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Protein Page:
TRIO (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TRIO Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, CAMK; Kinase, protein; GEFs; GEFs, misc.; CAMK group; Trio family
Cellular Component: cytosol
Molecular Function: protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity; protein binding; enzyme binding; guanyl-nucleotide exchange factor activity; ATP binding
Biological Process: axon guidance; regulation of small GTPase mediated signal transduction; regulation of GTPase activity; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine phosphatase signaling pathway
Reference #:  O75962 (UniProtKB)
Alt. Names/Synonyms: ARHGEF23; FLJ42780; PTPRF-interacting protein; tgat; TRIO; triple functional domain (PTPRF interacting); Triple functional domain protein
Gene Symbols: TRIO
Molecular weight: 346,900 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Select Structure to View Below

TRIO

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K281 DLDLEGQKLLQRIQS
0 2 S297-p ESFPKKNsGsGNADL
0 2 S299-p FPKKNsGsGNADLQN
0 1 S520 QRPLTPGSSDSLTAS
0 1 T525 PGSSDSLTASANYSK
0 1 S1271 IPASIPGSEVKLRDA
0 1 T1545-p FTSELGVtEHVEGDP
0 2 T1562 FALWVGRTPTSDNKI
0 1 S1627-p RDGEDLDsQGDGSSQ
0 1 S1633 DsQGDGSSQPDTISI
0 1 S1724-p CIAHSRSsMEMEGIF
0 1 S1745-p SVSSNDAsPPASVAS
0 3 T1778-p NTLRKWLtsPVRRLs
0 10 S1779-p TLRKWLtsPVRRLss
0 56 S1785-p tsPVRRLssGKADGH
0 54 S1786-p sPVRRLssGKADGHV
0 1 S1809-p KSREVRKsADAGsQK
0 1 S1814-p RKsADAGsQKDsDDs
0 1 S1818-p DAGsQKDsDDsAAtP
0 1 S1821-p sQKDsDDsAAtPQDE
0 1 T1824-p DsDDsAAtPQDETVE
0 1 T1843-p NEGLSSGtLSKSSSS
0 2 T1899-p SRLLVRPtSsEtPSA
0 3 S1901-p LLVRPtSsEtPSAAE
0 1 T1903-p VRPtSsEtPSAAELV
0 1 S1911 PSAAELVSAIEELVK
0 1 S1919 AIEELVKSKMALEDR
0 1 K2099 QLTDLLIKPVQRIMK
0 6 S2282-p NFLNALTsPIEyQRN
0 3 Y2286-p ALTsPIEyQRNHSGG
0 1 S2417-p PKMKVLEsPRKGAAN
0 1 S2429-p AANASGSsPDAPAKD
0 1 T2443 DARASLGTLPLGKPR
0 1 P2449 GTLPLGKPRAGAAsP
0 1 P2449 GTLPLGKPRAGAAsP
0 19 S2455-p KPRAGAAsPLNsPLS
0 16 S2459-p GAAsPLNsPLSSAVP
0 2 S2462 sPLNsPLSSAVPSLG
0 1 A2464 LNsPLSSAVPSLGKE
0 4 S2467 PLSSAVPSLGKEPFP
0 1 S2477-p KEPFPPSsPLQKGGS
0 6 S2492-p FWSSIPAsPAsRPGS
0 1 S2495-p SIPAsPAsRPGSFTF
0 1 T2513-p SDSLQRQtPRHAAPG
0 2 S2631-p GTLKKSTsWHTALRL
0 1 S2671 EGLSNKVSVKLLNPN
1 0 Y2681 LLNPNYIYDVPPEFV
1 0 Y2796-p KDNFDSFySEVAELG
  mouse

