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Protein Page:
KSR (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
KSR a serine/threonine kinase of the Raf family with no demonstrated kinase activity. A location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. Interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. In unstimulated cells, the phosphorylated form is bound to a 14-3-3 protein and sequestered in the cytoplasm. Translocates from the cytoplasm to the cell periphery following TNF treatment. When Bad is available, ceramide signaling through the Ras/Raf cascade can lead to apoptosis. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; RAF family
Cellular Component: endoplasmic reticulum membrane
Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; ATP binding; protein kinase activity
Biological Process: Ras protein signal transduction
Reference #:  Q8IVT5 (UniProtKB)
Alt. Names/Synonyms: kinase suppressor of ras; Kinase suppressor of Ras 1; KSR; KSR1; RSU2
Gene Symbols: KSR1
Molecular weight: 102,032 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KSR

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y160-p DECGRLQyALTCLRK
0 1 S227-p AQGPRSIsVSALPAS
0 2 S236-p SALPASDsPtPSFSE
0 1 T238-p LPASDsPtPSFSEGL
0 2 T248-p FSEGLSDtCIPLHAs
0 2 S255-p tCIPLHAsGRLTPRA
0 4 S265-p LTPRALHsFItPPtt
0 55 T268-p RALHsFItPPttPQL
0 11 T271-p HsFItPPttPQLRRH
3 36 T272-p sFItPPttPQLRRHT
4 3 T286-p TKLKPPRtPPPPsRK
0 3 S291-p PRtPPPPsRKVFQLL
0 2 S307-p SFPTLTRsKsHEsQL
2 12 S309-p PTLTRsKsHEsQLGN
0 1 S312-p TRsKsHEsQLGNRID
0 1 S329-p SSMRFDLsHGsPQMV
1 10 S332-p RFDLsHGsPQMVRRD
0 1 S349-p LSVTHRFsTKSWLSQ
0 12 T402-p PLTRLRRtEsVPsDI
5 74 S404-p TRLRRtEsVPsDINN
0 2 S407-p RRtEsVPsDINNPVD
0 12 T423-p AAEPHFGtLPKALTK
1 0 S447 LDSSSNPSSTTSSTP
2 0 S456 TTSSTPSSPAPFPTS
1 1 S476-p ATTPPNPsPGQRDSR
0 9 N485 GQRDSRFNFPAAYFI
0 12 S567-p EEPEAGKsEAEDDED
0 2 S595-p GPISRKAsQtSVYLQ
1 2 T597-p ISRKAsQtSVYLQEW
1 0 S598 SRKAsQtSVYLQEWD
1 0 Y600 KAsQtSVYLQEWDIP
0 2 K654-a DHLKLFKkEVMNYRQ
1 0 Y776 LSHDWLCYLAPEIVR
0 1 T842-p EGMKRVLtSVSLGKE
1 1 S886-p PKLNRRLsHPGHFWK
4951 : Phospho-KSR1 (Ser392) Antibody
  mouse

 
Q160 EECSRLQQALTCLRK
S215 TQGPRSISVSALPAS
S224 SALPASDSPVPGLSE
V226 LPASDSPVPGLSEGL
S236-p LSEGLSDsCIPLHTS
S243 sCIPLHTSGRLTPRA
S253-p LTPRALHsFItPPtt
T256-p RALHsFItPPttPQL
T259-p HsFItPPttPQLRRH
T260-p sFItPPttPQLRRHA
T274-p AKLKPPRtPPPPsRK
S279-p PRtPPPPsRKVFQLL
S295-p SFPTLTRsKsHESQL
S297-p PTLTRsKsHESQLGN
S300 TRsKsHESQLGNRID
P317 TPMKFELPHGsPQLV
S320-p KFELPHGsPQLVRRD
S337 LSVTHRFSTKSWLSQ
T390-p PLARLRRtEsVPsDI
S392-p ARLRRtEsVPsDINN
S395-p RRtEsVPsDINNPVD
T411-p AAEPHFGtLPKALTK
S434-p LDSSSNPsSTTSSTP
S443-p TTSSTPSsPAPFLTS
S463-p ATTPPNPsPGQRDSR
S472-p GQRDSRFsFPDISAC
S518-p EEPEAGKsEAEDDEE
S547 GPISRKASQtsVyLQ
T549-p ISRKASQtsVyLQEW
S550-p SRKASQtsVyLQEWD
Y552-p KASQtsVyLQEWDIP
K606 DHLKLFKKEVMNYRQ
Y728-p LSHDWLCyLAPEIVR
A794 EGVRRVLASVSLGKE
S838 PKLNRRLSHPGHFWK
4951 : Phospho-KSR1 (Ser392) Antibody
  rat

 
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T38 PLARLRRTESVPSDI
S40 ARLRRTESVPSDINN
S43 RRTESVPSDINNPVD
T59 AAEPHFGTLPKALTK
S82 LDSSSNPSSTTSSTP
S91 TTSSTPSSPAPFLTS
S111 ATTPPNPSPGQRDSR
N120 GQRDSRFNFPDISAC
S166-p EEPEAGKsEAEDDED
S194 GPISRKASQTSVYLQ
T196 ISRKASQTSVYLQEW
S197 SRKASQTSVYLQEWD
Y199 KASQTSVYLQEWDIP
K253 DHLKLFKKEVMNYRQ
Y375 LSHDWLCYLAPEIVR
A441 EGVKRVLASVSLGKE
S485 PKLNRRLSHPGHFWK
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