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Protein Page:
TRIO (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRIO Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, CAMK; EC 2.7.11.1; Apoptosis; GEFs, misc.; Protein kinase, Ser/Thr (non-receptor); GEFs; CAMK group; Trio family
Cellular Component: cytosol
Molecular Function: protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity; protein binding; enzyme binding; guanyl-nucleotide exchange factor activity; ATP binding
Biological Process: axon guidance; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine phosphatase signaling pathway; protein amino acid phosphorylation; positive regulation of Rho GTPase activity; positive regulation of GTPase activity
Reference #:  O75962 (UniProtKB)
Alt. Names/Synonyms: ARHGEF23; FLJ42780; PTPRF-interacting protein; tgat; TRIO; triple functional domain (PTPRF interacting); Triple functional domain protein
Gene Symbols: TRIO
Molecular weight: 346,900 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Select Structure to View Below

TRIO

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S116-p SYLACIPsEEVCKRG
0 1 K265-ac EEHSQLKkKVIKAPI
0 1 K281 DLDLEGQKLLQRIQS
0 2 S297-p ESFPKKNsGsGNADL
0 2 S299-p FPKKNsGsGNADLQN
0 1 T517-p DKLQRPLtPGSSDSL
0 1 S520 QRPLtPGSSDSLTAS
0 1 T525 PGSSDSLTASANYSK
0 1 K681-ac VSFHTHVkELWTWLE
0 1 T724-p QQTTLQVtVNVIKEG
0 1 K1131-ub LHYWTMRkRRLDQCQ
0 1 S1271 IPASIPGSEVKLRDA
0 1 S1459-p DGLEVMLsVPKRAND
0 1 T1545-p FTSELGVtEHVEGDP
0 2 T1562 FALWVGRTPTSDNKI
0 2 S1627-p RDGEDLDsQGDGSSQ
0 1 S1633 DsQGDGSSQPDTISI
0 1 T1700-p PDWCLVRtTDRsPAA
0 1 S1704-p LVRtTDRsPAAEGLV
0 1 S1724-p CIAHSRSsMEMEGIF
0 3 S1745-p SVSSNDAsPPAsVAs
0 1 S1749-p NDAsPPAsVAsLQPH
0 1 S1752-p sPPAsVAsLQPHMIG
0 3 T1778-p NTLRKWLtsPVRRLs
0 11 S1779-p TLRKWLtsPVRRLss
0 57 S1785-p tsPVRRLssGKADGH
0 55 S1786-p sPVRRLssGKADGHV
0 1 K1808-ac KKSREVRksADAGsQ
0 2 S1809-p KSREVRksADAGsQK
0 2 S1814-p RksADAGsQKDsDDs
