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MISR2 (human)

Overview MISR2 On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; TKL group; STKR family; Type2 subfamily Cellular Component: integral to plasma membrane Molecular Function: hormone binding; transforming growth factor beta receptor activity, type II; metal ion binding; receptor activity; ATP binding Biological Process: Mullerian duct regression; transforming growth factor beta receptor signaling pathway; signal transduction; sex differentiation Reference #:  Q16671 (UniProtKB) Alt. Names/Synonyms: AMH type II receptor; AMHR; AMHR2; Anti-Muellerian hormone type II receptor; Anti-Muellerian hormone type-2 receptor; anti-Mullerian hormone receptor, type II; MIS type II receptor; MISR2; MISRII; MRII; Mullerian inhibiting substance type II receptor Gene Symbols: AMHR2 Molecular weight: 62,750 Da Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MISR2

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  DISEASE 261550 600956  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S189-p	VPEPRPDsGRDWSVE
0	1		K394	MAPELLDKTLDLQDW
0	1		T469	RRPYIPSTWRCFATD
0	1		T475	STWRCFATDPDGLRE

	mouse
S185	GSDPEPGSGGDCSEE
K390-u	MAPELLDkTLDLQDW
T465-p	KRPNIPStWSCSAtD
T471-p	StWSCSAtDPRGLRE

	rat
S187	DPEPEPGSGGDCSEE
K392	MAPELLDKTLDLQDW
S467	KRPNIPSSWSCSATD
T473	SSWSCSATDPRGLRE

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