Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SLC17A6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC17A6 Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. Note: This description may include information from UniProtKB.
Protein type: Transporter; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass
Cellular Component: neuron projection; synaptic vesicle membrane; integral to membrane; cell junction
Molecular Function: symporter activity; L-glutamate transmembrane transporter activity
Biological Process: L-glutamate transport; sodium ion transport; neurotransmitter uptake; ion transport; transmembrane transport
Reference #:  Q9P2U8 (UniProtKB)
Alt. Names/Synonyms: Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; differentiation-associated Na-dependent inorganic phosphate cotransporter; DNPI; SLC17A6; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; Solute carrier family 17 member 6; Vesicular glutamate transporter 2; VGLU2; VGLUT2
Gene Symbols: SLC17A6
Molecular weight: 64,392 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC17A6

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K22 GLKNFAGKSLGQIyR
0 1 S23 LKNFAGKSLGQIyRV
0 4 Y28-p GKSLGQIyRVLEKKQ
0 1 Y195 GLVEGVTYPACHGIW
0 1 Y281-p ITDEERRyIEESIGE
0 1 K298 NLLGAMEKFKTPWRK
0 1 S512 WADPEETSEEKCGFI
0 1 K561 WPSGWEKKEEFVQGE
0 1 S574 GEVQDSHSYKDRVDY
0 1 Y575 EVQDSHSYKDRVDYS
  mouse

 
K22-ub GIKNFAGksLGQIYR
S23-p IKNFAGksLGQIYRV
Y28 GksLGQIYRVLEKKQ
Y195-p GLVEGVTyPACHGIW
Y281 ITDEERRYIEESIGE
K298-ub NLLGAMEkFKTPWRK
S512-p WADPEETsEEKCGFI
K561-ub WPNGWEKkEEFVQEG
T574-p EGAQDAYtyKDRDDY
Y575-p GAQDAYtyKDRDDYS
  rat

 
K22 GIKNFAGKSLGQIYR
S23 IKNFAGKSLGQIYRV
Y28 GKSLGQIYRVLEKKQ
Y195 GLVEGVTYPACHGIW
Y281 ITDEERRYIEESIGE
K298 NLLGAMEKFKTPWRK
S512 WADPEETSEEKCGFI
K561 WPNGWEKKEEFVQES
S574 ESAQDAYSYKDRDDY
Y575 SAQDAYSYKDRDDYS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.