0 2 S1818-p DAGsQKDsDDsAAtP
0 2 S1821-p sQKDsDDsAAtPQDE
0 3 T1824-p DsDDsAAtPQDETVE
0 1 S1840 RGRNEGLSSGtLSKs
0 1 T1843-p NEGLSSGtLSKsSSS
0 1 S1847-p SSGtLSKsSSSGMQs
0 1 S1854-p sSSSGMQsCGEEEGE
0 2 T1899-p SRLLVRPtssEtPSA
0 1 S1900-p RLLVRPtssEtPSAA
0 2 S1901-p LLVRPtssEtPSAAE
0 1 T1903-p VRPtssEtPSAAELV
0 1 S1911 PSAAELVSAIEELVK
0 1 S1919 AIEELVKSKMALEDR
0 1 S1945 SSPSFNPSDNSLLSS
0 1 Y2058-p HERRLHMyIAYCQNK
0 1 Y2075-p SEHIVSEyIDTFFED
0 1 K2099 QLTDLLIKPVQRIMK
0 1 S2198 FEQIVIFSEPLDKKK
0 1 S2208-p LDKKKGFsMPGFLFK
0 1 S2255-p TFILHSSsPSVRQTW
0 6 S2282-p NFLNALTsPIEyQRN
0 3 Y2286-p ALTsPIEyQRNHSGG
0 1 S2302-p GGGGSGGsGGGGGSG
0 1 P2314 GSGGGGAPSGGSGHS
0 1 S2326-p GHSGGPSsCGGAPST
0 1 G2328 SGGPSsCGGAPSTSR
0 1 G2329 GGPSsCGGAPSTSRS
0 1 S2334 CGGAPSTSRSRPSRI
0 1 S2388-p AAPEAGPsAPsRRPP
0 1 S2391-p EAGPsAPsRRPPGAD
0 2 S2417-p PKMKVLEsPRKGAAN
0 2 S2429-p AANASGSsPDAPAKD
0 1 S2440-p PAKDARAsLGTLPLG
0 1 T2443 DARAsLGTLPLGKPR
0 1 P2449 GTLPLGKPRAGAAsP
0 1 P2449 GTLPLGKPRAGAAsP
0 24 S2455-p KPRAGAAsPLNsPLS
0 20 S2459-p GAAsPLNsPLSSAVP
0 2 S2462 sPLNsPLSSAVPSLG
0 1 A2464 LNsPLSSAVPSLGKE
0 4 S2467 PLSSAVPSLGKEPFP
0 3 S2477-p KEPFPPSsPLQkGGS
0 1 K2481-ac PPSsPLQkGGSFWSS
0 8 S2492-p FWSSIPAsPAsRPGS
0 2 S2495-p SIPAsPAsRPGSFTF
0 1 S2508-p TFPGDSDsLQRQtPR
0 2 T2513-p SDsLQRQtPRHAAPG
0 1 T2523 HAAPGKDTDRMSTCS
0 1 S2531 DRMSTCSSASEQSVQ
0 1 S2536 CSSASEQSVQSTQSN
0 1 T2625-p IVENPDGtLKKSTsW
0 1 K2628 NPDGtLKKSTsWHTA
0 3 S2631-p GtLKKSTsWHTALRL
0 1 K2640-ac HTALRLRkKSEKKDK
0 1 K2647 kKSEKKDKDGKREGK
0 1 Y2659-p EGKLENGyRKSREGL
0 2 S2671-p EGLSNKVsVKLLNPN
1 0 Y2681 LLNPNYIYDVPPEFV
0 1 S2794-p TWKDNFDsFySEVAE
1 0 Y2796-p KDNFDsFySEVAELG
  mouse

► Hide Isoforms
 
S116 SYLACIPSEEVCKRG
K265 DEHSQLKKKVIKAPI
K281-ub DLDLEGQkLLQRIQS
S297 DSFPKKNSGSGNADL
S299 FPKKNSGSGNADLQN
T517 DKLQRPLTPGsSDSL
S520-p QRPLTPGsSDSLtAS
T525-p PGsSDSLtASANYSK
K681 VSFHTHVKELWTWLE
T724 QQTTLQVTVNVIKEG
K1131 LHYWTMRKRRLDQCQ
S1271-p IPASIPGsEVKLRDA
S1459 DGLEVMLSVPKRAND
