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langerin (human)

Overview langerin Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. Homotrimer. Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. Note: This description may include information from UniProtKB. Protein type: Receptor, misc.; Membrane protein, integral Cellular Component: endocytic vesicle; early endosome membrane; plasma membrane; integral to membrane Molecular Function: mannose binding; carbohydrate binding Biological Process: antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; defense response to virus Reference #:  Q9UJ71 (UniProtKB) Alt. Names/Synonyms: C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; CD207; CD207 antigen, langerin; CD207 molecule, langerin; CLC4K; CLEC4K; Langerhans cell specific c-type lectin; Langerin Gene Symbols: CD207 Molecular weight: 36,725 Da Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below langerin 3BBS - A/D/C/B=197-325 (human) 3BC6 - A/D/C/B=197-325 (human) 3BC7 - A/D/C/B=197-325 (human) 3C22 - A/D/C/B=188-328 (human) 3KQG - F/A/D/C/E/B=147-328 (human) 3P5D - A/D/C/B=193-328 (human) 3P5E - A/D/C/B=193-328 (human) 3P5F - A/D/C/B=193-328 (human) 3P5G - A/D/C/B=193-328 (human) 3P5H - A/D/C/B=193-328 (human) 3P5I - A/D/C/B=193-328 (human) 3P7F - A/D/C/B=193-328 (human) 3P7G - A/D/C/B=193-328 (human) 3P7H - A/D/C/B=193-328 (human) 4AK8 - A/D/C/B=188-328 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3BBS 3BC6 3BC7 3C22 3KQG 3P5D 3P5E 3P5F 3P5G 3P5H 3P5I 3P7F 3P7G 3P7H 4AK8  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K75-a	MGTISDVkTNVQLLK
0	1		S196-p	NDILQVVsQGWKYFK

	mouse
K78-a	MGKILDVkSDAQMLK
A199	SDILEMVARGWKYFS

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