Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Protein kinase, Ser/Thr (non-receptor); EC 18.104.22.168; Protein kinase, CAMK; Kinase, protein; GEFs; GEFs, misc.; CAMK group; Trio family
Cellular Component: cytosol
Molecular Function: protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity; protein binding; enzyme binding; guanyl-nucleotide exchange factor activity; ATP binding
Biological Process: axon guidance; regulation of small GTPase mediated signal transduction; regulation of GTPase activity; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine phosphatase signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.