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IRAK4 (human)

Overview IRAK4 a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; TKL group; IRAK family Cellular Component: plasma membrane; endosome membrane; cytosol Molecular Function: protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; magnesium ion binding; ATP binding; protein kinase activity Biological Process: MyD88-dependent toll-like receptor signaling pathway; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; toll-like receptor signaling pathway; cytokine production; JNK cascade; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 4 signaling pathway; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway Reference #:  Q9NWZ3 (UniProtKB) Alt. Names/Synonyms: Interleukin-1 receptor-associated kinase 4; IPD1; IRAK-4; IRAK4; NY-REN-64; Q8TDF7; REN64; Renal carcinoma antigen NY-REN-64 Gene Symbols: IRAK4 Molecular weight: 51,530 Da Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states CST Pathways:  NF-kB Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IRAK4 2NRU - A/B/C/D=154-460 (human) 2NRY - A/B/C/D=154-460 (human) 2O8Y - A/B=163-460 (human) 2OIB - A/B/C/D=160-460 (human) 2OIC - A/B/C/D=160-460 (human) 2OID - A/B/C/D=160-460 (human) 3MOP - H/J/I/G=4-106 (human) 1WH4 - A=1-114 (mouse) 2A9I - A=1-113 (mouse) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP  |  ENZYME  |  Phospho3D  |  DISEASE 606883 607676 610799  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, induced: T342‑p, T345‑p, S346‑p protein conformation: T345‑p, S346‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K3-a	_____MNkPItPsTY
1	0		T6-p	__MNkPItPsTYVRC
1	0		S8-p	MNkPItPsTYVRCLN
0	1		K34-a	DPQEGWKkLAVAIKK
1	0		S114-p	KTANTLPsKEAITVQ
1	0		S150-p	QSYMPPDsssPENKS
1	0		S151-p	SYMPPDsssPENKSL
1	3		S152-p	YMPPDsssPENKSLE
1	0		T208-p	YKGYVNNttVAVKKL
1	0		T209-p	KGYVNNttVAVKKLA
0	1		S336-p	DFGLARAsEKFAQtV
2	2		T342-p	AsEKFAQtVMtsRIV
3	2		T345-p	KFAQtVMtsRIVGTT
3	3		S346-p	FAQtVMtsRIVGTTA
0	1		Y354-p	RIVGTTAyMAPEALR
0	1		Y430-p	STSVEAMySVASQCL

	mouse
K3	_____MNKPLTPSTY
T6	__MNKPLTPSTYIRN
S8	MNKPLTPSTYIRNLN
K34	DPQEGWKKLAVAIKK
P114	QTVKSLPPREAATVA
S150	HSCEPPDSSSPDNRS
S151	SCEPPDSSSPDNRSV
S152	CEPPDSSSPDNRSVE
T208	YKGCVNNTIVAVKKL
I209	KGCVNNTIVAVKKLG
S336	DFGLARASARLAQtV
T342-p	ASARLAQtVMtsRIV
T345-p	RLAQtVMtsRIVGTT
S346-p	LAQtVMtsRIVGTTA
Y354	RIVGTTAYMAPEALR
Y430	PASVEAMYSAASQCL

	rat
K3	_____MSKPLTPSTY
T6	__MSKPLTPSTYVRS
S8	MSKPLTPSTYVRSLN
K34	DPQEGWKKLAVAIKK
P114	QAVHSLPPREAATVA
S152	PSCELPDSSSPGHQS
S153	SCELPDSSSPGHQSV
S154	CELPDSSSPGHQSVE
T210	YKGCVNNTTVAVKKL
T211	KGCVNNTTVAVKKLG
S338	DFGLARASAKLAQTV
T344	ASAKLAQTVMTSRIV
T347	KLAQTVMTSRIVGTT
S348	LAQTVMTSRIVGTTA
Y356	RIVGTTAYMAPEALR
Y432	PASVEAMYSVASQCL

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