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PDPN
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Belongs to the podoplanin family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
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Cellular Component: ruffle; filopodium membrane; microvillus membrane; integral to plasma membrane; lamellipodium; apical plasma membrane; plasma membrane; filopodium
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Molecular Function: folic acid transporter activity; water transporter activity; water channel activity; amino acid transmembrane transporter activity
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Biological Process: nervous system development; water transport; cell morphogenesis; positive regulation of cell motility; signal transduction; cell cycle; folic acid transport; prostaglandin metabolic process; cell proliferation; regulation of cell shape; cell-cell adhesion; embryonic development; response to hyperoxia; amino acid transport; lymphangiogenesis; cell motility; inflammatory response; tube morphogenesis; alveolus development; positive regulation of cell migration; lung development
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Reference #:
Q86YL7 (UniProtKB)
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| Alt. Names/Synonyms: Aggrus; Glycoprotein 36; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); OTS8; PA2.26; PA2.26 antigen; PDPN; Podoplanin; T1-alpha; T1A; T1A-2 |
| Gene Symbols: PDPN |
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Molecular weight: 16,698 Da
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Basal Isoelectric point: 4.37
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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