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Protein Page:
PDPN (human)

PDPN May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Belongs to the podoplanin family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.21
Cellular Component: ruffle; filopodium membrane; integral to plasma membrane; lamellipodium; microvillus membrane; apical plasma membrane; plasma membrane; external side of plasma membrane; filopodium
Molecular Function: folic acid transporter activity; water transporter activity; water channel activity; amino acid transmembrane transporter activity
Biological Process: nervous system development; water transport; cell morphogenesis; positive regulation of cell motility; signal transduction; folic acid transport; prostaglandin metabolic process; regulation of cell shape; cell proliferation; cell-cell adhesion; response to hyperoxia; amino acid transport; lymphangiogenesis; inflammatory response; tube morphogenesis; alveolus development; lung development; positive regulation of cell migration
Reference #:  Q86YL7 (UniProtKB)
Alt. Names/Synonyms: Aggrus; Glycoprotein 36; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); OTS8; PA2.26; PA2.26 antigen; PDPN; Podoplanin; T1-alpha; T1A; T1A-2
Gene Symbols: PDPN
Molecular weight: 16,698 Da
Basal Isoelectric point: 4.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

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SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.



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