-p SIPAsPAsRPGSFTF
0 1 S2508-p TFPGDSDsLQRQtPR
0 1 T2513-p SDsLQRQtPRHAAPG
0 1 T2523 HAAPGKDTDRMSTCS
0 1 S2531 DRMSTCSSASEQSVQ
0 1 S2536 CSSASEQSVQSTQSN
0 1 T2625-p IVENPDGtLKKSTsW
0 1 K2628 NPDGtLKKSTsWHTA
0 1 S2631-p GtLKKSTsWHTALRL
0 1 K2640-a HTALRLRkKSEKKDk
0 1 K2647-a kKSEKKDkDGKREGK
0 1 Y2659-p EGKLENGyRKSREGL
0 1 S2671 EGLSNKVSVKLLNPN
1 0 Y2681 LLNPNYIYDVPPEFV
1 0 Y2796-p KDNFDSFySEVAELG
  mouse

► Hide Isoforms 		 
S116 SYLACIPSEEVCKRG
K265 DEHSQLKKKVIKAPI
K281-u DLDLEGQkLLQRIQS
S297 DSFPKKNSGSGNADL
S299 FPKKNSGSGNADLQN
S520-p QRPLTPGsSDSLtAS
T525-p PGsSDSLtASANYSK
K681 VSFHTHVKELWTWLE
T724 QQTTLQVTVNVIKEG
K1131 LHYWTMRKRRLDQCQ
Y1228 VTAVDKRYRDFSLRM
S1271-p IPASIPGsEVKLRDA
S1459 DGLEVMLSVPKRAND
T1545 FTSELGVTEHVEGDP
T1562-p FALWVGRtPTSDNKI
S1627-p RDGEDLDsQGDGSsQ
S1633-p DsQGDGSsQPDTISI
S1724-p CIAHSRSsMEMEGIF
S1745-p SVSSNDAsPPASVAS
T1778-p NTLRKWLtsPVRRLs
S1779-p TLRKWLtsPVRRLss
S1785-p tsPVRRLssGKADGH
S1786-p sPVRRLssGKADGHA
K1808 KKSREVRKSADAGSQ
S1809 KSREVRKSADAGSQK
S1814 RKSADAGSQKDsDDs
S1818-p DAGSQKDsDDsAATP
S1821-p SQKDsDDsAATPQDE
T1824 DsDDsAATPQDETIE
S1840-p RGRNEGLsSGtLSKS
T1843-p NEGLsSGtLSKSSSS
S1847 sSGtLSKSSSSGMQS
S1854 SSSSGMQSCGEEEGE
T1899-p SRLLVRPtSsETPSA
S1900 RLLVRPtSsETPSAA
S1901-p LLVRPtSsETPSAAE
T1903 VRPtSsETPSAAELV
S1911-p PSAAELVsAIEELVK
S1919-p AIEELVKsKMALEDR
S1945-p SSPSFNPsDNSLLSS
Y2058 HERRLHMYIVYCQNK
Y2075 SEHIVSEYIDTFFED
K2099-u QLTDLLIkPVQRIMK
S2198-p FEQIVIFsEPLDKKK
S2208 LDKKKGFSMPGFLFK
S2282-p NFLNALTsPIEYQRN
Y2286 ALTsPIEYQRNHSGG
S2314-p GSGGSGAsSGGSSSH
S2329-p GSGPSSCssGPSSsR
S2330-p SGPSSCssGPSSsRS
S2335-p CssGPSSsRSRPSRI
G2391 LALEASLGQPSRLPL
- under review  
S2420 PKMKVMESPRKAPGS
S2446-p DARGNLGsLPLGKtR
T2452-p GsLPLGKtRPGAVsP
T2452-g GsLPLGKtRPGAVsP
S2458-p KtRPGAVsPLNsPLs
S2462-p GAVsPLNsPLsTtFP
S2465-p sPLNsPLsTtFPsPF
T2467-p LNsPLsTtFPsPFGK
S2470-p PLsTtFPsPFGKEAF
K2485 PPSSPLQKGGSFWSS
S2496-p FWSSIPAsPASRPSS
S2499 SIPAsPASRPSSFTF
