Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
IRAK4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRAK4 a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, TKL; TKL group; IRAK family
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: plasma membrane; endosome membrane; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; magnesium ion binding; ATP binding; protein kinase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; cytokine production; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor signaling pathway; innate immune response; JNK cascade; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  Q9NWZ3 (UniProtKB)
Alt. Names/Synonyms: Interleukin-1 receptor-associated kinase 4; IPD1; IRAK-4; IRAK4; NY-REN-64; Q8TDF7; REN64; Renal carcinoma antigen NY-REN-64
Gene Symbols: IRAK4
Molecular weight: 51,530 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRAK4

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
enzymatic activity, induced: T342‑p, T345‑p, S346‑p
protein conformation: T345‑p, S346‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K3-ac _____MNkPItPsTY
1 0 T6-p __MNkPItPsTYVRC
1 0 S8-p MNkPItPsTYVRCLN
0 1 K34-ac DPQEGWKkLAVAIKK
1 0 S114-p KTANTLPsKEAITVQ
1 0 S150-p QSYMPPDsssPENKs
1 0 S151-p SYMPPDsssPENKsL
1 4 S152-p YMPPDsssPENKsLE
0 1 S157-p sssPENKsLEVSDTR
1 0 T208-p YKGYVNNttVAVKKL
1 0 T209-p KGYVNNttVAVKKLA
0 1 S336-p DFGLARAsEKFAQtV
4 2 T342-p AsEKFAQtVMtsRIV
5 2 T345-p KFAQtVMtsRIVGTt
5 3 S346-p FAQtVMtsRIVGTtA
1 0 T352-p tsRIVGTtAyMAPEA
0 1 Y354-p RIVGTtAyMAPEALR
7652 : Phospho-IRAK4 (Thr345/Ser346) Antibody
11927 : Phospho-IRAK4 (Thr345/Ser346) (D6D7) Rabbit mAb
12914 : Phospho-IRAK4 (Thr345/Ser346) (D6D7) Rabbit mAb (PE Conjugate)
7652 : Phospho-IRAK4 (Thr345/Ser346) Antibody
11927 : Phospho-IRAK4 (Thr345/Ser346) (D6D7) Rabbit mAb
12914 : Phospho-IRAK4 (Thr345/Ser346) (D6D7) Rabbit mAb (PE Conjugate)
  mouse

 
K3 _____MNKPLTPSTY
T6 __MNKPLTPSTYIRN
S8 MNKPLTPSTYIRNLN
K34 DPQEGWKKLAVAIKK
P114 QTVKSLPPREAATVA
S150 HSCEPPDSSSPDNRS
S151 SCEPPDSSSPDNRSV
S152 CEPPDSSSPDNRSVE
S157 SSSPDNRSVESSDTR
T208 YKGCVNNTIVAVKKL
I209 KGCVNNTIVAVKKLG
S336 DFGLARASARLAQtV
T342-p ASARLAQtVMtsRIV
T345-p RLAQtVMtsRIVGTT
S346-p LAQtVMtsRIVGTTA
T352 tsRIVGTTAYMAPEA
Y354 RIVGTTAYMAPEALR
7652 : Phospho-IRAK4 (Thr345/Ser346) Antibody
11927 : Phospho-IRAK4 (Thr345/Ser346) (D6D7) Rabbit mAb
7652 : Phospho-IRAK4 (Thr345/Ser346) Antibody
11927 : Phospho-IRAK4 (Thr345/Ser346) (D6D7) Rabbit mAb
  rat

 
K3 _____MSKPLTPSTY
T6 __MSKPLTPSTYVRS
S8 MSKPLTPSTYVRSLN
K34 DPQEGWKKLAVAIKK
P114 QAVHSLPPREAATVA
S152 PSCELPDSSSPGHQS
S153 SCELPDSSSPGHQSV
S154 CELPDSSSPGHQSVE
S159 SSSPGHQSVEFSDTR
T210 YKGCVNNTTVAVKKL
T211 KGCVNNTTVAVKKLG
S338 DFGLARASAKLAQTV
T344 ASAKLAQTVMTSRIV
T347 KLAQTVMTSRIVGTT
S348 LAQTVMTSRIVGTTA
T354 TSRIVGTTAYMAPEA
Y356 RIVGTTAYMAPEALR
7652 : Phospho-IRAK4 (Thr345/Ser346) Antibody
11927 : Phospho-IRAK4 (Thr345/Ser346) (D6D7) Rabbit mAb
7652 : Phospho-IRAK4 (Thr345/Ser346) Antibody
11927 : Phospho-IRAK4 (Thr345/Ser346) (D6D7) Rabbit mAb
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.