T1545 FTSELGVTEHVEGDP
T1562-p FALWVGRtPTSDNKI
S1627-p RDGEDLDsQGDGSsQ
S1633-p DsQGDGSsQPDTISI
T1700 PDWCLVRTTDRSPAA
S1704 LVRTTDRSPAAEGLV
S1724-p CIAHSRSsMEMEGIF
S1745-p SVSSNDAsPPASVAS
S1749 NDAsPPASVASLQPH
S1752 sPPASVASLQPHMIG
T1778-p NTLRKWLtsPVRRLs
S1779-p TLRKWLtsPVRRLss
S1785-p tsPVRRLssGKADGH
S1786-p sPVRRLssGKADGHA
K1808 KKSREVRKSADAGSQ
S1809 KSREVRKSADAGSQK
S1814 RKSADAGSQKDsDDs
S1818-p DAGSQKDsDDsAATP
S1821-p SQKDsDDsAATPQDE
T1824 DsDDsAATPQDETIE
S1840-p RGRNEGLsSGtLSKS
T1843-p NEGLsSGtLSKSSSS
S1847 sSGtLSKSSSSGMQS
S1854 SSSSGMQSCGEEEGE
T1899-p SRLLVRPtSsETPSA
S1900 RLLVRPtSsETPSAA
S1901-p LLVRPtSsETPSAAE
T1903 VRPtSsETPSAAELV
S1911-p PSAAELVsAIEELVK
S1919-p AIEELVKsKMALEDR
S1945-p SSPSFNPsDNSLLSS
Y2058 HERRLHMYIVYCQNK
Y2075 SEHIVSEYIDTFFED
K2099-ub QLTDLLIkPVQRIMK
S2198-p FEQIVIFsEPLDKKK
S2208 LDKKKGFSMPGFLFK
S2255 TFVLHSSSPSVRQTW
S2282-p NFLNALTsPIEYQRN
Y2286 ALTsPIEYQRNHSGG
S2302 GSGSGGSSGGGGGSG
S2314-p GSGGSGAsSGGSSSH
S2327 SHGSGPSSCssGPSS
S2329-p GSGPSSCssGPSSsR
S2330-p SGPSSCssGPSSsRS
S2335-p CssGPSSsRSRPSRI
G2391 LALEASLGQPSRLPL
S2394 EASLGQPSRLPLSGD
S2420 PKMKVMESPRKAPGS
S2432 PGSTSGTSQDGNTKD
N2443 NTKDARGNLGsLPLG
S2446-p DARGNLGsLPLGKtR
T2452-p GsLPLGKtRPGAVsP
T2452-gl GsLPLGKtRPGAVsP
S2458-p KtRPGAVsPLNsPLs
S2462-p GAVsPLNsPLsTtFP
S2465-p sPLNsPLsTtFPsPF
T2467-p LNsPLsTtFPsPFGK
S2470-p PLsTtFPsPFGKEAF
S2481-p KEAFPPSsPLQKGGS
K2485 PPSsPLQKGGSFWSS
S2496-p FWSSIPAsPASRPSS
S2499 SIPAsPASRPSSFTF
S2512 TFPGDSDSLQRQTHR
T2517 SDSLQRQTHRHAAPS
T2527 HAAPSKDTDRMSTCS
S2535 DRMSTCSSASEQSVQ
S2540 CSSASEQSVQSTQSN
T2628 IMENPDGTLKkSTsW
K2631-ac NPDGTLKkSTsWHTA
S2634-p GTLKkSTsWHTALRL
K2643 HTALRLRKKSEKKDk
K2650-ac KKSEKKDkDGKRDGK
Y2662 DGKLENGYRKPREGL
S2674-p EGLSNKVsVKLLNPN
Y2684 LLNPNYIYDVPPEFV
A2797 TWKDNFDAFYSEVAE
Y2799 KDNFDAFYSEVAELG
  TRIO iso4  
S116 SYLACIPSEEVCKRG
K265 DEHSQLKKKVIKAPI
K281 DLDLEGQKLLQRIQS
S297 DSFPKKNSGSGNADL
S299 FPKKNSGSGNADLQN
T517 DKLQRPLTPGSSDSL
S520 QRPLTPGSSDSLTAS