S2512 TFPGDSDSLQRQTHR
T2517 SDSLQRQTHRHAAPS
T2527 HAAPSKDTDRMSTCS
S2535 DRMSTCSSASEQSVQ
S2540 CSSASEQSVQSTQSN
T2628 IMENPDGTLKkSTsW
K2631-a NPDGTLKkSTsWHTA
S2634-p GTLKkSTsWHTALRL
K2643 HTALRLRKKSEKKDk
K2650-a KKSEKKDkDGKRDGK
Y2662 DGKLENGYRKPREGL
S2674-p EGLSNKVsVKLLNPN
Y2684 LLNPNYIYDVPPEFV
Y2799 KDNFDAFYSEVAELG
  TRIO iso4  
S116 SYLACIPSEEVCKRG
K265 DEHSQLKKKVIKAPI
K281 DLDLEGQKLLQRIQS
S297 DSFPKKNSGSGNADL
S299 FPKKNSGSGNADLQN
S520 QRPLTPGSSDSLTAS
T525 PGSSDSLTASANYSK
K681 VSFHTHVKELWTWLE
T724 QQTTLQVTVNVIKEG
K1131 LHYWTMRKRRLDQCQ
Y1228 VTAVDKRYRDFSLRM
S1271 IPASIPGSEVKLRDA
S1459 DGLEVMLSVPKRAND
T1545 FTSELGVTEHVEGDP
T1562 FALWVGRTPTSDNKI
S1627 RDGEDLDSQGDGSSQ
S1633 DSQGDGSSQPDTISI
S1724 CIAHSRSSMEMEGIF
S1745 SVSSNDASPPASVAS
T1778 NTLRKWLTSPVRRLS
S1779 TLRKWLTSPVRRLSS
S1785 TSPVRRLSSGKADGH
S1786 SPVRRLSSGKADGHA
K1808 KKSREVRKSADAGSQ
S1809 KSREVRKSADAGSQK
S1814 RKSADAGSQKDSDDS
S1818 DAGSQKDSDDSAATP
S1821 SQKDSDDSAATPQDE
T1824 DSDDSAATPQDETIE
S1840 RGRNEGLSSGTLSKS
T1843 NEGLSSGTLSKSSSS
S1847 SSGTLSKSSSSGMQS
S1854 SSSSGMQSCGEEEGE
T1899 SRLLVRPTSSETPSA
S1900 RLLVRPTSSETPSAA
S1901 LLVRPTSSETPSAAE
T1903 VRPTSSETPSAAELV
S1911 PSAAELVSAIEELVK
S1919 AIEELVKSKMALEDR
S1945 SSPSFNPSDNSLLSS
Y2058 HERRLHMYIVYCQNK
Y2075 SEHIVSEYIDTFFED
K2099 QLTDLLIKPVQRIMK
S2198 FEQIVIFSEPLDKKK
S2208 LDKKKGFSMPGFLFK
S2282 NFLNALTSPIEYQRN
Y2286 ALTSPIEYQRNHSGG
S2314 GSGGSGASSGGSSSH
S2329 GSGPSSCSSGPSSSR
S2330 SGPSSCSSGPSSSRS
S2335 CSSGPSSSRSRPSRI
G2391 LALEASLGQPSRLPL
S2394 EASLGQPSRLPLSGD
S2420 PKMKVMESPRKAPGS
S2446 DARGNLGSLPLGKTR
T2452 GSLPLGKTRPGAVSP
T2452 GSLPLGKTRPGAVSP
S2458 KTRPGAVSPLNSPLS
S2462 GAVSPLNSPLSTTFP
S2465 SPLNSPLSTTFPSPF
T2467 LNSPLSTTFPSPFGK
S2470 PLSTTFPSPFGKEAF
K2485 PPSSPLQKGGSFWSS
S2496 FWSSIPASPASRPSS
S2499 SIPASPASRPSSFTF
S2512 TFPGDSDSLQRQTHR
T2517 SDSLQRQTHRHAAPS
T2527-p HAAPSKDtDRMSTCS
S2535-p DRMSTCSsASEQsVQ
S2540-p CSsASEQsVQSTQSN
T2629 IMENPDGTLKKSTSW
K2632 NPDGTLKKSTSWHTA