► Hide Isoforms
 
K281-u DLDLEGQkLLQRIQS
S297 DSFPKKNSGSGNADL
S299 FPKKNSGSGNADLQN
S520-p QRPLTPGsSDSLtAS
T525-p PGsSDSLtASANYSK
S1271-p IPASIPGsEVKLRDA
T1545 FTSELGVTEHVEGDP
T1562-p FALWVGRtPTSDNKI
S1627-p RDGEDLDsQGDGSsQ
S1633-p DsQGDGSsQPDTISI
S1724-p CIAHSRSsMEMEGIF
S1745-p SVSSNDAsPPASVAS
T1778-p NTLRKWLtsPVRRLs
S1779-p TLRKWLtsPVRRLss
S1785-p tsPVRRLssGKADGH
S1786-p sPVRRLssGKADGHA
S1809 KSREVRKSADAGSQK
S1814 RKSADAGSQKDsDDs
S1818-p DAGSQKDsDDsAATP
S1821-p SQKDsDDsAATPQDE
T1824 DsDDsAATPQDETIE
T1843-p NEGLSSGtLSKSSSS
T1899-p SRLLVRPtSsETPSA
S1901-p LLVRPtSsETPSAAE
T1903 VRPtSsETPSAAELV
S1911-p PSAAELVsAIEELVK
S1919-p AIEELVKsKMALEDR
K2099-u QLTDLLIkPVQRIMK
S2282-p NFLNALTsPIEYQRN
Y2286 ALTsPIEYQRNHSGG
S2420 PKMKVMESPRKAPGS
S2432 PGSTSGTSQDGNTKD
S2446-p DARGNLGsLPLGKtR
T2452-p GsLPLGKtRPGAVsP
T2452-gl GsLPLGKtRPGAVsP
S2458-p KtRPGAVsPLNsPLs
S2462-p GAVsPLNsPLsTtFP
S2465-p sPLNsPLsTtFPsPF
T2467-p LNsPLsTtFPsPFGK
S2470-p PLsTtFPsPFGKEAF
S2481-p KEAFPPSsPLQKGGS
S2496-p FWSSIPAsPASRPSS
S2499 SIPAsPASRPSSFTF
T2517 SDSLQRQTHRHAAPS
S2634-p GTLKKSTsWHTALRL
S2674-p EGLSNKVsVKLLNPN
Y2684 LLNPNYIYDVPPEFV
Y2799 KDNFDAFYSEVAELG
  TRIO iso4  
K281 DLDLEGQKLLQRIQS
S297 DSFPKKNSGSGNADL
S299 FPKKNSGSGNADLQN
S520 QRPLTPGSSDSLTAS
T525 PGSSDSLTASANYSK
S1271 IPASIPGSEVKLRDA
T1545 FTSELGVTEHVEGDP
T1562 FALWVGRTPTSDNKI
S1627 RDGEDLDSQGDGSSQ
S1633 DSQGDGSSQPDTISI
S1724 CIAHSRSSMEMEGIF
S1745 SVSSNDASPPASVAS
T1778 NTLRKWLTSPVRRLS
S1779 TLRKWLTSPVRRLSS
S1785 TSPVRRLSSGKADGH
S1786 SPVRRLSSGKADGHA
S1809 KSREVRKSADAGSQK
S1814 RKSADAGSQKDSDDS
S1818 DAGSQKDSDDSAATP
S1821 SQKDSDDSAATPQDE
T1824 DSDDSAATPQDETIE
T1843 NEGLSSGTLSKSSSS
T1899 SRLLVRPTSSETPSA
S1901 LLVRPTSSETPSAAE
T1903 VRPTSSETPSAAELV
S1911 PSAAELVSAIEELVK
S1919 AIEELVKSKMALEDR
K2099 QLTDLLIKPVQRIMK
S2282 NFLNALTSPIEYQRN
Y2286 ALTSPIEYQRNHSGG
S2420 PKMKVMESPRKAPGS
S2432 PGSTSGTSQDGNTKD
S2446 DARGNLGSLPLGKTR
T2452 GSLPLGKTRPGAVSP
T2452 GSLPLGKTRPGAVSP
S2458 KTRPGAVSPLNSPLS
S2462 GAVSPLNSPLSTTFP
S2465 SPLNSPLSTTFPSPF
T2467 LNSPLSTTFPSPFGK
S2470 PLSTTFPSPFGKEAF
S2481 KEAFPPSSPLQKGGS
S2496 FWSSIPASPASRPSS
S2499 SIPASPASRPSSFTF
T2517 SDSLQRQTHRHAAPS
S2635 GTLKKSTSWHTALRL
S2675 EGLSNKVSVKLLNPN
Y2685 LLNPNYIYDVPPEFV
Y2800 KDNFDAFYSEVAELG
  rat

 
K230 DLDLEGQKLLQRIQS
S246 ESFPKKNSGSGNADL
S248 FPKKNSGSGNADLQN
S469 QRPLTPGSSDSLTAS
T474 PGSSDSLTASANYSK
S1220 IPASIPGSEVKLRDA
T1494 FTSELGVTEHVEGDP
T1511 FALWVGRTPTSDNKI
S1576 RDGEDLDSQGDGSSQ
S1582 DSQGDGSSQPDTISI
S1673 CIAHSRSSMEMEGIF
S1694 SVSSNDASPPASVAS
T1727 NTLRKWLTSPVRRLS
S1728 TLRKWLTSPVRRLSS
S1734 TSPVRRLSSGKADGH
S1735 SPVRRLSSGKADGHA
S1758 KSREVRKSADAGSQK
S1763 RKSADAGSQKDSDDS
S1767 DAGSQKDSDDSAATP
S1770 SQKDSDDSAATPQDE
T1773 DSDDSAATPQDETIE
T1792 NEGLSSGTLSKSSSS
T1848 SRLLVRPTSSETPSA
S1850 LLVRPTSSETPSAAE
T1852 VRPTSSETPSAAELV
S1860 PSAAELVSAIEELVK
S1868 AIEELVKSKMALEDR
K2048 QLTDLLIKPVQRIMK
S2231 NFLNALTSPIEYQRN
Y2235 ALTSPIEYQRNHSGG
S2369 PKMKVMESPRKALGS
S2381 LGSTSGTSQDGNTKD
P2395 DARGNLGPLPLGKTR
T2401 GPLPLGKTRPGAVSP
T2401 GPLPLGKTRPGAVSP
S2407 KTRPGAVSPLNSPLS
S2411 GAVSPLNSPLSTTFP
S2414 SPLNSPLSTTFPSPF
T2416 LNSPLSTTFPSPFGK
S2419 PLSTTFPSPFGKEAF
S2430 KEAFPPSSPLQKGGS
S2445 FWSSIPASPASRPSS
S2448 SIPASPASRPSSFTF
T2466 SDSLQRQTHRHAAPS
S2584 GTFKKSTSWHTALRL
S2624 EGLSNKVSVKLLNPN
Y2634-p LLNPNYIyDVPPEFV
Y2749 KDNFDAFYSEVAELG
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