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ATP13A2 (human)

Overview ATP13A2 May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.6.3.-; Transporter; Membrane protein, integral; Hydrolase Cellular Component: lysosome; integral to membrane Molecular Function: metal ion binding; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; ATP binding Biological Process: cation transport Reference #:  Q9NQ11 (UniProtKB) Alt. Names/Synonyms: AT132; ATP13A2; ATPase type 13A2; FLJ26510; HSA9947; KRPPD; PARK9; Probable cation-transporting ATPase 13A2; putative ATPase Gene Symbols: ATP13A2 Molecular weight: 128,794 Da Basal Isoelectric point: 8.47  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ATP13A2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE 606693 610513  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S38	SVSSVRLSGYCGSPW
0	1		Y40	SSVRLSGYCGSPWRV
0	1		S43	RLSGYCGSPWRVIGY
0	1		Y50	SPWRVIGYHVVVWMM
0	1		K68-u	PLLLFRWkPLWGVRL
0	1		K143-u	AVPEGAWkDTAQLHk
0	1		K150-u	kDTAQLHkSEEAVSV
0	1		Y165-p	GQKRVLRyYLFQGQR
0	1		K213	LQDQMVRKAIYGPNV
0	1		G362	TALPEGLGPYCAETH
0	1		K506	LRINLGGKLQLVCFD
0	2		K693-u	RVVALASkPLPTVPS
0	1		K804-u	PTAVNGVkDPDQAAS
0	1		K839	IIVKHFPKLLPkVLV
0	1		K843-u	HFPKLLPkVLVQGTV

	mouse
S38-p	SASSVRLsGyCGsPW
Y40-p	SSVRLsGyCGsPWRA
S43-p	RLsGyCGsPWRAIGy
Y50-p	sPWRAIGyHAAVWML
K68	PWLLFRWKPLWGVRL
Q143	VTPEGTWQDTSELHR
R150	QDTSELHRQEEAKQV
Y160	EAKQVLRYYVLQGQR
K208-u	LQDQATRkTIYGPNV
K357-u	TALPEGPkPYCPETH
K501-u	LRINLGGkLRLVCFD
K686-u	RVVALAGkPLPIAPS
K797	SAVMNGAKATGYPTV
K828-u	VLRKHFPkLLPKVLV
K832	HFPkLLPKVLVQATV

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