T525 PGSSDSLTASANYSK
K681 VSFHTHVKELWTWLE
T724 QQTTLQVTVNVIKEG
K1131 LHYWTMRKRRLDQCQ
S1271 IPASIPGSEVKLRDA
S1459 DGLEVMLSVPKRAND
T1545 FTSELGVTEHVEGDP
T1562 FALWVGRTPTSDNKI
S1627 RDGEDLDSQGDGSSQ
S1633 DSQGDGSSQPDTISI
T1700 PDWCLVRTTDRSPAA
S1704 LVRTTDRSPAAEGLV
S1724 CIAHSRSSMEMEGIF
S1745 SVSSNDASPPASVAS
S1749 NDASPPASVASLQPH
S1752 SPPASVASLQPHMIG
T1778 NTLRKWLTSPVRRLS
S1779 TLRKWLTSPVRRLSS
S1785 TSPVRRLSSGKADGH
S1786 SPVRRLSSGKADGHA
K1808 KKSREVRKSADAGSQ
S1809 KSREVRKSADAGSQK
S1814 RKSADAGSQKDSDDS
S1818 DAGSQKDSDDSAATP
S1821 SQKDSDDSAATPQDE
T1824 DSDDSAATPQDETIE
S1840 RGRNEGLSSGTLSKS
T1843 NEGLSSGTLSKSSSS
S1847 SSGTLSKSSSSGMQS
S1854 SSSSGMQSCGEEEGE
T1899 SRLLVRPTSSETPSA
S1900 RLLVRPTSSETPSAA
S1901 LLVRPTSSETPSAAE
T1903 VRPTSSETPSAAELV
S1911 PSAAELVSAIEELVK
S1919 AIEELVKSKMALEDR
S1945 SSPSFNPSDNSLLSS
Y2058 HERRLHMYIVYCQNK
Y2075 SEHIVSEYIDTFFED
K2099 QLTDLLIKPVQRIMK
S2198 FEQIVIFSEPLDKKK
S2208 LDKKKGFSMPGFLFK
S2255 TFVLHSSSPSVRQTW
S2282 NFLNALTSPIEYQRN
Y2286 ALTSPIEYQRNHSGG
S2302 GSGSGGSSGGGGGSG
S2314 GSGGSGASSGGSSSH
S2327 SHGSGPSSCSSGPSS
S2329 GSGPSSCSSGPSSSR
S2330 SGPSSCSSGPSSSRS
S2335 CSSGPSSSRSRPSRI
G2391 LALEASLGQPSRLPL
S2394 EASLGQPSRLPLSGD
S2420 PKMKVMESPRKAPGS
S2432 PGSTSGTSQDGNTKD
N2443 NTKDARGNLGSLPLG
S2446 DARGNLGSLPLGKTR
T2452 GSLPLGKTRPGAVSP
T2452 GSLPLGKTRPGAVSP
S2458 KTRPGAVSPLNSPLS
S2462 GAVSPLNSPLSTTFP
S2465 SPLNSPLSTTFPSPF
T2467 LNSPLSTTFPSPFGK
S2470 PLSTTFPSPFGKEAF
S2481 KEAFPPSSPLQKGGS
K2485 PPSSPLQKGGSFWSS
S2496 FWSSIPASPASRPSS
S2499 SIPASPASRPSSFTF
S2512 TFPGDSDSLQRQTHR
T2517 SDSLQRQTHRHAAPS
T2527-p HAAPSKDtDRMSTCS
S2535-p DRMSTCSsASEQsVQ
S2540-p CSsASEQsVQSTQSN
T2629 IMENPDGTLKKSTSW
K2632 NPDGTLKKSTSWHTA
S2635 GTLKKSTSWHTALRL
K2644 HTALRLRKKSEKKDK
K2651 KKSEKKDKDGKRDGK
Y2663 DGKLENGYRKPREGL
S2675 EGLSNKVSVKLLNPN
Y2685 LLNPNYIYDVPPEFV
A2798 TWKDNFDAFYSEVAE
Y2800 KDNFDAFYSEVAELG
  rat

 
S116 SYLACIPSEEVCKRG
K265 DEHSQLKKKVIKAPI
K281 DLDLEGQKLLQRIQS
S297 ESFPKKNSGSGNADL
S299 FPKKNSGSGNADLQN