S2635 GTLKKSTSWHTALRL
K2644 HTALRLRKKSEKKDK
K2651 KKSEKKDKDGKRDGK
Y2663 DGKLENGYRKPREGL
S2675 EGLSNKVSVKLLNPN
Y2685 LLNPNYIYDVPPEFV
Y2800 KDNFDAFYSEVAELG
  rat

 
S65 SYLACIPSEEVCKRG
K214 DEHSQLKKKVIKAPI
K230 DLDLEGQKLLQRIQS
S246 ESFPKKNSGSGNADL
S248 FPKKNSGSGNADLQN
S469 QRPLTPGSSDSLTAS
T474 PGSSDSLTASANYSK
K630 VSFHTHVKELWTWLE
T673 QQTTLQVTVNVIKEG
K1080 LHYWTMRKRRLDQCQ
Y1177 VTAVDKRYRDFSLRM
S1220 IPASIPGSEVKLRDA
S1408 DGLEVMLSVPKRAND
T1494 FTSELGVTEHVEGDP
T1511 FALWVGRTPTSDNKI
S1576 RDGEDLDSQGDGSSQ
S1582 DSQGDGSSQPDTISI
S1673 CIAHSRSSMEMEGIF
S1694 SVSSNDASPPASVAS
T1727 NTLRKWLTSPVRRLS
S1728 TLRKWLTSPVRRLSS
S1734 TSPVRRLSSGKADGH
S1735 SPVRRLSSGKADGHA
K1757 KKSREVRKSADAGSQ
S1758 KSREVRKSADAGSQK
S1763 RKSADAGSQKDSDDS
S1767 DAGSQKDSDDSAATP
S1770 SQKDSDDSAATPQDE
T1773 DSDDSAATPQDETIE
S1789 RGRNEGLSSGTLSKS
T1792 NEGLSSGTLSKSSSS
S1796 SSGTLSKSSSSGMQS
S1803 SSSSGMQSCGEEEGE
T1848 SRLLVRPTSSETPSA
S1849 RLLVRPTSSETPSAA
S1850 LLVRPTSSETPSAAE
T1852 VRPTSSETPSAAELV
S1860 PSAAELVSAIEELVK
S1868 AIEELVKSKMALEDR
S1894 SSPSFNPSDNSLLSS
Y2007 HERRLHMYIVYCQNK
Y2024 SEHIVSEYIDTFFED
K2048 QLTDLLIKPVQRIMK
S2147 FEQIVIFSEPLDKKK
S2157 LDKKKGFSMPGFLFK
S2231 NFLNALTSPIEYQRN
Y2235 ALTSPIEYQRNHSGG
S2263 GSGGSGASSGGSSSH
S2278 GSGPSSCSSGPSSSR
S2279 SGPSSCSSGPSSSRS
S2284 CSSGPSSSRSRPSRI
- under review  
- under review  
S2369 PKMKVMESPRKALGS
P2395 DARGNLGPLPLGKTR
T2401 GPLPLGKTRPGAVSP
T2401 GPLPLGKTRPGAVSP
S2407 KTRPGAVSPLNSPLS
S2411 GAVSPLNSPLSTTFP
S2414 SPLNSPLSTTFPSPF
- under review  
- under review  
K2434 PPSSPLQKGGSFWSS
S2445 FWSSIPASPASRPSS
S2448 SIPASPASRPSSFTF
S2461 TFPGDSDSLQRQTHR
T2466 SDSLQRQTHRHAAPS
T2476 HAAPSKDTDRMSTCS
S2484 DRMSTCSSASEQSVQ
S2489 CSSASEQSVQSTQSN
T2578 IMENPDGTFKKSTSW
K2581 NPDGTFKKSTSWHTA
S2584 GTFKKSTSWHTALRL
K2593 HTALRLRKKSEKKDK
K2600 KKSEKKDKDGKRDGK
Y2612 DGKLENGYRKPREGL
S2624 EGLSNKVSVKLLNPN
Y2634-p LLNPNYIyDVPPEFV
Y2749 KDNFDAFYSEVAELG
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