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Protein Page:
ATP13A2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ATP13A2 May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Transporter; Hydrolase; Membrane protein, integral; EC 3.6.3.-; Transporter, ion channel
Cellular Component: lysosomal membrane; lysosome; integral to membrane
Molecular Function: protein binding; metal ion binding; cation-transporting ATPase activity; ATP binding
Biological Process: cell death; ATP catabolic process; cation transport
Reference #:  Q9NQ11 (UniProtKB)
Alt. Names/Synonyms: AT132; ATP13A2; ATPase type 13A2; FLJ26510; HSA9947; KRPPD; PARK9; Probable cation-transporting ATPase 13A2; putative ATPase
Gene Symbols: ATP13A2
Molecular weight: 128,794 Da
Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ATP13A2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S38 SVSSVRLSGYCGSPW
0 1 Y40 SSVRLSGYCGSPWRV
0 1 S43 RLSGYCGSPWRVIGY
0 1 Y50 SPWRVIGYHVVVWMM
0 1 K68-ub PLLLFRWkPLWGVRL
0 1 K143-ub AVPEGAWkDTAQLHk
0 1 K150-ub kDTAQLHksEEAVSV
0 1 S151-p DTAQLHksEEAVSVG
0 1 Y165-p GQKRVLRyYLFQGQR
0 1 K213 LQDQMVRKAIYGPNV
0 1 G362 TALPEGLGPYCAETH
0 1 K506 LRINLGGKLQLVCFD
0 2 K693-ub RVVALASkPLPTVPS
0 1 K804-ub PTAVNGVkDPDQAAS
0 1 K839 IIVKHFPKLLPkVLV
0 1 K843-ub HFPKLLPkVLVQGTV
  mouse

 
S38-p SASSVRLsGyCGsPW
Y40-p SSVRLsGyCGsPWRA
S43-p RLsGyCGsPWRAIGy
Y50-p sPWRAIGyHAAVWML
K68 PWLLFRWKPLWGVRL
Q143 VTPEGTWQDTSELHR
R150 QDTSELHRQEEAKQV
Q151 DTSELHRQEEAKQVL
Y160 EAKQVLRYYVLQGQR
K208-ub LQDQATRkTIYGPNV
K357-ub TALPEGPkPYCPETH
K501-ub LRINLGGkLRLVCFD
K686-ub RVVALAGkPLPIAPS
K797 SAVMNGAKATGYPTV
K828-ub VLRKHFPkLLPKVLV
K832 HFPkLLPKVLVQATV
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