T517 DKLQRPLTPGSSDSL
S520 QRPLTPGSSDSLTAS
T525 PGSSDSLTASANYSK
K681 VSFHTHVKELWTWLE
T724 QQTTLQVTVNVIKEG
K1131 LHYWTMRKRRLDQCQ
S1271 IPASIPGSEVKLRDA
S1459 DGLEVMLSVPKRAND
T1545 FTSELGVTEHVEGDP
T1562 FALWVGRTPTSDNKI
S1627-p RDGEDLDsQGDGSsQ
S1633-p DsQGDGSsQPDTISI
T1700 PDWCLVRTTDRSPAA
S1704 LVRTTDRSPAAEGLV
S1724-p CIAHSRSsMEMEGIF
S1745 SVSSNDASPPASVAS
S1749 NDASPPASVASLQPH
S1752 SPPASVASLQPHMMG
T1778 NTLRKWLTSPVRRLS
S1779 TLRKWLTSPVRRLSS
S1785 TSPVRRLSSGKADGH
S1786 SPVRRLSSGKADGHA
K1808 KKSREVRKSADAGSQ
S1809 KSREVRKSADAGSQK
S1814 RKSADAGSQKDSDDS
S1818 DAGSQKDSDDSAAtP
S1821 SQKDSDDSAAtPQDE
T1824-p DSDDSAAtPQDETIE
S1840 RGRNEGLSSGTLSKS
T1843 NEGLSSGTLSKSSSS
S1847 SSGTLSKSSSSGMQS
S1854 SSSSGMQSCGEEEGE
T1899 SRLLVRPTSSETPSA
S1900 RLLVRPTSSETPSAA
S1901 LLVRPTSSETPSAAE
T1903 VRPTSSETPSAAELV
S1911 PSAAELVSAIEELVK
S1919 AIEELVKSKMALEDR
S1945 SSPSFNPSDNSLLSS
Y2059 HERRLHMYIVYCQNK
Y2076 SEHIVSEYIDTFFED
K2100 QLTDLLIKPVQRIMK
S2199 FEQIVIFSEPLDKKK
S2209 LDKKKGFSMPGFLFK
S2256 TFILHSSSPSVRQTW
S2283-p NFLNALTsPIEYQRN
Y2287 ALTsPIEYQRNHSGG
S2303 GSGSGGSSGGGGGSG
S2315 GSGGSGASSGGSSSH
S2328 SHGSGPSSCSSGPSS
S2330 GSGPSSCSSGPSSSR
S2331 SGPSSCSSGPSSSRS
S2336 CSSGPSSSRSRPSRI
G2392 LALEASLGQPSRLPL
S2395 EASLGQPSRLPLSGD
S2421 PKMKVMESPRKALGS
S2433 LGSTSGTSQDGNTKD
N2444 NTKDARGNLGPLPLG
P2447 DARGNLGPLPLGKTR
T2453 GPLPLGKTRPGAVsP
T2453 GPLPLGKTRPGAVsP
S2459-p KTRPGAVsPLNsPLS
S2463-p GAVsPLNsPLSTTFP
S2466 sPLNsPLSTTFPSPF
T2468 LNsPLSTTFPSPFGK
S2471 PLSTTFPSPFGKEAF
S2482 KEAFPPSSPLQKGGS
K2486 PPSSPLQKGGSFWSS
S2497 FWSSIPASPASRPSS
S2500 SIPASPASRPSSFTF
S2513 TFPGDSDSLQRQTHR
T2518 SDSLQRQTHRHAAPS
T2528 HAAPSKDTDRMSTCS
S2536 DRMSTCSSASEQSVQ
S2541 CSSASEQSVQSTQSN
T2630 IMENPDGTFKKSTSW
K2633 NPDGTFKKSTSWHTA
S2636 GTFKKSTSWHTALRL
K2645 HTALRLRKKSEKKDK
K2652 KKSEKKDKDGKRDGK
Y2664 DGKLENGYRKPREGL
S2676 EGLSNKVSVKLLNPN
Y2686-p LLNPNYIyDVPPEFV
A2799 TWKDNFDAFYSEVAE
Y2801 KDNFDAFYSEVAELG
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