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Protein Page:
MISR2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MISR2 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; EC 2.7.11.30; TKL group; STKR family; Type2 subfamily
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: integral to plasma membrane
Molecular Function: protein binding; transforming growth factor beta receptor activity, type II; hormone binding; metal ion binding; receptor activity; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: Mullerian duct regression; transforming growth factor beta receptor signaling pathway; signal transduction; sex differentiation; protein amino acid phosphorylation
Reference #:  Q16671 (UniProtKB)
Alt. Names/Synonyms: AMH type II receptor; AMHR; AMHR2; Anti-Muellerian hormone type II receptor; Anti-Muellerian hormone type-2 receptor; anti-Mullerian hormone receptor, type II; MIS type II receptor; MISR2; MISRII; MRII; Mullerian inhibiting substance type II receptor
Gene Symbols: AMHR2
Molecular weight: 62,750 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MISR2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S189-p VPEPRPDsGRDWSVE
0 1 K394 MAPELLDKTLDLQDW
0 1 T469 RRPYIPSTWRCFATD
0 1 T475 STWRCFATDPDGLRE
  mouse

 
S185 GSDPEPGSGGDCSEE
K390-ub MAPELLDkTLDLQDW
T465-p KRPNIPStWSCSAtD
T471-p StWSCSAtDPRGLRE
  rat

 
S187 DPEPEPGSGGDCSEE
K392 MAPELLDKTLDLQDW
S467 KRPNIPSSWSCSATD
T473 SSWSCSATDPRGLRE
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