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KSR (human)

Overview KSR a serine/threonine kinase of the Raf family with no demonstrated kinase activity. A location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. Interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. In unstimulated cells, the phosphorylated form is bound to a 14-3-3 protein and sequestered in the cytoplasm. Translocates from the cytoplasm to the cell periphery following TNF treatment. When Bad is available, ceramide signaling through the Ras/Raf cascade can lead to apoptosis. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; RAF family Cellular Component: endoplasmic reticulum membrane; intracellular Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; ATP binding; protein kinase activity Biological Process: Ras protein signal transduction; protein amino acid phosphorylation Reference #:  Q8IVT5 (UniProtKB) Alt. Names/Synonyms: kinase suppressor of ras; Kinase suppressor of Ras 1; KSR; KSR1; RSU2 Gene Symbols: KSR1 Molecular weight: 102,032 Da Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below KSR 1KBE - A=331-378 (mouse) 1KBF - A=331-378 (mouse) 2LPE - A=25-170 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		Y160-p	DECGRLQyALTCLRK
0	1		S182-p	HKEDSSWsSLDARRE
0	1		S227-p	AQGPRSIsVSALPAS
0	2		S236-p	SALPASDsPtPSFSE
0	1		T238-p	LPASDsPtPSFSEGL
0	2		T248-p	FSEGLSDtCIPLHAs
0	2		S255-p	tCIPLHAsGRLTPRA
0	4		S265-p	LTPRALHsFItPPtt
0	53		T268-p	RALHsFItPPttPQL
0	10		T271-p	HsFItPPttPQLRRH
3	34		T272-p	sFItPPttPQLRRHT
4	2		T286-p	TKLKPPRtPPPPsRK
0	3		S291-p	PRtPPPPsRKVFQLL
0	2		S307-p	SFPTLTRsKsHEsQL
2	11		S309-p	PTLTRsKsHEsQLGN
0	1		S312-p	TRsKsHEsQLGNRID
0	1		S329-p	SSMRFDLsHGsPQMV
1	7		S332-p	RFDLsHGsPQMVRRD
0	11		T402-p	PLTRLRRtEsVPsDI
5	68		S404-p	TRLRRtEsVPsDINN
0	2		S407-p	RRtEsVPsDINNPVD
0	10		T423-p	AAEPHFGtLPKALTK
1	0		S447	LDSSSNPSSTTSSTP
2	0		S456	TTSSTPSSPAPFPTS
0	1		T471-p	SNPSSATtPPNPsPG
1	1		S476-p	ATtPPNPsPGQRDSR
0	9		N485	GQRDSRFNFPAAYFI
0	1		S526	KENAFNISAFAHAAP
0	9		S567-p	EEPEAGKsEAEDDED
0	2		S595-p	GPISRKAsQtSVYLQ
0	2		T597-p	ISRKAsQtSVYLQEW
0	2		K654-a	DHLKLFKkEVMNYRQ
0	1		K707-a	KTSLDINkTRQIAQE
0	1		Y721-p	EIIKGMGyLHAKGIV
1	1		S886-p	PKLNRRLsHPGHFWK

	mouse
Q160	EECSRLQQALTCLRK
S182	HKMDSGWSSTDARDS
S215	TQGPRSISVSALPAS
S224	SALPASDSPVPGLSE
V226	LPASDSPVPGLSEGL
S236-p	LSEGLSDsCIPLHTS
S243	sCIPLHTSGRLTPRA
S253-p	LTPRALHsFItPPtt
T256-p	RALHsFItPPttPQL
T259-p	HsFItPPttPQLRRH
T260-p	sFItPPttPQLRRHA
T274-p	AKLKPPRtPPPPsRK
S279-p	PRtPPPPsRKVFQLL
S295-p	SFPTLTRsKsHESQL
S297-p	PTLTRsKsHESQLGN
S300	TRsKsHESQLGNRID
P317	TPMKFELPHGsPQLV
S320-p	KFELPHGsPQLVRRD
T390-p	PLARLRRtEsVPsDI
S392-p	ARLRRtEsVPsDINN
S395-p	RRtEsVPsDINNPVD
T411-p	AAEPHFGtLPKALTK
S434-p	LDSSSNPsSTTSSTP
S443-p	TTSSTPSsPAPFLTS
T458	SNPSSATTPPNPsPG
S463-p	ATTPPNPsPGQRDSR
S472-p	GQRDSRFsFPDIsAC
S477-p	RFsFPDIsACSQAAP
S518-p	EEPEAGKsEAEDDEE
S547	GPISRKASQTSVYLQ
T549	ISRKASQTSVYLQEW
K606	DHLKLFKKEVMNYRQ
K659	KTSLDINKTRQIAQE
Y673	EIIKGMGYLHAKGIV
S838	PKLNRRLSHPGHFWK

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